abstract：:Penile squamous cell carcinoma (PSCC) is a rare cancer, with approximately 2000 new cases in the United States and 35,000 globally every year. Multiple risk factors are involved in PSCC, but most importantly, the high-risk human papillomavirus infection is thought to be present in approximately 50% of cases. Penile sq...

journal_title：Mayo Clinic proceedings

authors： Chahoud J,Kohli M,Spiess PE

更新日期：2020-12-08 00:00:00

abstract：OBJECTIVE:To evaluate the contemporary trends in outcomes and resource use associated with transcatheter aortic valve replacement (TAVR) in the United States. METHODS:We identified patients who underwent TAVR between January 1, 2012, and December 31, 2017, in the National Readmission Database. We assessed temporal tre...

journal_title：Mayo Clinic proceedings

authors： Kawsara A,Sulaiman S,Linderbaum J,Coffey SR,Alqahtani F,Nkomo VT,Crestanello JA,Alkhouli M

更新日期：2020-12-01 00:00:00

abstract：OBJECTIVE:To study the direct physiological and emotional impact of an animal-assisted activity (AAA) session (a form of complementary and integrative medicine) in patients with fibromyalgia (FM). PATIENTS AND METHODS:The study population consisted of 221 participants with FM who were attending Mayo Clinic's Fibromyal...

journal_title：Mayo Clinic proceedings

authors： Clark S,Martin F,McGowan RTS,Smidt J,Anderson R,Wang L,Turpin T,Langenfeld-McCoy N,Bauer B,Mohabbat AB

更新日期：2020-11-01 00:00:00

abstract：OBJECTIVE:To quantify the impact of the severe acute respiratory syndrome coronavirus 2 pandemic on emergency department volumes and patient presentations and evaluate changes in community mortality for the purpose of characterizing new patterns of emergency care use. PATIENTS AND METHODS:This is an observational cros...

journal_title：Mayo Clinic proceedings

authors： Walker LE,Heaton HA,Monroe RJ,Reichard RR,Kendall M,Mullan AF,Goyal DG

更新日期：2020-11-01 00:00:00

abstract：:Management of the global crisis of the coronavirus disease 2019 pandemic requires detailed appraisal of evidence to support clear, actionable, and consistent public health messaging. The use of cloth masks for general public use is being debated, and is in flux. We searched the MEDLINE and EMBASE databases and Google ...

journal_title：Mayo Clinic proceedings

authors： Clase CM,Fu EL,Ashur A,Beale RCL,Clase IA,Dolovich MB,Jardine MJ,Joseph M,Kansiime G,Mann JFE,Pecoits-Filho R,Winkelmayer WC,Carrero JJ

更新日期：2020-10-01 00:00:00

abstract：OBJECTIVE:To map the occurrence of amyloid types in a large clinical cohort using mass spectrometry-based shotgun proteomics, an unbiased method that unambiguously identifies all amyloid types in a single assay. METHODS:A mass spectrometry-based shotgun proteomics assay was implemented in a central reference laborator...

journal_title：Mayo Clinic proceedings

authors： Dasari S,Theis JD,Vrana JA,Rech KL,Dao LN,Howard MT,Dispenzieri A,Gertz MA,Hasadsri L,Highsmith WE,Kurtin PJ,McPhail ED

更新日期：2020-09-01 00:00:00

abstract：:Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) has rapidly caused a global pandemic associated with a novel respiratory infection: coronavirus disease-19 (COVID-19). Angiotensin-converting enzyme-2 (ACE2) is necessary to facilitate SARS-CoV-2 infection, but-owing to its essential metabolic roles-it may b...

journal_title：Mayo Clinic proceedings

authors： Baughn LB,Sharma N,Elhaik E,Sekulic A,Bryce AH,Fonseca R

更新日期：2020-09-01 00:00:00

abstract：OBJECTIVE:To characterize the clinicopathologic findings, comorbidities, and treatment outcomes of women with lichen planopilaris (LPP). METHOD:In this retrospective review of women with LPP at Mayo Clinic from 1992 to 2016, we searched for scarring alopecia in all female patients aged 1 to 100 years from January 1, 1...

journal_title：Mayo Clinic proceedings

authors： Larkin SC,Cantwell HM,Imhof RL,Torgerson RR,Tolkachjov SN

更新日期：2020-08-01 00:00:00

abstract：:The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), which presents an unprecedented challenge to medical providers worldwide. Although most SARS-CoV-2-infected individuals manifest with a self-limited mild disease that resolves with supportive care in the ...

