Haemodynamic effects of high doses of insulin during acute left ventricular failure in dogs.

Abstract:

:Haemodynamic effects of pharmacological doses of insulin during acute ischaemic heart failure were studied in 8 dogs. Severe depression of left ventricular function was induced by the injection of 50 micron plastic microspheres into the left main coronary artery. This was demonstrated by a significant increase in left ventricular end-diastolic pressure and a significant decrease in the maximum rate of left ventricular pressure rise (LVdP/dtmax), stroke volume and cardiac output. Eighty-five minutes after the embolization procedure, 300 IU of insulin free of glucagon and calcium was injected as a bolus. This was followed by infusion of glucose and potassium to maintain physiological levels of these factors. Five minutes after insulin administration, there was a significant improvement in left ventricular performance as shown by decreased left ventricular end-diastolic pressure (P less than 0.01) and increased LVdP/dtmax (P less than 0.01), stroke volume (P less than 0.05) and cardiac output (P less than 0.05). A significant reduction in heart rate occurred. A non-significant increase in mean aortic blood pressure and reduction in total peripheral resistance were seen. In conclusion, pharmacological doses of insulin significantly improve cardiac pump function during acute ischaemic left ventricular failure in dogs.

journal_name

Eur Heart J

journal_title

European heart journal

authors

Reikerås O,Gunnes P,Sørlie D,Ekroth R,Jorde R,Mjøs OD

doi

10.1093/oxfordjournals.eurheartj.a061885

subject

Has Abstract

pub_date

1985-05-01 00:00:00

pages

451-7

issue

5

eissn

0195-668X

issn

1522-9645

journal_volume

6

pub_type

杂志文章
  • A common variant in CCDC93 protects against myocardial infarction and cardiovascular mortality by regulating endosomal trafficking of low-density lipoprotein receptor.

    abstract:AIMS:Genome-wide association studies have previously identified INSIG2 as a candidate gene for plasma low-density lipoprotein cholesterol (LDL-c). However, we suspect a role for CCDC93 in the same locus because of its involvement in the recycling of the LDL-receptor (LDLR). METHODS AND RESULTS:Characterization of the ...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehz727

    authors: Rimbert A,Dalila N,Wolters JC,Huijkman N,Smit M,Kloosterhuis N,Riemsma M,van der Veen Y,Singla A,van Dijk F,Biobank-Based Integrative Omics Studies Consortium.,Frikke-Schmidt R,Burstein E,Tybjærg-Hansen A,van de Sluis B,Kui

    更新日期:2020-03-01 00:00:00

  • Sustained benefit at 10-14 years follow-up after thrombolytic therapy in myocardial infarction.

    abstract:AIMS:To investigate whether the benefit of thrombolytic therapy was sustained beyond the first decade. We report the 10-14 year outcome of 533 patients who were randomized to treatment with intracoronary streptokinase or to conventional therapy during the years 1980-1985. METHODS AND RESULTS:Details of survival and ca...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1053/euhj.1998.1443

    authors: Maas AC,van Domburg RT,Deckers JW,Vermeer F,Remme WJ,Kamp O,Manger Cats V,Simoons ML

    更新日期:1999-06-01 00:00:00

  • Temporal trends of the gaps in post-myocardial infarction secondary prevention strategies of co-morbid and elderly populations vs. younger counterparts: an analysis of three successive cohorts between 2003 and 2008.

    abstract::Aims Epidemiological studies reported two contrasting trends: on one hand, a significant improvement in the use of evidence-based treatments of patients discharged with a myocardial infarction (MI). On the other hand, the increasing number of elderly and co-morbid patients who are usually less treated. The aim of this...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehr410

    authors: Macchia A,Romero M,D'Ettorre A,Mariani J,Tognoni G

    更新日期:2012-02-01 00:00:00

  • A practical risk score for early prediction of neurological outcome after out-of-hospital cardiac arrest: MIRACLE2.

