当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS期刊下所有文献 > Characterisation of extended-spectrum β-lactamase/plasmid AmpC-β-lactamase-producing Escherichia coli isolates from long-term recurrent bloodstream infections.

Characterisation of extended-spectrum β-lactamase/plasmid AmpC-β-lactamase-producing Escherichia coli isolates from long-term recurrent bloodstream infections.

Abstract：

:The aim of this study was to investigate recurrent infections in individual patients caused by extended-spectrum β-lactamase and plasmid AmpC β-lactamase-producing Escherichia coli (ESBL/pAmpC-Ec) isolates with >12-month interval. The Danish national collection of ESBL/pAmpC-Ec isolates collected from January 2014 through June 2017 was screened for patients with multiple isolates with >12 months between the episodes. Isolates underwent whole-genome sequencing and were analysed for antimicrobial resistance genes, virulence genes and multilocus sequence typing (MLST). Isolates were subtyped by core genome MLST (cgMLST) and CH typing. From a total of 970 patients, 15 unrelated patients experienced recurrent infections with ESBL/pAmpC-Ec. Of the 15 patients, 10 (67%) were found to be infected a second or third time with a genetically identical or similar strain. The resistance and virulence properties of the strains were similar in individual patients, however they were quite diverse when comparing between patients. Recurrent ESBL/pAmpC-Ec bloodstream infections of genetically related strains occurring with >12-month interval might be related to the previous episode and to a lesser extent be caused by re-infection. With >1000 days between the first and second episode of genetically similar strains (four allele differences), the recurrent infection is likely due to long-term host colonisation by ESBL/pAmpC-Ec. From this analysis, strains able to cause such recurrent infection were relatively diverse between patients. Knowledge about host and strain factors influencing such recurrent infections is needed to implement preventive measures.

journal_name

Int J Antimicrob Agents

journal_title

International journal of antimicrobial agents

authors

Roer L,Hansen F,Hasman H,Hammerum AM,Cavaco LM

doi

10.1016/j.ijantimicag.2020.106041

subject

Has Abstract

pub_date

2020-07-01 00:00:00

pages

106041

issue

1

eissn

0924-8579

issn

1872-7913

pii

S0924-8579(20)30211-9

journal_volume

56

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS文献大全
  • An intervention programme for the management of multidrug-resistant tuberculosis in France.

    abstract：:As shown in a previous study, the outcome of multidrug-resistant tuberculosis (MDR-TB) in France is not satisfactory (41% success rate). To improve the management and outcome of patients with MDR-TB, a prospective intervention study was carried out in 1998-1999 by National Reference Centre (NRC) staff. NRC staff conta...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2006.11.023

    authors： Uffredi ML,Truffot-Pernot C,Dautzenberg B,Renard M,Jarlier V,Robert J

    更新日期：2007-04-01 00:00:00

  • Comparison of meropenem with amikacin plus ceftazidime in the empirical treatment of febrile neutropenia: a prospective randomised multicentre trial in patients without previous prophylactic antibiotics. Meropenem Study Group of Turkey.

    abstract：:Eighty three patients with neutropenia and cancer were randomised to receive either 1 g meropenem tds or amikacin 15 mg/kg single dose daily plus ceftazidime 2 g tds. No prophylactic antibiotics were allowed before entry to the trial. Seventy seven patients were available for analysis. Infection was microbiologically ...

    journal_title：International journal of antimicrobial agents

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0924-8579(99)00096-5

    authors： Akova M,Akan H,Korten V,Biberoğlu K,Hayran M,Unal S,Kars A,Kansu E

    更新日期：1999-09-01 00:00:00

  • Sequences of a co-existing SXT element, a chromosomal integron (CI) and an IncA/C plasmid and their roles in multidrug resistance in a Vibrio cholerae O1 El Tor strain.

    abstract：:The ongoing seventh cholera pandemic is attributed to Vibrio cholerae O1 El Tor biotype strains. Although antibiotic therapy ameliorates symptoms in patients and reduces pathogen transfer to the environment, multidrug resistance remains a major clinical threat. An O1 El Tor strain isolated from a patient in 1998 was i...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2016.05.020

    authors： Wang R,Li J,Kan B

    更新日期：2016-09-01 00:00:00

  • Antimicrobial susceptibilities of Campylobacter isolated from food-producing animals on farms (1999-2001): results from the Japanese Veterinary Antimicrobial Resistance Monitoring Program.

