Therapeutic efficacy of cardiosphere-derived cells in a transgenic mouse model of non-ischaemic dilated cardiomyopathy.

abstract：AIMS:Atrial fibrillation (AF) is the most frequent arrhythmia in humans. Rare familial forms exist. Recent evidence indicates a genetic susceptibility to common forms of AF. The alpha-subunit of the myocardial I(Kr)-channel, encoded by the KCNH2 gene, is crucial to ventricular and atrial repolarization. Patients with m...

journal_title：European heart journal

authors： Sinner MF,Pfeufer A,Akyol M,Beckmann BM,Hinterseer M,Wacker A,Perz S,Sauter W,Illig T,Näbauer M,Schmitt C,Wichmann HE,Schömig A,Steinbeck G,Meitinger T,Kääb S

更新日期：2008-04-01 00:00:00

abstract：AIMS:Calmodulinopathies are rare life-threatening arrhythmia syndromes which affect mostly young individuals and are, caused by mutations in any of the three genes (CALM 1-3) that encode identical calmodulin proteins. We established the International Calmodulinopathy Registry (ICalmR) to understand the natural history,...

journal_title：European heart journal

authors： Crotti L,Spazzolini C,Tester DJ,Ghidoni A,Baruteau AE,Beckmann BM,Behr ER,Bennett JS,Bezzina CR,Bhuiyan ZA,Celiker A,Cerrone M,Dagradi F,De Ferrari GM,Etheridge SP,Fatah M,Garcia-Pavia P,Al-Ghamdi S,Hamilton RM,Al-H

更新日期：2019-09-14 00:00:00

abstract：:Congestive heart failure is the most common cause of death in young adults with thalassaemia major. In the present study we compared atrial natriuretic peptide levels (ANP) in 30 asymptomatic patients with thalassaemia major (aged 16.6 +/- 6.4 years), normal left ventricular diastolic cavity dimension and systolic fun...

journal_title：European heart journal

authors： Derchi G,Bellone P,Forni GL,Lupi G,Jappelli S,Randazzo M,Zino V,Vecchio C

更新日期：1992-10-01 00:00:00

abstract：:Several targets for heart failure therapy may be met through different mechanisms which are not necessarily associated. In the Australia/New Zealand Heart Failure Research Collaborative Group Study, patients with chronic stable heart failure of ischaemic aetiology on treatment including ACE inhibitors were randomized ...

journal_title：European heart journal

authors： Sharpe N,Doughty RN

更新日期：1998-02-01 00:00:00

abstract：BACKGROUND:Polymorphisms within renin angiotensin system genes have been investigated as risk factors for coronary artery disease in different populations with contradicting results. The aim of this study was to investigate the genotype distribution and the allele frequencies of ACE, AT1R and AGT gene polymorphisms as ...

journal_title：European heart journal

authors： Fatini C,Abbate R,Pepe G,Battaglini B,Gensini F,Ruggiano G,Gensini GF,Guazzelli R

更新日期：2000-04-01 00:00:00

abstract：:Chronic increases in haemodynamic load modify the expression of cardiac genes, leading to a new phenotype better adapted to the new functional demand. Several mechanisms such as the global activation of genes, the modulation of single genes and/or differential expression of multigene families may account for these mod...

journal_title：European heart journal

authors： Samuel JL,Dubus I,Contard F,Schwartz K,Rappaport L

更新日期：1990-11-01 00:00:00

abstract：:In recent years, stress echocardiography has gained broad acceptance as a non-invasive method for the diagnosis of coronary artery disease. Facing different protocols, dosages and instrumentation, official guidelines for the performance, standardization and quality control of stress echocardiograms are needed; however...

journal_title：European heart journal

authors： Ketteler T,Krahwinkel W,Gödke J,Wolfertz J,Scheuble L,Hoffmeister T,Gülker H

更新日期：1997-06-01 00:00:00

abstract：:Late potentials detected by the signal-averaged ECG (SAECG) identify post-infarction patients at risk from sustained ventricular tachycardia (VT) and sudden death. Hypertrophic cardiomyopathy (HCM) is also associated with increased risk of sudden death. In adults, episodes of non-sustained VT on ambulatory ECG monitor...