    abstract:AIMS:The purpose of this study was to develop a practical risk score to predict poor neurological outcome after out-of-hospital cardiac arrest (OOHCA) for use on arrival to a Heart Attack Centre. METHODS AND RESULTS:From May 2012 to December 2017, 1055 patients had OOHCA in our region, of whom 373 patients were includ...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehaa570

    authors: Pareek N,Kordis P,Beckley-Hoelscher N,Pimenta D,Kocjancic ST,Jazbec A,Nevett J,Fothergill R,Kalra S,Lockie T,Shah AM,Byrne J,Noc M,MacCarthy P

    更新日期:2020-12-14 00:00:00

  • Outdoor light at night and risk of coronary heart disease among older adults: a prospective cohort study.

    abstract:AIMS:We estimated the association between outdoor light at night at the residence and risk of coronary heart disease (CHD) within a prospective cohort of older adults in Hong Kong. METHODS AND RESULTS:Over a median of 11 years of follow-up, we identified 3772 incident CHD hospitalizations and 1695 CHD deaths. Annual l...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehaa846

    authors: Sun S,Cao W,Ge Y,Ran J,Sun F,Zeng Q,Guo M,Huang J,Lee RS,Tian L,Wellenius GA

    更新日期:2020-11-17 00:00:00

  • Adenosine technetium-99m sestamibi (SPECT) for the early assessment of jeopardized myocardium after acute myocardial infarction.

    abstract::The purpose of this study was to evaluate the accuracy of adenosine Tc-99m sestamibi single photon emission computed tomography (SPECT) in the detection of jeopardized myocardium early after acute myocardial infarction. Coronary arteriography and myocardial scintigraphy were performed in 50 consecutive patients with a...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a061074

    authors: Claeys MJ,Vrints CJ,Krug B,Bosmans JM,Blockx PP,Bossaert LL,Snoeck JP

    更新日期:1995-09-01 00:00:00

  • The codex of science: honesty, precision, and truth--and its violations.

    abstract::Science has made enormous achievements for our understanding of the world and for everyday life: we now know that we live on a spherical planet of the solar system, we understand the origin of the species, we can take a train, survive myocardial infarction, and fly to the moon. This has been made possible thanks to a ...

    journal_title:European heart journal

    pub_type: 历史文章,杂志文章

    doi:10.1093/eurheartj/eht063

    authors: Lüscher TF

    更新日期:2013-04-01 00:00:00

  • Left atrial ball thrombus in combined mitral-aortic valve disease.

    abstract::This report describes a patient with left atrial ball thrombus which was detected during echocardiographic evaluation of combined mitral-aortic valve disease. Surgical correction was performed entirely on the basis of the echocardiographic diagnosis. ...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a060161

    authors: Schäfer RO,Evers G,Morgan P,Thiel H

    更新日期:1992-02-01 00:00:00

  • The imperative for metrics in training.

    abstract::A twenty-first century model for the training and assessment of cardiac interventionists’ skills, outlined by Prof. John Morgan FRCP FESC. ...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:

    authors: Morgan JM,Burri H,Binner L,Mansour H,Retzlaff H,Roca M,Gallagher A

    更新日期:2011-01-01 00:00:00

  • A double-blind dose-response study of amlodipine in patients with stable angina pectoris.

    abstract::Sixty patients (31 male, 29 female) were studied in a 4-week double-blind parallel dose-response study. Patients received amlodipine 1.25 mg (n = 12), 2.5 mg (n = 12), 5 mg (n = 12), 10 mg (n = 12) or placebo (n = 12) once a day. Anti-anginal efficacy was assessed by sequential treadmill testing 24 h post-dose, freque...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/oxfordjournals.eurheartj.a059864

    authors: Cocco G,Alfiero R

    更新日期:1991-02-01 00:00:00

  • Platelet and leukocyte activation after myocardial infarction. Influence of enalapril.

    abstract::In this double-blind placebo-controlled study with enalapril, 74 patients with acute myocardial infarction were followed at 0, 7, 30, 60 and 180 days after the event. Platelets and leukocytes were activated during the first 7 days. During the 6-month period fibrinogen, leukocytes, elastase, and B beta 30-43 remained e...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/oxfordjournals.eurheartj.a060831

    authors: Sylvén C,Hagerman I,Karlberg KE,Chen J,Wallin R,Eneroth P,Bergström K,Saldeen T

