abstract：BACKGROUND:There are no effective therapies for patients with coronavirus disease-2019 (COVID-19). METHODS:Forty-one patients with confirmed COVID-19 were enrolled in the study and divided into two groups: artemisinin-piperaquine (AP) (n = 23) and control (n = 18). The primary outcome were the time taken to reach unde...

journal_title：International journal of antimicrobial agents

authors： Li G,Yuan M,Li H,Deng C,Wang Q,Tang Y,Zhang H,Yu W,Xu Q,Zou Y,Yuan Y,Guo J,Jin C,Guan X,Xie F,Song J

更新日期：2021-01-01 00:00:00

abstract：:Enterococcus faecium is a significant opportunistic human pathogen with a broad host range, including humans, farm animals, pets and wildlife. Specialised subpopulations have globally evolved towards a powerful and convergent adaption to the healthcare environment by acquiring a cocktail of key antimicrobial resistanc...

journal_title：International journal of antimicrobial agents

authors： Freitas AR,Pereira AP,Novais C,Peixe L

更新日期：2021-01-01 00:00:00

abstract：:Cystic fibrosis (CF) patients are at risk of acquiring chronic Pseudomonas aeruginosa lung infections. The biofilm mode of growth of P. aeruginosa induces tolerance to antibiotics and the host response; accordingly, treatment failure occurs. Supplemental azithromycin has proven beneficial in CF owing to potential immu...

journal_title：International journal of antimicrobial agents

authors： Thomsen K,Christophersen L,Lerche CJ,Holmgaard DB,Calum H,Høiby N,Moser C

更新日期：2021-01-01 00:00:00

abstract：:Polymyxins were recently approved for the clinical treatment of carbapenem-resistant Enterobacteriaceae (CRE) infections in China. The aim of this study was to determine the prevalence and molecular mechanisms of polymyxin-resistant CRE prior to the clinical application of polymyxin and to evaluate the potential for e...

journal_title：International journal of antimicrobial agents

authors： Zhang X,Qu F,Jia W,Huang B,Shan B,Yu H,Tang Y,Chen L,Du H

更新日期：2020-12-23 00:00:00

abstract：:Knowing the ability of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to bind to the angiotensin-converting enzyme 2 (ACE2) receptor and to enter cells via endocytosis paved the way for repositioning of old drugs as potential treatment of COVID-19, the disease caused by SARS-CoV-2 infection. This paper h...

journal_title：International journal of antimicrobial agents

authors： Alkotaji M

更新日期：2020-12-01 00:00:00

abstract：:Polymyxins are increasingly used as a last resort for the treatment of infections caused by multidrug-resistant Gram-negative bacteria in patients. Over the last decade, significant progress has been made in understanding the pharmacokinetics/pharmacodynamics/toxicodynamics (PK/PD/TD) of parenteral and inhaled polymyx...

journal_title：International journal of antimicrobial agents

authors： Lin YW,Aye SM,Rao G,Zhou QT,Chan HK,Li J

更新日期：2020-12-01 00:00:00

abstract：OBJECTIVES:This study aimed to report the results of SARS-CoV-2 PCR-based screening campaigns conducted on dependent elderly residents (compared with staff members) in long-term care facilities (LTCFs) in Marseille, France, and the follow-up of positive cases. METHODS:Data from 1691 elderly residents and 1000 members ...

journal_title：International journal of antimicrobial agents

authors： Ly TDA,Zanini D,Laforge V,Arlotto S,Gentile S,Mendizabal H,Finaud M,Morel D,Quenette O,Malfuson-Clot-Faybesse P,Midejean A,Le-Dinh P,Daher G,Labarriere B,Morel-Roux AM,Coquet A,Augier P,Parola P,Chabriere E,Raoult D

更新日期：2020-12-01 00:00:00

abstract：:Representatives of the Mollicutes class are the smallest, wall-less bacteria capable of independent reproduction. They are widespread in nature, most are commensals, and some are pathogens of humans, animals and plants. They are also the main contaminants of cell cultures and vaccine preparations. Despite limited bios...

journal_title：International journal of antimicrobial agents

authors： Chernova OA,Chernov VM,Mouzykantov AA,Baranova NB,Edelstein IA,Aminov RI