journal_title：European heart journal

authors： Kulakowski P,Counihan PJ,Camm AJ,McKenna WJ

更新日期：1993-07-01 00:00:00

abstract：UNLABELLED:Peripheral vessels provide a useful in vivo haemodynamic model allowing evaluation of local intravascular fluid dynamics. Velocity measurements using a 0.018 inch Doppler-tipped angioplasty guidewire, quantitative angiography and laboratory data were gathered from 45 patients with a total of 48 percutaneous ...

journal_title：European heart journal

authors： Wellnhofer E,Biamino G,Sauer HU,Trebeljahr A,Stalke J,Ragg C,Oswald H,Gotze S,Fleck E,Felix R

更新日期：1995-10-01 00:00:00

abstract：AIMS:Statins have modest adverse effects on glycaemic control. Alirocumab, a proprotein convertase subtilisin/kexin type 9 inhibitor, lowers low-density lipoprotein cholesterol. This study assessed the effects of alirocumab on new-onset diabetes and pre-diabetes incidence in individuals without diabetes at baseline. M...

journal_title：European heart journal

authors： Colhoun HM,Ginsberg HN,Robinson JG,Leiter LA,Müller-Wieland D,Henry RR,Cariou B,Baccara-Dinet MT,Pordy R,Merlet L,Eckel RH

更新日期：2016-10-14 00:00:00

abstract：:Aims Epidemiological studies reported two contrasting trends: on one hand, a significant improvement in the use of evidence-based treatments of patients discharged with a myocardial infarction (MI). On the other hand, the increasing number of elderly and co-morbid patients who are usually less treated. The aim of this...

journal_title：European heart journal

authors： Macchia A,Romero M,D'Ettorre A,Mariani J,Tognoni G

更新日期：2012-02-01 00:00:00

abstract：:In past decades, numerous experimental and clinical studies have improved our knowledge of the electrophysiological effects of sodium channel blockers, as well as of the mechanisms of arrhythmogenesis. However, the mechanisms of antiarrhythmic as well as potentially proarrhythmic drug action have been less well clarif...

journal_title：European heart journal

authors： Haverkamp W,Hindricks G,Fechtrup C,Borggrefe M,Breithardt G

更新日期：1991-12-01 00:00:00

abstract：:The prevalence and type of arrhythmias has been studied in a representative sample of 2000 Athenians, aged 18-81 years, who underwent exercise testing on a treadmill according to the Bruce protocol. It was found that 121 persons (mean age 55.7 +/- 14.9 years, 31% greater than 65 years), exhibited arrhythmias on the EC...

journal_title：European heart journal

authors： Diamantopoulos EJ,Anthopoulos L,Nanas S,Maliaras G,Chrisos D,Moulopoulos SD

更新日期：1987-08-01 00:00:00

abstract：:Clinical reports show that electrical stimulation of the spinal cord reduces symptoms of angina pectoris, but so far have not provided evidence on the mechanisms involved. The hypothesis for this study was that inhibition of spinothalamic tract transmission may account for this result. Extracellular potentials of 28 s...

journal_title：European heart journal

authors： Chandler MJ,Brennan TJ,Garrison DW,Kim KS,Schwartz PJ,Foreman RD

更新日期：1993-01-01 00:00:00

abstract：Aims:Optimal blood pressure for prevention of cardiovascular (CV) events in patients with Type 2 diabetes mellitus (T2DM) remains uncertain and there is concern for increased risk with low diastolic blood pressure (DBP). This study analysed the association between blood pressure and CV outcomes in high-risk patients wi...

journal_title：European heart journal

authors： Bergmark BA,Scirica BM,Steg PG,Fanola CL,Gurmu Y,Mosenzon O,Cahn A,Raz I,Bhatt DL,SAVOR-TIMI 53 Investigators.

