Therapeutic potential of dalbavancin in a rat model of methicillin-resistant Staphylococcus aureus (MRSA)-osteomyelitis.

Abstract:

:Bacterial osteomyelitis is a major clinical challenge in human and veterinary patients. This infection is an infrequent but feared complication of orthopedic surgery and is mainly caused by methicillin-resistant Staphylococcus aureus (MRSA). The aim of this study was to evaluate the efficacy of dalbavancin (dosed for either 7 or 14 days) in an MRSA-osteomyelitis tibial bone model. A total of 39 rats were included in the study. All animals received an inoculum of a clinical strain of MRSA (106 colony-forming units [CFU]) injected into the proximal tibia under general anesthesia. Dalbavancin was injected intraperitoneally for 7 or 14 days in 13 animals each; the remaining 13 animals received saline solution. After treatment, the animals were sacrificed. Infected tibiae were recovered for histological evaluation and microbiological analysis (MRSA count per gram of bone). Rats that received dalbavancin showed a statistically significant reduction of MRSA counts compared with the control group: median 0 CFU/g bone (14 days of dalbavancin) vs. 70 CFU/g bone (7 days of dalbavancin) and 1600 CFU/g bone (control). Histological evaluation showed typical signs of osteomyelitis in the control group, whereas there were no signs of bone infection in 92% of the rats that received 14 days of dalbavancin. According to this model, dalbavancin seems to have good efficacy for treating serious Gram-positive bone infections, including those caused by MRSA.

authors

Silva V,Miranda C,Antão HS,Guimarães J,Prada J,Pires I,Maltez L,Pereira JE,Capelo JL,Igrejas G,Poeta P

doi

10.1016/j.ijantimicag.2020.106021

subject

Has Abstract

pub_date

2020-07-01 00:00:00

pages

106021

issue

1

eissn

0924-8579

issn

1872-7913

pii

S0924-8579(20)30184-9

journal_volume

56

pub_type

杂志文章
  • Invasive group A streptococcal infection: New concepts in antibiotic treatment.

    abstract::The incidence of severe group A streptococcal infection and the streptococcal toxic shock syndrome has increased since 1986. In contrast to earlier times, aggressive streptococal infection is now more likely to affect patients between 20 and 50 years of age who do not have predisposing underlying diseases. Its viral-l...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章

    doi:10.1016/0924-8579(94)90029-9

    authors: Stevens DL,Bryant AE,Yan S

    更新日期:1994-01-01 00:00:00

  • Prevalence and characterisation of CTX-M β-lactamases amongst Escherichia coli isolates from healthy food animals in China.

    abstract::The impact of extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae of food animal origins on human health has caught considerable attention worldwide. Intestinal Escherichia coli obtained from healthy food animals (pigs, cattle and poultry) in China were tested for the presence of ESBL genes. CTX-M-produc...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章

    doi:10.1016/j.ijantimicag.2011.12.001

    authors: Zheng H,Zeng Z,Chen S,Liu Y,Yao Q,Deng Y,Chen X,Lv L,Zhuo C,Chen Z,Liu JH

    更新日期:2012-04-01 00:00:00

  • Imipenem heteroresistance induced by imipenem in multidrug-resistant Acinetobacter baumannii: mechanism and clinical implications.

    abstract::Acinetobacter baumannii has emerged as a major pathogen causing nosocomial infections, particularly in critical patients admitted to the Intensive Care Unit. Increasing resistance to carbapenems in A. baumannii has been observed worldwide. Here we report the clinical impact and mechanism of imipenem heteroresistance (...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章

    doi:10.1016/j.ijantimicag.2010.12.015

    authors: Lee HY,Chen CL,Wang SB,Su LH,Chen SH,Liu SY,Wu TL,Lin TY,Chiu CH

    更新日期:2011-04-01 00:00:00

  • Approaching zero: temporal effects of a restrictive antibiotic policy on hospital-acquired Clostridium difficile, extended-spectrum β-lactamase-producing coliforms and meticillin-resistant Staphylococcus aureus.

    abstract::A restrictive antibiotic policy banning routine use of ceftriaxone and ciprofloxacin was implemented in a 450-bed district general hospital following an educational campaign. Monthly consumption of nine antibiotics was monitored in defined daily doses (DDDs) per 1000 patient-occupied bed-days (1000 pt-bds) 9 months be...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章

    doi:10.1016/j.ijantimicag.2012.10.013

    authors: Dancer SJ,Kirkpatrick P,Corcoran DS,Christison F,Farmer D,Robertson C

    更新日期:2013-02-01 00:00:00

  • Meropenem-nacubactam activity against AmpC-overproducing and KPC-expressing Pseudomonas aeruginosa in a neutropenic murine lung infection model.

