Adenosine technetium-99m sestamibi (SPECT) for the early assessment of jeopardized myocardium after acute myocardial infarction.

Abstract:

:The purpose of this study was to evaluate the accuracy of adenosine Tc-99m sestamibi single photon emission computed tomography (SPECT) in the detection of jeopardized myocardium early after acute myocardial infarction. Coronary arteriography and myocardial scintigraphy were performed in 50 consecutive patients with an uncomplicated myocardial infarction. Myocardium was considered jeopardized if a significant infarct-related vessel stenosis (> 50% diameter stenosis) supplied an infarct area with residual viable tissue. Perfusion reversibility in the infarct region occurred in 25 patients (50%) and was almost solely observed in the presence of jeopardized myocardium. Non-reversible perfusion defects in the infarct region were found in patients without jeopardized myocardium. This subgroup consisted of either patients without significant vessel stenosis or patients without significant residual viability in the infarct region. Adenosine Tc-99m sestamibi SPECT had an accuracy of 88% for the detection of jeopardized myocardium. Side effects during adenosine infusion were frequently observed but well tolerated. These results suggest that adenosine Tc-99m sestamibi SPECT is an accurate non-invasive method for detecting jeopardized myocardium after acute myocardial infarction and may be a valuable non-invasive test for the early selection of patients at risk for future ischaemic events.

journal_name

Eur Heart J

journal_title

European heart journal

authors

Claeys MJ,Vrints CJ,Krug B,Bosmans JM,Blockx PP,Bossaert LL,Snoeck JP

doi

10.1093/oxfordjournals.eurheartj.a061074

subject

Has Abstract

pub_date

1995-09-01 00:00:00

pages

1186-94

issue

9

eissn

0195-668X

issn

1522-9645

journal_volume

16

pub_type

杂志文章
  • Use of transthoracic Doppler echocardiography combined with clinical and electrocardiographic data to predict acute pulmonary embolism.

    abstract::Transthoracic echocardiography and continuous wave Doppler were prospectively performed in 132 out-patients with suspicion of pulmonary embolism, and who had no previous history of severe cardiac or pulmonary disease. Bedside echocardiography determined diagnosis other than pulmonary embolism in 55 patients. Further s...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a014946

    authors: Nazeyrollas P,Metz D,Jolly D,Maillier B,Jennesseaux C,Maes D,Chabert JP,Chapoutot L,Elaerts J

    更新日期:1996-05-01 00:00:00

  • Excimer laser coronary angioplasty: experience with a prototype multifibre catheter in patients with stable angina pectoris.

    abstract::Percutaneous excimer laser coronary angioplasty (ELCA) was performed in a first group of 20 patients with stable angina pectoris caused by significant coronary stenosis, and long-term follow-up was evaluated. Prototype 4 to 5.5 French multifibre catheters with 18-20 quartz fibres of 100 microns diameter, concentricall...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a060172

    authors: Kochs M,Haerer W,Eggeling T,Hoeher M,Schmidt A,Hombach V

    更新日期:1992-03-01 00:00:00

  • Pulmonary vein isolation using an occluding cryoballoon for circumferential ablation: feasibility, complications, and short-term outcome.

    abstract:AIMS:To assess safety, feasibility and short term outcome of pulmonary vein (PV) isolation in paroxysmal atrial fibrillation (AF) with a cryoballoon. METHODS:We consecutively treated 57 patients with a double lumen 23 or 28 mm cryoballoon. The acute results, complications and follow-up over the first three months were...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehm227

    authors: Van Belle Y,Janse P,Rivero-Ayerza MJ,Thornton AS,Jessurun ER,Theuns D,Jordaens L

    更新日期:2007-09-01 00:00:00

  • A comparison of two methods to measure coronary flow reserve in the setting of coronary angioplasty: intracoronary blood flow velocity measurements with a Doppler catheter, and digital subtraction cineangiography.

    abstract::Intracoronary blood flow velocity measurements with a Doppler balloon catheter and the radiographic assessment of myocardial perfusion with contrast media, before and after the intracoronary administration of papaverine, have previously been used to investigate regional coronary flow reserve. In the present study we a...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a059557

    authors: Serruys PW,Zijlstra F,Laarman GJ,Reiber HH,Beatt K,Roelandt J

    更新日期:1989-08-01 00:00:00

  • Greater decreases in cholesterol levels among individuals with high cardiovascular risk than among the general population: the northern Sweden MONICA study 1994 to 2014.

