Abstract:
OBJECTIVES:This prospective, randomized study was to investigate the role of nicorandil in the prevention of contrast-induced nephropathy (CIN) in patients with chronic renal dysfunction undergoing an elective coronary procedure. METHODS:A total of 252 eligible patients were enrolled in this study and allocated into the control group (n = 125) or nicorandil group (n = 127). Both groups received the standard hydration treatment, and patients in the nicorandil group were orally administrated 10 mg of nicorandil (t.i.d.) beginning 2 days before and continuing for 2 days after an elective coronary procedure. Serum creatinine (SCr) and cystatin C (CysC) were measured at 24 h before and 24, 48, and 72 h after the procedure. The occurrences of CIN and adverse events within 1 year were recorded. RESULTS:The nicorandil group had relatively lower SCr and CysC levels and a higher eGFR at 24 and 48 h after the procedure than the control group (p < 0.05). The incidence of CIN was significantly decreased in the nicorandil group compared to the control group. The multivariate logistic regression model revealed that nicorandil treatment was an independent protective factor for CIN (OR 0.669, 95% CI 0.522-0.857, p = 0.001). The multivariate COX proportional hazard model showed that nicorandil treatment was an independent protective predictor for adverse events (HR 0.881, 95% CI 0.781-0.993, p = 0.037). CONCLUSIONS:Nicorandil could exhibit a protective effect against CIN in patients with chronic renal dysfunction undergoing an elective coronary procedure and reduce the adverse events within 1 year after the procedure, which is superior to hydration treatment only.
journal_name
Kidney Blood Press Resjournal_title
Kidney & blood pressure researchauthors
Fan Z,Li Y,Ji H,Jian Xdoi
10.1159/000503160subject
Has Abstractpub_date
2019-01-01 00:00:00pages
1372-1382issue
6eissn
1420-4096issn
1423-0143pii
000503160journal_volume
44pub_type
杂志文章,随机对照试验abstract:BACKGROUND/AIMS:This study aimed to investigate the potential beneficial anti-proteinuric effect of an add-on aldosterone blockade and the impact of the aldosterone escape phenomenon. METHODS:We retrospectively analyzed data of 304 patients with persistent proteinuria, who were administered spironolactone (25 mg/day) ...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000368470
更新日期:2014-01-01 00:00:00
abstract:AIM:This study investigated the impact of hypertension combined with diabetic nephropathy on rat renal alpha(1)-adrenoceptor subtype composition. METHODS:In streptozotocin-induced diabetic spontaneously hypertensive rats (SHR), diabetic nephropathy developed as reflected by increased kidney index, plasma creatinine, a...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000249149
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND/AIM:Our aim was to determine whether altered human β-defensin (HBD), pro-inflammatory cytokines including interleukin (IL)-6 and tumor necrotic factor (TNF)-α could increase the risk of developing and exacerbation of chronic kidney disease (CKD), especially for patients with diabetic nephropathy (DN). METHO...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000355740
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Renal involvement in Takayasu's arteritis (TA) effects the disease outcome and endovascular treatment is an effective treatment of choice. We investigated nitric oxide (NO) levels and the effect of endovascular treatment in renovascular hypertensive TA patients. METHODS:In five hypertensive patients with re...