journal_title：Mayo Clinic proceedings

authors： Razonable RR,Pennington KM,Meehan AM,Wilson JW,Froemming AT,Bennett CE,Marshall AL,Virk A,Carmona EM

更新日期：2020-07-01 00:00:00

abstract：OBJECTIVE:To explore the transcriptomic differences between patients with hypertrophic cardiomyopathy (HCM) and controls. PATIENTS AND METHODS:RNA was extracted from cardiac tissue flash frozen at therapeutic surgical septal myectomy for 106 patients with HCM and 39 healthy donor hearts. Expression profiling of 37,846...

journal_title：Mayo Clinic proceedings

authors： Bos JM,Hebl VB,Oberg AL,Sun Z,Herman DS,Teekakirikul P,Seidman JG,Seidman CE,Dos Remedios CG,Maleszewski JJ,Schaff HV,Dearani JA,Noseworthy PA,Friedman PA,Ommen SR,Brozovich FV,Ackerman MJ

更新日期：2020-07-01 00:00:00

abstract：:Clostridioides difficile infection (CDI) is the leading cause of health care-associated infections in the United States. The increasing incidence and recurrence rates of CDI together with its associated morbidity and mortality are great concerns. Newer treatment methods, such as narrow-spectrum antibiotics, monoclonal...

journal_title：Mayo Clinic proceedings

authors： Cho JM,Pardi DS,Khanna S

更新日期：2020-04-01 00:00:00

abstract：:Hyperkalemia is a potentially life-threatening complication of chronic kidney disease (CKD). The management of CKD requires balancing the benefits of specific treatments, which may exacerbate the potential for hyperkalemia, with the risks of hyperkalemia itself. Renin-angiotensin-aldosterone system (RAAS) inhibitors, ...

journal_title：Mayo Clinic proceedings

authors： Palmer BF

更新日期：2020-02-01 00:00:00

abstract：OBJECTIVE:To investigate the pharmacodynamic properties of inclisiran, a small interfering RNA targeting proprotein convertase subtilisin-kexin type 9 (PCSK9), in individuals with normal renal function and renal impairment (RI). PATIENTS AND METHODS:The analysis included participants with normal renal function and mil...

journal_title：Mayo Clinic proceedings

authors： Wright RS,Collins MG,Stoekenbroek RM,Robson R,Wijngaard PLJ,Landmesser U,Leiter LA,Kastelein JJP,Ray KK,Kallend D

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVE:To examine the effects of interval walking training (IWT) on the estimated peak aerobic capacity (eV˙O2peak) and lifestyle-related disease (LSD) score while focusing on exercise intensity and volume in middle-aged and older people. PARTICIPANTS AND METHODS:Men and women (N=679; mean age, 65±7 SD years) compl...

journal_title：Mayo Clinic proceedings

authors： Masuki S,Morikawa M,Nose H

更新日期：2019-12-01 00:00:00

abstract：OBJECTIVES:To characterize public perception of physicians' conflicts of interest (COIs) across medical and surgical specialties. PATIENTS AND METHODS:A cross-sectional 6-arm randomized survey of a nonprobability sample from Amazon's Mechanical Turk occurred on December 11 to 16, 2018. Survey respondents were randomly...

journal_title：Mayo Clinic proceedings

authors： Niforatos JD,Chaitoff A,Mercer MB,Yu PC,Rose SL

更新日期：2019-12-01 00:00:00

abstract：OBJECTIVE:To evaluate the outcomes of robotic mitral valve repair (MVr) by primary indication per American Heart Association guidelines for surgery: class I vs class IIa. PATIENTS AND METHODS:From January 1, 2008, through September 30, 2016, 603 patients underwent robotic MVr for severe primary mitral regurgitation. M...

journal_title：Mayo Clinic proceedings

authors： Maltais S,Anwer LA,Daly RC,Poddi S,Topilsky Y,Enrique-Sarano M,Michelena HI,Mauermann WJ,Dearani JA

更新日期：2019-11-01 00:00:00

abstract：OBJECTIVE:To evaluate the impact of the sequence of treatment with rituximab and/or splenectomy on time to relapse for patients with steroid-refractory immune thrombocytopenia (ITP). PATIENTS AND METHODS:Patients 18 years or older with steroid-refractory immune thrombocytopenia who underwent treatment with splenectomy...

