abstract：:Aging-related changes to biological structures such as cardiovascular and musculoskeletal systems contribute to the development of comorbid conditions including cardiovascular disease and frailty, and ultimately lead to premature death. Although, frail older adults often demonstrate both cardiovascular and musculoskel...

journal_title：Experimental gerontology

authors： Jeon YK,Shin MJ,Saini SK,Custodero C,Aggarwal M,Anton SD,Leeuwenburgh C,Mankowski RT

更新日期：2021-03-01 00:00:00

abstract：OBJECTIVES:We explored the male-female health-survival paradox in the context of health expectancy (HE) at age 65 and thereafter, using three different morbidity measures and different severity cut-offs with and without adjustments for the share of nursing home residents. METHODS:HE at ages 65, 70, 75, 80, and 85 was ...

journal_title：Experimental gerontology

authors： Stephan AJ,Schwettmann L,Meisinger C,Ladwig KH,Linkohr B,Thorand B,Schulz H,Peters A,Grill E

更新日期：2021-03-01 00:00:00

abstract：BACKGROUND:An intermission in the training routine, in which older adults refrain from regular structured exercise, may have deleterious effects on muscle performance and bioelectric phase angle (PhA), which is a predictive marker for cellular integrity. PURPOSE:To determine the effects of a 2-week detraining period o...

journal_title：Experimental gerontology

authors： Freitas SP,Júdice PB,Hetherington-Rauth M,Magalhães JP,Correia IR,Lopes JM,Strong C,Matos D,Sardinha LB

更新日期：2021-02-01 00:00:00

abstract：:Even though Alzheimer's disease (AD) is the most common cause of dementia, the mechanisms governing the establishment and progression of the disease remain largely unknown. Here, we investigated the implication of the neuroprotective protein BMI1 (B lymphoma Mo-MLV insertion region 1 homolog) in AD and the possibility...

journal_title：Experimental gerontology

authors： Tzekaki EE,Papaspyropoulos A,Tsolaki M,Lazarou E,Kozori M,Pantazaki ΑA

更新日期：2021-02-01 00:00:00

abstract：BACKGROUND:The impact of regular exercise habits at middle-age on muscle mass and function at old age remains inconclusive. While regular exercise likely represents a primary source of health-enhancing physical activity (PA), the physical demand of occupation needs to be considered. Additionally, PA level at old age sh...

journal_title：Experimental gerontology

authors： Edholm P,Veen J,Kadi F,Nilsson A

更新日期：2021-01-28 00:00:00

abstract：AIM:The present study investigated whether hypertension, blood pressure, and antihypertensive therapy were associated with frailty status in community-dwelling older adults. In addition, we tested whether such associations were consistent across different frailty instruments. MATERIAL AND METHODS:Two-hundred older adu...

journal_title：Experimental gerontology

authors： Coelho-Junior HJ,Uchida MC,Picca A,Calvani R,Landi F,de Oliveira Gonçalves I,Rodrigues B,Bernabei R,Marzetti E

更新日期：2021-01-19 00:00:00

abstract：OBJECTIVES:To investigate whether the implementation of a multifactorial falls intervention in nursing homes is cost-beneficial and alleviates the professional workload. DESIGN:A comprehensive quantitative model was developed to calculate the impact of investments in multifactorial falls prevention in nursing homes in...

journal_title：Experimental gerontology

authors： Panneman MJM,Sterke CS,Eilering MJ,Blatter BM,Polinder S,Van Beeck EF

更新日期：2021-01-01 00:00:00

abstract：:Exercise training has been associated with the attenuation of cardiovascular impairment after menopause. This study aimed to compare central and peripheral blood pressure and aortic pulse wave reflection in sedentary and trained (aerobic exercise in the water) hypertensive postmenopausal women. Hypertensive postmenopa...

journal_title：Experimental gerontology

authors： de Andrade Barboza C,Moura EG,Ministro G,Castaño JB,Silva Santos GC,Dias Junior G,Moreno Junior H,Rodrigues B

更新日期：2021-01-01 00:00:00

abstract：:Adult Premature Aging Mice (PAM) show premature immunosenescence, oxidative and inflammatory stress and consequently a shorter lifespan than Exceptional Non-Prematurely Aging Mice (E-NPAM) at the same age. Indeed, adult female PAM exhibit behavioral age-related declines and abnormalities in its brain neurochemistry. N...

journal_title：Experimental gerontology

authors： Garrido A,De La Serna M,De La Fuente M,Marco EM,López-Gallardo M

更新日期：2020-12-31 00:00:00

abstract：OBJECTIVES:There is a scarcity of data on the association between mild cognitive impairment (MCI) and falls, especially from low- and middle-income countries (LMICs) where 70% of all older adults reside. Thus, we investigated the association between MCI and fall-related injury among older adults residing in six LMICs (...