    abstract:AIM:Decreasing cholesterol levels in Western populations is the main reason for decreasing mortality due to coronary heart disease. Our aim was to analyze trends in cholesterol levels in the population during a period of 20 years in relation to previous cardiovascular disease (CVD), other cardiovascular risk factors, a...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehw052

    authors: Eriksson M,Forslund AS,Jansson JH,Söderberg S,Wennberg M,Eliasson M

    更新日期:2016-07-01 00:00:00

  • Clopidogrel pre-treatment is associated with reduced in-hospital mortality in primary percutaneous coronary intervention for acute ST-elevation myocardial infarction.

    abstract::AIMS Pre-treatment with clopidogrel results in a reduction of ischaemic events in non-ST-elevation acute coronary syndromes. Data on upstream clopidogrel in the setting of primary percutaneous coronary intervention (PCI) are limited. The aim of this study was to investigate whether clopidogrel loading before arrival a...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究

    doi:10.1093/eurheartj/ehr360

    authors: Dörler J,Edlinger M,Alber HF,Altenberger J,Benzer W,Grimm G,Huber K,Pachinger O,Schuchlenz H,Siostrzonek P,Zenker G,Weidinger F,Austrian Acute PCI Investigators.

    更新日期:2011-12-01 00:00:00

  • Effect of alirocumab on major adverse cardiovascular events according to renal function in patients with a recent acute coronary syndrome: prespecified analysis from the ODYSSEY OUTCOMES randomized clinical trial.

    abstract:AIMS:Statins reduce cardiovascular risk in patients with acute coronary syndrome (ACS) and normal-to-moderately impaired renal function. It is not known whether proprotein convertase subtilisin-kexin type 9 (PCSK9) inhibitors provide similar benefit across a range of renal function. We determined whether effects of the...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehaa498

    authors: Tuñón J,Steg PG,Bhatt DL,Bittner VA,Díaz R,Goodman SG,Jukema JW,Kim YU,Li QH,Mueller C,Parkhomenko A,Pordy R,Sritara P,Szarek M,White HD,Zeiher AM,Schwartz GG,ODYSSEY OUTCOMES Investigators.

    更新日期:2020-11-07 00:00:00

  • Transthoracic echo/Doppler in the identification of patients with chronic non-valvular atrial fibrillation at risk for thromboembolic events.

    abstract:UNLABELLED:Left atrial spontaneous echo contrast, detected by transoesophageal echocardiography in patients with non-valvular atrial fibrillation reflects slow blood flow and is associated with an increased risk of cardio-embolism. The purpose of this study was to find echo/Doppler predictors of left atrial spontaneous...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a060428

    authors: Pop GA,Meeder HJ,Roelandt JR,van Oudenaarden W,Bulens C,Verweij W,Gijsbers C,van Domburg R,Koudstaal PJ

    更新日期:1994-11-01 00:00:00

  • Diagnostic performance of QT interval variables from 24-h electrocardiography in the long QT syndrome.

    abstract:AIMS:The long QT syndrome is mainly defined by QT interval prolongation (QTc > 0.44s). However, data obtained in genotyped patients showed that resting QTc measurement alone may be inaccurate for ascertaining the phenotype. The aim of this study was to evaluate the diagnostic performance of QT interval rate-dependence ...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1053/euhj.1997.0730

    authors: Neyroud N,Maison-Blanche P,Denjoy I,Chevret S,Donger C,Dausse E,Fayn J,Badilini F,Menhabi N,Schwartz K,Guicheney P,Coumel P

    更新日期:1998-01-01 00:00:00

  • Effects of ranolazine on exercise tolerance and HbA1c in patients with chronic angina and diabetes.

    abstract:AIMS:The anti-anginal efficacy and safety of ranolazine in diabetic and non-diabetic patients included in the Combination Assessment of Ranolazine In Stable Angina (CARISA) trial (JAMA 2004;291:309) were studied. Glycaemic control was also assessed in CARISA and its long-term open-label extension study. METHODS AND RE...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1093/eurheartj/ehi495

    authors: Timmis AD,Chaitman BR,Crager M

    更新日期:2006-01-01 00:00:00

  • Cardiac arrhythmia and ischaemic events after combination chemotherapy for testicular cancer.

