Hypertrophic remodelling in cardiac regulatory myosin light chain (MYL2) founder mutation carriers.

abstract：AIMS:Thrombin plays a key role in the clinical syndrome of unstable angina. We investigated the safety and efficacy of five dose levels of efegatran sulphate, a direct thrombin inhibitor, compared to heparin in patients with unstable angina. METHODS:Four hundred and thirty-two patients with unstable angina were enroll...

journal_title：European heart journal

authors： Klootwijk P,Lenderink T,Meij S,Boersma H,Melkert R,Umans VA,Stibbe J,Müller EJ,Poortermans KJ,Deckers JW,Simoons ML

更新日期：1999-08-01 00:00:00

abstract：AIMS:Nuclear receptors and their cofactors regulate key pathophysiological processes in atherosclerosis development. The transcriptional activity of these nuclear receptors is controlled by the nuclear receptor corepressors (NCOR), scaffolding proteins that form the basis of large corepressor complexes. Studies with pr...

journal_title：European heart journal

authors： Oppi S,Nusser-Stein S,Blyszczuk P,Wang X,Jomard A,Marzolla V,Yang K,Velagapudi S,Ward LJ,Yuan XM,Geiger MA,Guillaumon AT,Othman A,Hornemann T,Rancic Z,Ryu D,Oosterveer MH,Osto E,Lüscher TF,Stein S

更新日期：2020-03-01 00:00:00

abstract：:Transesophageal echocardiographic evaluation of right and left pulmonary arteries, up to the origin of their lobar branches, was prospectively performed with a single plane probe in 32 consecutive patients (18 M, 14 F, aged 55.5 +/- 14.6, from 32 to 80 years) with clinical or echocardiographic suspicion of pulmonary e...

journal_title：European heart journal

authors： Pruszczyk P,Torbicki A,Kuch-Wocial A,Chlebus M,Miśkiewicz ZC,Jedrusik P

更新日期：1995-04-01 00:00:00

abstract：AIMS :Individuals with low socioeconomic status (SES) face widespread prejudice in society. Whether SES disparities exist in treatment and survival following in-hospital cardiac arrest (IHCA) is unclear. The aim of the current retrospective registry study was to examine SES disparities in IHCA treatment and survival, a...

journal_title：European heart journal

authors： Agerström J,Carlsson M,Bremer A,Herlitz J,Israelsson J,Årestedt K

更新日期：2020-12-21 00:00:00

abstract：:Isolated quadricuspid aortic valve is very rare. The identification of this malformation can be made by cross-sectional echocardiography. Two cases of quadricuspid aortic valve diagnosed by cross-sectional echocardiography are described. ...

journal_title：European heart journal

authors： Chamsi-Pasha H,Barnes PC,Beton DC

更新日期：1988-11-01 00:00:00

abstract：AIMS:To evaluate the efficacy of atrial pacing in the suppression of early reinitiation of atrial fibrillation after successful internal cardioversion. METHODS AND RESULTS:The efficacy of atrial pacing in suppressing early reinitiation of atrial fibrillation was studied in 12 of 45 (29%) patients with early reinitiati...

journal_title：European heart journal

authors： Tse HF,Lau CP,Ayers GM

更新日期：2000-07-01 00:00:00

abstract：AIMS:The aims of the GISSI Prognosis Registry were to describe the diagnostic strategies initiated in acute myocardial infarction patients by a representative sample of Italian cardiological centres, and to determine which clinical or hospital characteristics were associated with the initiation of invasive diagnostic o...

journal_title：European heart journal

authors： Maggioni AP,Tavazzi L,Fabbri G,Lucci D,Santoro E,Canonico A,Galli M,Achilli F,Tognoni G

更新日期：1998-12-01 00:00:00

abstract：:In a total of 339 patients with hypertrophic cardiomyopathies (typical HOCM, n = 224; atypical HOCM, n = 30; HNCM, n = 80) the clinical course, the Sokolow-Lyon index in the ECG and the prognosis as demonstrated by cumulative survival rates were analysed to get more differentiated information for the characterization ...

journal_title：European heart journal

authors： Loogen F,Kuhn H,Gietzen F,Lösse B,Schulte HD,Bircks W

更新日期：1983-11-01 00:00:00

abstract：:Clinical studies suggest that neutrophil activation during acute myocardial infarction (MI) aggravates tissue injury. Activated neutrophils are an important source of oxygen free radicals (OFR), the injurious effects of which are counteracted by endogenous antioxidants. We have previously shown in healthy subjects tha...

journal_title：European heart journal

authors： Herbaczyńska-Cedro K,K+osiewicz-Wasek B,Cedro K,Wasek W,Panczenko-Kresowska B,Wartanowicz M

更新日期：1995-08-01 00:00:00

abstract：:Re-entry was demonstrated as a self-perpetuating mechanism as early as 1906. It may lead to single-cycle electrocardiographic phenomena as well as reciprocating tachycardias. Factors favouring re-entry are as follows. Unidirectional or temporary local block of conduction, a mechanism always involved in initiation of r...