    abstract::Nacubactam is a novel non-β-lactam diazabicyclooctane β-lactamase inhibitor under development for the treatment of serious Gram-negative infections. This study assessed the efficacy of human-simulated epithelial lining fluid (ELF) exposure of nacubactam in combination with meropenem against AmpC-overproducing (n=4) an...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章

    doi:10.1016/j.ijantimicag.2019.10.019

    authors: Asempa TE,Motos A,Abdelraouf K,Bissantz C,Zampaloni C,Nicolau DP

    更新日期:2020-02-01 00:00:00

  • Increased mortality associated with methicillin-resistant Staphylococcus aureus (MRSA) infection in the intensive care unit: results from the EPIC II study.

    abstract::Controversy continues regarding whether the presence of meticillin resistance increases mortality risk in Staphylococcus aureus infections. In this study, we assessed the role of meticillin resistance in survival of patients with S. aureus infection included in the EPIC II point-prevalence study of infection in critic...

    journal_title:International journal of antimicrobial agents

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1016/j.ijantimicag.2011.05.013

    authors: Hanberger H,Walther S,Leone M,Barie PS,Rello J,Lipman J,Marshall JC,Anzueto A,Sakr Y,Pickkers P,Felleiter P,Engoren M,Vincent JL,EPIC II Group of Investigators.

    更新日期:2011-10-01 00:00:00

  • Treatment of symptomatic amebic colitis in human immunodeficiency virus-infected persons.

    abstract::While most Entamoeba histolytica appearing in male homosexuals infected with human immunodeficiency virus (HIV) is considered non-invasive in Western countries, and treatment of amebiasis in these persons has received very little attention, in Japan some male homosexual amebiasis patients infected with HIV complain of...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章

    doi:10.1016/s0924-8579(96)00327-5

    authors: Ohnishi K,Murata M

    更新日期:1996-10-01 00:00:00

  • Review and mapping of carbapenem-resistant Enterobacteriaceae in Africa: Using diverse data to inform surveillance gaps.

    abstract::Carbapenem-resistant Enterobacteriaceae (CRE) are among the most difficult to treat emerging multidrug-resistant organisms. Major limitations exist in surveillance needed to address CRE, particularly in areas with inadequate resources. We utilised optimised strategies to search for data on carbapenem susceptibility of...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章,评审

    doi:10.1016/j.ijantimicag.2018.05.019

    authors: Mitgang EA,Hartley DM,Malchione MD,Koch M,Goodman JL

    更新日期:2018-09-01 00:00:00

  • In vitro anti-trichomonad effectiveness of a gossypol-metronidazol blend.

    abstract::With the aid of the Basic Sequential Analytical Simplex Method the in vitro anti-trichomonad effectiveness of several metronidazole/gossypol blends was determined. While the combination that produced 50% of growth inhibition on trichomonad cultures (IC50) contained 15.1 microM gossypol and 0.087 microM metronidazole, ...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章

    doi:10.1016/s0924-8579(97)00026-5

    authors: Teresa González-Garza M,Said-Fernández S

    更新日期:1997-06-01 00:00:00

  • Prevalence of predicted resistance to doravirine in HIV-1-positive patients after exposure to non-nucleoside reverse transcriptase inhibitors.

    abstract::This study investigated the prevalence of doravirine (DOR) resistance mutations in non-nucleoside reverse transcriptase inhibitor (NNRTI)-experienced patients. DOR resistance was assessed in samples from NNRTI-experienced patients who underwent genotypic testing for virological failure from the Antiretroviral Response...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章

    doi:10.1016/j.ijantimicag.2019.02.007

    authors: Sterrantino G,Borghi V,Callegaro AP,Bruzzone B,Saladini F,Maggiolo F,Maffongelli G,Andreoni M,De Gennaro M,Gianotti N,Bagnarelli P,Vergori A,Antinori A,Zazzi M,Zaccarelli M,ARCA Study Group.

