Abstract:
AIMS:Brugada syndrome is considered to be a distinctive subgroup of idiopathic ventricular fibrillation. Identification of the circadian pattern of ventricular fibrillation would contribute to the elucidation of its underlying pathophysiology, but this pattern remains unknown in patients with Brugada syndrome. METHODS:and Results A total of 12 consecutive Brugada syndrome patients (46+/-14 years, all male) who underwent implantation of an implantable cardioverter defibrillator were studied. The distribution of the time of ventricular fibrillation detection was examined and classified into four 6-hour time periods of the day. The mean follow-up period following implantation was 777+/-535 days. In six out of the 12 patients, ventricular fibrillation occurred during follow-up. The data logs revealed that ventricular fibrillation was detected 30 times (range, 3-9). Ventricular fibrillation was observed more frequently at night ( 1800 h to 0600 h) than in the day (0600 h to 1800 h) (93.3% [28/30] vs 6.7%[2/30], P<0.001), and during sleep than while awake (86.7% [26/30] vs 13.3%[4/30], P<0.001). Ventricular fibrillation occurred most frequently between midnight and 0600 h in patients with ventricular fibrillation episodes during sleep (76.9% [20/26] vs 23.1%[6/26], P<0.01). CONCLUSION:These results suggest that increased nocturnal vagal activity and withdrawal sympathetic activity may play an important role in the arrhythmogenesis of the Brugada syndrome.
journal_name
Eur Heart Jjournal_title
European heart journalauthors
Matsuo K,Kurita T,Inagaki M,Kakishita M,Aihara N,Shimizu W,Taguchi A,Suyama K,Kamakura S,Shimomura Kdoi
10.1053/euhj.1998.1332subject
Has Abstractpub_date
1999-03-01 00:00:00pages
465-70issue
6eissn
0195-668Xissn
1522-9645pii
S0195668X9891332Xjournal_volume
20pub_type
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更新日期:2000-11-01 00:00:00
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更新日期:2011-06-01 00:00:00
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更新日期:2000-03-01 00:00:00
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更新日期:2001-06-01 00:00:00
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