    abstract：:Nationwide monitoring of antimicrobial resistance in Campylobacter isolated from food-producing animals on farms was performed in Japan. A total of 468 Campylobacter isolates were obtained during the period from June 1999 to March 2001. Campylobacter species showed high frequencies of resistance to oxytetracycline and...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2004.03.017

    authors： Ishihara K,Kira T,Ogikubo K,Morioka A,Kojima A,Kijima-Tanaka M,Takahashi T,Tamura Y

    更新日期：2004-09-01 00:00:00

  • New genetic environments of the macrolide-lincosamide-streptogramin resistance determinant erm(X) and their influence on potential horizontal transferability in bifidobacteria.

    abstract：:With the abuse of macrolide, lincosamide, and streptogramin (MLS), the traditionally safe bifidobacterial strains in the human intestine could serve as a reservoir of MLS resistance genes. In this study, the erm(X) gene was detected in 29 MLS-resistant strains and one MLS-susceptible strain among 92 bifidobacterial st...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2017.04.007

    authors： Wang N,Hang X,Zhang M,Peng X,Yang H

    更新日期：2017-10-01 00:00:00

  • Tigecycline: clinical evidence and formulary positioning.

    abstract：:Tigecycline, is a novel broad-spectrum glycylcycline antibiotic, which has activity against a broad range of Gram-positive, Gram-negative, atypical, anaerobic and antibiotic-resistant bacteria. This includes activity against MRSA, VRE and penicillin resistant Streptococcus pneumoniae. Whilst exhibiting antibacterial a...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijantimicag.2004.11.006

    authors： Nathwani D

    更新日期：2005-03-01 00:00:00

  • Resistance to third-generation cephalosporins in Escherichia coli in the French community: The times they are a-changin'?

    abstract：OBJECTIVES:Since the early 2000s, Escherichia coli resistance to third-generation cephalosporins (3GCs) has been increasing in all European countries, mainly due to the spread of extended spectrum β-lactamases (ESBLs). Here we present a retrospective study that combines resistance of E. coli to 3GCs and quinolones with...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2020.105909

    authors： Jeanvoine A,Bouxom H,Leroy J,Gbaguidi-Haore H,Bertrand X,Slekovec C

    更新日期：2020-05-01 00:00:00

  • A need to revisit clinical breakpoints of tigecycline: effect of atypical non-linear plasma protein binding.

    abstract：:Tigecycline is highly active against various drug-resistant bacteria. The US Food and Drug Administration (FDA) recently issued a black box warning for tigecycline owing to an associated increase in all-cause mortality. Clinical breakpoints of antibiotics are vital in susceptibility testing of pathogens for the select...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2016.12.008

    authors： Singh RSP,Mukker JK,Drescher SK,Deitchman AN,Derendorf H

    更新日期：2017-04-01 00:00:00

  • Trypanocidal activity of piperazine-linked bisbenzamidines and bisbenzamidoxime, an orally active prodrug.

    abstract：:A series of 32 piperazine-linked bisbenzamidines (and related analogues) were analysed for their in vitro and in vivo trypanocidal activity against a drug-sensitive strain of Trypanosoma brucei brucei and a drug-resistant strain of Trypanosoma brucei rhodesiense. The compounds showed similar potencies against both str...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2007.07.021

    authors： Huang TL,Bacchi CJ,Kode NR,Zhang Q,Wang G,Yartlet N,Rattendi D,Londono I,Mazumder L,Vanden Eynde JJ,Mayence A,Donkor IO

    更新日期：2007-12-01 00:00:00

  • Co-existence of the oxazolidinone resistance genes cfr and optrA on two transferable multi-resistance plasmids in one Enterococcus faecalis isolate from swine.