更新日期：2020-11-29 00:00:00

abstract：:Octenidine (OCT) is a widely used antiseptic molecule with an antimicrobial spectrum covering a broad range of bacteria and fungi. However, the detailed molecular mechanism of killing has not yet been elucidated. The objective of our study was to investigate the mode of action of OCT's potent effect on Gram-negative b...

journal_title：International journal of antimicrobial agents

authors： Malanovic N,Ön A,Pabst G,Zellner A,Lohner K

更新日期：2020-11-01 00:00:00

abstract：:Healthcare resources are being diverted for the containment and control of coronavirus disease 2019 (COVID-19). During this outbreak, it is cautioned that antibiotic misuse may be increased, especially for respiratory tract infections. With stewardship interventions, the duration of antibiotic therapy and length of st...

journal_title：International journal of antimicrobial agents

authors： Liew Y,Lee WHL,Tan L,Kwa ALH,Thien SY,Cherng BPZ,Chung SJ

更新日期：2020-11-01 00:00:00

abstract：OBJECTIVES:There has been interest in administering cefepime, a β-lactam antibiotic, via intravenous push (IVP) as a means to improve time to first-dose antibiotic and reduce cost; however, the downstream impacts on antibiotic exposure and pharmacodynamic efficacy need to be further evaluated. METHODS:This study used ...

journal_title：International journal of antimicrobial agents

authors： Liu J,Rhodes NJ,Roberts JA,Pais GM,Turner B,Kiel PJ,Scheetz MH

更新日期：2020-11-01 00:00:00

abstract：:Due to limited therapeutic options, combination therapy has been used empirically to treat carbapenem-resistant Acinetobacter baumannii (CRAB). Polymyxin-based combinations have been widely studied and used in the clinical setting. However, the use of polymyxins is often limited due to nephrotoxicity and neurotoxicity...

journal_title：International journal of antimicrobial agents

authors： Mohd Sazlly Lim S,Naicker S,Ayfan AK,Zowawi H,Roberts JA,Sime FB

更新日期：2020-10-01 00:00:00

abstract：:Bumped kinase inhibitors (BKIs) are effective against a variety of apicomplexan parasites. Fifteen BKIs with promising in vitro efficacy against Neospora caninum tachyzoites, low cytotoxicity in mammalian cells, and no toxic effects in non-pregnant BALB/c mice were assessed in pregnant mice. Drugs were emulsified in c...

journal_title：International journal of antimicrobial agents

authors： Anghel N,Winzer PA,Imhof D,Müller J,Langa X,Rieder J,Barrett LK,Vidadala RSR,Huang W,Choi R,Hulverson MA,Whitman GR,Arnold SL,Van Voorhis WC,Ojo KK,Maly DJ,Fan E,Hemphill A

更新日期：2020-09-01 00:00:00

abstract：INTRODUCTION:Antimicrobial peptides are proving to be promising lead compounds for therapeutics. The major disadvantage of antimicrobial peptides is their proteolytic instability in the body, with half-lives averaging less than an hour. Peptoids, or N-substituted glycines, have emerged as a promising field of peptidomi...

journal_title：International journal of antimicrobial agents

authors： Green RM,Bicker KL

更新日期：2020-08-01 00:00:00

abstract：:Carbapenem-resistant Enterobacterales have become a major public-health issue worldwide. Here we report an outbreak caused by a clonal multidrug-resistant Proteus mirabilis strain producing VIM-4 metallo-β-lactamase (MBL) and TEM-2 β-lactamase in a Greek tertiary-care hospital. From July 2015 to February 2016, 27 imip...

journal_title：International journal of antimicrobial agents

authors： Protonotariou E,Poulou A,Politi L,Meletis G,Chatzopoulou F,Malousi A,Metallidis S,Tsakris A,Skoura L

更新日期：2020-08-01 00:00:00

abstract：:The emergence of SARS-coronavirus-2 (SARS-CoV-2) has led to a global pandemic disease referred to as coronavirus disease 19 (COVID-19). Hydroxychloroquine (CLQ-OH)/azithromycin (ATM) combination therapy is currently being tested for the treatment of COVID-19, with promising results. However, the molecular mechanism of...

