解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:Alzheimer disease (AD) is one of the most frequent neurodegenerative disorders that results in the progressive loss of memory and severe impairments and death. The experimental results showed that the neuroinflammation involving microglia and cytokines, especially the neuritic plaques composed of aggregates ...
journal_title:Clinical laboratory
pub_type: 杂志文章
doi:10.7754/Clin.Lab.2020.200252
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND:Tuberculosis and Human Immunodeficiency Virus (HIV) have been closely linked since the emergence of Acquired Immunodeficiency Syndrome (AIDS). Several studies have suggested an increased incidence of asthma among HIV positive individuals. This study aimed to determine the prevalence of Mycobacterium tubercul...
journal_title:Clinical laboratory
pub_type: 杂志文章
doi:10.7754/Clin.Lab.2020.200458
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND:The changes in the electrolyte profiles in patients with diabetic ketoacidosis (DKA) have rarely been reported. This study reports the abnormalities in the electrolyte profile, such as serum potassium, sodium, chloride, calcium, magnesium, and phosphorus. METHODS:Forty individuals in each of the DKA, diabet...
journal_title:Clinical laboratory
pub_type: 杂志文章
doi:10.7754/Clin.Lab.2020.200309
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND:For HLA genotyping, PCR sequence-specific oligonucleotide (SSO) methods using the Luminex platform are widely used. We evaluated the performance of LabType-SSO (One Lambda, USA) in Koreans. METHODS:LabType-SSO were performed on 50 residual DNA samples analyzed by sequence-based typing (SBT) for all HLA-A, -...
journal_title:Clinical laboratory
pub_type: 杂志文章
doi:10.7754/Clin.Lab.2020.190930
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND:Within the past two decades, the incidence of thyroid cancer has increased across the globe. In the differential diagnosis of benign tumors from malignant tumors in the thyroid gland, hypermethylation of the RASSF1A gene is used. The aim of this study is comparing the validity of quantitative and qualitative...
journal_title:Clinical laboratory
pub_type: 杂志文章
doi:10.7754/Clin.Lab.2020.200307
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:Glucose is an important material in human metabolism. The establishment of glucose reference measurement procedures and to study the uncertainties of measurement is of great significance. Linear fitting and dilution of reference material were used in the measurement of glucose concentration and they are comm...
journal_title:Clinical laboratory
pub_type: 杂志文章
doi:10.7754/Clin.Lab.2020.200326
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:Methicillin-resistant Staphylococcus aureus (MRSA) is a type of Staphylococcus aureus strain which is resistant to a group of beta-lactam antibiotics. Methicillin-resistance is due to a penicillin-binding protein, which has a low affinity for beta-lactam antibiotics. Excess and inappropriate use of clindamyc...
journal_title:Clinical laboratory
pub_type: 杂志文章
doi:10.7754/Clin.Lab.2020.200225
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND:Tuberculosis is one of the main infectious diseases threatening human health, especially in HIV co-infected patients. Xpert® MTB/RIF assay amplifies the rpoB gene of MTB was recommended by the World Health Organization as the initial diagnostic test in cases of suspected infections with Mycobacterium tubercu...
journal_title:Clinical laboratory
pub_type:
doi:10.7754/Clin.Lab.2020.200409
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND:We explored the dynamic expression of platelet-derived growth factor-D (PDGF-D) and phosphorylated platelet-derived growth factor receptor-β (p-PDGFR-β) after traumatic brain injury in rats to provide theoretical basis for selecting therapeutic target and intervention time after traumatic brain injury. METH...
journal_title:Clinical laboratory
pub_type: 杂志文章
doi:10.7754/Clin.Lab.2020.200328
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND:On January 30, 2020, WHO declared COVID-19 a pandemic. In this article we describe our experience at Richmond University Medical Center with Chembio serological IgM, IgG testing. METHODS:In this prospective cohort study of patients and hospital employees, we utilized Chembio COVID-19 IgM/IgG serological tes...
journal_title:Clinical laboratory
pub_type: 杂志文章
doi:10.7754/Clin.Lab.2020.200850
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND:Accumulating research suggests that hematopoiesis and bone metabolism are interconnected. Several studies have investigated the partial indexes of peripheral blood counts related to bone mineral density (BMD). The aim of this study was to investigate the associations between all of the parameters, especially...
