Abstract:
BACKGROUND/AIMS:ET-1 has independent effects on blood pressure regulation in vivo, it is involved in tubular water and salt excretion, promotes constriction of smooth muscle cells, modulates sympathetic nerve activity, and activates the liberation of nitric oxide. To determine the net effect of these partially counteracting mechanisms on blood pressure, a systematic meta-analysis was performed. METHODS:Based on the principles of Cochrane systematic reviews, we searched in major literature databases - MEDLINE (PubMed), Embase, Google Scholar, and the China Biological Medicine Database (CBM-disc) - for articles relevant to the topic of the blood pressure phenotype of endothelin-1 transgenic (ET-1+/+) mice from January 1, 1988 to March 31, 2016. Review Manager Version 5.0 (Rev-Man 5.0) software was applied for statistical analysis. In total thirteen studies reported blood pressure data. RESULTS:The meta-analysis of blood pressure data showed that homozygous ET-1 transgenic mice (ET-1+/+ mice) had a significantly lower blood pressure as compared to WT mice (mean difference: -2.57 mmHg, 95% CI: -4.98∼ -0.16, P = 0.04), with minimal heterogeneity (P = 0.86). A subgroup analysis of mice older than 6 months revealed that the blood pressure difference between ET-1+/+ mice and WT mice was even more pronounced (mean difference: -6.19 mmHg, 95% CI: -10.76∼ -1.62, P = 0.008), with minimal heterogeneity (P = 0.91). CONCLUSION:This meta-analysis provides robust evidence that global ET-1 overexpression in mice lowers blood pressure in an age-dependent manner. Older ET-1+/+ mice have a somewhat more pronounced reduction of blood pressure.
journal_name
Kidney Blood Press Resjournal_title
Kidney & blood pressure researchauthors
Lu YP,Tsuprykov O,Vignon-Zellweger N,Heiden S,Hocher Bdoi
10.1159/000450567subject
Has Abstractpub_date
2016-01-01 00:00:00pages
770-780issue
6eissn
1420-4096issn
1423-0143pii
000450567journal_volume
41pub_type
杂志文章,meta分析,评审abstract:BACKGROUND/AIMS:Aortic arch calcification (AoAC) is frequently detected in maintenance hemodialysis (MHD) patients and is associated with cardiovascular and all-cause mortality. We investigated the factors associated with AoAC and analyzed the relationship between the factors including bone-derived biomarkers and AoAC....
journal_title:Kidney & blood pressure research
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journal_title:Kidney & blood pressure research
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abstract::Acute kidney injury (AKI) is a complex kidney disorder that leads to numerous complications, such as elevated nitrogenous wastes, metabolic acidosis, high potassium levels and even death. The pathogenesis of AKI is very complicated, and its causes are commonly categorized as prerenal, intrinsic or postrenal. In the pa...
journal_title:Kidney & blood pressure research
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doi:10.1159/000450566
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abstract::Pravastatin is a potent inhibitor of HMG-CoA reductase and is effective in lowering serum lipid levels. Recent studies have shown that pravastatin also reduces the oxidative modification of low-density lipoprotein (LDL). To determine whether pravastatin has a direct effect on glomerular mesangial cells, we have measur...
journal_title:Kidney & blood pressure research
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abstract:BACKGROUND:Treating non-diabetic proteinuric patients with advanced renal disease with an angiotensin-converting enzyme (ACE) inhibitor is still subject to discussion. This study aims to determine the cost-effectiveness of ACE inhibitor therapy in this patient population in the Netherlands. METHODS:We compared two str...
journal_title:Kidney & blood pressure research
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abstract:BACKGROUND:The antiproteinuric effect of angiotensin-converting enzyme (ACE) inhibitors appears to vary depending on the ACE insertion (I)/deletion (D) genotype in non-diabetic nephropathy. This interaction may be overcome by using an angiotensin II receptor blocker. We evaluated the short-term antiproteinuric effect o...
journal_title:Kidney & blood pressure research
pub_type: 临床试验,杂志文章
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journal_title:Kidney & blood pressure research
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journal_title:Kidney & blood pressure research
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journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000066789
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journal_title:Kidney & blood pressure research
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doi:10.1159/000488699
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journal_title:Kidney & blood pressure research
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journal_title:Kidney & blood pressure research
pub_type: 杂志文章
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更新日期:2018-01-01 00:00:00
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pub_type: 临床试验,杂志文章
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journal_title:Kidney & blood pressure research
pub_type: 杂志文章
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更新日期:2017-01-01 00:00:00
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更新日期:2015-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1159/000447936
更新日期:2016-01-01 00:00:00
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journal_title:Kidney & blood pressure research
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journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000368541
更新日期:2016-01-01 00:00:00
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pub_type: 杂志文章
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