Non-random distribution and sensory functions of primary cilia in vascular smooth muscle cells.

abstract：BACKGROUND:1,25-Dihydroxyvitamin D(3) is mainly synthesized by renal proximal tubular cells. More recently, it has been shown to affect cell growth and TGF-beta(1) synthesis in glomerular and tubular renal cells in vitro, and to prevent glomerulosclerosis in vivo in subtotally nephrectomized rats. The mechanisms involv...

journal_title：Kidney & blood pressure research

authors： Weinreich T,Wüthrich RP,Booy C,Binswanger U

更新日期：2001-01-01 00:00:00

abstract：OBJECTIVE:Co-deposition of mannose-binding lectin (MBL) and IgG4 anti-phospholipase A2 receptor (anti-PLA2R) autoantibodies under subepithelial cells has been observed in patients with idiopathic membranous nephropathy (iMN), but the relationships of MBL deposition to iMN severity and progression remain unclear. METHO...

journal_title：Kidney & blood pressure research

authors： Zhang Y,Liu Y,Liang L,Liu L,Tang X,Tang L,Chen P,Chen J,Wang Z,Cao W,Chen Q,Zhao N,Xu D

更新日期：2020-01-01 00:00:00

abstract：BACKGROUNDS:ANCA-associated vasculitis (AAV) frequently present with a chronic relapsing course. Relapse leads to an increased need for therapeutic agents and consequent toxicity. SUMMARY:When referring to the available options for the management of AAV, the efficacy of glucocorticoids (GCs) is unquestionable. However...

journal_title：Kidney & blood pressure research

authors： Fenoglio R,Roccatello D,Sciascia S

更新日期：2020-01-01 00:00:00

abstract：:Heart failure and chronic kidney disease share a number of risk factors and pathophysiological pathways. Renal insufficiency is common in patients with chronic heart failure (CHF). The aim of the study was to assess whether neutrophil gelatinase-associated lipocalin (NGAL) could represent a novel, sensitive marker of ...

journal_title：Kidney & blood pressure research

authors： Poniatowski B,Malyszko J,Bachorzewska-Gajewska H,Malyszko JS,Dobrzycki S

更新日期：2009-01-01 00:00:00

abstract：:Acute kidney injury (AKI) is a complex kidney disorder that leads to numerous complications, such as elevated nitrogenous wastes, metabolic acidosis, high potassium levels and even death. The pathogenesis of AKI is very complicated, and its causes are commonly categorized as prerenal, intrinsic or postrenal. In the pa...

journal_title：Kidney & blood pressure research

authors： Zhou P,Chen Z,Zou Y,Wan X

更新日期：2016-01-01 00:00:00

abstract：:Obesity increases the risk for chronic kidney disease (CKD). By analyzing data on individuals who underwent general health screening in two consecutive years, we investigated whether changes in body mass index (BMI) or waist circumference (WC) were associated with the appearance or disappearance of the CKD components;...

journal_title：Kidney & blood pressure research

authors： Ishizaka Y,Ishizaka N,Tani M,Toda A,Toda E,Koike K,Nagai R,Yamakado M

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:The oxidative stress-responsive kinase 1 (OSR1) participates in the WNK-(with no K) kinase dependent regulation of renal salt excretion and blood pressure. Little is known, however, about the role of OSR1 in the regulation of further renal transport systems. The present study analyzed the effect of OSR1 on N...

journal_title：Kidney & blood pressure research

authors： Pathare G,Föller M,Daryadel A,Mutig K,Bogatikov E,Fajol A,Almilaji A,Michael D,Stange G,Voelkl J,Wagner CA,Bachmann S,Lang F

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Renal involvement in Takayasu's arteritis (TA) effects the disease outcome and endovascular treatment is an effective treatment of choice. We investigated nitric oxide (NO) levels and the effect of endovascular treatment in renovascular hypertensive TA patients. METHODS:In five hypertensive patients with re...

journal_title：Kidney & blood pressure research

authors： Parildar Z,Gulter C,Parildar M,Oran I,Erdener D,Memis A

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:In uremic patients coronary surgery and the entire perioperative management is demanding. METHODS:We analyzed retrospectively data from all patients requiring chronic hemodialysis who under went coronary artery bypass grafting (CABG) between January 1 2001 and December 31 2004 at the Deutsches Herzzentrum B...

journal_title：Kidney & blood pressure research

authors： Krabatsch T,Yeter R,Hetzer R

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND/AIMS:Cardiovascular morbidity and mortality are high in patients with chronic kidney disease. We evaluated the influence of small differences in preoperative kidney function on mortality and complications following cardiac surgery. METHODS:This is an observational study that included adult patients undergoi...

