A smoker's paradox in patients hospitalized for heart failure: findings from OPTIMIZE-HF.

abstract：:AIMS Pre-treatment with clopidogrel results in a reduction of ischaemic events in non-ST-elevation acute coronary syndromes. Data on upstream clopidogrel in the setting of primary percutaneous coronary intervention (PCI) are limited. The aim of this study was to investigate whether clopidogrel loading before arrival a...

journal_title：European heart journal

authors： Dörler J,Edlinger M,Alber HF,Altenberger J,Benzer W,Grimm G,Huber K,Pachinger O,Schuchlenz H,Siostrzonek P,Zenker G,Weidinger F,Austrian Acute PCI Investigators.

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:There is much interest in reported associations between serum C-reactive protein and incident ischaemic heart disease. It is uncertain what this association represents. We aimed to assess the effect of confounding from a number of different sources in the Caerphilly Prospective Heart Disease Study and in par...

journal_title：European heart journal

authors： Mendall MA,Strachan DP,Butland BK,Ballam L,Morris J,Sweetnam PM,Elwood PC

更新日期：2000-10-01 00:00:00

abstract：AIMS:Short QT syndrome (SQTS) is a genetically determined ion-channel disorder, which may cause malignant tachyarrhythmias and sudden cardiac death. Thus far, mutations in five different genes encoding potassium and calcium channel subunits have been reported. We present, for the first time, a novel loss-of-function mu...

journal_title：European heart journal

authors： Templin C,Ghadri JR,Rougier JS,Baumer A,Kaplan V,Albesa M,Sticht H,Rauch A,Puleo C,Hu D,Barajas-Martinez H,Antzelevitch C,Lüscher TF,Abriel H,Duru F

更新日期：2011-05-01 00:00:00

abstract：:The optimal length of clopidogrel therapy in patients with acute coronary syndromes or in those who have undergone percutaneous coronary intervention (PCI) remains controversial. We therefore sought to determine the risk of both perioperative and premature discontinuation of clopidogrel. PubMed and EMBASE databases we...

journal_title：European heart journal

authors： Gaglia MA Jr,Waksman R

更新日期：2011-10-01 00:00:00

abstract：:The alterations of the beta-adrenoceptor adenylyl cyclase are reviewed. In failing myocardium, the down-regulation of beta 1-adrenoceptors is accompanied by a decrease in steady state mRNA levels, as studied with quantitative polymerase chain reactions in dilated and ischaemic cardiomyopathy. The density of beta 2-adr...

journal_title：European heart journal

authors： Böhm M,Lohse MJ

更新日期：1994-12-01 00:00:00

abstract：:The efficacy and safety of a single infusion of cibenzoline, a class I antiarrhythmic drug, were assessed in 86 patients presenting with a supraventricular tachyarrhythmia following heart surgery in a placebo-controlled double-blind parallel study. Cibenzoline was effective in 13 patients (30%) vs three patients (6.9%...

journal_title：European heart journal

authors： Ollitrault J,Quilliet L,Scheck F,Lelong B,Richard A,Jarry G,Guize L

更新日期：1994-09-01 00:00:00

abstract：AIMS:LV reverse remodelling has been shown to be a favourable response after cardiac resynchronization therapy (CRT) in many clinical trials. This study investigated whether left ventricular (LV) reverse remodelling after CRT has any structural benefit, which include the improvement of LV mass or regional wall thicknes...

journal_title：European heart journal

authors： Zhang Q,Fung JW,Auricchio A,Chan JY,Kum LC,Wu LW,Yu CM

更新日期：2006-06-01 00:00:00

abstract：:Chronic increases in haemodynamic load modify the expression of cardiac genes, leading to a new phenotype better adapted to the new functional demand. Several mechanisms such as the global activation of genes, the modulation of single genes and/or differential expression of multigene families may account for these mod...

journal_title：European heart journal

authors： Samuel JL,Dubus I,Contard F,Schwartz K,Rappaport L

更新日期：1990-11-01 00:00:00

abstract：AIMS:We sought to define the mechanisms and correlates of leptin's vascular actions in humans with coronary artery disease. METHODS AND RESULTS:In 131 patients (age 65.7+/-0.7 years mean+/-SEM), ex vivo vascular reactivity to leptin (10(-13)-10(-7) M) was assessed in saphenous vein (SV) rings. Leptin led to SV relaxat...

journal_title：European heart journal

authors： Momin AU,Melikian N,Shah AM,Grieve DJ,Wheatcroft SB,John L,El Gamel A,Desai JB,Nelson T,Driver C,Sherwood RA,Kearney MT

更新日期：2006-10-01 00:00:00

abstract：UNLABELLED:Left atrial spontaneous echo contrast, detected by transoesophageal echocardiography in patients with non-valvular atrial fibrillation reflects slow blood flow and is associated with an increased risk of cardio-embolism. The purpose of this study was to find echo/Doppler predictors of left atrial spontaneous...

journal_title：European heart journal

authors： Pop GA,Meeder HJ,Roelandt JR,van Oudenaarden W,Bulens C,Verweij W,Gijsbers C,van Domburg R,Koudstaal PJ

更新日期：1994-11-01 00:00:00

abstract：AIMS:The increasing number of adults with congenital heart disease (CHD) has prompted the development of recommendations for the management of these patients and for the organization of their healthcare. The aim of this report is to describe the delivery of care in Europe for adults with congenital cardiac anomalies. ...

journal_title：European heart journal

authors： Moons P,Engelfriet P,Kaemmerer H,Meijboom FJ,Oechslin E,Mulder BJ,Expert Committee of Euro Heart Survey on Adult Congenital Heart Disease.