journal_title:Kidney & blood pressure research
pub_type: 临床试验,杂志文章
doi:10.1159/000063514
更新日期:2002-01-01 00:00:00
abstract:OBJECTIVE:Co-deposition of mannose-binding lectin (MBL) and IgG4 anti-phospholipase A2 receptor (anti-PLA2R) autoantibodies under subepithelial cells has been observed in patients with idiopathic membranous nephropathy (iMN), but the relationships of MBL deposition to iMN severity and progression remain unclear. METHO...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000508665
更新日期:2020-01-01 00:00:00
abstract::Angiotensin-(1-7), (Ang-(1-7)), a metabolite of Ang II and /or Ang I, was infused into the renal artery (i.r.a) of anesthetized dogs in order to demonstrate its possible direct renal action. The dose administered, 15 Ig/kg BW/min in isotonic saline (0.072 ml/kg BW/min) throughout the experiment, did not influence the ...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000025959
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND/AIMS:Renal tubulointerstitium plays an important role in the development and progression of diabetic nephropathy. METHODS:With the present study, we aimed at evaluating the levels of neutrophil gelatinase-associated lipocalin (NGAL), a tubular stress protein, in serum (sNGAL) and urine (uNGAL) from a cohort...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000209379
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND/AIMS:Chronic kidney disease (CKD) is one of the major complications of hypertension. It is not only associated with the future burden of end-stage renal disease but also affects mortality and cardiovascular outcomes caused by hypertension. To help understand the pathogenesis and early prevention of progressi...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000443443
更新日期:2016-01-01 00:00:00
abstract::Currently, the pathogenesis of nondipper hypertension remains largely unclear in patients without any renal or endocrine pathology. It is well known that overt hypothyroidism is strongly associated with diastolic hypertension. However, no study has addressed the pathogenic role of TSH, free T3 (FT3), and free T4 (FT4)...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000110082
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND/AIMS:Lowering dialysate temperature to increase intradialytic hemodynamic stability may interfere with the ultrafiltration-dependent intradialytic autonomic cardiovascular regulation. The present study aimed to investigate hemodynamic and autonomic responses depending on dialysate temperature and the presenc...
journal_title:Kidney & blood pressure research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000141926
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:To evaluate the relationship between FGF23 and changes in biochemical parameters, left ventricle mass index, coronary, aortic and, valve calcifications. METHODS:Totally 185 patients with chronic renal disease were included in this prospective, cross-sectional study. The patients were stratified according to...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000339026
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:In uremic patients coronary surgery and the entire perioperative management is demanding. METHODS:We analyzed retrospectively data from all patients requiring chronic hemodialysis who under went coronary artery bypass grafting (CABG) between January 1 2001 and December 31 2004 at the Deutsches Herzzentrum B...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000090180
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND/AIMS:This study aimed to report the clinical efficacy of continuous renal replacement therapy (CRRT) in combination with ultrasound-guided percutaneous transhepatic gallbladder drainage (PTGD) (CRRT+PTGD) in the treatment of acute severe biliary pancreatitis (ASBP). METHODS:Between January 2010 and January ...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000485437
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND/AIMS:To date, there is no imaging technique to assess tubular function in vivo. Blood oxygen level-dependent magnetic resonance imaging (BOLD MRI) measures tissue oxygenation based on the transverse relaxation rate (R2*). The present study investigates whether BOLD MRI can assess tubular function using a tub...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000485600
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND/AIMS:Lung dysfunction associates with increased mortality but the impact of chronic kidney disease (CKD) is less clear. We evaluated lung function and its association with mortality among individuals with normal to severely reduced glomerular filtration rate (GFR). METHODS:404 individuals representing GFR c...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000488699
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND/AIMS:Diabetes mellitus can exacerbate renal ischemia-reperfusion (I/R) injury (RI/RI). The aim of the present study was to evaluate the protective effect of GSK-3β inhibition (TDZD-8) on I/R-induced renal injury through the Nrf2/HO-1 pathway in a streptozocin (STZ)-induced diabetic rat model. METHODS:STZ-in...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000477947
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND/AIMS:The association between ACYP2(Acylphosphatase 2) polymorphisms and immunoglobulin A nephropathy (IgAN) risk in the Chinese Han population remains unclear. We aimed to evaluate the association between ACYP2 polymorphisms and IgAN risk by performing a case-control study. METHODS:Eleven ACYP2 single nucle...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000501703
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Hypertension in the elderly is commonly characterized by an elevation of pulse pressure. With regard to advanced arteriosclerosis and limited physical fitness, doubt was casted whether elderly patients still achieve relevant cardiovascular benefits by physical exercise. The present work examines the impact o...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章,随机对照试验
doi:10.1159/000104093
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND/AIMS:Renalase (gene name RNLS), a recently discovered enzyme with monoamine oxidase activity, is implicated in the degradation of catecholamines. Recent studies indicate that common variations in the gene with RNLS are associated with hypertension. The aim of this study was to examine the association between...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000368460
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND/AIMS:Hemodialysis (HD) patients often have inadequate nutrition, especially with respect to ascorbic acid (AA). It is reported that every HD session may cause a 50%- 75% decrease in plasma AA levels. Some studies have shown that supplementation of AA can change the outcome of chronic kidney disease-mineral b...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章,meta分析
doi:10.1159/000493661
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Fatty acid-bearing albumin [FA(+) albumin] exerts more deleterious effects in tubular cells than albumin alone. We investigated the effect of FA(+) albumin on the vascular cell adhesion molecule-1 (VCAM-1) expression and elucidated the underlying signaling pathways. We further examined the effect of L-carnit...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000289576
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND/AIMS:Aortic arch calcification (AoAC) is frequently detected in maintenance hemodialysis (MHD) patients and is associated with cardiovascular and all-cause mortality. We investigated the factors associated with AoAC and analyzed the relationship between the factors including bone-derived biomarkers and AoAC....
