abstract：INTRODUCTION:Diabetic nephropathy (DN) and hypertensive nephrosclerosis (HN) represent the most common causes of chronic kidney disease (CKD) and many patients progress to -end-stage renal disease. Patients are treated primarily through the management of cardiovas-cular risk factors and hypertension; however patients w...

journal_title：Kidney & blood pressure research

authors： Smith A,Iablokov V,Mazza M,Guarnerio S,Denti V,Ivanova M,Stella M,Piga I,Chinello C,Heijs B,van Veelen PA,Benediktsson H,Muruve DA,Magni F

更新日期：2020-01-01 00:00:00

abstract：INTRODUCTION:Renal dysfunction is a frequent complication in patients suffering from β-thalassemia major (β-TM). The aim of this study was to analyze the renal function and urine metabolomic profile of β-TM patients undergoing transfusions and deferasirox (DFX) therapy, in order to better characterize and shed light on...

journal_title：Kidney & blood pressure research

authors： Capolongo G,Zacchia M,Beneduci A,Costantini S,Cinque P,Spasiano A,De Luca G,Di Pietro ME,Ricchi P,Trepiccione F,Capasso G,Filosa A

更新日期：2020-01-01 00:00:00

abstract：INTRODUCTION:Diabetic nephropathy (DN) is a serious complication of diabetes mellitus and is considered to be a sterile inflammatory disease. Increasing evidence suggest that pyroptosis and subsequent inflammatory response play a key role in the pathogenesis of DN. However, the underlying cellular and molecular mechani...

journal_title：Kidney & blood pressure research

authors： Zhan JF,Huang HW,Huang C,Hu LL,Xu WW

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVE:Co-deposition of mannose-binding lectin (MBL) and IgG4 anti-phospholipase A2 receptor (anti-PLA2R) autoantibodies under subepithelial cells has been observed in patients with idiopathic membranous nephropathy (iMN), but the relationships of MBL deposition to iMN severity and progression remain unclear. METHO...

journal_title：Kidney & blood pressure research

authors： Zhang Y,Liu Y,Liang L,Liu L,Tang X,Tang L,Chen P,Chen J,Wang Z,Cao W,Chen Q,Zhao N,Xu D

更新日期：2020-01-01 00:00:00

abstract：BACKGROUNDS:ANCA-associated vasculitis (AAV) frequently present with a chronic relapsing course. Relapse leads to an increased need for therapeutic agents and consequent toxicity. SUMMARY:When referring to the available options for the management of AAV, the efficacy of glucocorticoids (GCs) is unquestionable. However...

journal_title：Kidney & blood pressure research

authors： Fenoglio R,Roccatello D,Sciascia S

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Diabetic nephropathy constitutes a large proportion of end-stage kidney failure in diabetic patients. However, the underlying molecular mechanisms remain unclear. METHODS:Db/db diabetic mouse models and high glucose (HG)-induced human renal mesangial cells (HRMCs) were used as research models in vivo and in...

journal_title：Kidney & blood pressure research

authors： Min XQ,Xie Y

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Metabolic acidosis may be diagnosed as chronic (cMA) if it persists for at least 5 days, although an exact definition has not been provided by any guidelines yet. The most common cause is CKD; numerous less-known diseases can also account for cMA. SUMMARY:In recent years, CKD-associated cMA has been propose...

journal_title：Kidney & blood pressure research

authors： Patschan D,Patschan S,Ritter O

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND/AIMS:Additional validation study was warranted to confirm the clinical significance of C score, which was recently added to the Oxford classification for immunoglobulin A nephropathy (IgAN). METHODS:We performed a multicenter retrospective cohort study in four hospitals in Korea. Patients who had biopsied g...

journal_title：Kidney & blood pressure research

authors： Park S,Baek CH,Park SK,Kang HG,Hyun HS,Park E,Han SH,Ryu DR,Kim DK,Oh KH,Joo KW,Kim YS,Moon KC,Chin HJ,Lee H

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND/AIMS:Refugee dialysis is a worldwide growing dilemma with limited experience. This report presents the largest hemodialysis (HD) patient registry data of Syrian refugees in Turkey. METHODS:Demographic, clinical, laboratory, and dialysis practice data of 345 Syrian HD patients during one year were collected ...

journal_title：Kidney & blood pressure research

authors： Gursu M,Arici M,Ates K,Kazancioglu R,Yavas PG,Ozturk M,Altun B,Arinsoy T

更新日期：2019-01-01 00:00:00

abstract：:MicroRNAs (miRNAs) are short, single-stranded, noncoding RNAs that modulate many key biological processes by simultaneously suppressing multiple target genes. Among them, miR-26a, a conserved miRNA among vertebrates, is highly expressed in various tissues. Accumulating evidence demonstrates that miR-26a plays pivotal ...

