Hereditary Cancer Syndromes-A Primer on Diagnosis and Management, Part 2: Gastrointestinal Cancer Syndromes.

Abstract:

:Hereditary causes due to mutations and defects in certain genes account for roughly 5% to 10% of all colorectal cancers. These inherited syndromes have been associated with a 60% to 100% lifetime risk for development of colorectal cancer, depending on the genetic syndrome, and many also carry an increased risk for multiple extracolonic malignancies. In this second part of a review series on hereditary cancer syndromes, the focus will be to provide guidance on the features and management of the most commonly encountered hereditary colorectal cancers and polyposis conditions including Lynch syndrome, familial adenomatous polyposis, MUTYH-associated polyposis, and hamartomatous polyposis.

journal_name

Mayo Clin Proc

journal_title

Mayo Clinic proceedings

authors

Samadder NJ,Baffy N,Giridhar KV,Couch FJ,Riegert-Johnson D

doi

10.1016/j.mayocp.2019.01.042

subject

Has Abstract

pub_date

2019-06-01 00:00:00

pages

1099-1116

issue

6

eissn

0025-6196

issn

1942-5546

pii

S0025-6196(19)30214-9

journal_volume

94

pub_type

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