    更新日期:2019-04-01 00:00:00

  • Co-existence of two novel phosphoethanolamine transferase gene variants in Aeromonas jandaei from retail fish.

    abstract::Two novel phosphoethanolamine transferase genes, eptAv7 and eptAv3, were identified in the chromosome of an Aeromonas jandaei isolate from retail fish. The variants showed 79.9% and 80.0% amino acid identity to MCR-7.1 and MCR-3.1, respectively, and increased colistin resistance 128- to 256-fold in Aeromonas salmonici...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章

    doi:10.1016/j.ijantimicag.2019.11.013

    authors: Liu D,Song H,Ke Y,Xia J,Shen Y,Ou Y,Hao Y,He J,Li X,Zhou Y,Fu J,Wang Y,Lv Z,Wu C

    更新日期:2020-01-01 00:00:00

  • Efficacy of anidulafungin, caspofungin and fluconazole in the early phase of infection in a neutropenic murine invasive candidiasis model.

    abstract::In this study, we investigated the in vivo efficacy of anidulafungin during the early phase of disseminated candidiasis in a neutropenic murine model and compared the results with those obtained for fluconazole. Antifungal efficacy was evaluated by reduction of fungal burden in the tissues of infected animals at perio...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章

    doi:10.1016/j.ijantimicag.2010.02.020

    authors: Krishnan-Natesan S,Manavathu EK,Cutright JL,Chandrasekar PH

    更新日期:2010-07-01 00:00:00

  • Surveillance of antimicrobial resistance in Escherichia coli strains isolated from pigs at Spanish slaughterhouses.

    abstract::Antimicrobial resistance can make the efficient treatment of bacterial infections in humans and animals more difficult. Antimicrobial use in food animals may be one of the factors contributing to resistance. The Spanish surveillance network VAV has established a baseline of antimicrobial resistance in Escherichia coli...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章

    doi:10.1016/s0924-8579(00)00153-9

    authors: Teshager T,Herrero IA,Porrero MC,Garde J,Moreno MA,Domínguez L

    更新日期:2000-07-01 00:00:00

  • Lipopolysaccharide loss produces partial colistin dependence and collateral sensitivity to azithromycin, rifampicin and vancomycin in Acinetobacter baumannii.

    abstract::Treatment options for multidrug-resistant (MDR) strains of Acinetobacter baumannii that acquire resistance to colistin are limited. Acinetobacter baumannii can become highly resistant to colistin through complete loss of lipopolysaccharide (LPS) owing to mutations in the genes encoding the first three enzymes involved...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章

    doi:10.1016/j.ijantimicag.2015.07.017

    authors: García-Quintanilla M,Carretero-Ledesma M,Moreno-Martínez P,Martín-Peña R,Pachón J,McConnell MJ

    更新日期:2015-12-01 00:00:00

  • Class 1 integrons in Acinetobacter baumannii: a weak expression of gene cassettes to counterbalance the lack of LexA-driven integrase repression.

    abstract::Integrons recruit resistance genes through integrase-driven recombination events that are regulated by the bacterial SOS response and require the repressor LexA. Class 1 integrons genes are expressed from a common promoter, Pc, of which at least 5 predominant variants, classified from weak to strong, have been describ...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章

    doi:10.1016/j.ijantimicag.2018.11.012

    authors: Couvé-Deacon E,Jové T,Afouda P,Barraud O,Tilloy V,Scaon E,Hervé B,Burucoa C,Kempf M,Marcos JY,Ploy MC,Garnier F

    更新日期:2019-04-01 00:00:00

  • Emergence of Escherichia coli sequence type 410 (ST410) with KPC-2 β-lactamase.

    abstract::Fifteen carbapenem-non-susceptible Escherichia coli isolates obtained during the period May 2010 to April 2011 in a hospital and a long-term care facility (LTCF) in Larissa (Central Greece) were investigated. Minimum inhibitory concentrations (MICs) to various antimicrobial agents were determined by Etest. Carriage of...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章

    doi:10.1016/j.ijantimicag.2011.11.003

    authors: Mavroidi A,Miriagou V,Malli E,Stefos A,Dalekos GN,Tzouvelekis LS,Petinaki E

    更新日期:2012-03-01 00:00:00

  • Mupirocin resistance among Malaysian isolates of methicillin-resistant Staphylococcus aureus.

    abstract::Four hundred methicillin-resistant Staphylococcus aureus strains (MRSA) from different geographical areas in Malaysia were tested for mupirocin susceptibility using minimum inhibitory concentration (MIC) determination. The majority of these strains (98.75%) were susceptible to mupirocin with MICs of < or = 4 mg/l. Fif...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章

    doi:10.1016/s0924-8579(01)00314-4

    authors: Norazah A,Koh YT,Ghani Kamel A,Alias R,Lim VK

    更新日期:2001-05-01 00:00:00

  • Dichotomous selection of high-level oxacillin resistance in Staphylococcus aureus by fluoroquinolones.

