Abstract：
BACKGROUND/AIM:Expression of the constitutively active form of serum and glucocorticoid-dependent kinase ((S422D)SGK1) in Xenopus oocytes has recently been shown to upregulate endogenous Na(+)/K(+)-ATPase activity, an effect presumably participating in the regulation of cellular K(+) uptake and transepithelial Na(+) transport. SGK1 and the two isoforms SGK2 and SGK3 are stimulated by insulin and insulin-like growth factor-1 (IGF-1), which have been shown to enhance Na(+)/K(+)-ATPase activity in a variety of cells. The present experiments have been performed to elucidate whether or not wild-type SGK1, SGK2 and SGK3 are similar to (S422D)SGK1 in being effective regulators of Na(+)/K(+)-ATPase. METHODS:To this end, dual-electrode voltage clamp experiments were performed in Xenopus oocytes injected either with water or with mRNA of constitutively active (S422D)SGK1 and wild-type SGK1, SGK2 or SGK3. Na(+)/K(+)-ATPase activity was estimated from the outward-directed current created by readdition of extracellular K(+) in the presence of K(+) channel blocker Ba(2+) following a 10-min exposure to K(+)-free extracellular fluid. RESULTS:The outward-directed current was fully abolished by incubation with 1 mM ouabain and was significantly larger in oocytes expressing (S422D)SGK1, SGK1, SGK2 or SGK3, as compared to those injected with water. CONCLUSION:The stimulating effect of SGK1 on the Xenopus oocyte Na(+)/K(+)-ATPase is mimicked by the isoforms SGK2 and SGK3. Thus, all three kinases may participate in the regulation of Na(+)/K(+)-ATPase activity by hormones such as insulin and IGF-1.
journal_name
Kidney Blood Press Resjournal_title
Kidney & blood pressure researchauthors
Henke G,Setiawan I,Böhmer C,Lang Fdoi
10.1159/000068699keywords:
subject
Has Abstractpub_date
2002-01-01 00:00:00pages
370-4issue
6eissn
1420-4096issn
1423-0143pii
68699journal_volume
25pub_type
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