Urinary angiotensin converting enzyme 2 increases in patients with type 2 diabetic mellitus.

abstract：BACKGROUND/AIMS:Hypertensive patients present with increased oxidative stress and frequently receive angiotensin II (ANGII) receptor type I blockers (ARB) for blood pressure (BP) reduction. Recent studies revealed an important role of ANGII in maintaining vascular oxidative homeostasis, including sustaining normal sodi...

journal_title：Kidney & blood pressure research

authors： Mihalj M,Tadzic R,Vcev A,Rucevic S,Drenjancevic I

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND/AIMS:Diabetes mellitus can exacerbate renal ischemia-reperfusion (I/R) injury (RI/RI). The aim of the present study was to evaluate the protective effect of GSK-3β inhibition (TDZD-8) on I/R-induced renal injury through the Nrf2/HO-1 pathway in a streptozocin (STZ)-induced diabetic rat model. METHODS:STZ-in...

journal_title：Kidney & blood pressure research

authors： Shen X,Hu B,Xu G,Chen F,Ma R,Zhang N,Liu J,Ma X,Zhu J,Wu Y,Shen R

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND/AIMS:To determine the effect of arterial blood pressure (BP) reduction on endocan and soluble cell adhesion molecules' (sCAM) plasma concentration and expression of their ligands on circulatory leukocyte subpopulations. METHODS:24 hypertensive subjects of both sexes (age: 53±8 yrs) were treated with Ca-chan...

journal_title：Kidney & blood pressure research

authors： Tadzic R,Mihalj M,Vcev A,Ennen J,Tadzic A,Drenjancevic I

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Studies have demonstrated that cholesterol variability is an independent predictor of cerebrovascular and cardiovascular events. OBJECTIVE:This study aimed to investigate the association of visit-to-visit variability in total cholesterol (TC) with kidney decline in a Chinese community-based population. MET...

journal_title：Kidney & blood pressure research

authors： Yan Y,Huang Y,Zhou D,Tang S,Feng YQ

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Uremic toxins have been shown to promote glomerular hypertrophy. The present study was performed to elucidate the relation between uremic toxins and tubulointerstitial changes. METHODS:Sixty male Sprague-Dawley rats underwent 2/3 nephrectomy (Nx; n = 30) and 4/5 Nx (n = 30). Experiments were initiated 2 wee...

journal_title：Kidney & blood pressure research

authors： Okada K,Matsumoto K,Takahashi S

更新日期：2005-01-01 00:00:00

abstract：:In the failing heart, the local angiotensin II concentration is increased, and the extent of cardiac angiotensin II release is related to the clinical signs of heart failure. The enzymes involved in myocardial generation of angiotensin II are the angiotensin-converting enzyme (ACE) and chymases. While myocardial angio...

journal_title：Kidney & blood pressure research

authors： Schulz R,Heusch G

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND/AIMS:The kidney plays a critical role in the control of blood pressure and its elevation in salt-induced hypertension. Mitochondrial dysfunction, especially in energy metabolism, has been associated with hypertension. Here, we aimed to investigate mitochondrial function and metabolic features in renal mitoch...

journal_title：Kidney & blood pressure research

authors： Wang Z,Sun Q,Sun N,Liang M,Tian Z

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND/AIMS:We examined the factors associated with blood pressure variability in a multi-ethnicity prospective study in China to gain more evidence to guide the prevention and management of hypertension through risk factor intervention. METHODS:A total of 318 consecutive adult subjects aged 29-94 years with suspe...

journal_title：Kidney & blood pressure research

authors： Li W,Yu Y,Liang D,Jia EZ

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND/AIMS:Refugee dialysis is a worldwide growing dilemma with limited experience. This report presents the largest hemodialysis (HD) patient registry data of Syrian refugees in Turkey. METHODS:Demographic, clinical, laboratory, and dialysis practice data of 345 Syrian HD patients during one year were collected ...

journal_title：Kidney & blood pressure research

authors： Gursu M,Arici M,Ates K,Kazancioglu R,Yavas PG,Ozturk M,Altun B,Arinsoy T

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Cardiovascular complications are a major cause of morbidity and mortality in chronic renal failure (CRF) patients. Chronic anemia is a complication of CRF and a cardiovascular risk factor per se. It was the aim of the present study to clarify whether uremia and anemia are additive or supra-additive with resp...

journal_title：Kidney & blood pressure research

authors： Jürgensen JS,Grimm R,Benz K,Philipp S,Eckardt KU,Amann K

更新日期：2010-01-01 00:00:00

abstract：:The present investigation examined the possible influence of urinary calcium excretion on the concentration of renal calbindin-D28k. Thiazide diuretics stimulate calcium transport across the epithelial cells of the distal tubule, which express calbindin-D28k in high concentrations. Calbindin-D28k is assumed to facilit...