journal_title：Experimental gerontology

authors： Smith L,Jacob L,Kostev K,Butler L,Barnett Y,Pfeifer B,Soysal P,Grabovac I,López-Sánchez GF,Veronese N,Yang L,Oh H,Koyanagi A

更新日期：2020-12-29 00:00:00

abstract：:Aging adipose tissues (ATs) manifest reduced vascularity and increased hypoxia and inflammation that contribute to local and systemic metabolic dysfunction. However, the mechanisms that underlie these age-related changes are incompletely understood. In this study, we sought to examine insulin-stimulated vasodilation a...

journal_title：Experimental gerontology

authors： Islam MT,Henson GD,Machin DR,Bramwell RC,Donato AJ,Lesniewski LA

更新日期：2020-12-01 00:00:00

abstract：:The study examined the influence of sex on the alterations occurring with ageing in rat lymph node (LN) T cell compartment. In female and male rats the decrease in LN T cell counts was followed by a shift in CD4+/CD8+ T cell ratio towards CD8+ T cells, which was more prominent in males than in females. With ageing, in...

journal_title：Experimental gerontology

authors： Nacka-Aleksić M,Stojić-Vukanić Z,Pilipović I,Blagojević V,Kotur-Stevuljević J,Leposavić G

更新日期：2020-12-01 00:00:00

abstract：:Aging is the primary risk factor for functional decline; thus, understanding and preventing disability among older adults has emerged as an important public health challenge of the 21st century. The science of gerontology - or geroscience - has the practical purpose of "adding life to the years." The overall goal of g...

journal_title：Experimental gerontology

authors： Anton SD,Cruz-Almeida Y,Singh A,Alpert J,Bensadon B,Cabrera M,Clark DJ,Ebner NC,Esser KA,Fillingim RB,Goicolea SM,Han SM,Kallas H,Johnson A,Leeuwenburgh C,Liu AC,Manini TM,Marsiske M,Moore F,Qiu P,Mankowski RT,M

更新日期：2020-12-01 00:00:00

abstract：:Degeneration of tongue muscles with aging may contribute to swallowing deficits observed in elderly people. However, the capacity for tongue muscle stem cells (SCs) to regenerate and repair the aged tongue and improve tongue strength following tongue exercise (a current clinical treatment) has never been examined. We ...

journal_title：Experimental gerontology

authors： Kletzien H,Kelm-Nelson CA,Wang S,Suzuki M,Connor NP

更新日期：2020-12-01 00:00:00

abstract：:Studying the changes of serum N-glycome during mouse aging is beneficial to explore the molecular basis behind the alterations reported in human. However, such studies remainscarce and lack some information such as sialylation due to the method limitation. Here, we introduced Bionic Glycome method to quantify the seru...

journal_title：Experimental gerontology

authors： Han J,Pan Y,Qin W,Gu Y,Xu X,Zhao R,Sha J,Zhang R,Gu J,Ren S

更新日期：2020-11-01 00:00:00

abstract：OBJECTIVES:To evaluate lean mass index (LMI) measured by bioimpedance (BIA) and anthropometry compared to densitometry (DXA) in elderly outpatients from a tertiary care hospital. METHODS:Participants were over 60-year-old men, presenting no dementia or disability, from a tertiary geriatric ambulatory. LMI obtained by ...

journal_title：Experimental gerontology

authors： Zambone MA,Liberman S,Garcia MLB

更新日期：2020-09-01 00:00:00

abstract：:Aging is associated with diminished regenerative capacity and increased risk of chronic diseases. There is now compelling evidence suggests that aging process is reversible. Besides metabolic modification and systematic factors, both senescence elimination and cellular reprogramming showed beneficial effects on tissue...

journal_title：Experimental gerontology

authors： Chiche A,Chen C,Li H

更新日期：2020-09-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to compare the effects of 12 weeks of traditional resistance training (TRT) or resistance training using Cluster-set (CS) on functional performance and physical fitness of postmenopausal and elderly women. METHODS:Participants (61.1 ± 4.9 years, body mass 64.5 ± 1.8 kg, height 155.7...

journal_title：Experimental gerontology

authors： Dias RKN,Penna EM,Noronha ASN,de Azevedo ABC,Barbalho M,Gentil PV,Coswig VS

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Low muscle strength (dynapenia) is a primary characteristic of sarcopenia, the age-related loss of muscle mass and strength or low walking speed. New evidence suggests that muscle strength positively affects blood pressure (BP) responses to exercise. As older adults with lowest handgrip strength also have lo...