    abstract：OBJECTIVES:To identify and characterize oxazolidinone resistance genes cfr and optrA in enterococcal isolates. METHODS:Two hundred and ninety-three enterococcal isolates were screened for the presence of cfr and optrA by polymerase chain reaction. The transferability of cfr and optrA was examined by conjugation. S1 nu...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2020.105993

    authors： Chen L,Han D,Tang Z,Hao J,Xiong W,Zeng Z

    更新日期：2020-07-01 00:00:00

  • Characterisation of the metallo-beta-lactamase VIM-6 and its genetic support.

    abstract：:The purpose of this study was to characterise the metallo-beta-lactamase VIM-6 and the genetic environment of the bla(VIM-6) gene. The bla(VIM-6) gene was cloned into an Escherichia coli expression system and the purified VIM-6 enzyme was obtained. VIM-6 has an isoelectric point of 4.9 and a molecular weight of 28.368...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2008.05.017

    authors： Koh TH,Yamaguchi K,Ishii Y

    更新日期：2008-11-01 00:00:00

  • Phenothiazinium-fluoroquinolone drug conjugates.

    abstract：:Synthesis and antibacterial screening of a homologous series of 3-dialkylaminophenothiazinium-7-norfloxacin conjugates was carried out alongside a corresponding series of symmetrical methylene blue derivatives. The norfloxacin conjugates maintained typical methylene blue derivative photoproperties, such as long wavele...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2009.11.022

    authors： Wainwright M,Shah A,Meegan K,Loughran C,Smith A,Valli N,Dempster N

    更新日期：2010-04-01 00:00:00

  • Variability of piperacillin concentrations in relation to tazobactam concentrations in critically ill patients.

    abstract：:Therapeutic drug monitoring for critically ill patients receiving piperacillin/tazobactam is described as a useful tool. However, the minimum inhibitory concentration of piperacillin depends on a sufficiently high concentration of tazobactam in case of β-lactamase-producing strains. Therefore, the relationship between...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2016.06.013

    authors： Zander J,Döbbeler G,Nagel D,Scharf C,Huseyn-Zada M,Jung J,Frey L,Vogeser M,Zoller M

    更新日期：2016-10-01 00:00:00

  • Moxifloxacin is non-inferior to combination therapy with ceftriaxone plus metronidazole in patients with community-origin complicated intra-abdominal infections.

    abstract：:Management of community-origin complicated intra-abdominal infections (cIAIs) requires surgical intervention and antimicrobial therapy. This multinational, randomised, double-blind clinical trial carried out in Asia compared the efficacy and safety of moxifloxacin monotherapy and ceftriaxone/metronidazole combination ...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.ijantimicag.2009.06.022

    authors： Solomkin J,Zhao YP,Ma EL,Chen MJ,Hampel B,DRAGON Study Team.

    更新日期：2009-11-01 00:00:00

  • In vitro susceptibility of cultured human methanogens to lovastatin.

    abstract：:Lovastatin is a prodrug that is hydrolysed in vivo to β-hydroxy acid lovastatin, which inhibits 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-Co-A) reductase (HMGR), thereby lowering cholesterol in humans. A side effect of lovastatin is inhibition of isoprenoid synthesis and cell membrane formation in methanogenic Archae...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2016.09.026

    authors： Demonfort Nkamga V,Armstrong N,Drancourt M

    更新日期：2017-02-01 00:00:00

  • In vitro activity of linezolid and 12 other antimicrobials against coryneform bacteria.

    abstract：OBJECTIVES:To compare the in vitro activity of linezolid with 12 other antimicrobials against 190 strains of the coryneform bacteria, including 60 strains of C. amycolatum, 30 of C. striatum, 30 of C. jeikeium, 10 of C. urealyticum, 20 of B. casei, 20 of D. hominis and 20 of T. otitidis. METHODS:Minimum inhibitory con...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2006.11.032

    authors： Gómez-Garcés JL,Alos JI,Tamayo J

    更新日期：2007-06-01 00:00:00

  • The dosing and monitoring of vancomycin: what is the best way forward?

    abstract：:We have evaluated the literature to review optimal dosing and monitoring of intravenous vancomycin in adults, in response to evolving understanding of targets associated with efficacy and toxicity. The area under the total concentration-time curve (0-24 h) divided by the minimum inhibitory concentration (AUC24/MIC) is...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijantimicag.2018.12.014

    authors： Drennan PG,Begg EJ,Gardiner SJ,Kirkpatrick CMJ,Chambers ST

    更新日期：2019-04-01 00:00:00

  • Association between augmented renal clearance, antibiotic exposure and clinical outcome in critically ill septic patients receiving high doses of β-lactams administered by continuous infusion: a prospective observational study.