更新日期：2006-06-01 00:00:00

abstract：AIMS:In mechanical heart valve recipients, low-dose international normalized ratio (INR) self-management of oral anticoagulants can reduce the risk of developing thrombo-embolic events and improve long-term survival compared with INR control by a general practitioner. Here, we present data on the safety of low-dose INR...

journal_title：European heart journal

authors： Koertke H,Zittermann A,Tenderich G,Wagner O,El-Arousy M,Krian A,Ennker J,Taborski U,Klövekorn WP,Moosdorf R,Saggau W,Koerfer R

更新日期：2007-10-01 00:00:00

abstract：AIMS:Myocarditis is a potentially fatal complication of immune checkpoint inhibitors (ICI). Sparse data exist on the use of cardiovascular magnetic resonance (CMR) in ICI-associated myocarditis. In this study, the CMR characteristics and the association between CMR features and cardiovascular events among patients with...

journal_title：European heart journal

authors： Zhang L,Awadalla M,Mahmood SS,Nohria A,Hassan MZO,Thuny F,Zlotoff DA,Murphy SP,Stone JR,Golden DLA,Alvi RM,Rokicki A,Jones-O'Connor M,Cohen JV,Heinzerling LM,Mulligan C,Armanious M,Barac A,Forrestal BJ,Sullivan RJ,

更新日期：2020-05-07 00:00:00

abstract：:The effects of fentanyl at a dose of 100 micrograms.kg-1 on cardiac automaticity, refractoriness and conduction have been studied in a model of heterotopic heart transplantation which combines a denervated heart (donor) and a non-denervated heart (recipient) in each of 20 dogs employed. Once the surgical procedure had...

journal_title：European heart journal

authors： Alvarez L,Escudero C,Carmona JA,Silva L,Castillo-Olivares JL

更新日期：1992-09-01 00:00:00

abstract：AIMS:The aim of this study was to compare on-thienopyridine platelet reactivity of elderly patients (≥75 years) vs. younger patients (<75 years). Elderly patients represent a growing and challenging segment of the coronary population for whom the effect of dual antiplatelet therapy on platelet inhibition has not been s...

journal_title：European heart journal

authors： Silvain J,Cayla G,Hulot JS,Finzi J,Kerneis M,O'Connor SA,Bellemain-Appaix A,Barthélémy O,Beygui F,Collet JP,Montalescot G

更新日期：2012-05-01 00:00:00

abstract：AIMS:Major guidelines recommend lowering systolic blood pressure (SBP) to <140 mmHg in all hypertensives, but evidence is missing whether this is beneficial in (i) uncomplicated hypertensives, (ii) grade 1 hypertensives, and (iii) elderly hypertensives. Providing this missing evidence is important to justify efforts an...

journal_title：European heart journal

authors： Zhang Y,Zhang X,Liu L,Zanchetti A,FEVER Study Group.

更新日期：2011-06-01 00:00:00

abstract：:Heart disease frequently occurs in advanced acromegaly. In order to investigate cardiac mass and function in acromegaly in the absence of obvious cardiac disease, we performed Doppler echocardiography in 15 asymptomatic acromegalic patients (six of them had systemic hypertension). The data were compared with those of ...

journal_title：European heart journal

authors： Morvan D,Komajda M,Grimaldi A,Turpin G,Grosgogeat Y

更新日期：1991-06-01 00:00:00

abstract：Aims:To appraise the clinical and genetic evidence that low-density lipoproteins (LDLs) cause atherosclerotic cardiovascular disease (ASCVD). Methods and results:We assessed whether the association between LDL and ASCVD fulfils the criteria for causality by evaluating the totality of evidence from genetic studies, pro...

journal_title：European heart journal

authors： Ference BA,Ginsberg HN,Graham I,Ray KK,Packard CJ,Bruckert E,Hegele RA,Krauss RM,Raal FJ,Schunkert H,Watts GF,Borén J,Fazio S,Horton JD,Masana L,Nicholls SJ,Nordestgaard BG,van de Sluis B,Taskinen MR,Tokgözoglu L,

更新日期：2017-08-21 00:00:00

abstract：:Myocardial relaxation is an energy-dependent process. Indeed, adenosine triphosphate (ATP) is required to pump free myoplasmic calcium back into the sarcoplasmic reticulum. It is also necessary to extrude the calcium ions which enter the cell during the plateau phase of the action potential. The calcium-sodium exchang...