    abstract::The objective of this study was to determine whether exposure of Staphylococcus aureus to early (ciprofloxacin or levofloxacin) and a recent fluoroquinolone (moxifloxacin) has differential potential as a mutator or selector for meticillin resistance. The potential of fluoroquinolones to act as mutators or selectors wa...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章

    doi:10.1016/j.ijantimicag.2010.04.014

    authors: Dalhoff A,Schubert S

    更新日期:2010-09-01 00:00:00

  • Susceptibility profiles and clinical efficacy of antifungals against candida bloodstream isolates from critically ill patients: Focus on intravenous itraconazole.

    abstract::In vitro and clinical data were analysed to evaluate the susceptibility profile of itraconazole in light of the new cut-off points. The in vitro activity of itraconazole was compared with that of eight comparators against 119 Candida bloodstream isolates from 2015 to 2018. Minimum inhibitory concentrations (MICs) were...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章

    doi:10.1016/j.ijantimicag.2019.06.019

    authors: Giamarellos-Bourboulis EJ,Stamou A,Maraki S,Solomonidi N,Belesiotou E,Pistiki A,Antoniadou E,Vlachogianni G,Mandragos K,Tasioudis C,Katsenos C,Routsi C,Samonis G,Dimopoulos G

    更新日期:2019-10-01 00:00:00

  • Antimicrobial drug resistance mechanisms among Mollicutes.

    abstract::Representatives of the Mollicutes class are the smallest, wall-less bacteria capable of independent reproduction. They are widespread in nature, most are commensals, and some are pathogens of humans, animals and plants. They are also the main contaminants of cell cultures and vaccine preparations. Despite limited bios...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章,评审

    doi:10.1016/j.ijantimicag.2020.106253

    authors: Chernova OA,Chernov VM,Mouzykantov AA,Baranova NB,Edelstein IA,Aminov RI

    更新日期:2020-11-29 00:00:00

  • Differences in the rate of carbapenem-resistant Enterobacteriaceae colonisation or Clostridium difficile infection following frontline treatment with tigecycline vs. meropenem for intra-abdominal infections.

    abstract:OBJECTIVES:We hypothesised that treatment with a tigecycline-based antimicrobial regimen for intra-abdominal infection (IAI) could be associated with lower rates of subsequent carbapenem-resistant Enterobacteriaceae (CRE) colonisation or Clostridium difficile infection (CDI) compared with a meropenem-based regimen. ME...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章

    doi:10.1016/j.ijantimicag.2018.01.010

    authors: Bartoletti M,Tedeschi S,Pascale R,Raumer L,Maraolo AE,Palmiero G,Tumietto F,Cristini F,Ambretti S,Giannella M,Lewis RE,Viale P

    更新日期:2018-03-01 00:00:00

  • Combination effects of cephalexin and gentamicin on Edwardsiella tarda and Streptococcus iniae.

    abstract::The objective of this study was to determine the in vitro activity of cephalexin-gentamicin combination by a microbroth chequerboard technique against clinical isolates of Edwardsiella tarda and Streptococcus iniae. Gentamicin was shown more susceptible than cephalexin against both bacteria. The effect of cephalexin-g...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章

    doi:10.1016/s0924-8579(03)00086-4

    authors: Lim JH,Hwang YH,Park BK,Yun HI

    更新日期:2003-07-01 00:00:00

  • Impact of vancomycin minimum inhibitory concentration on clinical outcomes of patients with vancomycin-susceptible Staphylococcus aureus infections: a meta-analysis and meta-regression.

    abstract::Although the vancomycin minimum inhibitory concentration (VMIC) susceptibility breakpoint for Staphylococcus aureus was recently lowered to ≤2 mg/L, it is argued that isolates in the higher levels of the susceptible range may bear adverse clinical outcomes. Clinical outcomes (all-cause mortality and treatment failure)...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章,meta分析,评审

    doi:10.1016/j.ijantimicag.2012.07.023

    authors: Mavros MN,Tansarli GS,Vardakas KZ,Rafailidis PI,Karageorgopoulos DE,Falagas ME

    更新日期:2012-12-01 00:00:00

  • Novel anti-microbial therapies for dental plaque-related diseases.