journal_title：Mayo Clinic proceedings

authors： Hammond WA,Vishnu P,Rodriguez EM,Li Z,Dholaria B,Shreders AJ,Rivera CE

更新日期：2019-11-01 00:00:00

abstract：:Constipation is a common symptom that may be primary (idiopathic or functional) or associated with a number of disorders or medications. Although most constipation is self-managed by patients, 22% seek health care, mostly to primary care physicians (>50%) and gastroenterologists (14%), resulting in large expenditures ...

journal_title：Mayo Clinic proceedings

authors： Bharucha AE,Wald A

更新日期：2019-11-01 00:00:00

abstract：OBJECTIVE:To compare health care usage between suicide decedents and living controls in the year before suicide in a large representative US population. PATIENTS AND METHODS:Cases (n=1221) and controls (n=3663) belonged to an integrated health care system from January 1, 2009, through December 31, 2014. Cases and cont...

journal_title：Mayo Clinic proceedings

authors： Chock MM,Lin JC,Athyal VP,Bostwick JM

更新日期：2019-10-01 00:00:00

abstract：OBJECTIVE:To define mortality associated with isolated tricuspid regurgitation (TR) and identify risk factors associated with decreased survival. PATIENTS AND METHODS:We conducted a retrospective cohort study of residents of southeastern Minnesota with moderate-severe or more severe isolated TR diagnosed between Janua...

journal_title：Mayo Clinic proceedings

authors： Fender EA,Petrescu I,Ionescu F,Zack CJ,Pislaru SV,Nkomo VT,Cochuyt JJ,Hodge DO,Nishimura RA

更新日期：2019-10-01 00:00:00

abstract：OBJECTIVE:To investigate the impact of obesity and underweight on adverse in-hospital outcomes in pulmonary embolism (PE). PATIENTS AND METHODS:Patients diagnosed as having PE based on International Statistical Classification of Diseases and Related Health Problems, 10th Revision, German Modification code I26 in the G...

journal_title：Mayo Clinic proceedings

authors： Keller K,Hobohm L,Münzel T,Ostad MA,Espinola-Klein C,Lavie CJ,Konstantinides S,Lankeit M

更新日期：2019-10-01 00:00:00

abstract：OBJECTIVE:To describe the differences in clinical characteristics and outcome between adult- and childhood-onset biopsy-proven IgA vasculitis (IgAV) in North America. PATIENTS AND METHODS:Patients with IgAV diagnosed from January 1, 1997, through December 31, 2016, were retrospectively identified. Data were abstracted...

journal_title：Mayo Clinic proceedings

authors： Villatoro-Villar M,Crowson CS,Warrington KJ,Makol A,Ytterberg SR,Koster MJ

更新日期：2019-09-01 00:00:00

abstract：OBJECTIVE:To determine whether N-acetylcysteine rinse was safe and could improve thickened secretions and dry mouth during and after radiotherapy. PATIENTS AND METHODS:We designed a prospective pilot double-blind, placebo-controlled randomized clinical trial (Alliance MC13C2). Adult patients (age ≥18 years) were enrol...

journal_title：Mayo Clinic proceedings

authors： Sio TT,Blanchard MJ,Novotny PJ,Patel SH,Rwigema JM,Pederson LD,McGee LA,Gamez ME,Seeger GR,Martenson JA,Grover Y,Neben Wittich MA,Garces YI,Foote RL,Miller RC,Halyard MY

更新日期：2019-09-01 00:00:00

abstract：OBJECTIVE:To comparatively assess the natural history of patients of different ages undergoing transcatheter aortic valve replacement (TAVR). PATIENTS AND METHODS:For this study, we used the YOUNG TAVR, an international, multicenter registry investigating mortality trends up to 2 years in patients with aortic valve st...

journal_title：Mayo Clinic proceedings

authors： Navarese EP,Andreotti F,Kołodziejczak M,Wanha W,Lauten A,Veulemans V,Frediani L,Kubica J,de Cillis E,Wojakowski W,Ochala A,Zeus T,Bortone A,Buffon A,Jung C,Pestrichella V,Gurbel PA

更新日期：2019-08-01 00:00:00

abstract：OBJECTIVE:To perform a systematic review and meta-analysis of randomized controlled trials (RCTs) evaluating risk-benefit for adjuvant postoperative treatments in high-risk renal cell carcinoma by assessing reported disease-free survival (DFS), overall survival (OS), toxicity, and quality of life. METHODS:A literature...