journal_title：Kidney & blood pressure research

authors： Li X,Pan X,Fu X,Yang Y,Chen J,Lin W

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND/AIMS:Acute kidney injury (AKI) is a serious complication of sepsis and has a high morbidity and mortality rate. Caspase-11 induces pyroptosis, a form of programmed cell death that plays a critical role in endotoxic shock, but its role in tubular epithelial cell death and whether it contributes to sepsis-asso...

journal_title：Kidney & blood pressure research

authors： Ye Z,Zhang L,Li R,Dong W,Liu S,Li Z,Liang H,Wang L,Shi W,Malik AB,Cheng KT,Liang X

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND/AIMS:The association between ACYP2(Acylphosphatase 2) polymorphisms and immunoglobulin A nephropathy (IgAN) risk in the Chinese Han population remains unclear. We aimed to evaluate the association between ACYP2 polymorphisms and IgAN risk by performing a case-control study. METHODS:Eleven ACYP2 single nucle...

journal_title：Kidney & blood pressure research

authors： Jin G,Liang Y,Yan X,Zhang L,Li Z,Yin A,Wang X,Tian P

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Studies have demonstrated that cholesterol variability is an independent predictor of cerebrovascular and cardiovascular events. OBJECTIVE:This study aimed to investigate the association of visit-to-visit variability in total cholesterol (TC) with kidney decline in a Chinese community-based population. MET...

journal_title：Kidney & blood pressure research

authors： Yan Y,Huang Y,Zhou D,Tang S,Feng YQ

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND/AIM:Calcifications of large arteries are frequent in chronic kidney disease (CKD) and may contribute to the high cardiovascular risk in this population. The aim of this study was to examine whether abdominal aortic calcification volume (AACV) was a predictor of the rate of decline in glomerular filtration ra...

journal_title：Kidney & blood pressure research

authors： Jansson H,Saeed A,Svensson MK,Finnved K,Hellström M,Guron G

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Urine osmolality indicates the ability of the kidney to concentrate the urine and reflects the antidiuretic action of vasopressin. However, results about the association between urine osmolality and adverse renal outcomes in chronic kidney disease (CKD) are conflicting. We investigated the association betwee...

journal_title：Kidney & blood pressure research

authors： Lee MJ,Chang TI,Lee J,Kim YH,Oh KH,Lee SW,Kim SW,Park JT,Yoo TH,Kang SW,Choi KH,Ahn C,Han SH

更新日期：2019-01-01 00:00:00

abstract：INTRODUCTION:Cardiovascular disease is one of the main causes of morbidity and mortality in patients with autosomal dominant polycystic kidney disease (ADPKD). Autonomic dysfunction is associated with an increased risk for all cardiovascular events in the general population and can be evaluated with heart rate variabil...

journal_title：Kidney & blood pressure research

authors： Lai S,Mangiulli M,Perrotta AM,Di Lazzaro Giraldi G,Testorio M,Rosato E,Cianci R,Gigante A

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVES:This prospective, randomized study was to investigate the role of nicorandil in the prevention of contrast-induced nephropathy (CIN) in patients with chronic renal dysfunction undergoing an elective coronary procedure. METHODS:A total of 252 eligible patients were enrolled in this study and allocated into t...

journal_title：Kidney & blood pressure research

authors： Fan Z,Li Y,Ji H,Jian X

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Mesenchymal stem cells (MSC) improve renal function and renovascular hypertension in the 2-kidney 1-clip model (2K-1C). While MSC play an immunomodulatory role, induce neoangiogenesis, and reduce fibrosis, they do not correct sodium loss by the contra-lateral kidney. OBJECTIVES:We investigated the tubular f...

journal_title：Kidney & blood pressure research

authors： Varela VA,Oliveira-Sales EB,Maquigussa E,Borges FT,Gattai PP,Novaes ADS,Shimoura CG,Campos RR,Boim MA

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:There is limited evidence on the etiology and outcomes of renal infarction. A provoking factor is identified only in one- to two-thirds of patients. METHODS:This is a retrospective observational study. The clinical characteristics and outcomes of patients with acute renal infarction were studied; the sample...

journal_title：Kidney & blood pressure research

authors： García-García A,Demelo-Rodríguez P,Ordieres-Ortega L,Cervilla-Muñoz E,García-Fernández-Bravo I,Pulfer MD,López-Aparicio A,Galeano-Valle F,Del Toro-Cervera J

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Cardiac death is increased in peritoneal dialysis (PD) patients. Pulse wave velocity (PWV) is a measurement of arterial stiffness, and previous reports linked PWV to increased extracellular water (ECW). As cyclers and icodextrin are increasingly used, we wished to determine whether this association between P...