更新日期：2018-06-21 00:00:00

abstract：AIMS:To quantify the prevalence of coronary artery calcification (CAC) in relation to cardiovascular risk factors in marathon runners, and to study its role for myocardial damage and coronary events. METHODS AND RESULTS:In 108 apparently healthy male marathon runners aged >or=50 years, with >or=5 marathon competitions...

journal_title：European heart journal

authors： Möhlenkamp S,Lehmann N,Breuckmann F,Bröcker-Preuss M,Nassenstein K,Halle M,Budde T,Mann K,Barkhausen J,Heusch G,Jöckel KH,Erbel R,Marathon Study Investigators.,Heinz Nixdorf Recall Study Investigators.

更新日期：2008-08-01 00:00:00

abstract：AIM:The present study aimed to assess the benefits of two-stent techniques for patients with DEFINITION criteria-defined complex coronary bifurcation lesions. METHODS AND RESULTS:In total, 653 patients with complex bifurcation lesions at 49 international centres were randomly assigned to undergo the systematic two-ste...

journal_title：European heart journal

authors： Zhang JJ,Ye F,Xu K,Kan J,Tao L,Santoso T,Munawar M,Tresukosol D,Li L,Sheiban I,Li F,Tian NL,Rodríguez AE,Paiboon C,Lavarra F,Lu S,Vichairuangthum K,Zeng H,Chen L,Zhang R,Ding S,Gao F,Jin Z,Hong L,Ma L,We

更新日期：2020-07-14 00:00:00

abstract：AIMS:To perform a retrospective analysis of subgroups of patients enrolled into the European Myocardial Infarct Amiodarone Trial (EMIAT) in order to identify patients who might benefit from prophylactic amiodarone treatment and patients in whom amiodarone might be harmful. METHODS:Baseline characteristics of the 1486 ...

journal_title：European heart journal

authors： Janse MJ,Malik M,Camm AJ,Julian DG,Frangin GA,Schwartz PJ

更新日期：1998-01-01 00:00:00

abstract：AIMS:In acute coronary syndromes (ACS), the optimal revascularization strategy for unprotected left main coronary disease (ULMCD) has been little studied. The objectives of the present study were to describe the practice of ULMCD revascularization in ACS patients and its evolution over an 8-year period, analyse the pro...

journal_title：European heart journal

authors： Montalescot G,Brieger D,Eagle KA,Anderson FA Jr,FitzGerald G,Lee MS,Steg PG,Avezum A,Goodman SG,Gore JM,GRACE Investigators.

更新日期：2009-10-01 00:00:00

abstract：:Forty patients with prosthetic valve endocarditis (PVE) presenting during a 12-year period at a single hospital were studied. Twenty-six were male and 14 female and ages ranged from 19 to 67 years. During the first six post-operative months, most episodes were caused by staphylococci (38%) and Gram negative bacilli (2...

journal_title：European heart journal

authors： Gayet JL,Etienne J,Malquarti V,Gruer LD,Didier B,Chuzel M,Champsaur G,Chassignolle J,Fleurette J,Delaye J

更新日期：1984-10-01 00:00:00

abstract：UNLABELLED:OBJECTIVE, DESIGN AND PATIENTS: Between August 1981 and July 1983, 5839 consecutive myocardial infarction patients were hospitalized in 13 coronary care units in Israel. The present study examines 10 year survival among 4037 consecutive patients with a first myocardial infarction with either Q or non-Q waves...

journal_title：European heart journal

authors： Behar S,Haim M,Hod H,Kornowski R,Reicher-Reiss H,Zion M,Kaplinsky E,Abinader E,Palant A,Kishon Y,Reisin L,Zahavi I,Goldbourt U

更新日期：1996-10-01 00:00:00

abstract：:Increased QT dispersion, which has been proposed as a marker of ventricular repolarization inhomogeneity, may predispose to ventricular arrhythmias. Data on QT dispersion in patients with congestive heart failure are scarce. In this study, conventional 12-lead ECGs were recorded in 135 consecutive patients with conges...

journal_title：European heart journal

authors： Fei L,Goldman JH,Prasad K,Keeling PJ,Reardon K,Camm AJ,McKenna WJ

更新日期：1996-02-01 00:00:00

abstract：AIM:To investigate fatalities from myocardial infarction at 28 days and one-year among patients aged 35-64 years in the Nordic and Lithuanian centres participating in the World Health Organization MONICA (Monitoring of Trends and Determinants of Cardiovascular Disease) Project. METHODS AND RESULTS:Altogether 9100 myoc...