journal_title：International journal of antimicrobial agents

authors： Fantini J,Chahinian H,Yahi N

更新日期：2020-08-01 00:00:00

abstract：:This paper presents the results of a pilot study of difficult-to-treat patients (exhibiting several previous treatment failures or detection of extended-spectrum beta-lactamase [ESBL] strains) with chronic bacterial prostatitis (CBP) who underwent treatment with fosfomycin trometamol (FT) and N-acetyl-L-cysteine (NAC)...

journal_title：International journal of antimicrobial agents

authors： Cai T,Tamanini I,Mattevi D,Verze P,Palmieri A,Malossini G,Mirone V,Novelli A,Tascini C,Johansen TEB

更新日期：2020-07-01 00:00:00

abstract：OBJECTIVES:To identify and characterize oxazolidinone resistance genes cfr and optrA in enterococcal isolates. METHODS:Two hundred and ninety-three enterococcal isolates were screened for the presence of cfr and optrA by polymerase chain reaction. The transferability of cfr and optrA was examined by conjugation. S1 nu...

journal_title：International journal of antimicrobial agents

authors： Chen L,Han D,Tang Z,Hao J,Xiong W,Zeng Z

更新日期：2020-07-01 00:00:00

abstract：:The rise and spread of antimicrobial resistance represents one of the most pressing health issues of today. Antimicrobial resistance in micro-organisms can arise due to a multiplicity of factors, including permeability changes in the cell membrane, increase of drug efflux pumps, enzymatic modification or inactivation ...

journal_title：International journal of antimicrobial agents

authors： Barbosa F,Pinto E,Kijjoa A,Pinto M,Sousa E

更新日期：2020-07-01 00:00:00

abstract：:Bacterial osteomyelitis is a major clinical challenge in human and veterinary patients. This infection is an infrequent but feared complication of orthopedic surgery and is mainly caused by methicillin-resistant Staphylococcus aureus (MRSA). The aim of this study was to evaluate the efficacy of dalbavancin (dosed for ...

journal_title：International journal of antimicrobial agents

authors： Silva V,Miranda C,Antão HS,Guimarães J,Prada J,Pires I,Maltez L,Pereira JE,Capelo JL,Igrejas G,Poeta P

更新日期：2020-07-01 00:00:00

abstract：:Carbapenemase-producing (CP) Pseudomonas aeruginosa is rare compared with mutation-driven carbapenem-resistance, but this situation may be changing. A collection of CP P. aeruginosa isolates was characterized in this study. In 2016, 232 unduplicated carbapenem-resistant P. aeruginosa isolates, of which 71 (30.6%) carr...

journal_title：International journal of antimicrobial agents

authors： PÉrez-VÁzquez M,Sola-Campoy PJ,Zurita ÁM,Ávila A,GÓmez-Bertomeu F,SolÍs S,LÓpez-Urrutia L,GÓnzalez-BarberÁ EM,Cercenado E,Bautista V,Lara N,Aracil B,Oliver A,Campos J,Oteo-Iglesias J,Spanish Antibiotic Resistance Surveillan

更新日期：2020-07-01 00:00:00

abstract：:The aim of this study was to investigate recurrent infections in individual patients caused by extended-spectrum β-lactamase and plasmid AmpC β-lactamase-producing Escherichia coli (ESBL/pAmpC-Ec) isolates with >12-month interval. The Danish national collection of ESBL/pAmpC-Ec isolates collected from January 2014 thr...

journal_title：International journal of antimicrobial agents

authors： Roer L,Hansen F,Hasman H,Hammerum AM,Cavaco LM

更新日期：2020-07-01 00:00:00

abstract：:Colistin remains a last-line antibiotic for the treatment of infections by multidrug-resistant Acinetobacter species. However, mortality rates are high in patients with Acinetobacter infection receiving colistin treatment. This multicentre study evaluated whether colistin susceptibility, additional antimicrobial agent...

journal_title：International journal of antimicrobial agents

authors： Lee YT,Sun JR,Wang YC,Chiu CH,Kuo SC,Chen TL,ACTION Study Group.,Yang YS

更新日期：2020-06-01 00:00:00

abstract：:Pseudomonas aeruginosa (PA) is a major cause of healthcare-associated infections. Antipseudomonal carbapenems are among the antimicrobial agents used to treat PA infections, but several mechanisms of resistance, including the production of a carbapenemase (CP), may compromise their clinical efficacy. The objectives of...

journal_title：International journal of antimicrobial agents

authors： Kresken M,Körber-Irrgang B,Korte-Berwanger M,Pfennigwerth N,Gatermann SG,Seifert H,German Carbapenem Resistance Study Group.