    更新日期:1995-12-01 00:00:00

  • Acute haemodynamic effects of the beta 1-adrenoceptor partial agonist xamoterol at rest and during supine exercise in patients with left ventricular dysfunction due to ischaemic heart disease: a double-blind randomized trial.

    abstract::The effects of xamoterol 0.2 mg kg-1 i.v. and placebo on left ventricular function at rest and on exercise were compared in patients with left ventricular dysfunction due to ischaemic heart disease. Improvements were seen in systolic and diastolic function at rest, and at up to 50% of maximal exercise, without evidenc...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/eurheartj/11.suppl_a.48

    authors: de Feyter PJ,Serruys PW

    更新日期:1990-04-01 00:00:00

  • Plasma concentrations of platelet-specific proteins and serum thromboxane B2 production in response to treatment with dipyridamole. A pilot study of 27 post-myocardial infarction patients.

    abstract::In the present study 27 post-myocardial infarction patients were treated with Persantin capsules (Depot-Kapseln, sustained release form), containing 200 mg dipyridamole, b.i.d. over a period of 3 weeks. Baseline levels for plasma beta-thromboglobulin (BTG), platelet factor 4 (PF4), and serum thromboxane B2 (TXB2) were...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a061891

    authors: Safai-Kutti S,Kutti J,Vedin A,Wilhelmsson C

    更新日期:1985-06-01 00:00:00

  • Nitric oxide for inhalation in ST-elevation myocardial infarction (NOMI): a multicentre, double-blind, randomized controlled trial.

    abstract:Aims:Inhalation of nitric oxide (iNO) during myocardial ischaemia and after reperfusion confers cardioprotection in preclinical studies via enhanced cyclic guanosine monophosphate (cGMP) signalling. We tested whether iNO reduces reperfusion injury in patients with ST-elevation myocardial infarction (STEMI; NCT01398384)...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1093/eurheartj/ehy232

    authors: Janssens SP,Bogaert J,Zalewski J,Toth A,Adriaenssens T,Belmans A,Bennett J,Claus P,Desmet W,Dubois C,Goetschalckx K,Sinnaeve P,Vandenberghe K,Vermeersch P,Lux A,Szelid Z,Durak M,Lech P,Zmudka K,Pokreisz P,Vranckx

    更新日期:2018-08-01 00:00:00

  • Temperature-controlled radiofrequency catheter ablation of manifest accessory pathways.

    abstract:OBJECTIVES:The primary objectives of this study were to assess the feasibility of temperature-controlled radiofrequency catheter ablation of left and right sided manifest accessory pathways in patients with Wolff-Parkinson-White syndrome and to gain more insights into biophysical aspects of temperature-controlled cathe...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a014878

    authors: Willems S,Chen X,Kottkamp H,Hindricks G,Haverkamp W,Rotman B,Shenasa M,Breithardt G,Borggrefe M

    更新日期:1996-03-01 00:00:00

  • Pre-hospital thrombolysis, is it useful?

    abstract::Thrombolytic treatment efficacy is greater when the delay between onset of pain and treatment is short. One way to shorten this delay is to give treatment at home, but one cannot recommend this technique if it has not been demonstrated first, that pre-hospital thrombolysis is feasible and safe, and second, that it is ...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1093/eurheartj/11.suppl_f.43

    authors: Castaigne AD,Hervé C,Duval-Moulin AM,Gaillard M,Dubois-Randé JL,Lellouche D

    更新日期:1990-08-01 00:00:00

  • The circadian pattern of the development of ventricular fibrillation in patients with Brugada syndrome.

    abstract:AIMS:Brugada syndrome is considered to be a distinctive subgroup of idiopathic ventricular fibrillation. Identification of the circadian pattern of ventricular fibrillation would contribute to the elucidation of its underlying pathophysiology, but this pattern remains unknown in patients with Brugada syndrome. METHODS...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1053/euhj.1998.1332

    authors: Matsuo K,Kurita T,Inagaki M,Kakishita M,Aihara N,Shimizu W,Taguchi A,Suyama K,Kamakura S,Shimomura K

    更新日期:1999-03-01 00:00:00

  • Clinical and economic impact of exercise electrocardiography and exercise echocardiography in clinical practice.

