Modulation of sympathetic control by ACE inhibitors.

Abstract:

:ACE inhibitors may influence the actual concentrations of the peptides angiotensin I, angiotensin II and bradykinin. Since all three peptides are able to modulate catecholamine release, a change in noradrenaline and adrenaline release should be expected when angiotensin I converting enzyme (kininase II) is inhibited. Furthermore, converting enzyme inhibitors may also act indirectly on sympathetic membranes affecting, for instance, the reuptake mechanism of noradrenaline. It was shown that chronic ACE inhibition did not change biosynthesis, storage or release of catecholamines. However, the reuptake of noradrenaline was slightly but significantly diminished by ramipril. Whereas Ang I exerted no facilitating action on noradrenaline, bradykinin stimulated noradrenaline release dose-dependently, almost during converting enzyme inhibition. It is concluded that bradykinin may compensate for the lack of effect of converting enzyme inhibitors on catecholamine release.

journal_name

Eur Heart J

journal_title

European heart journal

authors

Dominiak P

subject

Has Abstract

pub_date

1993-11-01 00:00:00

pages

169-72

eissn

0195-668X

issn

1522-9645

journal_volume

14 Suppl I

pub_type

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    pub_type: 临床试验,杂志文章,随机对照试验

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    authors: Nussberger J,Fleck E,Bahrmann H,Delius W,Schultheiss HP,Brunner HR

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    doi:10.1093/eurheartj/ehp160

    authors: Jouven X,Schwartz PJ,Escolano S,Straczek C,Tafflet M,Desnos M,Empana JP,Ducimetière P

    更新日期:2009-07-01 00:00:00

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    doi:10.1093/eurheartj/ehi327

    authors: Claes N,Buntinx F,Vijgen J,Arnout J,Vermylen J,Fieuws S,Van Loon H

    更新日期:2005-10-01 00:00:00

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    abstract:AIMS:Determination of the influence of therapy with bisoprolol and nifedipine on the heart rate variability of patients from the Total Ischemic Burden Bisoprolol Study and examination of the prognostic value. METHODS AND RESULTS:Four hundred and twenty-two patients with stable angina were included. The heart rate vari...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

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    authors: Weber F,Schneider H,von Arnim T,Urbaszek W

    更新日期:1999-01-01 00:00:00