journal_title：Kidney & blood pressure research

authors： Shavit L,Tauber R,Lifschitz M,Bitran D,Slotki I,Fink D

更新日期：2012-01-01 00:00:00

abstract：:Despite developments in the technology of dialysis procedures and improvements in the understanding of systemic derangements related to chronic kidney disease (CKD), cardiovascular disease is the major cause of death. Unfortunately, the leading subset of cardiovascular disease death is sudden cardiac death (SCD). To d...

journal_title：Kidney & blood pressure research

authors： Kanbay M,Solak Y,Covic A,Goldsmith D

更新日期：2011-01-01 00:00:00

abstract：:Post-transplant hypertension is a common occurrence during treatment with calcineurin inhibitors (CNIs) in kidney transplant population. The pathogenesis of vasoconstriction induced by CNIs involves vascular tone alterations and kidney sodium transport regulation. Among the factors involved a key role is played by the...

journal_title：Kidney & blood pressure research

authors： Calò LA,Ravarotto V,Simioni F,Naso E,Marchini F,Bonfante L,Furian L,Rigotti P

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND/AIMS:ET-1 has independent effects on blood pressure regulation in vivo, it is involved in tubular water and salt excretion, promotes constriction of smooth muscle cells, modulates sympathetic nerve activity, and activates the liberation of nitric oxide. To determine the net effect of these partially countera...

journal_title：Kidney & blood pressure research

authors： Lu YP,Tsuprykov O,Vignon-Zellweger N,Heiden S,Hocher B

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND/AIMS:The Janus kinase 3 JAK3 participates in the signaling of immune cells. Lack of JAK3 triggers inflammatory bowel disease, which in turn has been shown to affect intestinal activity of the epithelial Na(+) channel ENaC and thus colonic sodium absorption. At least in theory, inflammatory bowel disease in J...

journal_title：Kidney & blood pressure research

authors： Umbach AT,Luo D,Bhavsar SK,Hosseinzadeh Z,Lang F

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND/AIMS:The aim of our study was to retrospectively analyse data of 520 Czech patients with IgA nephropathy (IgAN) and to specify the risk factors affecting renal survival of IgAN patients. METHODS:Cox proportional hazards regression model was used to evaluate the effects of different variables on renal surviv...

journal_title：Kidney & blood pressure research

authors： Maixnerova D,Neprasova M,Skibova J,Mokrisova J,Rysava R,Reiterova J,Jancova E,Merta M,Zadrazil J,Honsova E,Tesar V

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:The antiproteinuric effect of angiotensin-converting enzyme (ACE) inhibitors appears to vary depending on the ACE insertion (I)/deletion (D) genotype in non-diabetic nephropathy. This interaction may be overcome by using an angiotensin II receptor blocker. We evaluated the short-term antiproteinuric effect o...

journal_title：Kidney & blood pressure research

authors： Park HC,Choi HY,Kim BS,Kang SW,Choi KH,Ha SK,Lee HY,Han DS

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Cardiovascular disease caused by atherosclerosis remains a major cause of morbidity and mortality in patients with end-stage renal disease (ESRD). We evaluated the potential association of cardiovascular risk factors including asymmetric dimethyl L-arginine (ADMA) and the soluble receptor for advanced glycat...

journal_title：Kidney & blood pressure research

authors： Pitha J,Teplan V,Kalousova M,Racek J,Stollova M,Marečková O,Lanska V

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND/AIMS:Rapamycin inhibits cyst growth in polycystic kidney disease by targeting the mammalian target of rapamycin (mTOR). To determine if this is a class effect of the mTOR inhibitors, we examined the effect of everolimus, the analogue of rapamycin, on disease progression in the Han:SPRD rat model of polycysti...

journal_title：Kidney & blood pressure research

authors： Wu M,Wahl PR,Le Hir M,Wackerle-Men Y,Wuthrich RP,Serra AL

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND/AIMS:Hypertensive patients present with increased oxidative stress and frequently receive angiotensin II (ANGII) receptor type I blockers (ARB) for blood pressure (BP) reduction. Recent studies revealed an important role of ANGII in maintaining vascular oxidative homeostasis, including sustaining normal sodi...

journal_title：Kidney & blood pressure research

authors： Mihalj M,Tadzic R,Vcev A,Rucevic S,Drenjancevic I

更新日期：2016-01-01 00:00:00

abstract：:The value of neutrophil-gelatinase-associated lipocalin (NGAL) was highlighted as a novel biomarker for the detection of acute renal failure. We tested the hypothesis whether NGAL could represent an early biomarker of contrast-induced nephropathy (CIN) in 100 patients with normal serum creatinine values undergoing per...

journal_title：Kidney & blood pressure research

authors： Bachorzewska-Gajewska H,Malyszko J,Sitniewska E,Malyszko JS,Pawlak K,Mysliwiec M,Lawnicki S,Szmitkowski M,Dobrzycki S

