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Restless legs syndrome: A new comorbidity in idiopathic pulmonary fibrosis.

Abstract：

OBJECTIVE:Sleep disorders have a high prevalence among patients with idiopathic pulmonary fibrosis (IPF). The prevalence of restless legs syndrome (RLS) is not known in these patients, neither is its clinical impact as a comorbidity. We investigated the association of RLS with IPF and characterized the clinical features of RLS in a cohort of IPF patients. METHODS:Fifty patients with diagnosis of IPF were prospectively enrolled. RLS was diagnosed using the validated 5-item RLS criteria. Sleep quality was evaluated using the Pittsburgh Sleep Quality Index. The prevalence of RLS in the IPF group was compared to that observed in a group of 293 patients referred for suspect of sleep disorders. The relationships between RLS and clinical parameters were determined using multivariate logistic regression. RESULTS:Prevalence of RLS in the IPF group was significantly higher than in the control population of patients referred for sleep disorders (IPF: 24%, controls 10%: χ2 6.49, p = 0.011). Higher PSQI score confirmed to be associated with RLS after adjusting for demographics and clinical parameters of disease severity (OR = 1.38, 95%CI 1.08-1.76; p = 0.01). CONCLUSIONS:RLS is highly prevalent in IPF and significantly worsen sleep quality in these patients. The benefit/risk ratio of a specific therapeutic intervention for RLS in IPF should be assessed in further prospective research.

journal_name

Respir Med

journal_title

Respiratory medicine

authors

Varone F,Friello L,Di Blasi C,Sgalla G,Luigetti M,Iovene B,Richeldi L,Della Marca G,Brunetti V

doi

10.1016/j.rmed.2020.105982

subject

Has Abstract

pub_date

2020-01-01 00:00:00

pages

105982

eissn

0954-6111

issn

1532-3064

pii

S0954-6111(20)30122-0

journal_volume

170

pub_type

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