abstract：BACKGROUND:Patients with Chronic Obstructive Pulmonary Disease with chronic respiratory failure (COPD-CRF) experience high mortality and healthcare utilization. Non-invasive home ventilation (NIVH) is increasingly used in such patients. We examined the associations between NIVH and survival, hospitalizations, and emerg...

journal_title：Respiratory medicine

authors： Frazier WD,Murphy R,van Eijndhoven E

更新日期：2020-12-30 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Idiopathic pulmonary fibrosis (IPF) is a progressive and irreversible interstitial lung disease with poor prognosis despite the recent availability of two antifibrotic drugs. Patients are more susceptible to cardiovascular comorbidities. In this study, we aimed to determine the impact of concom...

journal_title：Respiratory medicine

authors： M Lambert E,A Wuyts W,Yserbyt J,De Sadeleer LJ

更新日期：2020-11-26 00:00:00

abstract：:In the UK approximately 1.2 million people have COPD with around 25-40% being underweight and 35% have a severely low fat-free mass index. Measuring their body mass index is recommended and Health care professionals should endeavour to ensure that COPD patients are achieving their nutritional requirements. A narrative...

journal_title：Respiratory medicine

authors： Keogh E,Mark Williams E

更新日期：2020-11-21 00:00:00

abstract：BACKGROUND:Although massive bleeding following transbronchial lung biopsies (TBLB) is rare, even minor hemorrhage may prolong the procedure and result in inadequate sampling. Tranexamic acid (TXA) is an antifibrinolytic agent, which reduces bleeding in numerous scenarios, however, its prophylactic use in mitigating pos...

journal_title：Respiratory medicine

authors： Kuint R,Levy L,Cohen Goichman P,Huszti E,Abu Rmeileh A,Shriki O,Abutbul A,Fridlender ZG,Berkman N

更新日期：2020-11-01 00:00:00

abstract：:Viral respiratory infections (VRI) can act as triggers for acute asthma exacerbations and contribute significantly to asthma-related healthcare costs. Knowing the patterns of viruses amongst asthmatics can be useful in treating and preventing these exacerbations and help decrease the burden they impose on patients and...

journal_title：Respiratory medicine

authors： Feddema JJ,Claassen E

更新日期：2020-11-01 00:00:00

abstract：AIM:Recent studies have shown that anti-Ro52 antibody is associated with both interstitial lung disease (ILD) and the degree of disease severity in juvenile patients with dermatomyositis (DM). We found that more than half of adult patients with DM were positive for anti-Ro52 antibody. In this study, we analysed the cor...

journal_title：Respiratory medicine

authors： Xing X,Li A,Li C

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:Individuals with chronic respiratory conditions are at-risk for depression and anxiety. In the largest mental health screening study of over 6000 people with cystic fibrosis (CF) and 4000 parent caregivers (TIDES, 2014), rates of symptomatology were two to three times higher than in the general population. I...

journal_title：Respiratory medicine

authors： Graziano S,Spanò B,Majo F,Righelli D,Vincenzina L,Quittner A,Tabarini P

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:There are chronic forms of hypersensitivity pneumonitis (cHP) that can progress to pulmonary fibrosis. There is no recommended treatment for patients whose respiratory condition continues to deteriorate in spite of antigen avoidance. Whether rituximab may be beneficial to patients with cHP is unknown. The ai...

journal_title：Respiratory medicine

authors： Ferreira M,Borie R,Crestani B,Rigaud P,Wemeau L,Israel-Biet D,Leroy S,Quétant S,Plantier L,Dalphin JC,Cottin V,Marchand-Adam S,of the OrphaLung network.

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:Idiopathic pleuroparenchymal fibroelastosis (IPPFE) is a rare idiopathic interstitial pneumonia characterized by an upper lobe-dominant interstitial increase in predominantly elastic fibers. The accumulation of cases has resulted in a refinement of the disease concept, but there are no blood biomarkers to ai...

journal_title：Respiratory medicine

authors： Kinoshita Y,Ikeda T,Kushima H,Fujita M,Nakamura T,Nabeshima K,Ishii H

更新日期：2020-09-01 00:00:00

abstract：:Patients with immune deficiencies can present with variable clinical phenotypes. This often translates into a significant delay in their diagnosis, and resultant patient morbidity. This review summarises the most common types of immunodeficiency disorders, primary and secondary, along with their key features. It provi...

journal_title：Respiratory medicine

authors： Grammatikos A,Bright P,Bhatnagar R,Johnston S

更新日期：2020-09-01 00:00:00

abstract：OBJECTIVE:To assess the exercise capacity, exercise habits, and lung function of preterm born children with bronchopulmonary dysplasia (BPD) compared to term born controls at school age. METHODS:Cardiopulmonary exercise test (CPET) by cycle ergometer and pulmonary function test were performed in children with BPD (n =...