    abstract::The aim of the present investigation was to evaluate the type and the incidence of cardiac arrhythmias and ischaemic events in patients suffering from testicular cancer and submitted to combination chemotherapy with cisplatin, bleomycin and vinblastine (PVB) or etoposide (PEB). Forty-seven patients took part in the st...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a060426

    authors: Villani F,Misrachi D,Galimberti M

    更新日期:1994-11-01 00:00:00

  • The European Study of Epidemiology and Treatment of Cardiac Inflammatory Disease (ESETCID).

    abstract::Diagnosis of myocarditis has improved with the application of new techniques such as immunohistochemistry, polymerase chain reaction, in situ hybridization and Southern blot in endomyocardial biopsies. Treatment of inflammatory heart disease is still difficult and not yet validated by a study with patient numbers suff...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1093/eurheartj/16.suppl_o.173

    authors: Maisch B,Hufnagel G,Schönian U,Hengstenberg C

    更新日期:1995-12-01 00:00:00

  • Therapeutic efficacy of cardiosphere-derived cells in a transgenic mouse model of non-ischaemic dilated cardiomyopathy.

    abstract:AIM:Cardiosphere-derived cells (CDCs) produce regenerative effects in the post-infarct setting. However, it is unclear whether CDCs are beneficial in non-ischaemic dilated cardiomyopathy (DCM). We tested the effects of CDC transplantation in mice with cardiac-specific Gαq overexpression, which predictably develop progr...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehu196

    authors: Aminzadeh MA,Tseliou E,Sun B,Cheng K,Malliaras K,Makkar RR,Marbán E

    更新日期:2015-03-21 00:00:00

  • Prevalence and significance of an abnormal exercise ECG in asymptomatic males. Outcome of thallium myocardial scintigraphy.

    abstract::During a 3-year period 2500 asymptomatic male aviators were screened routinely for coronary artery disease by maximal bicycle exercise testing. In 55 cases (2.1%) the exercise ECG was abnormal (40 subjects exhibited ST depression, 14 ventricular ectopic activity and in one subject both abnormalities were observed). Fu...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/12.7.766

    authors: Pedersen F,Sandøe E,Laerkeborg A

    更新日期:1991-07-01 00:00:00

  • Atherogenic risk reduction in patients with dyslipidaemia. comparison between bezafibrate and lovastatin.

    abstract:OBJECTIVE:To examine the atherogenic risk-reducing effect of bezafibrate and lovastatin. DESIGN, SETTING, PATIENTS, INTERVENTIONS:Double-blind, randomized clinical trial of male and female patients with moderate hypercholesterolaemia with or without hypertriglyceridaemia. Two months dietary treatment followed by 400 m...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1093/oxfordjournals.eurheartj.a060769

    authors: Sinzinger H,Pirich C,Kondor P,Etti H

    更新日期:1995-11-01 00:00:00

  • Reactivation of coagulation after stopping infusions of recombinant hirudin and unfractionated heparin in unstable angina and myocardial infarction without ST elevation: results of a randomized trial. OASIS Pilot Study Investigators. Organization to Asses

    abstract:AIMS:To compare effects of heparin and hirudin on biochemical markers of coagulation. METHODS AND RESULTS:Patients (n=395) with unstable angina or myocardial infarction without ST elevation were randomized to a 72-h infusion of one of three regimens: unfractionated heparin (bolus of 5000 IU followed by an infusion of ...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1053/euhj.1999.2005

    authors: Flather MD,Weitz JI,Yusuf S,Pogue J,Sussex B,Campeau J,Gill J,Schuld R,Joyner CD,Morris AL,Lai C,Théroux P,Marquis JF,Chan YK,Venkatesh G,Jessel A

    更新日期:2000-09-01 00:00:00

  • Elevation of asymmetric dimethylarginine in patients with unstable angina and recurrent cardiovascular events.