更新日期：2020-06-01 00:00:00

abstract：:In addition to the absolute case number, a rapid increase in the number of COVID-19 cases within a short time results in insufficiency of healthcare systems and further negatively affects patient outcomes. This study was conducted to investigate the association between the outcomes of COVID-19 patients and daily cumul...

journal_title：International journal of antimicrobial agents

authors： Lai CC,Wang CY,Wang YH,Hsueh PR

更新日期：2020-06-01 00:00:00

abstract：:A recent report identified significant reductions or disappearance of viral load in COVID-19 patients given a combination of hydroxychloroquine and azithromycin. The present communication discusses some common pharmacokinetic properties of these two drugs that may be linked to a potential underlying mechanism of actio...

journal_title：International journal of antimicrobial agents

authors： Derendorf H

更新日期：2020-06-01 00:00:00

abstract：OBJECTIVES:Since the early 2000s, Escherichia coli resistance to third-generation cephalosporins (3GCs) has been increasing in all European countries, mainly due to the spread of extended spectrum β-lactamases (ESBLs). Here we present a retrospective study that combines resistance of E. coli to 3GCs and quinolones with...

journal_title：International journal of antimicrobial agents

authors： Jeanvoine A,Bouxom H,Leroy J,Gbaguidi-Haore H,Bertrand X,Slekovec C

更新日期：2020-05-01 00:00:00

abstract：:Recently, a novel coronavirus (2019-nCoV), officially known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged in China. Despite drastic containment measures, the spread of this virus is ongoing. SARS-CoV-2 is the aetiological agent of coronavirus disease 2019 (COVID-19) characterised by pulmonar...

journal_title：International journal of antimicrobial agents

authors： Devaux CA,Rolain JM,Colson P,Raoult D

更新日期：2020-05-01 00:00:00

abstract：:This study aimed to characterise UTIs caused by Pseudomonas aeruginosa in hospitalised adults and to identify risk factors for infections caused by multidrug-resistant (MDR) strains. A retrospective case-case-control study was conducted in two Italian teaching hospitals. Totally, 242 monomicrobial P. aeruginosa UTIs w...

journal_title：International journal of antimicrobial agents

authors： Tumbarello M,Raffaelli F,Peghin M,Losito AR,Chirico L,Giuliano G,Spanu T,Sartor A,Fiori B,Bassetti M

更新日期：2020-04-01 00:00:00

abstract：INTRODUCTION:Tazobactam-piperacillin (TZP) is a mixture of a broad-spectrum penicillin and an irreversible β-lactamase inhibitor. TZP is effective against Gram-negative bacteria that produce extended-spectrum β-lactamases, and it is used as a first-line or second-line drug to treat serious infections. METHODS:This stu...

journal_title：International journal of antimicrobial agents

authors： Suzuki Y,Sato T,Fukushima Y,Nakajima C,Suzuki Y,Takahashi S,Yokota SI

更新日期：2020-04-01 00:00:00

abstract：:In December 2019, a novel coronavirus, named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged from China causing pneumonia outbreaks, first in the Wuhan region of China and then spread worldwide because of its probable high transmission efficiency. Owing to the lack of efficient and specific treat...

journal_title：International journal of antimicrobial agents

authors： Baron SA,Devaux C,Colson P,Raoult D,Rolain JM

更新日期：2020-04-01 00:00:00

abstract：:This study aimed to assess the clinical impact and potential risk factors associated with polymyxin-resistant Enterobacteriaceae strains isolated from patients hospitalized in adult and neonatal intensive care units. A case-control study was conducted from September 2015 to January 2017. Antimicrobial susceptibility o...

journal_title：International journal of antimicrobial agents

authors： da Silva KE,Baker S,Croda J,Nguyen TNT,Boinett CJ,Barbosa LS,Tetila A,Simionatto S