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000494441
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND/AIMS:Post-transplant hypertension is highly prevalent in renal transplant recipients and is a risk factor for graft loss, cardiovascular disease and death. Glucocorticoid is used to prevent rejection, but simultaneously increases the risk of post-transplant hypertension. The glucocorticoid-induced transcript...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000485862
更新日期:2017-01-01 00:00:00
abstract::The nonmetabolizable glucose analogue [(3)H]-2-deoxy-D-glucose ((3)H-2DG) was used to study glucose transport in cultured rat podocytes. Intracellular accumulation of (3)H-2DG was linear up to 20 min and was inhibited by cytochalasin B (80% inhibition) and by phlorizin (20% inhibition). Pretreatment with insulin stimu...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000080889
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND/AIMS:Endothelial-to-mesenchymal transition (EndMT) of glomerular endothelial cells (GEnCs) can induce albuminuria in diabetic nephropathy. Melatonin attenuates diabetic nephropathy, but its role and mechanism in EndMT of GEnCs in diabetic nephropathy remain unknown. METHODS:The effect of melatonin on EndMT ...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000493380
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Cardiac death is increased in peritoneal dialysis (PD) patients. Pulse wave velocity (PWV) is a measurement of arterial stiffness, and previous reports linked PWV to increased extracellular water (ECW). As cyclers and icodextrin are increasingly used, we wished to determine whether this association between P...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000503424
更新日期:2019-01-01 00:00:00
abstract::In the present study, the effects of hexachlorobenzene (HCB) on lipid peroxidation and heme metabolism in the different constitutive suborgans of the kidney were determined. For this purpose, conjugated diene and malondialdehyde levels, as lipid peroxidation parameters, and porphyrin accumulation, uroporphyrinogen dec...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000025950
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND/AIMS:Angiotensin-converting enzyme inhibitors and angiotensin II receptor antagonists have beneficial effects on impaired fibrinolytic activity of hypertensive patients. The aim of the study was to evaluate the effect of antialdosterone treatment on impaired fibrinolysis of hypertensive patients. METHODS:Fo...
journal_title:Kidney & blood pressure research
pub_type: 临床试验,杂志文章
doi:10.1159/000066348
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND/AIMS:Rapamycin inhibits cyst growth in polycystic kidney disease by targeting the mammalian target of rapamycin (mTOR). To determine if this is a class effect of the mTOR inhibitors, we examined the effect of everolimus, the analogue of rapamycin, on disease progression in the Han:SPRD rat model of polycysti...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000104818
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Mesenchymal stem cells (MSC) improve renal function and renovascular hypertension in the 2-kidney 1-clip model (2K-1C). While MSC play an immunomodulatory role, induce neoangiogenesis, and reduce fibrosis, they do not correct sodium loss by the contra-lateral kidney. OBJECTIVES:We investigated the tubular f...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000503346
更新日期:2019-01-01 00:00:00