journal_title：Mayo Clinic proceedings

authors： Riaz IB,Faridi W,Husnain M,Malik SU,Sipra QUAR,Gondal FR,Xie H,Yadav S,Kohli M

更新日期：2019-08-01 00:00:00

abstract：OBJECTIVE:To investigate the impact on cardiovascular events (CVEs) in a real-world population of patients with atrial fibrillation (AF) by implementing the Atrial fibrillation Better Care (ABC: A, Avoid stroke with anticoagulation; B, better symptom management; C, Cardiovascular and comorbidity risk management) pathwa...

journal_title：Mayo Clinic proceedings

authors： Pastori D,Pignatelli P,Menichelli D,Violi F,Lip GYH

更新日期：2019-07-01 00:00:00

abstract：OBJECTIVE:To investigate an association between tumor necrosis factors-alpha (TNFα) inhibitors or other immunosuppressants and the development of uveal and cutaneous melanoma. PATIENTS AND METHODS:We performed a retrospective incidence and case-control analysis of patients in Olmsted County, MN, who were diagnosed wit...

journal_title：Mayo Clinic proceedings

authors： Damento GM,Pulido JS,Abbott BA,Hodge DO,Dalvin LA

更新日期：2019-07-01 00:00:00

abstract：:Hereditary causes due to mutations and defects in certain genes account for roughly 5% to 10% of all colorectal cancers. These inherited syndromes have been associated with a 60% to 100% lifetime risk for development of colorectal cancer, depending on the genetic syndrome, and many also carry an increased risk for mul...

journal_title：Mayo Clinic proceedings

authors： Samadder NJ,Baffy N,Giridhar KV,Couch FJ,Riegert-Johnson D

更新日期：2019-06-01 00:00:00

abstract：:Cardiorespiratory fitness (CRF) is an established risk factor for cardiovascular disease outcomes. However, the relationship of CRF with risk of ventricular arrhythmias (VAs) is unknown. We aimed to assess the prospective association of CRF with the risk of serious VAs. Cardiorespiratory fitness, as measured by maxima...

journal_title：Mayo Clinic proceedings

authors： Laukkanen JA,Lavie CJ,Khan H,Kurl S,Kunutsor SK

更新日期：2019-05-01 00:00:00

abstract：:Patient-centered care requires that treatments respond to the problematic situation of each patient in a manner that makes intellectual, emotional, and practical sense, an achievement that requires shared decision making (SDM). To implement SDM in practice, tools-sometimes called conversation aids or decision aids-are...

journal_title：Mayo Clinic proceedings

authors： Zeballos-Palacios CL,Hargraves IG,Noseworthy PA,Branda ME,Kunneman M,Burnett B,Gionfriddo MR,McLeod CJ,Gorr H,Brito JP,Montori VM,Shared Decision Making for Atrial Fibrillation (SDM4AFib) Trial Investigators.

更新日期：2019-04-01 00:00:00

abstract：OBJECTIVES:To determine the prevalence of intra- and extra-articular sacroiliac joint (SIJ) pain, which injection is more beneficial, and whether fluoroscopy improves outcomes. PATIENTS AND METHODS:This patient- and evaluator-blinded comparative effectiveness study randomized 125 participants with SIJ pain from April ...

journal_title：Mayo Clinic proceedings

authors： Cohen SP,Bicket MC,Kurihara C,Griffith SR,Fowler IM,Jacobs MB,Liu R,Anderson White M,Verdun AJ,Hari SB,Fisher RL,Pasquina PF,Vorobeychik Y

更新日期：2019-04-01 00:00:00

abstract：OBJECTIVE:To evaluate the prognostic impact of Holter findings in patients with light chain amyloidosis. PATIENTS AND METHODS:We evaluated 239 patients in whom light chain amyloidosis was diagnosed from January 1, 2010, through December 31, 2015, who underwent 24-hour Holter monitoring. RESULTS:Holter testing was don...

journal_title：Mayo Clinic proceedings

authors： Sidana S,Tandon N,Brady PA,Grogan M,Gertz MA,Dispenzieri A,Lin G,Dingli D,Buadi FK,Lacy MQ,Kapoor P,Gonsalves WI,Muchtar E,Warsame R,Kumar SK,Kourelis TV