journal_title:Clinical laboratory
pub_type: 杂志文章
doi:10.7754/Clin.Lab.2020.191238
更新日期:2020-10-01 00:00:00
abstract::Hereditary xanthinuria was the first inherited purine metabolism disorder described. It is a rare pathology, which is most often asymptomatic and whose incidence is therefore underestimated. We report the case of a patient with an undetectable level of uric acid in the blood, discovered during a systematic biological ...
journal_title:Clinical laboratory
pub_type:
doi:10.7754/Clin.Lab.2020.200253
更新日期:2020-10-01 00:00:00
abstract:BACKGROUND:The measurement of glycemic control among patients with diabetes mellitus is important for predicting the risk of diabetic complications. Glycated hemoglobin (HbA1c) measurements have been used for long-term glycemic control in clinical practice. However, glycated albumin (GA) or glycated serum protein (GSP)...
journal_title:Clinical laboratory
pub_type: 杂志文章
doi:10.7754/Clin.Lab.2020.200213
更新日期:2020-10-01 00:00:00
abstract:BACKGROUND:This study aimed to evaluate delta check limits set by reference change value (RCV) and patient data. METHODS:Patient data of 11 clinical chemistry analytes from June 2018 to May 2019 were collected. RCV with 95% or 99% levels of probability were calculated based on biological variation. The corresponding d...
journal_title:Clinical laboratory
pub_type: 杂志文章
doi:10.7754/Clin.Lab.2020.191252
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:The role of creatine (Cr) and creatine kinase (CK) in sperm function remains unclear. The study aimed to assess Cr and CK in seminal plasma and test their association with sperm characteristics. METHODS:The study included 62 males with couple's infertility and 26 males who have already fathered children. Se...
journal_title:Clinical laboratory
pub_type: 杂志文章
doi:10.7754/Clin.Lab.2020.191248
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:The aim of the study is to investigate lncRNA STARD13-AS's expression and clinical characteristics in the cancer tissues of gastric cancer (GC) patients. METHODS:Microarray assessment will be used to analyze GC and non-tumor tissues. The lncRNA STARD13-AS expression in 82 GC and non-tumor tissues were measu...
journal_title:Clinical laboratory
pub_type: 杂志文章
doi:10.7754/Clin.Lab.2020.191261
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:Early detection of hepatocellular carcinoma is very important in the treatment which is feasible. Alpha-fetoprotein plus ultrasound in surveillance programs is controversial. GP73 is a protein. Golgi increase significantly in the sera of patients with hepatitis B virus and HCV-related HCC, providing a marker...
journal_title:Clinical laboratory
pub_type: 杂志文章
doi:10.7754/Clin.Lab.2020.190911
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND:Cell population data (CPD) are leukocyte morphologic parameters, measured by automated hematology analyzers with VCS technology. Many studies have demonstrated that these parameters may have clinical utility for diagnosing or screening certain pathological conditions. This study is to investigate the effects...
journal_title:Clinical laboratory
pub_type: 杂志文章
doi:10.7754/Clin.Lab.2020.191135
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND:Anemia is a frequent disorder worldwide. Iron deficiency anemia (IDA) is the most common form of anemia. Although oral iron is the first choice for treatment, the efficacy of oral iron preparations may be limited. Ferric carboxymaltose (FCM) is a novel parenteral iron preparation which can rapidly replenish ...
journal_title:Clinical laboratory
pub_type: 杂志文章
doi:10.7754/Clin.Lab.2020.191030
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND:High red cell distribution width (RDW) is correlated with poor prognosis in acute coronary syndromes (ACS), including ST-segment elevation myocardial infarction (STEMI). However, the association of red cell distribution width to erythrocyte count ratio (RER) with STEMI undergoing percutaneous coronary interv...
journal_title:Clinical laboratory
pub_type: 杂志文章
doi:10.7754/Clin.Lab.2019.191123
更新日期:2020-07-01 00:00:00
abstract:BACKGROUND:To explore the clinical value of secondary screening using noninvasive prenatal testing (NIPT) for women with critical-risk and low-risk pregnancies who had multiple of the median (MoM) abnormalities in serological screening. METHODS:NIPT was used to analyze fetal free DNA in the peripheral blood of 2,325 w...