    abstract：:This study assessed whether augmented renal clearance (ARC) impacts negatively on antibiotic concentrations and clinical outcomes in patients treated by high-dose β-lactams administered continuously. Over a 9-month period, all critically ill patients without renal impairment treated by one of the monitored β-lactams f...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2017.11.013

    authors： Carrié C,Petit L,d'Houdain N,Sauvage N,Cottenceau V,Lafitte M,Foumenteze C,Hisz Q,Menu D,Legeron R,Breilh D,Sztark F

    更新日期：2018-03-01 00:00:00

  • Impact of an antibiotic restriction policy on the antibiotic resistance patterns of Gram-negative microorganisms in an Intensive Care Unit in Greece.

    abstract：:The purpose of this study was to investigate the influence of an antibiotic policy programme based on restriction of the empirical use of fluoroquinolones and ceftazidime on the susceptibilities of Gram-negative microorganisms in a general Intensive Care Unit (ICU). The epidemiology of infections caused by the predomi...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2007.05.012

    authors： Ntagiopoulos PG,Paramythiotou E,Antoniadou A,Giamarellou H,Karabinis A

    更新日期：2007-10-01 00:00:00

  • Prevalence of predicted resistance to doravirine in HIV-1-positive patients after exposure to non-nucleoside reverse transcriptase inhibitors.

    abstract：:This study investigated the prevalence of doravirine (DOR) resistance mutations in non-nucleoside reverse transcriptase inhibitor (NNRTI)-experienced patients. DOR resistance was assessed in samples from NNRTI-experienced patients who underwent genotypic testing for virological failure from the Antiretroviral Response...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2019.02.007

    authors： Sterrantino G,Borghi V,Callegaro AP,Bruzzone B,Saladini F,Maggiolo F,Maffongelli G,Andreoni M,De Gennaro M,Gianotti N,Bagnarelli P,Vergori A,Antinori A,Zazzi M,Zaccarelli M,ARCA Study Group.

    更新日期：2019-04-01 00:00:00

  • Crossover assessment of serum bactericidal activity of grepafloxacin, ofloxacin and clarithromycin against respiratory pathogens after oral administration to healthy volunteers.

    abstract：:Serum bactericidal activity was studied in a crossover manner in 10 volunteers, after 2-day administration of grepafloxacin 600 mg qd, ofloxacin 400 mg bid and clarithromycin 500 mg bid. Bactericidal activity against clinical isolates of Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis and Klebs...

    journal_title：International journal of antimicrobial agents

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0924-8579(01)00333-8

    authors： Dan M,Poch F,Asherov J

    更新日期：2001-06-01 00:00:00

  • Antimicrobial resistance of Neisseria gonorrhoeae in Japan, 1993-2002: continuous increasing of ciprofloxacin-resistant isolates.

    abstract：:Susceptibility testing was conducted on 1357 isolates of Neisseria gonorrhoeae isolated from 1993 through 2002 in Japan to assess the antimicrobial resistance. Selected isolates were characterised by auxotype and analysis was done for mutations within the quinolone resistance-determining region (QRDR) in the gyrA and ...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2004.02.005

    authors： Tanaka M,Nakayama H,Notomi T,Irie S,Tsunoda Y,Okadome A,Saika T,Kobayashi I

    更新日期：2004-09-01 00:00:00

  • Increasing burden of urinary tract infections due to intrinsic colistin-resistant bacteria in hospitals in Marseille, France.

    abstract：:The emergence of multidrug-resistant (MDR) Gram-negative bacteria has become a major public health problem, eliciting renewed interest in colistin, an old antibiotic that is now routinely used to treat MDR bacterial infections. Here we investigated whether colistin use has affected the prevalence of infections due to ...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2014.10.010

    authors： Abat C,Desboves G,Olaitan AO,Chaudet H,Roattino N,Fournier PE,Colson P,Raoult D,Rolain JM

