Abstract:
:The value of neutrophil-gelatinase-associated lipocalin (NGAL) was highlighted as a novel biomarker for the detection of acute renal failure. We tested the hypothesis whether NGAL could represent an early biomarker of contrast-induced nephropathy (CIN) in 100 patients with normal serum creatinine values undergoing percutaneous coronary interventions (PCI). In addition, we assessed serum and urinary NGAL in relation to cystatin C, estimated glomerular filtration rate, and serum and urinary creatinine in these patients. We measured urinary and serum NGAL values before and 2, 4, 8, 24, and 48 h after the PCI. We found a significant rise in serum NGAL levels 2, 4, and 8 h after the PCI and in urinary NGAL values 4, 8, and 24 h after a PCI procedure. Cystatin C rose significantly 24 h after the procedure. The prevalence of CIN was 11%. The NGAL levels were significantly higher 2 h after the PCI (serum NGAL) or 4 h after the PCI (urinary NGAL), whereas the cystatin C values were higher only 8 and 24 h after a PCI procedure in patients with CIN. In multivariate analysis, only serum creatinine was a predictor of serum NGAL before a PCI. NGAL may represent a sensitive early biomarker of renal impairment after PCI. Serum creatinine level, the presence of diabetes, and the duration of the PCI may affect serum NGAL values and kidney function following a PCI procedure.
journal_name
Kidney Blood Press Resjournal_title
Kidney & blood pressure researchauthors
Bachorzewska-Gajewska H,Malyszko J,Sitniewska E,Malyszko JS,Pawlak K,Mysliwiec M,Lawnicki S,Szmitkowski M,Dobrzycki Sdoi
10.1159/000109102subject
Has Abstractpub_date
2007-01-01 00:00:00pages
408-15issue
6eissn
1420-4096issn
1423-0143pii
000109102journal_volume
30pub_type
临床试验,杂志文章abstract:BACKGROUND/AIMS:The association between ACYP2(Acylphosphatase 2) polymorphisms and immunoglobulin A nephropathy (IgAN) risk in the Chinese Han population remains unclear. We aimed to evaluate the association between ACYP2 polymorphisms and IgAN risk by performing a case-control study. METHODS:Eleven ACYP2 single nucle...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000501703
更新日期:2019-01-01 00:00:00
abstract::Despite developments in the technology of dialysis procedures and improvements in the understanding of systemic derangements related to chronic kidney disease (CKD), cardiovascular disease is the major cause of death. Unfortunately, the leading subset of cardiovascular disease death is sudden cardiac death (SCD). To d...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章,评审
doi:10.1159/000326904
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND/AIMS:The kidney plays a critical role in the control of blood pressure and its elevation in salt-induced hypertension. Mitochondrial dysfunction, especially in energy metabolism, has been associated with hypertension. Here, we aimed to investigate mitochondrial function and metabolic features in renal mitoch...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000479846
更新日期:2017-01-01 00:00:00
abstract::Cardiovascular (CV) morbidity and mortality is greatly enhanced in patients with chronic kidney disease, compared to the non-renal population. One key element of this high CV burden appears to be arterial stiffness, as an expression of premature vascular aging. Increased arterial stiffness in renal patients may be a c...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章,评审
doi:10.1159/000100905
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:There is limited evidence on the etiology and outcomes of renal infarction. A provoking factor is identified only in one- to two-thirds of patients. METHODS:This is a retrospective observational study. The clinical characteristics and outcomes of patients with acute renal infarction were studied; the sample...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000503425
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND/AIMS:Calcium sensing receptor (CaSR) is expressed, among others also in testis. Cinacalcet binds to the CaSR, increases sensitivity of CaSR to serum calcium and is used in the treatment of secondary hyperparathyroidism (sHPT) in chronic hemodialysis patients (HDP). In most of male HDP, serum testosterone con...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000368541
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Mesenchymal stem cells (MSC) improve renal function and renovascular hypertension in the 2-kidney 1-clip model (2K-1C). While MSC play an immunomodulatory role, induce neoangiogenesis, and reduce fibrosis, they do not correct sodium loss by the contra-lateral kidney. OBJECTIVES:We investigated the tubular f...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000503346
更新日期:2019-01-01 00:00:00
abstract::Renal proximal tubular Na/phosphate cotransport is the key target in the control of renal phosphate handling. Using molecular tools for the type II Na/phosphate cotransporter, it could be documented that altered brush border membrane phosphate transport reflects a state of altered brush border expression of the specif...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章,评审
doi:10.1159/000174063
更新日期:1996-01-01 00:00:00
abstract::Primary cardiac hemangioma is a very rare benign vascular tumor, with valvular hemangiomas being even less frequent as valves are generally avascular structures. We present the first case of mitral valve hemangioma in a renal transplant recipient. Patient presented with progressive dyspnea. Transesophageal echocardiog...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章,评审
doi:10.1159/000343395
更新日期:2013-01-01 00:00:00
abstract:AIM:To assess the influence on blood pressure in schoolchildren, of elevated sodium (Na(+)) and nitrate (NO(-)(3)) levels in the drinking water. METHODS:The blood pressure was recorded in three groups of age- and weight-matched schoolchildren (fourth and fifth graders) ingesting differing Na(+) and NO(-)(3) concentrat...