更新日期：2019-03-01 00:00:00

abstract：OBJECTIVE:To compare all-cause mortality rates across the severity range of white matter hyperintensities (WMH). PATIENTS AND METHODS:Between October 26, 2010, and October 5, 2017, the ongoing Mayo Clinic Florida Familial Cerebrovascular Diseases Registry prospectively enrolled 1011 diverse participants with and witho...

journal_title：Mayo Clinic proceedings

authors： Hasan TF,Barrett KM,Brott TG,Badi MK,Lesser ER,Hodge DO,Meschia JF

更新日期：2019-03-01 00:00:00

abstract：:Serum cystatin C has been proposed as a kidney biomarker to inform drug dosing. We conducted a systematic review to synthesize available data for the association between serum cystatin C and drug pharmacokinetics, dosing, and clinical outcomes in adults (≥18 years). PubMed, Ovid MEDLINE, Ovid EMBASE, EBSCO CINAHL, and...

journal_title：Mayo Clinic proceedings

authors： Barreto EF,Rule AD,Murad MH,Kashani KB,Lieske JC,Erwin PJ,Steckelberg JM,Gajic O,Reid JM,Kane-Gill SL

更新日期：2019-03-01 00:00:00

abstract：OBJECTIVE:To assess the effects of body mass index (BMI) variability on the incidence of new-onset atrial fibrillation (AF), stroke, cardiovascular (CV) risk factors, and CV outcomes in a general Asian population. PATIENTS AND METHODS:Data from the National Health Insurance Service-Health Screening cohort in Korea wer...

journal_title：Mayo Clinic proceedings

authors： Lim YM,Yang PS,Jang E,Yu HT,Kim TH,Uhm JS,Kim JY,Pak HN,Lee MH,Joung B,Lip GYH

更新日期：2019-02-01 00:00:00

abstract：:Abdominal wall pain (AWP) is a common and underrecognized cause of chronic abdominal pain. The etiology of AWP varies. History and physical examination are critical to an accurate diagnosis of AWP. Trigger point injection using either a corticosteroid, a local anesthetic, or a combination of both often gives relief of...

journal_title：Mayo Clinic proceedings

authors： Sweetser S

更新日期：2019-02-01 00:00:00

abstract：OBJECTIVE:To test the hypothesis that chromosomal rearrangements (CRs) can distinguish low risk of progression (LRP) from intermediate and high risk of progression (IHRP) to prostate cancer (PCa) and if these CRs have the potential to identify men with LRP on needle biopsy that harbor IHRP PCa in the prostate gland. P...

journal_title：Mayo Clinic proceedings

authors： Vasmatzis G,Kosari F,Murphy SJ,Terra S,Kovtun IV,Harris FR,Zarei S,Smadbeck JB,Johnson SH,Gaitatzes AG,Therneau TM,Rangel LJ,Knudson RA,Greipp P,Sukov WR,Knutson DL,Kloft-Nelson SM,Karnes RJ,Cheville JC

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVE:To determine the incidence and temporal trends of food allergies. PATIENTS AND METHODS:We performed a historical cohort study to describe the epidemiology of food allergies among residents of all ages in Olmsted County, Minnesota, during a 10-year period from January 2, 2002, through December 31, 2011, using...

journal_title：Mayo Clinic proceedings

authors： Willits EK,Park MA,Hartz MF,Schleck CD,Weaver AL,Joshi AY

更新日期：2018-10-01 00:00:00

abstract：OBJECTIVE:To compare the indications for hospital admission between current, former, and never smokers and to compare their costs per hospital admission, testing the hypothesis that the cost per hospital admission would be higher for smokers than for former and never smokers. PATIENTS AND METHODS:This study used a ret...

journal_title：Mayo Clinic proceedings

authors： Nolan MB,Borah BJ,Moriarty JP,Warner DO

更新日期：2018-08-01 00:00:00

abstract：OBJECTIVE:To investigate the incidence and risk of adverse clinical outcomes in a "real-world" cohort of patients with atrial fibrillation (AF) anticoagulated with vitamin K antagonists (VKAs) from the Murcia AF Project in comparison with the warfarin arm of the randomized clinical trial (RCT) AMADEUS (Evaluating the U...

journal_title：Mayo Clinic proceedings

authors： Rivera-Caravaca JM,Esteve-Pastor MA,Marín F,Valdés M,Vicente V,Roldán V,Lip GYH

更新日期：2018-08-01 00:00:00