journal_title：Respiratory medicine

authors： Prenzel F,Vogel M,Siekmeyer W,Körner A,Kiess W,Vom Hove M

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:It is essential to recognize and treat findings that can simulate or worsen symptoms to improve asthma control and thereby to reduce costs. Guidelines highlight a paranasal (PS) and chest computed tomography (CT) scan as a tool for disease evaluation and, although they suggest its indication in patients whom...

journal_title：Respiratory medicine

authors： Zamarron E,Romero D,Fernández-Lahera J,Villasante C,Pinilla I,Barranco P,Dominguez-Ortega J,Álvarez-Sala Walther R R

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:An ongoing outbreak of coronavirus disease 2019 (COVID-19) has spread around the world. It is debatable whether asymptomatic COVID-19 virus carriers are contagious. We report here a case of the asymptomatic patient and present clinical characteristics of 455 contacts, which aims to study the infectivity of a...

journal_title：Respiratory medicine

authors： Gao M,Yang L,Chen X,Deng Y,Yang S,Xu H,Chen Z,Gao X

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND AND AIM:Vocal Cord Dysfunction (VCD) and chronic cough (CC) are challenging conditions which lead to significant quality of life impairment. The underlying mechanisms are poorly understood, but laryngeal dysfunction may be common to both conditions. The aim of this study was to determine the characteristics ...

journal_title：Respiratory medicine

authors： Vertigan AE,Kapela SL,Gibson PG

更新日期：2020-07-01 00:00:00

abstract：INTRODUCTION:Brit-Hogg-Dubé syndrome (BHD) is a rare disorder that is estimated to affects about 600 families in the World. The disease-causing mutations is on FLCN gene which codes for folliculin. This protein has a role in different organs as skin, kidney and lung, thanks to the interaction with type I and II cadheri...

journal_title：Respiratory medicine

authors： Marziali V,Geropoulos G,Frasca L,Longo F,Patrini D,Panagiotopoulos N,Crucitti P

更新日期：2020-07-01 00:00:00

abstract：PURPOSE:The Korea Centers for Disease Control & Prevention has implemented a review process for the approval of new drugs used to treat patients with multidrug-resistant tuberculosis (MDR-TB) since September 2016. Therefore, this study aimed to evaluate the efficacy and safety of these new drugs bedaquiline (Bdq) and d...

journal_title：Respiratory medicine

authors： Kang H,Jo KW,Jeon D,Yim JJ,Shim TS

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:The choice of inhaler device for asthma patients depends upon multiple attributes. We investigated factors that may drive general practitioners (GPs) and respiratory specialists in the prescription of inhaler devices for asthma patients who initiated inhalation therapy. METHODS:We retrospectively analysed p...

journal_title：Respiratory medicine

authors： Lavorini F,Bianco A,Blasi F,Braido F,Corsico AG,Di Marco F,Gentile A,Paggiaro PL,Pegoraro V,Pelaia G,Rogliani P,Santus P,Scichilone N,Soldi A,Canonica GW

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Chronic pulmonary aspergillosis (CPA) is associated with mortality in patients with Mycobacterium avium complex lung disease (MAC-LD). However, the clinical significance of the positivity of Aspergillus precipitating antibody (APAb), a serodiagnostic test for pulmonary aspergillosis (PA), at th...

journal_title：Respiratory medicine

authors： Shirai T,Furuuchi K,Fujiwara K,Nakamoto K,Tanaka Y,Ishii H,Yoshiyama T,Yoshimori K,Takizawa H,Sasaki Y,Kurashima A,Ohta K,Morimoto K

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Asthma is a common chronic disease in childhood, resulting in high costs for health care systems and society. As of June 2011, the Brazilian Unified Health System (SUS) provides free asthma medications for the population. This study evaluated the impact of this program on asthma admissions in the population ...

journal_title：Respiratory medicine

authors： Koltermann V,Friedrich FO,Fensterseifer AC,Ongaratto R,Pinto LA

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:Pulmonary arterial capacitance (PAC) is a strong hemodynamic predictor of outcomes in patients with pulmonary hypertension (PH). Its value across subgroups of race/ethnicity, sex, and PH etiologies is unclear. We hypothesized that the association of PAC with outcomes would not vary across World Health Organi...

journal_title：Respiratory medicine

authors： Mayfield JJ,Papolos A,Vasti E,De Marco T,Tison GH

更新日期：2020-03-01 00:00:00

abstract：INRODUCTION:The mechanistic target of rapamycin inhibitors (mTORi) sirolimus and everolimus stabilize lung function in patients with pulmonary lymphangioleiomyomatosis (LAM) but do not induce remission. Pre-clinical studies suggest that simvastatin in combination with sirolimus induces LAM cell death. The objective of ...

