Abstract：
INTRODUCTION:Primary ciliary dyskinesia (PCD) is a rare genetically heterogeneous disorder of motile cilia, which leads to recurrent and chronic airway infections. Detailed information about infection causing pathogens is scarce. With this study, we aimed to determine the prevalence and susceptibility of the most common respiratory pathogens in PCD patients retrospectively in a cross-sectional and the dynamics of the microbiological diversity in a longitudinal study. METHODS:Microbiological and clinical data of 106 patients between 2010 and 2016 were analysed cross-sectionally and of 28 patients longitudinally. Dynamics in microbiological diversity were assessed by calculating the mean rate of alteration (MRA). RESULTS:Haemophilus influenzae was the most common pathogen (n = 41; 38.7%) followed by Staphylococcus aureus (n = 36; 34%), Moraxella catarrhalis (n = 18; 17%) and Pseudomonas aeruginosa (n = 16; 15.1%). Nontuberculous mycobacteria were cultured from two patients (1.9%). H. influenzae was the most prevalent pathogen in children (n = 31; 45.6%), S. aureus in adults (n = 15; 39%). Two patients were infected by methicillin-resistant S. aureus. P. aeruginosa was mostly susceptible to standard antibiotics with highest rates of resistance against fosfomycin (63.6%; 7/11). The culture of P. aeruginosa correlated negatively with age adjusted FEV1% predicted (p = 0.04), while the MRA was positively associated with age (rho 0.411, p = 0.032). DISCUSSION:In PCD patients, the prevalence of pathogens differed in children and adults with H. influenzae and S. aureus being the most common pathogens in children, S. aureus and P. aeruginosa in adults, respectively. Unexpectedly, the MRA increased by age.
journal_name
Respir Medjournal_title
Respiratory medicineauthors
Roden L,Görlich D,Omran H,Peters G,Große-Onnebrink J,Kahl BCdoi
10.1016/j.rmed.2019.08.009subject
Has Abstractpub_date
2019-09-01 00:00:00pages
69-77eissn
0954-6111issn
1532-3064pii
S0954-6111(19)30266-5journal_volume
156pub_type
杂志文章abstract：:Asthma has become an important public health issue worldwide and certain groups, such as children, are at particular risk of the disease. Often asthma remains under-diagnosed and under-treated. Despite these worrying trends, the disease management approach to asthma control can help most asthma patients achieve a 'nor...
journal_title：Respiratory medicine
pub_type： 杂志文章,评审
doi：
更新日期：2002-02-01 00:00:00
abstract：:Macrolide antibiotics have anti-inflammatory and immunomodulatory properties in addition to antibacterial activity. Until recently, only a small number of studies evaluating macrolides in patients with non-cystic fibrosis (CF) bronchiectasis had been published. These were open-label, uncontrolled, short-duration studi...
journal_title：Respiratory medicine
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journal_title：Respiratory medicine
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0954-6111(98)90113-5
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journal_title：Respiratory medicine
pub_type： 杂志文章,随机对照试验
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abstract：INTRODUCTION:In vivo, the airway epithelium stretches and relaxes with each respiratory cycle, but little is known about the effect this pattern of elongation and relaxation has on bronchial epithelial cells. We have used a model of cell deformation to measure the effect of stretch on inflammatory cytokine release by t...
journal_title：Respiratory medicine
pub_type： 杂志文章
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journal_title：Respiratory medicine
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pub_type： 临床试验,杂志文章,多中心研究
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pub_type： 杂志文章
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journal_title：Respiratory medicine
pub_type： 杂志文章,多中心研究
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journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2009.10.004
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journal_title：Respiratory medicine
pub_type： 杂志文章,评审
doi：10.1016/s0954-6111(06)80252-0
更新日期：1991-01-01 00:00:00
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journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/s0954-6111(98)90296-7
更新日期：1998-03-01 00:00:00
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journal_title：Respiratory medicine
pub_type： 杂志文章,多中心研究
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pub_type： 杂志文章,随机对照试验
doi：10.1016/j.rmed.2007.05.005
更新日期：2007-09-01 00:00:00
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journal_title：Respiratory medicine
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期：2012-02-01 00:00:00
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pub_type： 杂志文章,随机对照试验
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更新日期：2018-11-01 00:00:00
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pub_type： 临床试验,杂志文章,多中心研究
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更新日期：2013-01-01 00:00:00
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doi：10.1016/0954-6111(95)90235-x
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doi：10.1016/j.rmed.2014.01.007
更新日期：2014-04-01 00:00:00
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更新日期：2013-01-01 00:00:00
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journal_title：Respiratory medicine
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期：2002-04-01 00:00:00
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journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2003.10.005
更新日期：2004-03-01 00:00:00
abstract：:Chemokines such as regulated on activation, normal T-cell expressed and secreted (RANTES), monocyte chemoattractant protein (MCP)-1, monocyte inflammatory protein (MIP)-lalpha have been reported to play an important role in the pathogenesis of interstitial lung diseases. Among idiopathic interstitial pneumonia (IIP), ...
journal_title：Respiratory medicine
pub_type： 杂志文章
doi：10.1016/j.rmed.2004.03.008
更新日期：2004-10-01 00:00:00