journal_title:Clinical laboratory
pub_type: 杂志文章
doi:10.7754/Clin.Lab.2020.191212
更新日期:2020-07-01 00:00:00
abstract:BACKGROUND:Atypical lymphocytes (AL), or reactive lymphocyte, exist in peripheral blood when stimulated by viral infection, drugs, inflammatory signals or allergens. Studies have shown that specific changes in peripheral blood (PB) analysis can predict morphological changes in blood cells. The objective of this study w...
journal_title:Clinical laboratory
pub_type: 杂志文章
doi:10.7754/Clin.Lab.2019.191113
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND:The objective of this study is to investigate the correlation of mean platelet volume (MPV), MPV/ platelet count, and monocyte to lymphocyte ratio (MLR) between cervical cancer patients and healthy people and to evaluate the value of those parameters in early diagnosis of cervical cancer. METHODS:The study ...
journal_title:Clinical laboratory
pub_type: 杂志文章
doi:10.7754/Clin.Lab.2019.190902
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND:The aim of the study is to determine the effects of blood lead levels (BLLs) on spontaneous abortion. METHODS:A well-matched case-control study was performed at Peking Union Medical College Hospital from 2016 - 2018. Spontaneous abortion cases requiring suction and curettage within 12 weeks gestational age ...
journal_title:Clinical laboratory
pub_type: 杂志文章
doi:10.7754/Clin.Lab.2019.190940
更新日期:2020-05-01 00:00:00
abstract:BACKGROUND:Enteric viruses are responsible for waterborne and foodborne infections affecting a large number of people around the world. Picobirnavirus (PBV) is a highly versatile virus, detected in a wide range of hosts and has been reported to be associated with gastroenteritis in humans and animals. METHODS:Molecula...
journal_title:Clinical laboratory
pub_type: 杂志文章
doi:10.7754/Clin.Lab.2019.191013
更新日期:2020-05-01 00:00:00
abstract:BACKGROUND:Increased intact proinsulin in plasma is a highly specific biomarker for a major disruption of insulin-processing in the pancreatic β-cells with associated insulin resistance. Increased intact proinsulin in morning fasting plasma indicates not only incipient diabetes, but also increased risk of macrovascular...
journal_title:Clinical laboratory
pub_type:
doi:10.7754/Clin.Lab.2019.191011
更新日期:2020-05-01 00:00:00
abstract:BACKGROUND:Therapeutic drug monitoring (TDM) of the immunosuppressant mycophenolic acid (MPA) is especially recommended for the control of personalized immunosuppressive therapy. Various test systems are available for MPA monitoring, including high performance liquid chromatography combined with UV detection (HPLC-UV) ...
journal_title:Clinical laboratory
pub_type: 杂志文章
doi:10.7754/Clin.Lab.2019.190820
更新日期:2020-04-01 00:00:00
abstract:BACKGROUND:The current study aims to investigate the expression of lncRNA BLACAT1 in patients with acute myeloid leukemia (AML) and to analyze its correlation with clinical prognosis. METHODS:Peripheral blood samples were collected from 68 AML patients, including 48 patients with acute myeloid leukemia (AML), 20 patie...
journal_title:Clinical laboratory
pub_type: 杂志文章
doi:10.7754/Clin.Lab.2019.190802
更新日期:2020-04-01 00:00:00
abstract:BACKGROUND:To investigate the diagnostic values of blood count values and ratios in distinguishing between peptic ulcer bleeding (PUB) and esophagogastric variceal bleeding (EGVB). METHODS:Due to acute hematemesis and or melaena, 57 patients diagnosed with PUB (PUB group) and 33 cases with EGVB (EGVB group) were enrol...
journal_title:Clinical laboratory
pub_type: 杂志文章
doi:10.7754/Clin.Lab.2019.190927
更新日期:2020-04-01 00:00:00
abstract:BACKGROUND:To determine the role of vitamin B12 deficiency in pernicious anemia and the efficacy of oral vitamin B12 replacement therapy given regardless of the etiology, and to compare the endoscopic and pathological findings in patients diagnosed with vitamin B12 deficiency. METHODS:The study included 216 patients, ...
journal_title:Clinical laboratory
pub_type: 杂志文章
doi:10.7754/Clin.Lab.2019.190809
更新日期:2020-03-01 00:00:00
abstract:BACKGROUND:Primary hyperparathyroidism (pHPT) is a common endocrine disorder, due to an excessive secretion of parathyroid hormone (PTH) from one or more parathyroid gland(s), where the only cure remains surgery. The surgical approach has become less invasive over the years, thanks to the advances in the preoperative l...