journal_title：Respiratory medicine

authors： Krymskaya VP,Courtwright AM,Fleck V,Dorgan D,Kotloff R,McCormack FX,Kreider M

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:The aim of the present study was to estimate the societal costs and the key cost drivers for patients with severe asthma in Sweden. In addition, health-related quality of life (HRQOL) and morbidity of patients with severe asthma is described. METHODS:The study population comprised adults with severe asthma ...

journal_title：Respiratory medicine

authors： Jansson SA,Backman H,Andersson M,Telg G,Lindberg A,Stridsman C,Lundbäck B,Rönmark E

更新日期：2020-02-01 00:00:00

abstract：INTRODUCTION:Current and former smokers with normal spirometry and with Preserved Ratio Impaired Spirometry (PRISm) experience respiratory events similar to chronic obstructive pulmonary disease (COPD) exacerbations. Exacerbations significantly reduce quality of life (QoL) in COPD patients however the effect of respira...

journal_title：Respiratory medicine

authors： Parekh TM,Bhatia S,Cherrington A,Kim YI,Lambert A,Iyer A,Regan EA,DeMeo DL,Han M,Dransfield MT

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Although respiratory muscle weakness (RMW) is known to predict prognosis in patients with heart failure with reduced ejection fraction (HFrEF), RMW prevalence and its prognosis in those with preserved ejection fraction (HFpEF) remain unknown. We aimed to investigate whether the RMW predicted mortality in HFp...

journal_title：Respiratory medicine

authors： Hamazaki N,Kamiya K,Matsuzawa R,Nozaki K,Ichikawa T,Tanaka S,Nakamura T,Yamashita M,Maekawa E,Noda C,Yamaoka-Tojo M,Matsunaga A,Masuda T,Ako J

更新日期：2020-01-01 00:00:00

abstract：:Inhalation therapy is the mainstay of chronic obstructive pulmonary disease management, and inhaler selection can have a profound impact on drug delivery and medication adherence, as well as on treatment outcomes. Although multiple delivery systems, such as pressurized metered-dose inhalers, dry powder inhalers, slow-...

journal_title：Respiratory medicine

authors： Mahler DA

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Data on the risk of death following an asthma exacerbation are scarce. With this multinational cohort study, we assessed all-cause mortality rates, mortality rates following an exacerbation, and patient characteristics associated with all-cause mortality in asthma. METHODS:Asthma patients aged ≥18 years and...

journal_title：Respiratory medicine

authors： Engelkes M,de Ridder MA,Svensson E,Berencsi K,Prieto-Alhambra D,Lapi F,Giaquinto C,Picelli G,Boudiaf N,Albers FC,Cockle SM,Bradford ES,Suruki RY,Brusselle GG,Rijnbeek PR,Sturkenboom MC,Verhamme KM

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Pulmonary rehabilitation is very effective in improving exercise capacity, dyspnea and quality of life in the small group of patients with moderate to severe COPD. Given that little is known about exercise training in the large group of patients with mild to moderate COPD, we assessed the effectiveness of an...

journal_title：Respiratory medicine

authors： Fastenau A,van Schayck OC,Winkens B,Aretz K,Gosselink R,Muris JW

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVE:Sleep disorders have a high prevalence among patients with idiopathic pulmonary fibrosis (IPF). The prevalence of restless legs syndrome (RLS) is not known in these patients, neither is its clinical impact as a comorbidity. We investigated the association of RLS with IPF and characterized the clinical feature...

journal_title：Respiratory medicine

authors： Varone F,Friello L,Di Blasi C,Sgalla G,Luigetti M,Iovene B,Richeldi L,Della Marca G,Brunetti V

更新日期：2020-01-01 00:00:00

abstract：INTRODUCTION:Allergic rhino-conjunctivitis is a highly prevalent condition. In moderate to severe cases, allergen immunotherapy (AIT) is a cost-effective therapeutic option. Previous data have reported a large difference in treatment compliance of subcutaneously (SCIT) and sublingually (SLIT) administered AIT. METHODS...

journal_title：Respiratory medicine

authors： Borg M,Løkke A,Hilberg O

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Given the high incidence of confirmed infection by SARS-CoV-2 and mortality by COVID-19 in the Spanish population, its impact was analysed among persons with Cystic Fibrosis (CF) as a group at risk of a worse evolution. The possible causes of the incidence observed in them are explained and how CF Units have...

journal_title：Respiratory medicine

authors： Mondejar-Lopez P,Quintana-Gallego E,Giron-Moreno RM,Cortell-Aznar I,Ruiz de Valbuena-Maiz M,Diab-Caceres L,Prados-Sanchez C,Alvarez-Fernandez A,Garcia-Marcos PW,Peñalver-Mellado C,Pastor-Vivero MD,Olveira C,Lopez-Neyra A,Castil