journal_title：Experimental gerontology

authors： Wong A,Jaime SJ,Grubbs B,Panton LB,Fischer SM,Figueroa A

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Resistance exercise training (RET) has proven effective at reducing the risk of chronic disease in older populations, and it appears to regulate redox homeostasis. AIMS:To determine the effects of RET on redox homeostasis in older people. STUDY DESIGN:A systematic review and meta-analysis of randomized cli...

journal_title：Experimental gerontology

authors： Cuyul-Vásquez I,Berríos-Contreras L,Soto-Fuentes S,Hunter-Echeverría K,Marzuca-Nassr GN

更新日期：2020-09-01 00:00:00

abstract：:Maintaining physical mobility is important for preventing age-related comorbidities in older adults. Endurance and resistance training prevent mobility loss in aging, but exercise alone does not always achieve the expected improvements in physical and cardiopulmonary function. Recent preclinical evidence suggests that...

journal_title：Experimental gerontology

authors： Custodero C,Saini SK,Shin MJ,Jeon YK,Christou DD,McDermott MM,Leeuwenburgh C,Anton SD,Mankowski RT

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:Fatigue resistance (FR) was here defined as the time during which grip strength (GS) drops to 50% of its maximum during sustained contraction. Since different GS systems exist, we compared FR obtained with Pneumatic (Pneu) and Hydraulic (Hydr) handgrip systems. Hand pain induced by both systems was also inve...

journal_title：Experimental gerontology

authors： De Dobbeleer L,Beckwée D,Arnold P,Baudry S,Beyer I,Demarteau J,Lieten S,Punie Y,Bautmans I

更新日期：2020-07-15 00:00:00

abstract：BACKGROUND:Sarcopenic obesity is a combination of both sarcopenia and obesity, which potentiate each other and maximize the negative influences of each, such as physical disability, morbidity, or even mortality. OBJECTIVES:To describe the criteria used to identify people with sarcopenic obesity and the components of t...

journal_title：Experimental gerontology

authors： Yin YH,Liu JYW,Välimäki M

更新日期：2020-07-01 00:00:00

abstract：OBJECTIVE:Mitochondria produce cellular energy via oxidative phosphorylation (OXPHOS), mediated by respiratory chain complexes I to IV and ATP synthase (complex V). Mitochondrial respiratory complexes have been shown to decline with age in several tissues. As the intestinal epithelium is a tissue with a high energy dem...

journal_title：Experimental gerontology

authors： Özsoy M,Zimmermann FA,Feichtinger RG,Mayr JA,Kofler B,Neureiter D,Klieser E,Schütz S,Weghuber D,Schneider AM

更新日期：2020-07-01 00:00:00

abstract：:Studies have suggested that older individuals are more fatigable than young adults when power loss, measured during single-joint contractions, is considered the fatigue index; however, age-related differences in fatigue considering power measurements during multi-joint movements (e.g., cycling) have not been fully elu...

journal_title：Experimental gerontology

authors： Krüger RL,Aboodarda SJ,Jaimes LM,Vaz MA,Samozino P,Millet GY

更新日期：2020-05-01 00:00:00

abstract：:The purpose of this study was to examine the effect of a mentally fatiguing task on postural responses to unexpected backward perturbations in sixteen young and sixteen older women. Postural responses were characterized by center of pressure (COP) displacement, corrective COP peak velocity, and electromyography (EMG) ...

journal_title：Experimental gerontology

authors： Morris AJ,Christie AD

更新日期：2020-04-01 00:00:00

abstract：:Diabetic peripheral neuropathy (DPN) is associated with peripheral arterial disease and endothelial dysfunction. We investigated the effect of exercise training on the measures of superficial femoral artery (SFA) and neuropathic symptoms in patients with DPN. In a randomized-controlled trial, 31 volunteers with establ...

journal_title：Experimental gerontology

authors： Gholami F,Nazari H,Alimi M

更新日期：2020-03-01 00:00:00

abstract：:The purposes of this study were to examine the age-related differences in absolute and normalized torque-time parameters in five distinct groups across the adult lifespan, and the relationship between rapid strength and limb acceleration capacities across the lifespan. One-hundred and thirty-six healthy men were categ...

journal_title：Experimental gerontology

authors： Thompson BJ,Sobolewski EJ,Ryan ED

更新日期：2020-03-01 00:00:00

abstract：:Lipids constitute a significant group of biological metabolites and the building blocks of all cell membranes. The abundance and stoichiometries of different lipid species are known to vary across the lifespan and metabolic state, yet the functional effects of these changes have been challenging to understand. Here we...

journal_title：Experimental gerontology

authors： Skowronska-Krawczyk D,Budin I

更新日期：2020-03-01 00:00:00

abstract：:Reductive stress, which is due to a paradoxical excess of antioxidants such as reduced glutathione (GSH) and GSH-related enzymes associated with decreased oxidant levels, has emerged as a pathogenetic mechanism of myocardial damage in pathological conditions such as protein aggregation cardiomyopathy. Notably, in the ...