    更新日期：2015-02-01 00:00:00

  • Levofloxacin versus ceftriaxone plus clarithromycin in the treatment of adults with community-acquired pneumonia requiring hospitalization.

    abstract：:Consecutive adult patients admitted to the hospital with community-acquired pneumonia from January 2000 to September 2003 were included in this prospective observational cohort study. A total of 459 patients, 259 treated with levofloxacin in single drug therapy at a dose of 500 mg once a day and 209 with the combinati...

    journal_title：International journal of antimicrobial agents

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.ijantimicag.2004.07.013

    authors： Querol-Ribelles JM,Tenías JM,Querol-Borrás JM,Labrador T,Nieto A,González-Granda D,Martínez I

    更新日期：2005-01-01 00:00:00

  • Mutations in transcription factor Mrr2p contribute to fluconazole resistance in clinical isolates of Candida albicans.

    abstract：:The Candida albicans zinc cluster proteins are a family of transcription factors (TFs) that play essential roles in the development of antifungal drug resistance. Gain-of-function mutations in several TFs, such as Tac1p, Mrr1p and Upc2p, have been previously well documented in azole-resistant clinical C. albicans isol...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2015.08.001

    authors： Wang Y,Liu JY,Shi C,Li WJ,Zhao Y,Yan L,Xiang MJ

    更新日期：2015-11-01 00:00:00

  • Clinical isolates of macrolide-resistant Streptococcus pyogenes in Central Greece.

    abstract：:A total of 300 Streptococcus pyogenes isolates, collected during 2001 from five hospitals in the Thessalia district (Central Greece), were examined for their resistance to macrolides. Resistance to erythromycin was detected in 58 isolates (19.3%). Of these, 68.9% were susceptible to clindamycin (M-phenotype) and carri...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/s0924-8579(02)00253-4

    authors： Petinaki E,Kontos F,Pratti A,Skulakis C,Maniatis AN

    更新日期：2003-01-01 00:00:00

  • Resistance to macrolides by ribosomal mutation in clinical isolates of Turicella otitidis.

    abstract：:The genetic basis of erythromycin resistance in Turicella otitidis, a coryneform bacteria associated with otitis, was studied in five macrolide-resistant clinical isolates. Macrolide resistance genes were searched for by polymerase chain reaction (PCR). Genes for domain V of 23S rRNA (rrl) as well as rplD (L4 protein)...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/j.ijantimicag.2009.03.023

    authors： Boumghar-Bourtchai L,Chardon H,Malbruny B,Mezghani S,Leclercq R,Dhalluin A

    更新日期：2009-09-01 00:00:00

  • Global resistance trends and the potential impact on empirical therapy.

    abstract：:Globally, antibiotic resistance continues to be an increasing problem. The emergence of methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococci (VRE), and extended spectrum beta-lactamase-producing Enterobacteriaceae has seriously reduced the number of empirical agents suitable for selecte...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章,评审

    doi：10.1016/S0924-8579(09)70003-2

    authors： Isturiz R

    更新日期：2008-12-01 00:00:00

  • Over-the-counter acquisition of antibiotics in the Maltese general population.

    abstract：:Few studies have studied the frequency of over-the-counter acquisition of antibiotics in western countries. In order to provide an insight into these practices in Malta, attitudes towards antibiotic use in the general public were researched through a structured interview. Nineteen percent admitted that they took antib...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/s0924-8579(02)00194-2

    authors： Borg MA,Scicluna EA

    更新日期：2002-10-01 00:00:00

  • Bacterial agents of lower respiratory tract infections (LRTIs), beta-lactamase production, and resistance to antibiotics in elderly people. DEDALO Study Group.

    abstract：:This study determined the etiology of lower respiratory tract infections in the elderly and assessed whether the growth of beta-lactamase producing bacteria is particularly favoured in these patients. Between December 1998 and May 1999, 187 patients with community-acquired pneumonia (CAP), and 887 patients with acute ...

    journal_title：International journal of antimicrobial agents

    pub_type： 杂志文章

    doi：10.1016/s0924-8579(00)00277-6

    authors： Sanguinetti CM,De Benedetto F,Miragliotta G

    更新日期：2000-12-01 00:00:00