    abstract::Control of dental plaque-related diseases has traditionally relied on non-specific removal of plaque by mechanical means. As our knowledge of oral disease mechanisms increases, future treatment is likely to be more targeted, for example at small groups of organisms, single species or at key virulence factors they prod...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章,评审

    doi:10.1016/j.ijantimicag.2008.07.014

    authors: Allaker RP,Douglas CW

    更新日期:2009-01-01 00:00:00

  • Use of colistin-containing products within the European Union and European Economic Area (EU/EEA): development of resistance in animals and possible impact on human and animal health.

    abstract::Since its introduction in the 1950s, colistin has been used mainly as a topical treatment in human medicine owing to its toxicity when given systemically. Sixty years later, colistin is being used as a last-resort drug to treat infections caused by multidrug-resistant (MDR) Pseudomonas aeruginosa, Acinetobacter bauman...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章,评审

    doi:10.1016/j.ijantimicag.2015.06.005

    authors: Catry B,Cavaleri M,Baptiste K,Grave K,Grein K,Holm A,Jukes H,Liebana E,Lopez Navas A,Mackay D,Magiorakos AP,Moreno Romo MA,Moulin G,Muñoz Madero C,Matias Ferreira Pomba MC,Powell M,Pyörälä S,Rantala M,Ružauskas M,Sa

    更新日期:2015-09-01 00:00:00

  • Comparative activities of colistin, rifampicin, imipenem and sulbactam/ampicillin alone or in combination against epidemic multidrug-resistant Acinetobacter baumannii isolates producing OXA-58 carbapenemases.

    abstract::This study evaluated the activity of colistin, rifampicin, imipenem and sulbactam/ampicillin alone or in combination against nine epidemic multidrug-resistant Acinetobacter baumannii isolates producing OXA-58 carbapenemase in Naples, Italy. The isolates were susceptible to colistin but differed in their resistance to ...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章

    doi:10.1016/j.ijantimicag.2007.07.007

    authors: Tripodi MF,Durante-Mangoni E,Fortunato R,Utili R,Zarrilli R

    更新日期:2007-12-01 00:00:00

  • Low in vitro selection frequencies of enterococcal and staphylococcal mutants resistant to the oxazolidinone AZD2563.

    abstract::Mutants with oxazolidinone MICs, 2- to 16-fold higher than those of parents, were selected from two of five clinical isolates of Enterococcus faecalis during exposure to AZD2563, but only at frequencies of ca. 10(-8). Resistance was not selected in Enterococcus faecium, Staphylococcus aureus or coagulase-negative stap...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章

    doi:10.1016/j.ijantimicag.2003.06.004

    authors: Stockdale MW,Tysall L,Johnson AP,Livermore DM,Woodford N

    更新日期:2004-01-01 00:00:00

  • Risk factors for polymyxin-resistant carbapenemase-producing Enterobacteriaceae in critically ill patients: An epidemiological and clinical study.

    abstract::This study aimed to assess the clinical impact and potential risk factors associated with polymyxin-resistant Enterobacteriaceae strains isolated from patients hospitalized in adult and neonatal intensive care units. A case-control study was conducted from September 2015 to January 2017. Antimicrobial susceptibility o...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章

    doi:10.1016/j.ijantimicag.2020.105882

    authors: da Silva KE,Baker S,Croda J,Nguyen TNT,Boinett CJ,Barbosa LS,Tetila A,Simionatto S

    更新日期:2020-03-01 00:00:00

  • Infective endocarditis caused by USA300 methicillin-resistant Staphylococcus aureus (MRSA).

    abstract::We report seven cases of infective endocarditis caused by USA300 methicillin-resistant Staphylococcus aureus (MRSA) at an urban, tertiary care, academic institution. Five strains were community associated and two were healthcare associated. All patients were injection drug users. Staphylococcus aureus isolates were ch...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章

    doi:10.1016/j.ijantimicag.2007.02.007

    authors: Haque NZ,Davis SL,Manierski CL,Vager D,Donabedian SM,Perri MB,Sabbagh R,Cheema F,Zervos MJ

    更新日期:2007-07-01 00:00:00

  • Evaluation of the potential of colicins to prevent extraluminal contamination of urinary catheters by Escherichia coli.

    abstract::The feasibility of using colicins to create an antimicrobial lubricant to prevent extraluminal catheter contamination during urinary catheter insertion was assessed. Levels of resistance of uropathogenic Escherichia coli to antibiotics and colicins were compared. The results showed that antibiotics and colicins posses...

    journal_title:International journal of antimicrobial agents

    pub_type: 杂志文章

    doi:10.1016/j.ijantimicag.2019.07.004

    authors: Roy SM,Riley MA

    更新日期:2019-11-01 00:00:00