更新日期：2020-01-01 00:00:00

abstract：PURPOSE:Although pulmonary rehabilitation (PR) improves function in people with chronic obstructive pulmonary disease (COPD), a community-based exercise program may be necessary to maintain functional capacity. We aimed to determine the effectiveness of a post-rehabilitation, community-based maintenance program on exer...

journal_title：Respiratory medicine

authors： Butler SJ,Desveaux L,Lee AL,Beauchamp MK,Brusco NK,Wang W,Goldstein RS,Brooks D

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVES:To evaluate whether elevated levels of cardiac troponin increases the risk of mortality in patients with acute PE. METHODS:We conducted a systematic review and meta-analysis with rigorous statistical evaluation using publications (2000-2018) from Cochrane Library, MEDLINE, PubMed, Scopus, Cochrane Central R...

journal_title：Respiratory medicine

authors： El-Menyar A,Sathian B,Al-Thani H

更新日期：2019-10-01 00:00:00

abstract：INTRODUCTION:There are insufficient data on the treatment of latent tuberculosis infection (LTBI) in elderly patients. We investigated the completion rate of treatment in elderly LTBI patients. METHODS:A retrospective multicentre study was conducted at five university hospitals in South Korea. We reviewed the electron...

journal_title：Respiratory medicine

authors： Noh CS,Kim HI,Choi H,Kim Y,Kim CH,Choi JH,Hyun IG,Baek MS

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:Supplemental oxygen is a recommended therapy option in stable hypoxemic COPD patients. Often, supplemental oxygen is provided by continuous flow (CF). However, demand oxygen delivery systems (DODS) that provide an oxygen bolus only during inspiration have gained increasing use as they prolong oxygen cylinder...

journal_title：Respiratory medicine

authors： Gloeckl R,Jarosch I,Schneeberger T,Fiedler C,Lausen M,Weingaertner J,Hitzl W,Kenn K,Koczulla AR

更新日期：2019-09-01 00:00:00

abstract：INTRODUCTION:Primary ciliary dyskinesia (PCD) is a rare genetically heterogeneous disorder of motile cilia, which leads to recurrent and chronic airway infections. Detailed information about infection causing pathogens is scarce. With this study, we aimed to determine the prevalence and susceptibility of the most commo...

journal_title：Respiratory medicine

authors： Roden L,Görlich D,Omran H,Peters G,Große-Onnebrink J,Kahl BC

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:Multiple criteria have been proposed to define community-acquired pneumonia (CAP) severity and predict ICU admission. Validity studies have found differing results. We tested four models to assess severe CAP built upon the criteria included in the 2007 IDSA/ATS guidelines, hypothesizing that a model providin...

journal_title：Respiratory medicine

authors： Gearhart AM,Furmanek S,English C,Ramirez J,Cavallazzi R

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:For patients with idiopathic pulmonary fibrosis (IPF), there is limited real-world data on patient journey and treatment patterns. AIM:To explore predictors of early diagnosis and treatment initiation, and treatment patterns in IPF patients using linked data from Swedish registers and electronic medical rec...

journal_title：Respiratory medicine

authors： Sköld CM,Arnheim-Dahlström L,Bartley K,Janson C,Kirchgaessler KU,Levine A,Ferrara G

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:Smoking continues to be a major risk factor for COPD and may impact the efficacy of COPD treatments, with guidelines supporting the crucial importance for current smokers of smoking cessation. A post-hoc analysis of the FLIGHT1 and FLIGHT2 studies assessed the impact of smoking status on the efficacy and saf...

journal_title：Respiratory medicine

authors： Tashkin DP,Goodin T,Bowling A,Price B,Ozol-Godfrey A,Sharma S,Sanjar S

更新日期：2019-08-01 00:00:00

abstract：:Several monoclonal antibodies (mAbs) (omalizumab, mepolizumab, reslizumab, benralizumab, and dupilumab) are currently approved for the treatment of severe asthma. They have complex pharmacokinetic profiles. These profiles are unique in that they are dependent on their structure as well as can be markedly influenced by...

journal_title：Respiratory medicine

authors： Matera MG,Calzetta L,Rogliani P,Cazzola M

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:Cystic fibrosis affects 1/3200 Caucasians. This genetic disease disturbs the ion and water homeostasis across epithelia, thus rendering mucus more viscous and harder to expel. Conventional treatments rely on the clapping method coupled with postural drainage. Despite the effectiveness of these procedures, th...

journal_title：Respiratory medicine

authors： Schieppati D,Germon R,Galli F,Rigamonti MG,Stucchi M,Boffito DC

更新日期：2019-07-01 00:00:00