journal_title：Kidney & blood pressure research

authors： Hemmingsen C,Staun M,Meibom K,Bang K,Olgaard K

更新日期：1997-01-01 00:00:00

abstract：:NGAL (neutrophil gelatinase-associated lipocalin) is an acute phase protein, participating in antibacterial immunity. NGAL forms a complex with metalloproteinase 9 (MMP-9), thereby increasing its activity and preventing its degradation. NGAL is freely filtered through the glomerular membrane and reabsorbed by endocyto...

journal_title：Kidney & blood pressure research

authors： Helanova K,Spinar J,Parenica J

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:There is limited evidence on the etiology and outcomes of renal infarction. A provoking factor is identified only in one- to two-thirds of patients. METHODS:This is a retrospective observational study. The clinical characteristics and outcomes of patients with acute renal infarction were studied; the sample...

journal_title：Kidney & blood pressure research

authors： García-García A,Demelo-Rodríguez P,Ordieres-Ortega L,Cervilla-Muñoz E,García-Fernández-Bravo I,Pulfer MD,López-Aparicio A,Galeano-Valle F,Del Toro-Cervera J

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND/AIMS:We have reported that the long-term administration of angiotensin II receptor blockers (ARBs) induced unusual proliferative changes of renal afferent arteriolar smooth muscle cells (SMCs) in rats, associated with the overproduction of renin. In this study, we examined that a direct renin inhibitor (DRI:...

journal_title：Kidney & blood pressure research

authors： Nagai Y,Nakanishi K,Yamanaka N

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND/AIMS:To prevent contrast induced renal dysfunction a periprocedural prophylactic hydration is applied. Due to dilution it should cause a drop in serum creatinine concentration (SCR). Surprisingly, no reduction in SCR after contrast admission is found in up to 25% of patients as early as 12-18 hours after cor...

journal_title：Kidney & blood pressure research

authors： Burchardt P,Rzezniczak J,Synowiec T,Angerer D,Palasz A,Zurawski J

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND/AIMS:Either protein-to-creatinine ratio (PCR) or albumin-to-creatinine ratio (ACR) can be adopted for estimation of proteinuria in patients with chronic kidney disease (CKD). Estimated protein excretion rate (ePER) and estimated albumin excretion rate (eAER) may be superior to ACR and PCR. Reports show that ...

journal_title：Kidney & blood pressure research

authors： Hong DS,Oh IH,Park JS,Lee CH,Kang CM,Kim GH

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND/AIMS:We previously showed that urine and serum Angiopoietin-2 (Ang-2) levels increased significantly with the degree of albuminuria in diabetes patients, but the reasons remain unclear. Consequently we aimed to determine whether there was an association between Ang-2, inflammatory cytokines (TNF-α and IL-18)...

journal_title：Kidney & blood pressure research

authors： He FF,Li HQ,Huang QX,Wang QY,Jiang HJ,Chen S,Su H,Zhang C,Wang YM

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND/AIMS:We explored the effects of catechins (decaffeinated green tea extracts containing (-)-epicatechin, (-)-epigallocatechin, (-)-epicatechin gallate and (-)-epigallocatechin gallate) on atherosclerosis risk factors, oxidized low-density lipoprotein (oxLDL) and its primary metabolite, phosphatidylcholine hyd...

journal_title：Kidney & blood pressure research

authors： Chang HH,Chien CY,Chen KH,Huang SC,Chien CT

更新日期：2017-01-01 00:00:00

abstract：AIM:The aim of the present study was to evaluate the influence of cycle exercise during hemodialysis (HD) on patients' physical proficiency, muscle strength, quality of life and selected laboratory parameters. PATIENTS AND METHODS:In a group of 29 (15 female, 14 male) HD patients (age 64.2 ± 13.1 years), 3 months of c...

journal_title：Kidney & blood pressure research

authors： Gołębiowski T,Kusztal M,Weyde W,Dziubek W,Woźniewski M,Madziarska K,Krajewska M,Letachowicz K,Strempska B,Klinger M

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND/AIMS:The WNK-dependent STE20/SPS1-related proline/alanine-rich kinase SPAK participates in the regulation of NaCl and Na(+),K(+),2Cl(-) cotransport and thus renal salt excretion. The present study explored whether SPAK has similarly the potential to regulate the epithelial Na(+) channel (ENaC). METHODS:ENaC...

journal_title：Kidney & blood pressure research

authors： Ahmed M,Salker MS,Elvira B,Umbach AT,Fakhri H,Saeed AM,Shumilina E,Hosseinzadeh Z,Lang F