journal_title：European heart journal

authors： Olsson SB

更新日期：1984-09-01 00:00:00

abstract：:Myocardial bridging of the left anterior descending coronary artery producing complete systolic occlusion was demonstrated in a patient with hypertrophic cardiomyopathy, who had localized myocardial hypertrophy in the lateral left ventricular wall outside the territory of that artery. Although a cause and effect relat...

journal_title：European heart journal

authors： Doi YL,Yamada M,Hamashige N,Yonezawa Y,Odawara H,Ozawa T

更新日期：1987-07-01 00:00:00

abstract：AIMS:To investigate the association between neutrophil count, outcomes, and benefit of clopidogrel therapy in ST-elevation myocardial infarction (STEMI). METHODS AND RESULTS:Baseline neutrophil count was measured in 2865 patients in CLARITY-TIMI 28, a randomized trial of clopidogrel vs. placebo in STEMI patients under...

journal_title：European heart journal

authors： O'Donoghue M,Morrow DA,Cannon CP,Guo W,Murphy SA,Gibson CM,Sabatine MS

更新日期：2008-04-01 00:00:00

abstract：AIMS:To describe patient characteristics, pre-hospital delay, treatment, complications and outcome in patients with acute myocardial infarction admitted to hospitals in Germany. METHODS AND RESULTS:The study was of prospective observational multicentre design. Those involved were consecutive patients with acute Q-wave...

journal_title：European heart journal

authors： Rustige J,Schiele R,Burczyk U,Koch A,Gottwik M,Neuhaus KL,Tebbe U,Uebis R,Senges J

更新日期：1997-09-01 00:00:00

abstract：:Streptococcus adjacens and S. defectivus are two recently individualized species of viridans streptococci. Both species were previously designated as nutritionally variant streptococci and characterized by their growth as small satellite colonies supported by 'helper' bacteria, or requiring complex media enriched with...

journal_title：European heart journal

authors： Bouvet A

更新日期：1995-04-01 00:00:00

abstract：:The implementation of molecular biological approaches has led to the discovery of single genetic variations that contribute to the development of cardiac failure. In the present review, the characteristics that are invariably associated with the development of failure in experimental animals and clinical studies are d...

journal_title：European heart journal

authors： Lips DJ,deWindt LJ,van Kraaij DJ,Doevendans PA

更新日期：2003-05-01 00:00:00

abstract：:In this study, the acute haemodynamic effects of angiotensin converting enzyme (ACE) inhibition with intravenous enalaprilat alone or in combination with preload restoration were determined in patients with severe heart failure complicating acute myocardial infarction. Ten patients with raised pulmonary arterial wedge...

journal_title：European heart journal

authors： Tohmo H,Karanko M,Korpilahti K

更新日期：1994-04-01 00:00:00

abstract：:From a clinicopharmacological standpoint, the urinary excretory potency of diuretics should be assessed comparatively, on the basis of placebo-controlled changes in 24 h natriuresis, following single oral doses administered to healthy adult subjects who are in steady-state habitual external sodium balance. The potency...

journal_title：European heart journal

authors： Reyes AJ

更新日期：1992-12-01 00:00:00

abstract：:In the adult cardiac myocyte the functional and structural integrity of the sarcolemma depends on the presence of calcium ions in the extracellular fluid. Ultrastructural damage to the myocardial cell after Ca is repleted following brief periods of Ca depletion includes (1) sarcolemmal disruption, (2) mitochondrial da...

journal_title：European heart journal

authors： Frank JS

更新日期：1983-12-01 00:00:00

abstract：UNLABELLED:To study the ablation effects induced by excimer laser coronary angioplasty (ELCA), we examined 41 segments of nine isolated coronary arteries. An electronic intracoronary ultrasound device (ICUS: 20 MHz, 3.5F, Endosonics) was positioned coaxially within the vessel. Angioplasty was performed using a 1.7 mm E...

journal_title：European heart journal

authors： Schmid KM,Xie D,Voelker W,Oberhoff M,Wehrmann M,Baumbach A,Haase KK,Karsch KR

更新日期：1995-02-01 00:00:00

abstract：AIMS:This study assessed the relationship between inflammatory mediators and indices of infarct size and left-ventricular (LV) remodelling following successful primary percutaneous coronary intervention (PCI) in patients with first time ST elevation myocardial infarction (MI). METHODS AND RESULTS:Forty-two patients ad...

journal_title：European heart journal

authors： Ørn S,Manhenke C,Ueland T,Damås JK,Mollnes TE,Edvardsen T,Aukrust P,Dickstein K

更新日期：2009-05-01 00:00:00

abstract：AIMS:The management and outcomes of patients with functional moderate/severe mitral regurgitation and severe left ventricular (LV) systolic dysfunction are not well defined. We sought to determine the characteristics, management strategies, and outcomes of patients with moderate or severe mitral regurgitation (MR) and ...