journal_title:Clinical laboratory
pub_type: 杂志文章,评审
doi:10.7754/Clin.Lab.2019.190411
更新日期:2020-03-01 00:00:00
abstract:BACKGROUND:Vitamin B12 is very important for the human body. Early diagnosis of vitamin B12 deficiency is essential because it is associated with many problems such as fatigue, lethargy, depression, poor memory, breathlessness, headaches, pale skin, mania, psychosis, etc. Most of the vitamin B12 molecules in serum bind...
journal_title:Clinical laboratory
pub_type: 杂志文章
doi:10.7754/Clin.Lab.2019.190604
更新日期:2020-03-01 00:00:00
abstract:BACKGROUND:The current study aims to analyze the expression of miR-34a in bone marrow mononuclear cells (BMMCs) of acute myeloid leukemia (AML) patients and its possible role in the development of leukemia. METHODS:Real-time fluorescent quantitative PCR was used to detect the expression of miR-34a in bone marrow of 40...
journal_title:Clinical laboratory
pub_type: 杂志文章
doi:10.7754/Clin.Lab.2019.190730
更新日期:2020-03-01 00:00:00
abstract:BACKGROUND:Fatty acids composition of the spermatozoa may be an important determinant of sperm quality and fertility. This study aimed to evaluate the fatty acids profile of seminal plasma and membrane spermatozoa and to study the association between fatty acids and sperm properties. METHODS:Semen samples were collect...
journal_title:Clinical laboratory
pub_type: 杂志文章
doi:10.7754/Clin.Lab.2019.190515
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Nocardia infection is a very rare bacterial infection caused by Gram-positive, aerobic nocardia species. However, in recent years, it has become a serious infection in immunocompromised patients. Earlier diagnosis plays a pivotal in the effective treatment of nocardia infection. METHODS:In this study, we re...
journal_title:Clinical laboratory
pub_type:
doi:10.7754/Clin.Lab.2019.190638
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Point-of-care tests (POCT) measure analytes close to the patients and are a complementary supplement to the test menu of medical laboratories. However, the involvement of many different stakeholders makes it challenging to ensure reliable results. METHODS:In a survey, we asked experienced POCT users how the...
journal_title:Clinical laboratory
pub_type: 杂志文章
doi:10.7754/Clin.Lab.2019.190619
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:HOTAIR is a variety of long non-coding RNA that has been recognized as a predictive factor for most cancers. This meta-analysis examined the complete investigative effectiveness of the level of HOTAIR expression for various cancers. METHODS:Research on the diagnostic value of HOTAIR in different carcinomas ...
journal_title:Clinical laboratory
pub_type: 杂志文章,meta分析
doi:10.7754/Clin.Lab.2019.190406
更新日期:2019-12-01 00:00:00
abstract:BACKGROUND:To investigate the role of the miR-218-xanthine oxidoreductase (XOR) pathway in the pathogenesis of nonalcoholic steatohepatitis (NASH) and to explore the potential downstream mechanisms involving oxidative stress and energy metabolism. METHODS:The NASH animal model was established by feeding BALB/c mice wi...
journal_title:Clinical laboratory
pub_type: 杂志文章
doi:10.7754/Clin.Lab.2019.190421
更新日期:2019-12-01 00:00:00
abstract:BACKGROUND:The G202010A prothrombin gene mutation is a documented prothrombotic risk factor in Caucasian patients. Several other mutations have been described within the prothrombin gene, predominantly in non-Caucasians, including the C20209T mutation. The clinical significance of this mutation is uncertain, but it has...
journal_title:Clinical laboratory
pub_type: 杂志文章
doi:10.7754/Clin.Lab.2019.190603
更新日期:2019-12-01 00:00:00
abstract:BACKGROUND:Spontaneous subarachnoid hemorrhage (SSAH) and nontraumatic acute headache patients presented with symptoms similar to headache. This study was to investigate the diagnostic value of D-dimer (DD) in distinguishing patients with SSAH from those with nontraumatic acute headache. METHODS:This retrospective stu...
journal_title:Clinical laboratory
pub_type: 杂志文章
doi:10.7754/Clin.Lab.2019.190230
更新日期:2019-11-01 00:00:00