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND/AIMS:The association between ACYP2(Acylphosphatase 2) polymorphisms and immunoglobulin A nephropathy (IgAN) risk in the Chinese Han population remains unclear. We aimed to evaluate the association between ACYP2 polymorphisms and IgAN risk by performing a case-control study. METHODS:Eleven ACYP2 single nucle...

journal_title：Kidney & blood pressure research

authors： Jin G,Liang Y,Yan X,Zhang L,Li Z,Yin A,Wang X,Tian P

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND AND METHODS:We investigated kidney function, renal endothelin-1 concentration, prepro-endothelin-1 mRNA as well as endothelin receptor A and B mRNA expression and receptor properties in normotensive Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHR) with intact renal nerves and 7 days after re...

journal_title：Kidney & blood pressure research

authors： Girchev RA,Bäcker A,Markova PP,Kramer HJ

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Though the association between microalbuminuria (MA) and inflammatory markers has been studied, the possible gender differences in these associations have not yet been analyzed. Our study aims to analyze the role of gender in the associations of MA and inflammatory markers. METHODS:1,060 hypertensive patien...

journal_title：Kidney & blood pressure research

authors： Shantha GP,Kumar AA,Bharadhi MK,Arthur P

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND/AIMS:Calcium sensing receptor (CaSR) is expressed, among others also in testis. Cinacalcet binds to the CaSR, increases sensitivity of CaSR to serum calcium and is used in the treatment of secondary hyperparathyroidism (sHPT) in chronic hemodialysis patients (HDP). In most of male HDP, serum testosterone con...

journal_title：Kidney & blood pressure research

authors： Kuczera P,Adamczak M,Wiecek A

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND/AIMS:This study aimed to report the clinical efficacy of continuous renal replacement therapy (CRRT) in combination with ultrasound-guided percutaneous transhepatic gallbladder drainage (PTGD) (CRRT+PTGD) in the treatment of acute severe biliary pancreatitis (ASBP). METHODS:Between January 2010 and January ...

journal_title：Kidney & blood pressure research

authors： Zhu Q,Pan X,Cao Y,Wang H,Yu N,Liu F,Yang S,Wang Y,Sun Y,Wang Z

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND/AIMS:Serum/Glucocorticoid Regulated Kinase 1 (SGK1) plays a significant role in regulating renal Na(+) reabsorption, K(+) secretion, and blood pressure (BP). This study aimed to assess the association of common genetic variants in the SGK1 gene with BP responses to controlled dietary sodium or potassium inte...

journal_title：Kidney & blood pressure research

authors： Chu C,Wang Y,Wang M,Mu JJ,Liu FQ,Wang L,Ren KY,Wang D,Yuan ZY

更新日期：2015-01-01 00:00:00

abstract：:Inhibitors of angiotensin-converting enzyme (ACE) or beta isoforms of protein kinase C (PKC) are nephroprotective in diabetes mellitus. We investigated the influence of streptozotocin (STZ)-induced diabetes mellitus and of treatment with the ACE inhibitor lisinopril (4 mg/kg p.o. twice daily for 4 weeks) on the expres...

journal_title：Kidney & blood pressure research

authors： Pfaff IL,Vallon V

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND/AIMS:The kinases SPAK (SPS1-related proline/alanine-rich kinase) and OSR1 (oxidative stress-responsive kinase 1) participate in the regulation of the NaCl cotransporter NCC and the Na+, K+, 2Cl- cotransporter NKCC2. The kinases are regulated by WNK (with-no-K[Lys]) kinases. Mutations of genes encoding WNK ki...

journal_title：Kidney & blood pressure research

authors： Elvira B,Munoz C,Borras J,Chen H,Warsi J,Ajay SS,Shumilina E,Lang F

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND/AIMS:The aim of our study was to retrospectively analyse data of 520 Czech patients with IgA nephropathy (IgAN) and to specify the risk factors affecting renal survival of IgAN patients. METHODS:Cox proportional hazards regression model was used to evaluate the effects of different variables on renal surviv...

journal_title：Kidney & blood pressure research

authors： Maixnerova D,Neprasova M,Skibova J,Mokrisova J,Rysava R,Reiterova J,Jancova E,Merta M,Zadrazil J,Honsova E,Tesar V

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND/AIMS:Renal tubulointerstitium plays an important role in the development and progression of diabetic nephropathy. METHODS:With the present study, we aimed at evaluating the levels of neutrophil gelatinase-associated lipocalin (NGAL), a tubular stress protein, in serum (sNGAL) and urine (uNGAL) from a cohort...

journal_title：Kidney & blood pressure research

authors： Bolignano D,Lacquaniti A,Coppolino G,Donato V,Fazio MR,Nicocia G,Buemi M

更新日期：2009-01-01 00:00:00