Abstract:
BACKGROUND:Uremic toxins have been shown to promote glomerular hypertrophy. The present study was performed to elucidate the relation between uremic toxins and tubulointerstitial changes. METHODS:Sixty male Sprague-Dawley rats underwent 2/3 nephrectomy (Nx; n = 30) and 4/5 Nx (n = 30). Experiments were initiated 2 weeks after surgery, and were performed over an 8-week period. Half of each group (Nx-A) was administered 1 g/day of an oral carbonaceous adsorbent, AST-120, with pair-feeding, and the other half (Nx-C) served as controls. All rats were sacrificed at week 8 after a clearance study. RESULTS:The shortest diameter of proximal tubules (PTD) and interstitial fibrosis area (IFA) at week 8 in 2/3 Nx-A rats was significantly decreased compared to that in 2/3 Nx-C rats (similar body weights, systolic blood pressures, glomerular filtration rates, and urinary protein excretion levels). The values of PTD and IFA, glomerular filtration rate and urinary protein excretion level at week 8 in 4/5 Nx-A rats were significantly decreased compared to those in 4/5 Nx-C rats (similar body weights and systolic blood pressures). CONCLUSION:Administration of AST-120 minimized the appearance of proximal tubular hypertrophy and interstitial fibrosis, and subsequently prevented the occurrence of proteinuria and decreased renal function. The present study indicates that uremic toxins adsorbed by AST-120 promote tubular hypertrophy and interstitial fibrosis in nephrectomized rats.
journal_name
Kidney Blood Press Resjournal_title
Kidney & blood pressure researchauthors
Okada K,Matsumoto K,Takahashi Sdoi
10.1159/000080935keywords:
subject
Has Abstractpub_date
2005-01-01 00:00:00pages
8-13issue
1eissn
1420-4096issn
1423-0143pii
80935journal_volume
28pub_type
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journal_title:Kidney & blood pressure research
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pub_type: 杂志文章
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journal_title:Kidney & blood pressure research
pub_type: 杂志文章
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pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Kidney & blood pressure research
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journal_title:Kidney & blood pressure research
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Kidney & blood pressure research
pub_type: 临床试验,杂志文章
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更新日期:2006-01-01 00:00:00
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journal_title:Kidney & blood pressure research
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pub_type: 杂志文章
doi:10.1159/000339707
更新日期:2012-01-01 00:00:00
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更新日期:2010-01-01 00:00:00
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journal_title:Kidney & blood pressure research
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更新日期:2016-01-01 00:00:00
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更新日期:2018-01-01 00:00:00
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journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000132462
更新日期:2008-01-01 00:00:00
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journal_title:Kidney & blood pressure research
pub_type: 杂志文章,评审
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更新日期:1999-01-01 00:00:00
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journal_title:Kidney & blood pressure research
pub_type: 杂志文章,meta分析,评审
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更新日期:2016-01-01 00:00:00
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journal_title:Kidney & blood pressure research
pub_type: 杂志文章
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更新日期:2017-01-01 00:00:00
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journal_title:Kidney & blood pressure research
pub_type: 杂志文章,评审
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