更新日期：2020-03-01 00:00:00

abstract：:Nacubactam is a novel non-β-lactam diazabicyclooctane β-lactamase inhibitor under development for the treatment of serious Gram-negative infections. This study assessed the efficacy of human-simulated epithelial lining fluid (ELF) exposure of nacubactam in combination with meropenem against AmpC-overproducing (n=4) an...

journal_title：International journal of antimicrobial agents

authors： Asempa TE,Motos A,Abdelraouf K,Bissantz C,Zampaloni C,Nicolau DP

更新日期：2020-02-01 00:00:00

abstract：:Aspergillus fumigatus is the main causal agent of invasive aspergillosis (IA), however other species of the genus can also cause IA, such as Aspergillus flavus, Aspergillus terreus, Aspergillus niger and related cryptic species. This infectious disease mainly affects immunosuppressed patients and is linked to elevated...

journal_title：International journal of antimicrobial agents

authors： Pérez-Cantero A,López-Fernández L,Guarro J,Capilla J

更新日期：2020-01-01 00:00:00

abstract：:In Europe, a novel mecA homologue - mecC (formerly mecALGA251) - has emerged recently in staphylococci from animals, humans and the environment. This paper reports the first occurrence of the mecC gene in Staphylococcus sciuri from cows and manure in Tunisia and Africa. Forty-nine coagulase-negative staphylococci (CNS...

journal_title：International journal of antimicrobial agents

authors： Dhaouadi S,Soufi L,Campanile F,Dhaouadi F,Sociale M,Lazzaro L,Cherif A,Stefani S,Elandoulsi RB

更新日期：2020-01-01 00:00:00

abstract：:The activity of the novel, fully synthetic fluorocycline antibiotic TP-6076 against carbapenem-resistant Acinetobacter baumannii (CRAB) isolates with defined carbapenem resistance mechanisms was compared against reference antimicrobials with known activity against Acinetobacter spp. The susceptibility of 323 non-dupli...

journal_title：International journal of antimicrobial agents

authors： Seifert H,Stefanik D,Olesky M,Higgins PG

更新日期：2020-01-01 00:00:00

abstract：:Two novel phosphoethanolamine transferase genes, eptAv7 and eptAv3, were identified in the chromosome of an Aeromonas jandaei isolate from retail fish. The variants showed 79.9% and 80.0% amino acid identity to MCR-7.1 and MCR-3.1, respectively, and increased colistin resistance 128- to 256-fold in Aeromonas salmonici...

journal_title：International journal of antimicrobial agents

authors： Liu D,Song H,Ke Y,Xia J,Shen Y,Ou Y,Hao Y,He J,Li X,Zhou Y,Fu J,Wang Y,Lv Z,Wu C

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVES:Very few studies have characterised community-onset polymicrobial bloodstream infections (BSIs). This study determined the incidence, risk factors, and outcomes of polymicrobial BSI as compared with monomicrobial BSI in a cohort of patients with community-onset BSIs. METHODS:This prospective cohort study en...

journal_title：International journal of antimicrobial agents

authors： Yo CH,Hsein YC,Wu YL,Hsu WT,Ma MH,Tsai CH,Chen SC,Lee CC

更新日期：2019-12-01 00:00:00

abstract：:The feasibility of using colicins to create an antimicrobial lubricant to prevent extraluminal catheter contamination during urinary catheter insertion was assessed. Levels of resistance of uropathogenic Escherichia coli to antibiotics and colicins were compared. The results showed that antibiotics and colicins posses...

journal_title：International journal of antimicrobial agents

authors： Roy SM,Riley MA

更新日期：2019-11-01 00:00:00

abstract：:Skin bacterial colonization/infection is a frequent cause of morbidity in patients with chronic wounds and allergic/inflammatory skin diseases. This study aimed to develop a novel approach to eradicate meticillin-resistant Staphylococcus aureus (MRSA) from human skin. To achieve this, the stability and antibacterial a...

journal_title：International journal of antimicrobial agents

authors： Nibbering PH,Göblyös A,Adriaans AE,Cordfunke RA,Ravensbergen B,Rietveld MH,Zwart S,Commandeur S,van Leeuwen R,Haisma EM,Schimmel KJM,den Hartigh J,Drijfhout JW,Ghalbzouri AE

更新日期：2019-11-01 00:00:00