journal_title：European heart journal

authors： Pouleur H

更新日期：1990-05-01 00:00:00

abstract：:The cytokine hypothesis presently suggests that an excessive production of pro-inflammatory cytokines, such as tumour necrosis factor alpha (TNF) and interleukin 6 (IL6), contributes to the pathogenesis of heart failure. The concept, successfully proved in genetically modified animal models, failed to translate to hum...

journal_title：European heart journal

authors： Lecour S,James RW

更新日期：2011-03-01 00:00:00

abstract：AIMS:To determine the diagnostic utility of circulating angiopoietin-1 (Ang-1) and its antagonist angiopoietin-2 (Ang-2) as potential biomarkers of disease severity or response to treatment in idiopathic pulmonary arterial hypertension (IPAH). Imbalances in angiogenic factors including vascular endothelial cell growth ...

journal_title：European heart journal

authors： Kümpers P,Nickel N,Lukasz A,Golpon H,Westerkamp V,Olsson KM,Jonigk D,Maegel L,Bockmeyer CL,David S,Hoeper MM

更新日期：2010-09-01 00:00:00

abstract：:Priorities for unanswered questions concerning major areas of cardiovascular disease are being sought by the British Cardiovascular Society, using the methods of the James Lind Alliance, which involves clinicians and patients in an equal partnership, reports Barry Shurlock PhD. ...

journal_title：European heart journal

authors：

更新日期：2015-06-01 00:00:00

abstract：:This case report describes the delayed improvement of left ventricular function by recanalization of an occluded coronary artery in a patient with intractable heart failure and three-vessel disease. The left anterior descending coronary artery was occluded distal to the first septal branch, the dominant right coronary...

journal_title：European heart journal

authors： Klein HH,Neuhaus KL

更新日期：1990-03-01 00:00:00

abstract：:In myocarditis an antigen-specific immune response to cardiac epitopes has been demonstrated by several investigators. In 25 patients with histologically proven myocarditis, autoantibodies to cardiac tissue were observed in 65% by immunofluorescence assay. By immunoblot analysis 46% of sera reacted with cardiac tissue...

journal_title：European heart journal

authors： Pankuweit S,Lottspeich F,Maisch B

更新日期：1995-12-01 00:00:00

abstract：:In a prospective trial in 124 patients with acute myocardial infarction, Holter and surface ECG recordings were obtained simultaneously and compared for their ability to assess thrombolysis-induced ST segment changes. Accuracy in predicting patency of the infarct-related artery was evaluated in both methods. Success o...

journal_title：European heart journal

authors： Zabel M,Hohnloser SH,Parussel A,Just H

更新日期：1992-12-01 00:00:00

abstract：:The L-arginine pathway within endothelial cells in the blood vessel wall is the source of production of the endogenous nitrovasodilator, nitric oxide (NO). NO is released under basal conditions and in response to various stimuli such as shear stress and in response to platelet-derived products, coagulation factors and...

journal_title：European heart journal

authors： Lüscher TF

更新日期：1991-11-01 00:00:00

abstract：:It is now recognised after many years of speculation regarding the role of mammalian atria in the direct regulation of intravascular volume, that atrial myocites produce a peptide hormone that results in natriuresis and diuresis, under the condition of atrial distention. This atrial natriuretic factor (ANF) is secrete...

journal_title：European heart journal

authors： Cody RJ,Atlas SA,Laragh JH

更新日期：1988-06-01 00:00:00

abstract：:In isolated atherosclerotic human coronary arteries endothelium-dependent vascular relaxation is abolished with acetylcholine whereas another EDRF-dependent vasodilator, substance P, still produces significant relaxation. To study further these in vitro findings, graded doses of acetylcholine and substance P, which pr...

journal_title：European heart journal

authors： Bossaller C,Hehlert-Friedrich C,Jost S,Rafflenbeul W,Lichtlen P

更新日期：1989-11-01 00:00:00

abstract：:During urgent cardiac catheterization total occlusion of a severe left main coronary artery stenosis occurred, leading to profound cardiogenic shock. The patient survived, after prompt left main coronary angioplasty was performed, followed by emergency coronary bypass surgery. ...

journal_title：European heart journal

authors： Groves PH,Ikram S,Hayward MW,Hall RJ

更新日期：1989-12-01 00:00:00

abstract：AIMS:In patients with sick sinus syndrome, bradycardia can be treated with a single-lead pacemaker or a dual-chamber pacemaker. Previous trials have revealed that pacing modes preserving atrio-ventricular synchrony are superior to single-lead ventricular pacing, but it remains unclear if there is any difference between...

journal_title：European heart journal

authors： Nielsen JC,Thomsen PE,Højberg S,Møller M,Vesterlund T,Dalsgaard D,Mortensen LS,Nielsen T,Asklund M,Friis EV,Christensen PD,Simonsen EH,Eriksen UH,Jensen GV,Svendsen JH,Toff WD,Healey JS,Andersen HR,DANPACE Investigato

更新日期：2011-03-01 00:00:00