journal_title:Kidney & blood pressure research
pub_type: 临床试验,杂志文章
doi:10.1159/000025989
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND/AIMS:Subclinical hypovolemia may contribute to allograft dysfunction in long-term kidney transplant (KT) patients. In order to predict responsiveness to saline hydration, indices for tubular transport were investigated. METHODS:Fifty-four clinically euvolemic long-term KT patients with recently aggravated a...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000341124
更新日期:2012-01-01 00:00:00
abstract::The nonmetabolizable glucose analogue [(3)H]-2-deoxy-D-glucose ((3)H-2DG) was used to study glucose transport in cultured rat podocytes. Intracellular accumulation of (3)H-2DG was linear up to 20 min and was inhibited by cytochalasin B (80% inhibition) and by phlorizin (20% inhibition). Pretreatment with insulin stimu...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000080889
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:Cardiac death is increased in peritoneal dialysis (PD) patients. Pulse wave velocity (PWV) is a measurement of arterial stiffness, and previous reports linked PWV to increased extracellular water (ECW). As cyclers and icodextrin are increasingly used, we wished to determine whether this association between P...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000503424
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND/AIMS:The presence of protein-energy wasting (PEW) among dialysis patients is a crucial risk factor for outcomes. The complicated pathogenesis of PEW makes it difficult to assess and treat. This single-center retrospective study focuses on the association between nutritional markers and the outcomes of contin...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000485926
更新日期:2017-01-01 00:00:00
abstract::Progressive renal disease poses an increasing problem for the medical community. Though the causes of end-stage renal failure are multiple, the histologic pictures of chronic renal disease are remarkably similar being characterized by interstitial infiltration, fibrosis, tubular atrophy and dilatation. This similarity...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章,评审
doi:10.1159/000025911
更新日期:1999-01-01 00:00:00
abstract:BACKGROUND/AIMS:To date, there is no imaging technique to assess tubular function in vivo. Blood oxygen level-dependent magnetic resonance imaging (BOLD MRI) measures tissue oxygenation based on the transverse relaxation rate (R2*). The present study investigates whether BOLD MRI can assess tubular function using a tub...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000485600
更新日期:2017-01-01 00:00:00
abstract:INTRODUCTION:Renal dysfunction is a frequent complication in patients suffering from β-thalassemia major (β-TM). The aim of this study was to analyze the renal function and urine metabolomic profile of β-TM patients undergoing transfusions and deferasirox (DFX) therapy, in order to better characterize and shed light on...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000507369
更新日期:2020-01-01 00:00:00
abstract::Patients affected by end-stage renal disease (ESRD) show quite lower physical activity and exercise capacity when compared to healthy individuals. In addition, a sedentary lifestyle is favoured by lack of a specific counseling on exercise implementation in the nephrology care setting. Increasing physical activity leve...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章,评审
doi:10.1159/000355787
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND/AIMS:Analysis of gene expression in renal tissue is considered to be a diagnostic tool predicting the clinical course of glomerulonephritis. The present study quantified the relative transcript levels of VEGF, CTGF and HIF-1α in renal tissue to establish their relationship with some clinical variables in pat...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000355754
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND/AIMS:The main purpose of the present study was to determine the effect of peritoneal charge barrier dysfunction on hypoalbuminemia during CAPD. METHODS:We measured the association of dialysis dose, peritoneal equilibration test (PET) results (ratio of dialysate and plasma creatinine), and peritoneal charge ...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000350150