    abstract:BACKGROUND:Patients with known or suspected coronary disease are often investigated to facilitate risk assessment. We sought to examine the cost-effectiveness of strategies based on exercise echocardiography and exercise electrocardiography. METHODS AND RESULTS:We studied 7656 patients undergoing exercise testing; of ...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1016/s0195-668x(03)00113-1

    authors: Marwick TH,Shaw L,Case C,Vasey C,Thomas JD

    更新日期:2003-06-01 00:00:00

  • Cardiovascular disease in Europe: epidemiological update.

    abstract::This overview provides a Europe-wide update on the current burden of cardiovascular disease, and specifically of coronary heart disease and stroke. Cardiovascular disease continues to cause a large proportion of deaths and disability in Europe, and places a substantial burden on the health care systems and economies o...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/eht356

    authors: Nichols M,Townsend N,Scarborough P,Rayner M

    更新日期:2013-10-01 00:00:00

  • In-hospital mortality of patients with atrial arrhythmias: insights from the German-wide Helios hospital network of 161 502 patients and 34 025 arrhythmia-related procedures.

    abstract:Aims:Atrial fibrillation (AFib) and atrial flutter (AFlut) are common arrhythmias with increased use of invasive procedures. A steady re-evaluation of relevant safety endpoints is recommended and both quality management and pay-for-performance programs are evolving. Therefore, the aims of this study were (i) to investi...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究

    doi:10.1093/eurheartj/ehy528

    authors: König S,Ueberham L,Schuler E,Wiedemann M,Reithmann C,Seyfarth M,Sause A,Tebbenjohanns J,Schade A,Shin DI,Staudt A,Zacharzowsky U,Andrié R,Wetzel U,Neuser H,Wunderlich C,Kuhlen R,Tijssen JGP,Hindricks G,Bollmann A

    更新日期:2018-11-21 00:00:00

  • The effects of aetiology on outcome in patients treated with cardiac resynchronization therapy in the CARE-HF trial.

    abstract:AIMS:Cardiac dyssynchrony is common in patients with heart failure, whether or not they have ischaemic heart disease (IHD). The effect of the underlying cause of cardiac dysfunction on the response to cardiac resynchronization therapy (CRT) is unknown. This issue was addressed using data from the CARE-HF trial. METHOD...

    journal_title:European heart journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/eurheartj/ehn577

    authors: Wikstrom G,Blomström-Lundqvist C,Andren B,Lönnerholm S,Blomström P,Freemantle N,Remp T,Cleland JG,CARE-HF study investigators.

    更新日期:2009-04-01 00:00:00

  • Evidence for obesity paradox in patients with acute coronary syndromes: a report from the Swedish Coronary Angiography and Angioplasty Registry.

    abstract:AIMS:The obesity paradox refers to the epidemiological evidence that obesity compared with normal weight is associated with counter-intuitive improved health in a variety of disease conditions. The aim of this study was to investigate the relationship between body mass index (BMI) and mortality in patients with acute c...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehs217

    authors: Angerås O,Albertsson P,Karason K,Råmunddal T,Matejka G,James S,Lagerqvist B,Rosengren A,Omerovic E

    更新日期:2013-02-01 00:00:00

  • Implications of variability in definition and reporting of major bleeding in randomized trials of oral P2Y12 inhibitors for acute coronary syndromes.

    abstract:AIMS:Various definitions of major bleeding have been used to evaluate safety in randomized controlled trials of antiplatelet therapy. We compared the definitions and rates of major bleeding in phase III randomized controlled trials of oral P2Y(12) inhibitors in the management of patients with acute coronary syndromes (...

    journal_title:European heart journal

    pub_type: 杂志文章,meta分析,评审

    doi:10.1093/eurheartj/ehr143

    authors: Quinlan DJ,Eikelboom JW,Goodman SG,Welsh RC,Fitchett DH,Théroux P,Mehta SR

    更新日期:2011-09-01 00:00:00

  • Effect of breathing oxygen-enriched air on exercise performance in patients with precapillary pulmonary hypertension: randomized, sham-controlled cross-over trial.