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Diabetic nephropathy constitutes a large proportion of end-stage kidney failure in diabetic patients. However, the underlying molecular mechanisms remain unclear. METHODS:Db/db diabetic mouse models and high glucose (HG)-induced human renal mesangial cells (HRMCs) were used as research models in vivo and in...

journal_title：Kidney & blood pressure research

authors： Min XQ,Xie Y

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:The biological properties of oxidized and non-oxidized PTH are substantially different. Oxidized PTH (oxPTH) loses its PTH receptor-stimulating properties, whereas non-oxidized PTH (n-oxPTH) is a full agonist of the receptor. This was described in more than 20 well published studies in the 1970(s) and 80(s)....

journal_title：Kidney & blood pressure research

authors： Hocher B,Oberthür D,Slowinski T,Querfeld U,Schaefer F,Doyon A,Tepel M,Roth HJ,Grön HJ,Reichetzeder C,Betzel C,Armbruster FP

更新日期：2013-01-01 00:00:00

abstract：:The nonmetabolizable glucose analogue [(3)H]-2-deoxy-D-glucose ((3)H-2DG) was used to study glucose transport in cultured rat podocytes. Intracellular accumulation of (3)H-2DG was linear up to 20 min and was inhibited by cytochalasin B (80% inhibition) and by phlorizin (20% inhibition). Pretreatment with insulin stimu...

journal_title：Kidney & blood pressure research

authors： Lewko B,Bryl E,Witkowski JM,Latawiec E,Gołos M,Endlich N,Hähnel B,Koksch C,Angielski S,Kriz W,Stepinski J

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Cardiovascular complications are a major cause of morbidity and mortality in chronic renal failure (CRF) patients. Chronic anemia is a complication of CRF and a cardiovascular risk factor per se. It was the aim of the present study to clarify whether uremia and anemia are additive or supra-additive with resp...

journal_title：Kidney & blood pressure research

authors： Jürgensen JS,Grimm R,Benz K,Philipp S,Eckardt KU,Amann K

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND/AIMS:Arterial hypertension is one of the leading factors aggravating the course of chronic kidney disease (CKD). It seems that the novel parameters used in the assessment of the blood pressure (BP) load (i.e. central blood pressure, nighttime blood pressure) may be more precise in predicting the cardiovascul...

journal_title：Kidney & blood pressure research

authors： Kuczera P,Kwiecień K,Adamczak M,Bączkowska T,Gozdowska J,Madziarska K,Augustyniak-Bartosik H,Klinger M,Durlik M,Ritz E,Wiecek A

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND AND METHODS:We investigated kidney function, renal endothelin-1 concentration, prepro-endothelin-1 mRNA as well as endothelin receptor A and B mRNA expression and receptor properties in normotensive Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHR) with intact renal nerves and 7 days after re...

journal_title：Kidney & blood pressure research

authors： Girchev RA,Bäcker A,Markova PP,Kramer HJ

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND/AIMS:Renal tubulointerstitial fibrosis (TIF) is the common pathway of progressive chronic kidney disease. Inflammation has been widely accepted as the major driving force of TIF. Cystathionine β-synthase (CBS) is the first and rate-limiting enzyme in the transsulfuration pathway. CBS is considered to play pr...

journal_title：Kidney & blood pressure research

authors： Yuan X,Zhang J,Xie F,Tan W,Wang S,Huang L,Tao L,Xing Q,Yuan Q

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND/AIMS:The kinases SPAK (SPS1-related proline/alanine-rich kinase) and OSR1 (oxidative stress-responsive kinase 1) participate in the regulation of the NaCl cotransporter NCC and the Na+, K+, 2Cl- cotransporter NKCC2. The kinases are regulated by WNK (with-no-K[Lys]) kinases. Mutations of genes encoding WNK ki...

journal_title：Kidney & blood pressure research

authors： Elvira B,Munoz C,Borras J,Chen H,Warsi J,Ajay SS,Shumilina E,Lang F

更新日期：2014-01-01 00:00:00

abstract：:Pravastatin is a potent inhibitor of HMG-CoA reductase and is effective in lowering serum lipid levels. Recent studies have shown that pravastatin also reduces the oxidative modification of low-density lipoprotein (LDL). To determine whether pravastatin has a direct effect on glomerular mesangial cells, we have measur...

journal_title：Kidney & blood pressure research

authors： Chen HC,Guh JY,Shin SJ,Tomino Y,Lai YH

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND/AIMS:We examined the factors associated with blood pressure variability in a multi-ethnicity prospective study in China to gain more evidence to guide the prevention and management of hypertension through risk factor intervention. METHODS:A total of 318 consecutive adult subjects aged 29-94 years with suspe...

journal_title：Kidney & blood pressure research

authors： Li W,Yu Y,Liang D,Jia EZ

更新日期：2017-01-01 00:00:00