更新日期:2013-01-01 00:00:00
abstract::In developed countries, the incidence of end-stage renal failure is constantly increasing, and uremia will soon be a disease typically found in mature and elderly adults. Almost invariably, the physical condition of the elderly patient with terminal uremia is extremely poor, and therapeutic approach complex. Frequent ...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章,评审
doi:10.1159/000164277
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND/AIMS:The kinases SPAK (SPS1-related proline/alanine-rich kinase) and OSR1 (oxidative stress-responsive kinase 1) participate in the regulation of the NaCl cotransporter NCC and the Na+, K+, 2Cl- cotransporter NKCC2. The kinases are regulated by WNK (with-no-K[Lys]) kinases. Mutations of genes encoding WNK ki...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000355812
更新日期:2014-01-01 00:00:00
abstract::In the pathogenesis of anti-neutrophil cytoplasm antibodies (ANCA)-associated vasculitis, T cell contribution is indicated by T cell-dependent ANCA production combined with the presence of T cells in inflammatory infiltrates. However, the exact pathogenic role of T cells in ANCA-associated vasculitis remains to be det...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章,评审
doi:10.1159/000072987
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND/AIM:Our aim was to determine whether altered human β-defensin (HBD), pro-inflammatory cytokines including interleukin (IL)-6 and tumor necrotic factor (TNF)-α could increase the risk of developing and exacerbation of chronic kidney disease (CKD), especially for patients with diabetic nephropathy (DN). METHO...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000355740
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:Co-deposition of mannose-binding lectin (MBL) and IgG4 anti-phospholipase A2 receptor (anti-PLA2R) autoantibodies under subepithelial cells has been observed in patients with idiopathic membranous nephropathy (iMN), but the relationships of MBL deposition to iMN severity and progression remain unclear. METHO...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000508665
更新日期:2020-01-01 00:00:00
abstract:AIMS:To investigate whether the regulation of aquaporin (AQP) channels is altered by inhibition of type 2 11beta-hydroxysteroid dehydrogenase (11betaHSD2). METHODS:Male Sprague-Dawley rats were treated with glycyrrhizic acid (GA, 2 g/l drinking water) for 7 days. The expression of AQP2 and AQP3 was determined in the k...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000098435
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Studies have demonstrated that cholesterol variability is an independent predictor of cerebrovascular and cardiovascular events. OBJECTIVE:This study aimed to investigate the association of visit-to-visit variability in total cholesterol (TC) with kidney decline in a Chinese community-based population. MET...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000501367
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND/AIMS:Chronic kidney disease (CKD) is often accompanied by hyperlipidemia, which accelerates progression of the disease. Podocyte injury can lead to dysfunction of the glomerular filtration barrier, which is associated with proteinuria, a risk marker for the progression of CKD. Our previous studies demonstrat...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000487673
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:1,25-Dihydroxyvitamin D(3) is mainly synthesized by renal proximal tubular cells. More recently, it has been shown to affect cell growth and TGF-beta(1) synthesis in glomerular and tubular renal cells in vitro, and to prevent glomerulosclerosis in vivo in subtotally nephrectomized rats. The mechanisms involv...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000054213
更新日期:2001-01-01 00:00:00
abstract:INTRODUCTION:Cardiovascular disease is one of the main causes of morbidity and mortality in patients with autosomal dominant polycystic kidney disease (ADPKD). Autonomic dysfunction is associated with an increased risk for all cardiovascular events in the general population and can be evaluated with heart rate variabil...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000502419
更新日期:2019-01-01 00:00:00