journal_title：European heart journal

authors： Salomaa VV,Lundberg V,Agnarsson U,Radisauskas R,Kirchhoff M,Wilhelmsen L

更新日期：1997-01-01 00:00:00

abstract：:Intracoronary blood flow velocity measurements with a Doppler balloon catheter and the radiographic assessment of myocardial perfusion with contrast media, before and after the intracoronary administration of papaverine, have previously been used to investigate regional coronary flow reserve. In the present study we a...

journal_title：European heart journal

authors： Serruys PW,Zijlstra F,Laarman GJ,Reiber HH,Beatt K,Roelandt J

更新日期：1989-08-01 00:00:00

abstract：AIMS:We analysed the contemporary incidence, outcomes, and predictors of heart failure (HF) and/or left ventricular systolic dysfunction (LVSD) before discharge in patients with acute myocardial infarction (MI). The baseline presence of HF or LVSD, or its development during hospitalisation, increases short- and long-te...

journal_title：European heart journal

authors： Velazquez EJ,Francis GS,Armstrong PW,Aylward PE,Diaz R,O'Connor CM,White HD,Henis M,Rittenhouse LM,Kilaru R,van Gilst W,Ertl G,Maggioni AP,Spac J,Weaver WD,Rouleau JL,McMurray JJ,Pfeffer MA,Califf RM,VALIANT registr

更新日期：2004-11-01 00:00:00

abstract：:After single chamber atrial pacemaker implantation, serial electrophysiologic studies were performed noninvasively at intervals of 3 months over a total period of 3 years in 24 patients with symptomatic sinus node dysfunction. All patients underwent invasive electrophysiologic studies before pacemaker implantation and...

journal_title：European heart journal

authors： van Mechelen R,Segers A,Hagemeijer F

更新日期：1984-08-01 00:00:00

abstract：:Hypercholesterolaemia is an important risk factor for cardiovascular disease. Both total and LDL cholesterol levels are three-fold higher at the end of the first year of life and about four-fold higher in adulthood compared with the neonatal period. In the USA, only 25% of infants are exclusively breastfed and simple ...

journal_title：European heart journal

authors： Zubin Maslov P,Hill JA,Lüscher TF,Narula J

更新日期：2020-12-16 00:00:00

abstract：:To assess the systolic and diastolic dysfunction of the left ventricle (LV) in relation to age and the severity of impairment in Duchenne muscular dystrophy (DMD), we performed M-mode, two-dimensional and pulsed-wave Doppler echocardiography in 45 male subjects with DMD aged 8 to 25 years and in 40 age-matched healthy...

journal_title：European heart journal

authors： Takenaka A,Yokota M,Iwase M,Miyaguchi K,Hayashi H,Saito H

更新日期：1993-05-01 00:00:00

abstract：BACKGROUND:the prototype of a transoesophageal echocardiographic transducer with a rotatable cross-sectional scanning plane underwent initial evaluation. METHODS:the 5 MHz, phased array, 64 element transducer is incorporated into a 16 by 11 by 40 mm echoscope tip. The instrument also has pulsed wave and colour flow Do...

journal_title：European heart journal

authors： Flachskampf FA,Hoffmann R,Verlande M,Schneider W,Ameling W,Hanrath P

更新日期：1992-09-01 00:00:00

abstract：AIMS:Takotsubo syndrome (TTS) is typically provoked by negative stressors such as grief, anger, or fear leading to the popular term 'broken heart syndrome'. However, the role of positive emotions triggering TTS remains unclear. The aim of the present study was to analyse the prevalence and characteristics of patients w...

journal_title：European heart journal

authors： Ghadri JR,Sarcon A,Diekmann J,Bataiosu DR,Cammann VL,Jurisic S,Napp LC,Jaguszewski M,Scherff F,Brugger P,Jäncke L,Seifert B,Bax JJ,Ruschitzka F,Lüscher TF,Templin C,InterTAK Co-investigators:.

更新日期：2016-10-01 00:00:00