journal_title：European heart journal

authors： Samad Z,Shaw LK,Phelan M,Ersboll M,Risum N,Al-Khalidi HR,Glower DD,Milano CA,Alexander JH,O'Connor CM,Wang A,Velazquez EJ

更新日期：2015-10-21 00:00:00

abstract：AIM:To study the relationship between outcomes and peak creatine kinase (CK)-MB levels after percutaneous coronary intervention (PCI) in patients with non-ST-segment elevation acute coronary syndromes (NSTE ACS). METHODS AND RESULTS:Peak CK-MB ratios (peak CK-MB level/upper limit of normal [ULN]) after PCI were analys...

journal_title：European heart journal

authors： Roe MT,Mahaffey KW,Kilaru R,Alexander JH,Akkerhuis KM,Simoons ML,Harrington RA,Tardiff BE,Granger CB,Ohman EM,Moliterno DJ,Lincoff AM,Armstrong PW,Van de Werf F,Califf RM,Topol EJ

更新日期：2004-02-01 00:00:00

abstract：:An inventory has been made of the practice of angioplasty in 14 European countries from 1985 onwards. The numbers of procedures performed varied in 1985 from 3 to 186 per million inhabitants, in 1991 from 52 to 716. All countries showed a steady increase, but the highest performer. Belgium, achieved only 55% of the nu...

journal_title：European heart journal

authors： van den Brand M

更新日期：1993-03-01 00:00:00

abstract：:Approximately 20% of patients undergoing diagnostic coronary arteriography for acute or chronic cardiac ischaemia have angiographically normal coronary arteries. The mechanism behind this phenomenon is likely to be the result of a combination of functional or anatomical abnormalities in the coronary microcirculation, ...

journal_title：European heart journal

authors： Chierchia SL,Fragasso G

更新日期：1996-12-01 00:00:00

abstract：:This overview provides a Europe-wide update on the current burden of cardiovascular disease, and specifically of coronary heart disease and stroke. Cardiovascular disease continues to cause a large proportion of deaths and disability in Europe, and places a substantial burden on the health care systems and economies o...

journal_title：European heart journal

authors： Nichols M,Townsend N,Scarborough P,Rayner M

更新日期：2013-10-01 00:00:00

abstract：:Aims To assess whether coronary flow velocity reserve following stent implantation is predictive of the subsequent need of target lesion revascularization. Methods and Results The outcome was examined of 417 patients enrolled in a multicentre prospective randomized study (DESTINI), who received a successful single ves...

journal_title：European heart journal

authors： Nishida T,Di Mario C,Kern MJ,Anderson TJ,Moussa I,Bonan R,Muramatsu T,Jain AC,Suarez de Lezo J,Cho SY,Meredith IT,Moses JW,Colombo A

更新日期：2002-02-01 00:00:00

abstract：AIMS:Calmodulinopathies are rare life-threatening arrhythmia syndromes which affect mostly young individuals and are, caused by mutations in any of the three genes (CALM 1-3) that encode identical calmodulin proteins. We established the International Calmodulinopathy Registry (ICalmR) to understand the natural history,...

journal_title：European heart journal

authors： Crotti L,Spazzolini C,Tester DJ,Ghidoni A,Baruteau AE,Beckmann BM,Behr ER,Bennett JS,Bezzina CR,Bhuiyan ZA,Celiker A,Cerrone M,Dagradi F,De Ferrari GM,Etheridge SP,Fatah M,Garcia-Pavia P,Al-Ghamdi S,Hamilton RM,Al-H

更新日期：2019-09-14 00:00:00

abstract：:The incidence of cardiogenic shock (CS) has increased remarkably over the past decade and remains a challenging condition with mortality rates of ∼50%. Cardiogenic shock encompasses cardiac contractile dysfunction; however, it is also a multiorgan dysfunction syndrome, often complicated by a systemic inflammatory resp...

journal_title：European heart journal

authors： Iborra-Egea O,Rueda F,García-García C,Borràs E,Sabidó E,Bayes-Genis A

更新日期：2020-10-14 00:00:00

abstract：:Forty-one consecutive children with the Wolff-Parkinson-White (1-15 years: mean 8 years), 22 symptomatic [including 20 with supraventricular tachycardia (SVT) and one with ventricular fibrillation (VF) episode--Group A) and 19 asymptomatic (Group B)], underwent transoesophageal electrophysiological examination. The me...

journal_title：European heart journal

authors： Vignati G,Mauri L,Lunati M,Gasparini M,Figini A

更新日期：1992-02-01 00:00:00

abstract：:Reverse cholesterol transport is a multi-step process resulting in the net movement of cholesterol from peripheral tissues back to the liver via the plasma compartment. Cellular cholesterol efflux is mediated by HDL, acting in conjunction with the cholesterol esterifying enzyme, lecithin: cholesterol acyltransferase. ...

journal_title：European heart journal

authors： Tall AR

更新日期：1998-02-01 00:00:00