    abstract:AIMS:We investigated the role of asymmetric dimethylarginine (ADMA) for clinical outcome of patients with unstable angina. METHODS AND RESULTS:Forty-five patients with stable angina, 36 patients with unstable angina, and 40 healthy controls were included in this study. Coronary artery disease (CAD) patients were prosp...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehi287

    authors: Krempl TK,Maas R,Sydow K,Meinertz T,Böger RH,Kähler J

    更新日期:2005-09-01 00:00:00

  • Changes in sarcolemmal Ca entry and sarcoplasmic reticulum Ca content in ventricular myocytes from patients with end-stage heart failure following myocardial recovery after combined pharmacological and ventricular assist device therapy.

    abstract:AIMS:Support with left ventricular assist devices (LVAD) improves cardiac performance in patients with end-stage heart failure. In some cases this strategy, combined with pharmacological treatment, has led to a clinical improvement which remained after LVAD explant. This study defines changes in Ca handling at the cell...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1016/s0195-668x(03)00242-2

    authors: Terracciano CM,Harding SE,Adamson D,Koban M,Tansley P,Birks EJ,Barton PJ,Yacoub MH

    更新日期:2003-07-01 00:00:00

  • Oxygen therapy in acute coronary syndrome: are the benefits worth the risk?

    abstract::Oxygen supplementation is a standard treatment for all patients who present with acute coronary syndrome, regardless of oxygen saturation levels. Most of the data regarding the function of oxygen in myocardial infarction is based on a limited number of basic and clinical studies. We performed a systematic literature r...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/eht110

    authors: Shuvy M,Atar D,Gabriel Steg P,Halvorsen S,Jolly S,Yusuf S,Lotan C

    更新日期:2013-06-01 00:00:00

  • Indices of effectiveness of medical and surgical treatment in 40 cases of prosthetic valve endocarditis.

    abstract::Forty patients with prosthetic valve endocarditis (PVE) presenting during a 12-year period at a single hospital were studied. Twenty-six were male and 14 female and ages ranged from 19 to 67 years. During the first six post-operative months, most episodes were caused by staphylococci (38%) and Gram negative bacilli (2...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/5.suppl_c.133

    authors: Gayet JL,Etienne J,Malquarti V,Gruer LD,Didier B,Chuzel M,Champsaur G,Chassignolle J,Fleurette J,Delaye J

    更新日期:1984-10-01 00:00:00

  • Familial co-occurrence of congenital heart defects follows distinct patterns.

    abstract:Aims:Congenital heart defects (CHD) affect almost 1% of all live born children and the number of adults with CHD is increasing. In families where CHD has occurred previously, estimates of recurrence risk, and the type of recurring malformation are important for counselling and clinical decision-making, but the recurren...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究

    doi:10.1093/eurheartj/ehx314

    authors: Ellesøe SG,Workman CT,Bouvagnet P,Loffredo CA,McBride KL,Hinton RB,van Engelen K,Gertsen EC,Mulder BJM,Postma AV,Anderson RH,Hjortdal VE,Brunak S,Larsen LA

    更新日期:2018-03-21 00:00:00

  • Thrombolytic therapy in Europe: current status.

    abstract::Thrombolytic therapy is a practical, effective approach to the management of acute myocardial infarction that is widely used in Europe today. Early European trials demonstrated a clear reduction in mortality in patients who received thrombolytic therapy compared with those given conventional treatment. The findings of...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/17.suppl_e.21

    authors: Vahanian A

    更新日期:1996-09-01 00:00:00

  • Sudden death in the working population: a collaborative study in central Japan.

    abstract:AIM:Few epidemiological data are available describing the sudden death of persons in their prime. This study aims to elucidate when and how sudden death occurs among employees. METHODS:A total of 196775 employees from 10 workplaces in Central Japan were surveyed for non-traumatic sudden death during 1989-1995. Demogra...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1053/euhj.1998.1189

    authors: Kawamura T,Kondo H,Hirai M,Wakai K,Tamakoshi A,Terazawa T,Osugi S,Ohno M,Okamoto N,Tsuchida T,Ohno Y,Toyama J

    更新日期:1999-03-01 00:00:00

  • Plasma concentrations of platelet-specific proteins in young female acute myocardial infarction survivors and their age-matched female controls.

