Accuracy and reproducibility of biplane two-dimensional echocardiographic measurements of left ventricular dimensions and function.

Abstract:

OBJECTIVE:To investigate sources of variability in serial echocardiographic recordings in a core laboratory we assessed the impact of repeated echo recordings, repeated video measurements and measurements made by different investigators. PATIENTS, METHODS:Two investigators each recorded and analysed two-dimensional echos in 12 individuals (n = 24 in total) three times at one week intervals. Left ventricular end-diastolic and end-systolic volumes were measured using the biplane modified Simpson's rule. Ejection fraction was derived from these volumes and left ventricular mass estimated using the area-length method. The left ventricular spherity index was expressed as the ratio of the short axis area and the long axis area at end-diastole. A video recording from each examination was reexamined twice by both investigators. RESULTS:Deviations between repeated echo recordings and repeated video measurements ranged from -5 to +5% between investigators. A three-way repeated analysis of variance indicated a small, but systematic difference between investigators. Reproducibility, measured by coefficients of variation, ranged from 3-9% for different investigators, 3-6% for repeated video measurements and 7-19% for repeated echo recordings across the different variables. The total variability of all three factors should be considered when the smallest detectable significant change in a variable is assessed. These ranged from 16-28% across the five variables studied, when a 10% error of classification was accepted for a one-sided change in a variable. CONCLUSION:Repeated echo recordings were the dominant component of variation. Two-dimensional echo measurements are reproducible and accurate, but the same investigator should follow the same patients.

journal_name

Eur Heart J

journal_title

European heart journal

authors

Otterstad JE,Froeland G,St John Sutton M,Holme I

doi

10.1093/oxfordjournals.eurheartj.a015273

subject

Has Abstract

pub_date

1997-03-01 00:00:00

pages

507-13

issue

3

eissn

0195-668X

issn

1522-9645

journal_volume

18

pub_type

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