journal_title：Experimental gerontology

authors： Lapenna D,Ciofani G,Lelli Chiesa P,Porreca E

更新日期：2020-02-06 00:00:00

abstract：:Accumulating evidence from diverse experiments, including heterochronic parabiosis-the surgical joining of two animals of different ages-has highlighted the importance of systemic factors in the progressive functional decline of various organs and tissues during aging. The major metabolic pathway of tryptophan, an ess...

journal_title：Experimental gerontology

authors： Kim BJ,Lee SH,Koh JM

更新日期：2020-02-01 00:00:00

abstract：:The aging of the skin is the most visible and obvious manifestation of organismal aging and may serve as a predictor of life expectancy and health. It is, however, also the human desire for long-lasting beauty that further raises interests in the topic, and thus considerable means and efforts are put into studying the...

journal_title：Experimental gerontology

authors： Gruber F,Kremslehner C,Eckhart L,Tschachler E

更新日期：2020-02-01 00:00:00

abstract：:Collagens and elastin are 'building blocks' of tissues and extracellular matrix. Mutations in these proteins cause severe congenital syndromes. Adverse genetic variations may accelerate the aging process in adults contributing to premature morbidity, disability and/or mortality. Favorable variants may contribute to lo...

journal_title：Experimental gerontology

authors： Romero-Ortuno R,Kenny RA,McManus R

更新日期：2020-01-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most common cause of dementia accounting for 60-70% of all demented cases and one of the leading sources of morbidity and mortality in the aging population. Most of the recent literature regards the relationship between plasma oxidative stress and AD, showing that markers of lipid perox...

journal_title：Experimental gerontology

authors： Vignini A,Alia S,Pugnaloni S,Giulietti A,Bacchetti T,Mazzanti L,Luzzi S,Fiorini R

更新日期：2019-12-01 00:00:00

abstract：:Activation of the unfolded protein response (UPR) in the endoplasmic reticulum (ER) and mitochondrial apoptotic pathway serves as a central regulator for maintaining cell function and survival, and is associated with ageing and spermatogenesis. However, changes in UPR activation and mitochondrial apoptotic pathway in ...

journal_title：Experimental gerontology

authors： Zhao H,Ma N,Chen Q,You X,Liu C,Wang T,Yuan D,Zhang C

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:The World Health Organization (WHO) recently proposed an innovative model of care focusing on functional rather than disease-based perspectives, based on a construct of intrinsic capacity (IC). OBJECTIVE:This study aimed to analyze if low-grade inflammation (LGI) (chronically raised C-reactive protein - CRP...

journal_title：Experimental gerontology

authors： Giudici KV,de Souto Barreto P,Guerville F,Beard J,Araujo de Carvalho I,Andrieu S,Rolland Y,Vellas B,MAPT\/DSA group.

更新日期：2019-11-01 00:00:00

abstract：:Menopause is associated with a decline in overall health in women. One health aspect impacted is glucose metabolism. As women experience menopause, their metabolism declines dramatically. The current study addressed the influence of ovarian somatic cells on the improvement of metabolic health through transplantations ...

journal_title：Experimental gerontology

authors： Tyler KA,Habermehl TL,Mason JB

更新日期：2019-10-15 00:00:00

abstract：:Skeletal muscle atrophy reduces quality of life and increases morbidity and mortality in patients with chronic conditions. Oxidative stress is a key factor contributing to skeletal muscle atrophy by altering both protein synthesis and protein degradation pathways. Beta-lapachone (Beta-L) is known to act as a pro-oxida...

journal_title：Experimental gerontology

authors： Park S,Shin MG,Kim JR,Park SY

更新日期：2019-10-15 00:00:00

abstract：INTRODUCTION:Age-related decreases in cerebral blood flow (CBF) may lead to cognitive decline, while physical activity (PA) can maintain CBF and cognition in aging. The intensity of PA needed to affect CBF in aging, and the independent effects of sedentary time on CBF are currently unknown. Moreover, research conducted...

journal_title：Experimental gerontology

authors： Zlatar ZZ,Hays CC,Mestre Z,Campbell LM,Meloy MJ,Bangen KJ,Liu TT,Kerr J,Wierenga CE

更新日期：2019-10-01 00:00:00

abstract：:Muscle wasting diseases are gradually increasing with the increase in global life expectancy. This study was designed to evaluate the efficacy of HIM-CHX, a herbal combination of Boswellia serrata, Cissus quadrangularis, and Withania somnifera, on Sarcopenia. The effects of HIM-CHX on parameters such as muscle mass, g...

journal_title：Experimental gerontology

authors： Azeemuddin MM,Rao CM,Rafiq M,Babu UV,Rangesh P

更新日期：2019-10-01 00:00:00