    abstract::The steady state plasma concentrations of the two platelet-specific proteins beta-thromboglobulin (BTG) and platelet factor 4 (PF4) were determined in two groups of females: 36 acute myocardial infarction (AMI) survivors, and 38 age-matched control subjects. For the AMI patients the mean BTG and PF4 values were 57 +/-...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a061465

    authors: Kutti J,Johansson S,Eriksson KA,Sigvaldason A,Vedin A,Wadenvik H,Wilhelmsson C

    更新日期:1983-05-01 00:00:00

  • Predictive value of high sensitivity C-reactive protein in patients with ST-elevation myocardial infarction treated with percutaneous coronary intervention.

    abstract:AIMS:To evaluate the predictive value of high sensitivity (hs) C-reactive protein levels on long-term survival in patients with ST-elevation myocardial infarction (STEMI) treated with primary PCI. METHODS AND RESULTS:We conducted a retrospective analysis of 758 STEMI patients (from January 2003 to December 2005), with...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehm338

    authors: Ortolani P,Marzocchi A,Marrozzini C,Palmerini T,Saia F,Taglieri N,Baldazzi F,Silenzi S,Bacchi-Reggiani ML,Guastaroba P,Grilli R,Branzi A

    更新日期:2008-05-01 00:00:00

  • Cardiac hypertrophy and function in asymptomatic acromegaly.

    abstract::Heart disease frequently occurs in advanced acromegaly. In order to investigate cardiac mass and function in acromegaly in the absence of obvious cardiac disease, we performed Doppler echocardiography in 15 asymptomatic acromegalic patients (six of them had systemic hypertension). The data were compared with those of ...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:

    authors: Morvan D,Komajda M,Grimaldi A,Turpin G,Grosgogeat Y

    更新日期:1991-06-01 00:00:00

  • Rate of telomere shortening and cardiovascular damage: a longitudinal study in the 1946 British Birth Cohort.

    abstract:AIM:Cross-sectional studies reported associations between short leucocyte telomere length (LTL) and measures of vascular and cardiac damage. However, the contribution of LTL dynamics to the age-related process of cardiovascular (CV) remodelling remains unknown. In this study, we explored whether the rate of LTL shorten...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehu226

    authors: Masi S,D'Aiuto F,Martin-Ruiz C,Kahn T,Wong A,Ghosh AK,Whincup P,Kuh D,Hughes A,von Zglinicki T,Hardy R,Deanfield JE,NSHD scientific and data collection teams.

    更新日期:2014-12-07 00:00:00

  • Sudden cardiac death in hypertrophic cardiomyopathy. Variability in phenotypic expression of beta-myosin heavy chain mutations.

    abstract:BACKGROUND:Recent identification of mutations in the beta-myosin heavy chain gene (MYH7), a major responsible gene for HCM, has provided the opportunity to characterize genotype-phenotype correlation in HCM families. In this study we analysed the phenotypic expression of two beta-myosin heavy chain (beta MHC) mutations...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a060920

    authors: Marian AJ,Mares A Jr,Kelly DP,Yu QT,Abchee AB,Hill R,Roberts R

    更新日期:1995-03-01 00:00:00

  • Myocardial reperfusion injury: looking beyond primary PCI.

    abstract::Coronary heart disease (CHD) is the leading cause of death and disability in Europe. For patients presenting with an acute ST-segment elevation myocardial infarction (STEMI), timely myocardial reperfusion using either thrombolytic therapy or primary percutaneous coronary intervention (PPCI) is the most effective thera...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/eht090

    authors: Fröhlich GM,Meier P,White SK,Yellon DM,Hausenloy DJ

    更新日期:2013-06-01 00:00:00

  • Predicting the risk of early atherosclerotic disease development in children after repair of aortic coarctation.

    abstract:AIMS:Increased cardiovascular morbidity is manifested a long time after the repair of aortic coarctation (CoA). By way of impaired flow-mediated vasodilation (FMD) and increased intima media thickness (IMT), surrogate parameters of atherosclerosis, cardiovascular risk factors (RFs) can be correlated with early vascular...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehi037

    authors: Meyer AA,Joharchi MS,Kundt G,Schuff-Werner P,Steinhoff G,Kienast W

    更新日期:2005-03-01 00:00:00