    abstract:Aims:The purpose of the current trial was to test the hypothesis that breathing oxygen-enriched air increases exercise performance of patients with pulmonary arterial or chronic thrombo-embolic pulmonary hypertension (PAH/CTEPH) and to investigate involved mechanisms. Methods and results:Twenty-two patients with PAH/C...

    journal_title:European heart journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/eurheartj/ehx099

    authors: Ulrich S,Hasler ED,Saxer S,Furian M,Müller-Mottet S,Keusch S,Bloch KE

    更新日期:2017-04-14 00:00:00

  • In-hospital mortality of habitual cigarette smokers after acute myocardial infarction; the "smoker's paradox" in a countrywide study.

    abstract:AIMS:Habitual cigarette smokers, paradoxically, present improved short-term prognosis after acute myocardial infarction, a phenomenon often termed "smoker's paradox". We sought to examine cigarette smokers' post-infarction survival advantage in a countrywide survey of unselected, consecutive patients presenting with ac...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1053/euhj.2000.2315

    authors: Andrikopoulos GK,Richter DJ,Dilaveris PE,Pipilis A,Zaharoulis A,Gialafos JE,Toutouzas PK,Chimonas ET

    更新日期:2001-05-01 00:00:00

  • Myocardial map derived from two-dimensional echocardiography: reproducible and standardized description of infarction topographies.

    abstract::The aim of this study was to improve the reproducibility and the standardization of the topographical assessment of myocardial infarctions in routine two-dimensional echocardiography. A myocardial map of the left ventricle was derived from a necropsy study of normal human hearts; interventricular grooves and papillary...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a061399

    authors: Touche T,Vervin P,Prasquier R,Diebold B,Curien N,Gourgon R

    更新日期:1983-11-01 00:00:00

  • Transgenic short-QT syndrome 1 rabbits mimic the human disease phenotype with QT/action potential duration shortening in the atria and ventricles and increased ventricular tachycardia/ventricular fibrillation inducibility.

    abstract:AIMS:Short-QT syndrome 1 (SQT1) is an inherited channelopathy with accelerated repolarization due to gain-of-function in HERG/IKr. Patients develop atrial fibrillation, ventricular tachycardia (VT), and sudden cardiac death with pronounced inter-individual variability in phenotype. We generated and characterized transg...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehy761

    authors: Odening KE,Bodi I,Franke G,Rieke R,Ryan de Medeiros A,Perez-Feliz S,Fürniss H,Mettke L,Michaelides K,Lang CN,Steinfurt J,Pantulu ND,Ziupa D,Menza M,Zehender M,Bugger H,Peyronnet R,Behrends JC,Doleschall Z,Zur Hausen

    更新日期:2019-03-07 00:00:00

  • Adipose dysplasia of the right ventricle: is endomyocardial biopsy useful?

    abstract::Right ventricular dysplasia (RVD) is a cardiac anomaly characterized by replacement of right ventricular myocardium by adipose and fibrous tissue that was first described at autopsy, and is now being recognized pre-mortem. Sudden death and ventricular arrhythmias are the most common clinical manifestation of the condi...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/10.suppl_d.84

    authors: Strain J

    更新日期:1989-09-01 00:00:00

  • The diagnoses of patients admitted with acute chest pain but without myocardial infarction.

    abstract:OBJECTIVE:The purpose of this study was to describe the frequencies of various diagnoses in patients admitted with acute chest pain, but without acute myocardial infarction, and to evaluate a non-invasive screening programme for these patients. PATIENTS:A total of 204 consecutive non-acute myocardial infarction patien...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a014998

    authors: Fruergaard P,Launbjerg J,Hesse B,Jørgensen F,Petri A,Eiken P,Aggestrup S,Elsborg L,Mellemgaard K

    更新日期:1996-07-01 00:00:00

  • Prognostic value of left ventricular volume response during dobutamine stress echocardiography.

    abstract:AIMS:An abnormal left ventricular volume response during dobutamine echocardiography identified patients with severe coronary artery disease. The aim of the study was to assess the prognostic value of left ventricular volume changes during dobutamine stress echocardiography in 136 patients. METHODS AND RESULTS:Endpoin...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a015139

    authors: Coletta C,Galati A,Ricci R,Sestili A,Guagnozzi G,Re F,Ceci V

    更新日期:1997-10-01 00:00:00