Abstract:
BACKGROUND/AIMS:Lung dysfunction associates with increased mortality but the impact of chronic kidney disease (CKD) is less clear. We evaluated lung function and its association with mortality among individuals with normal to severely reduced glomerular filtration rate (GFR). METHODS:404 individuals representing GFR category G1 (n=31; GFR >90 mL/min/1.73 m2), G2 (n=46), G3 (n=33), G4 (n=49) and G5 (n=245; GFR< 15 mL/min/1.73 m2) underwent spirometry yielding lung function indices forced vital capacity (FVC), forced expiratory volume in the first second (FEV1) and peak expiratory flow (PEF). Associations of lung function indices expressed as percentages of predicted values (%FEV1, %FVC and %PEF) with 5-year mortality were analyzed by competing-risk regression models. RESULTS:The prevalence of obstructive (6% in G1 and 11% in G5) and especially restrictive (9% in G1 to 36% in G5) lung dysfunction increased with declining GFR and with higher comorbidity burden. In patients (n=22) with protein-energy wasting, inflammation and cardiovascular disease, the prevalence of restrictive lung function was 64%. The highest tertiles of % FEV1 and %FVC associated with lower sub-hazard ratios (sHR) for all-cause mortality, 0.49 (95% CI, 0.27-0.88)) and 0.56 (95% CI, 0.32-0.98), and that of %FEV1 also with lower cardiovascular mortality risk (sHR 0.16; 95%CI 0.04-0.69) after adjusting for multiple confounders. Restrictive lung dysfunction (FEV1/FVC ≥ 0.70, and %FVC < 80) associated with increased mortality risk (sHR 1.80, 95%CI, 1.04-3.13) while the association with obstructive lung impairment was not statistically significant. CONCLUSION:Lung dysfunction and in particular restrictive lung dysfunction associates with degree of renal function impairment and presence of comorbidities, and is an independent predictor of increased mortality in CKD patients.
journal_name
Kidney Blood Press Resjournal_title
Kidney & blood pressure researchauthors
Mukai H,Ming P,Lindholm B,Heimbürger O,Barany P,Stenvinkel P,Qureshi ARdoi
10.1159/000488699subject
Has Abstractpub_date
2018-01-01 00:00:00pages
522-535issue
2eissn
1420-4096issn
1423-0143pii
000488699journal_volume
43pub_type
杂志文章abstract:BACKGROUND:1,25-Dihydroxyvitamin D(3) is mainly synthesized by renal proximal tubular cells. More recently, it has been shown to affect cell growth and TGF-beta(1) synthesis in glomerular and tubular renal cells in vitro, and to prevent glomerulosclerosis in vivo in subtotally nephrectomized rats. The mechanisms involv...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
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更新日期:2001-01-01 00:00:00
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journal_title:Kidney & blood pressure research
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journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000479295
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journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000208989
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journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000068699
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journal_title:Kidney & blood pressure research
pub_type: 杂志文章,评审
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更新日期:2008-01-01 00:00:00
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journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000493380
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journal_title:Kidney & blood pressure research
pub_type: 杂志文章
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journal_title:Kidney & blood pressure research
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journal_title:Kidney & blood pressure research
pub_type: 杂志文章
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journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000443425
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journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000174052
更新日期:1996-01-01 00:00:00
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journal_title:Kidney & blood pressure research
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doi:10.1159/000368510
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journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000484422
更新日期:2017-01-01 00:00:00
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journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000443429
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND/AIMS:We examined the factors associated with blood pressure variability in a multi-ethnicity prospective study in China to gain more evidence to guide the prevention and management of hypertension through risk factor intervention. METHODS:A total of 318 consecutive adult subjects aged 29-94 years with suspe...
journal_title:Kidney & blood pressure research
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doi:10.1159/000477424
更新日期:2017-01-01 00:00:00
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journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000339707
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journal_title:Kidney & blood pressure research
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journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000503424
更新日期:2019-01-01 00:00:00
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journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000073942
更新日期:2003-01-01 00:00:00
abstract::The value of neutrophil-gelatinase-associated lipocalin (NGAL) was highlighted as a novel biomarker for the detection of acute renal failure. We tested the hypothesis whether NGAL could represent an early biomarker of contrast-induced nephropathy (CIN) in 100 patients with normal serum creatinine values undergoing per...
journal_title:Kidney & blood pressure research
pub_type: 临床试验,杂志文章
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更新日期:2007-01-01 00:00:00
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journal_title:Kidney & blood pressure research
pub_type: 杂志文章,评审
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更新日期:2003-01-01 00:00:00
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journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000343405
更新日期:2012-01-01 00:00:00
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journal_title:Kidney & blood pressure research
pub_type: 杂志文章,评审
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更新日期:2014-01-01 00:00:00
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journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000025917
更新日期:1999-01-01 00:00:00
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journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000066789
更新日期:2002-01-01 00:00:00
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journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000316709
更新日期:2010-01-01 00:00:00