journal_title：Kidney & blood pressure research

authors： Tangvoraphonkchai K,Davenport A

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND/AIMS:Chronic renal allograft dysfunction (CRAD) is a leading cause of long-term renal allograft loss. Oxidative stress may account for the nonspecific interstitial fibrosis and tubular atrophy that occur in CRAD. An antioxidant intervention via Nrf2 signaling pathway activation might be a promising therapy f...

journal_title：Kidney & blood pressure research

authors： Lv D,Zhou Q,Xia Y,You X,Zhao Z,Li Y,Zou H

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND/AIMS:Chronic kidney disease (CKD) is often accompanied by hyperlipidemia, which accelerates progression of the disease. Podocyte injury can lead to dysfunction of the glomerular filtration barrier, which is associated with proteinuria, a risk marker for the progression of CKD. Our previous studies demonstrat...

journal_title：Kidney & blood pressure research

authors： Liu T,Chen XM,Sun JY,Jiang XS,Wu Y,Yang S,Huang HZ,Ruan XZ,Du XG

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND/AIMS:IgA nephropathy is associated with aberrant O-glycosylation of IgA1, which is recognized by autoantibodies leading to the formation of circulating immune complexes. Some of them, after deposition into kidney mesangium, trigger glomerular injury. In patients with active disease nonresponding to angiotens...

journal_title：Kidney & blood pressure research

authors： Kosztyu P,Hill M,Jemelkova J,Czernekova L,Kafkova LR,Hruby M,Matousovic K,Vondrak K,Zadrazil J,Sterzl I,Mestecky J,Raska M

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND/AIMS:Lung dysfunction associates with increased mortality but the impact of chronic kidney disease (CKD) is less clear. We evaluated lung function and its association with mortality among individuals with normal to severely reduced glomerular filtration rate (GFR). METHODS:404 individuals representing GFR c...

journal_title：Kidney & blood pressure research

authors： Mukai H,Ming P,Lindholm B,Heimbürger O,Barany P,Stenvinkel P,Qureshi AR

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND/AIMS:The metabolic syndrome (MetS), as assessed using dichotomous criteria, is associated with increased risk of future chronic kidney disease (CKD), though this relationship is unclear among African Americans, who have lower risk for MetS but higher risk for CKD. METHODS:We performed logistic regression us...

journal_title：Kidney & blood pressure research

authors： DeBoer MD,Filipp SL,Musani SK,Sims M,Okusa MD,Gurka M

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND/AIMS:Apparent treatment resistant hypertension (aTRH) is highly prevalent in patients with type 2 diabetes (T2D) and chronic kidney disease (CKD). The impact of aTRH and achievement of recommended blood pressure (BP) values on the rate of glomerular filtration rate (eGFR) loss in CKD patients is poorly known...

journal_title：Kidney & blood pressure research

authors： Viazzi F,Greco E,Ceriello A,Fioretto P,Giorda C,Guida P,Russo G,De Cosmo S,Pontremoli R,AMD-Annals Study Group.

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND/AIMS:Arterial hypertension is one of the leading factors aggravating the course of chronic kidney disease (CKD). It seems that the novel parameters used in the assessment of the blood pressure (BP) load (i.e. central blood pressure, nighttime blood pressure) may be more precise in predicting the cardiovascul...

journal_title：Kidney & blood pressure research

authors： Kuczera P,Kwiecień K,Adamczak M,Bączkowska T,Gozdowska J,Madziarska K,Augustyniak-Bartosik H,Klinger M,Durlik M,Ritz E,Wiecek A

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND/AIMS:Endothelial-to-mesenchymal transition (EndMT) of glomerular endothelial cells (GEnCs) can induce albuminuria in diabetic nephropathy. Melatonin attenuates diabetic nephropathy, but its role and mechanism in EndMT of GEnCs in diabetic nephropathy remain unknown. METHODS:The effect of melatonin on EndMT ...

journal_title：Kidney & blood pressure research

authors： Liu F,Zhang S,Xu R,Gao S,Yin J

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND/AIMS:Hemodialysis (HD) patients often have inadequate nutrition, especially with respect to ascorbic acid (AA). It is reported that every HD session may cause a 50%- 75% decrease in plasma AA levels. Some studies have shown that supplementation of AA can change the outcome of chronic kidney disease-mineral b...

journal_title：Kidney & blood pressure research

authors： Ke G,Huang J,Zhu Y,Yang J,Zhang Y,Chen L,Hu J,Tao S,Hu Y,Yang D,Liu S

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND/AIMS:Aortic arch calcification (AoAC) is frequently detected in maintenance hemodialysis (MHD) patients and is associated with cardiovascular and all-cause mortality. We investigated the factors associated with AoAC and analyzed the relationship between the factors including bone-derived biomarkers and AoAC....

journal_title：Kidney & blood pressure research

authors： Nitta K,Hanafusa N,Okazaki M,Komatsu M,Kawaguchi H,Tsuchiya K

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND/AIMS:Peritoneal dialysis (PD) has gained interest over the last decade as a viable option for early start dialysis. It is still unknown if shorter break-in periods and less time for proper patient evaluation and training could influence technique survival in comparison to planned-start PD. METHODS:A prospec...

journal_title：Kidney & blood pressure research

authors： Silva BC,Adelina E,Pereira BJ,Cordeiro L,Rodrigues CE,Duarte RJ,Abensur H,Elias RM

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND/AIMS:IgA nephropathy is the most prevalent form of primary glomerulonephritis worldwide. Among patients with kidney disease, hypertension is one of the most important risk factors of disease progression. Considering the limited evidence regarding the appropriate blood pressure (BP) goal for patients with IgA...

journal_title：Kidney & blood pressure research

authors： Zheng Y,Wang Y,Liu S,Wu J,Duan S,Zhu H,Wu D,Cai G,Chen X

更新日期：2018-01-01 00:00:00

abstract：:Fibroblast growth factor 23 (FGF23) is released primarily from osteoblasts/osteocytes in bone. In cooperation with the transmembrane protein Klotho, FGF23 is a powerful inhibitor of 1α 25OH Vitamin D Hydroxylase (Cyp27b1) and thus of the formation of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3). As 1,25(OH)2D3 up-regulates ...

journal_title：Kidney & blood pressure research

authors： Lang F,Leibrock C,Pandyra AA,Stournaras C,Wagner CA,Föller M

更新日期：2018-01-01 00:00:00

abstract：:Backgroud/Aims: The aim of this study was to investigate the potential renoprotective effect of rapamycin on the autophagy of podocytes treated with the supernatant of mesangial cells cultured with aggregated IgA1 (aIgA1) from immunoglobulin A nephropathy (IgAN) patients. METHODS:Monomeric IgA1 (mIgA1) was isolated f...

journal_title：Kidney & blood pressure research

authors： Liang S,Jin J,Lin B,Gong J,Li Y,He Q

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND/AIMS:We examined the factors associated with blood pressure variability in a multi-ethnicity prospective study in China to gain more evidence to guide the prevention and management of hypertension through risk factor intervention. METHODS:A total of 318 consecutive adult subjects aged 29-94 years with suspe...

journal_title：Kidney & blood pressure research

authors： Li W,Yu Y,Liang D,Jia EZ

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND/AIMS:Diabetes mellitus can exacerbate renal ischemia-reperfusion (I/R) injury (RI/RI). The aim of the present study was to evaluate the protective effect of GSK-3β inhibition (TDZD-8) on I/R-induced renal injury through the Nrf2/HO-1 pathway in a streptozocin (STZ)-induced diabetic rat model. METHODS:STZ-in...

journal_title：Kidney & blood pressure research

authors： Shen X,Hu B,Xu G,Chen F,Ma R,Zhang N,Liu J,Ma X,Zhu J,Wu Y,Shen R

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND/AIMS:Renal tubulointerstitial fibrosis (TIF) is the common pathway of progressive chronic kidney disease. Inflammation has been widely accepted as the major driving force of TIF. Cystathionine β-synthase (CBS) is the first and rate-limiting enzyme in the transsulfuration pathway. CBS is considered to play pr...

journal_title：Kidney & blood pressure research

authors： Yuan X,Zhang J,Xie F,Tan W,Wang S,Huang L,Tao L,Xing Q,Yuan Q

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND/AIMS:Ischemia/reperfusion (I/R) is the most common cause of acute renal injury. I/R-induced oxidative stress is involved in the development of acute renal injury, which can be reversed by supplementation with L-arginine, a precursor of nitric oxide (NO). This study was conducted to evaluate alterations in th...

journal_title：Kidney & blood pressure research

authors： Tong F,Zhou X

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND/AIMS:The kidney plays a critical role in the control of blood pressure and its elevation in salt-induced hypertension. Mitochondrial dysfunction, especially in energy metabolism, has been associated with hypertension. Here, we aimed to investigate mitochondrial function and metabolic features in renal mitoch...

journal_title：Kidney & blood pressure research

authors： Wang Z,Sun Q,Sun N,Liang M,Tian Z

更新日期：2017-01-01 00:00:00

abstract：:Post-transplant hypertension is a common occurrence during treatment with calcineurin inhibitors (CNIs) in kidney transplant population. The pathogenesis of vasoconstriction induced by CNIs involves vascular tone alterations and kidney sodium transport regulation. Among the factors involved a key role is played by the...

journal_title：Kidney & blood pressure research

authors： Calò LA,Ravarotto V,Simioni F,Naso E,Marchini F,Bonfante L,Furian L,Rigotti P

更新日期：2017-01-01 00:00:00