Abstract:
BACKGROUND/AIMS:The aim of our study was to retrospectively analyse data of 520 Czech patients with IgA nephropathy (IgAN) and to specify the risk factors affecting renal survival of IgAN patients. METHODS:Cox proportional hazards regression model was used to evaluate the effects of different variables on renal survival during a median follow up of six years. McNemar´s test was used to analyse the progression of renal function according to Bartosik´s formula. RESULTS:In our retrospective analysis of 520 Czech IgAN patients Cox proportional hazards regression model with five variables [hypertension, sex, GFR, proteinuria, age] was used. Significant regression coefficient was found for GFR, hypertension and proteinuria. Using stepwise algorithm GFR (OR = 3.09), hypertension (OR = 2.09) and proteinuria (OR = 1.97) were found as the most important factors for renal survival in our group of IgAN patients. Among patients with CKD 3 we found significantly better renal survival in patients with proteinuria < 1g/day compared to patients with higher proteinuria. We did not find the significant difference between predicted progression of renal function due to Bartosik´s formula and real progression of renal parametres assessed by GFR at the end of the follow up in our group of IgAN patients. CONCLUSION:Our retrospective study of 520 Czech IgAN patients confirmed GFR, hypertension and proteinuria as the most important factors affecting the prognosis of IgAN patients. We validated Toronto Bartosik´s formula to predict prognosis of IgAN patients.
journal_name
Kidney Blood Press Resjournal_title
Kidney & blood pressure researchauthors
Maixnerova D,Neprasova M,Skibova J,Mokrisova J,Rysava R,Reiterova J,Jancova E,Merta M,Zadrazil J,Honsova E,Tesar Vdoi
10.1159/000368467subject
Has Abstractpub_date
2014-01-01 00:00:00pages
555-62issue
6eissn
1420-4096issn
1423-0143pii
000368467journal_volume
39pub_type
杂志文章abstract:BACKGROUND/AIMS:Angiotensin converting enzyme 2 (ACE2) is highly expressed in the kidney and recognized to be renoprotective by degrading Angiotensin II to Angiotensin (1-7) in diabetic nephropathy. However, little is known about the role of urinary ACE2 (UACE2) in diabetes. The present study was performed to evaluate ...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000368486
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Flucloxacillin is an important antimicrobial drug in the treatment of infections with Staphylococcus aureus and therefore is often used in staphylococcal infections. Furthermore, flucloxacillin has a high protein binding rate as for example ceftriaxone or teicoplanin--drugs which have formerly been character...
journal_title:Kidney & blood pressure research
pub_type: 临床试验,杂志文章
doi:10.1159/000070997
更新日期:2003-01-01 00:00:00
abstract::Despite developments in the technology of dialysis procedures and improvements in the understanding of systemic derangements related to chronic kidney disease (CKD), cardiovascular disease is the major cause of death. Unfortunately, the leading subset of cardiovascular disease death is sudden cardiac death (SCD). To d...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章,评审
doi:10.1159/000326904
更新日期:2011-01-01 00:00:00
abstract::Backgroud/Aims: The aim of this study was to investigate the potential renoprotective effect of rapamycin on the autophagy of podocytes treated with the supernatant of mesangial cells cultured with aggregated IgA1 (aIgA1) from immunoglobulin A nephropathy (IgAN) patients. METHODS:Monomeric IgA1 (mIgA1) was isolated f...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000475484
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND/AIMS:Hypertensive patients present with increased oxidative stress and frequently receive angiotensin II (ANGII) receptor type I blockers (ARB) for blood pressure (BP) reduction. Recent studies revealed an important role of ANGII in maintaining vascular oxidative homeostasis, including sustaining normal sodi...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000450562
更新日期:2016-01-01 00:00:00
abstract::Recently, Chlamydia pneumoniae is the microorganism frequently implicated in the infection-based inflammatory atherogenous hypothesis. Although in vitro experimental data and initial sero-epidemiologic, pathology-based studies and antibiotic trials supported this interesting hypothesis, later data are conflicting. Som...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章,评审
doi:10.1159/000078146
更新日期:2004-01-01 00:00:00
abstract:AIMS:The aim of this study was to screen several novel genes associated with renal cell carcinoma (RCC), and analyze the gene functions and signal pathways which were critical to RCCs with DNA microarray. METHODS:The gene expression profile of GSE781 was downloaded from Gene Expression Omnibus database, including 9 RC...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000355726
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND/AIMS:Analysis of gene expression in renal tissue is considered to be a diagnostic tool predicting the clinical course of glomerulonephritis. The present study quantified the relative transcript levels of VEGF, CTGF and HIF-1α in renal tissue to establish their relationship with some clinical variables in pat...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000355754
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Elevated serum uric acid experimentally stimulates renal vasoconstriction and activation of the renin- angiotensin system and consequently modulates erythropoietin (EPO) production. We used a dopamine-induced glomerular filtration response test (DIR) to assess whether elevated uric acid is associated with do...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000330717
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND/AIMS:The main purpose of the present study was to determine the effect of peritoneal charge barrier dysfunction on hypoalbuminemia during CAPD. METHODS:We measured the association of dialysis dose, peritoneal equilibration test (PET) results (ratio of dialysate and plasma creatinine), and peritoneal charge ...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000350150
更新日期:2013-01-01 00:00:00
abstract::Renal proximal tubular Na/phosphate cotransport is the key target in the control of renal phosphate handling. Using molecular tools for the type II Na/phosphate cotransporter, it could be documented that altered brush border membrane phosphate transport reflects a state of altered brush border expression of the specif...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章,评审
doi:10.1159/000174063
更新日期:1996-01-01 00:00:00
abstract::Acute kidney injury (AKI) is a complex kidney disorder that leads to numerous complications, such as elevated nitrogenous wastes, metabolic acidosis, high potassium levels and even death. The pathogenesis of AKI is very complicated, and its causes are commonly categorized as prerenal, intrinsic or postrenal. In the pa...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章,评审
doi:10.1159/000450566
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND/AIMS:We previously showed that urine and serum Angiopoietin-2 (Ang-2) levels increased significantly with the degree of albuminuria in diabetes patients, but the reasons remain unclear. Consequently we aimed to determine whether there was an association between Ang-2, inflammatory cytokines (TNF-α and IL-18)...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000368510
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Cardiac death is increased in peritoneal dialysis (PD) patients. Pulse wave velocity (PWV) is a measurement of arterial stiffness, and previous reports linked PWV to increased extracellular water (ECW). As cyclers and icodextrin are increasingly used, we wished to determine whether this association between P...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000503424
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND/AIMS:Cardiovascular morbidity and mortality are high in patients with chronic kidney disease. We evaluated the influence of small differences in preoperative kidney function on mortality and complications following cardiac surgery. METHODS:This is an observational study that included adult patients undergoi...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000335950
更新日期:2012-01-01 00:00:00
abstract::Pravastatin is a potent inhibitor of HMG-CoA reductase and is effective in lowering serum lipid levels. Recent studies have shown that pravastatin also reduces the oxidative modification of low-density lipoprotein (LDL). To determine whether pravastatin has a direct effect on glomerular mesangial cells, we have measur...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000049428
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND/AIMS:The metabolic syndrome (MetS), as assessed using dichotomous criteria, is associated with increased risk of future chronic kidney disease (CKD), though this relationship is unclear among African Americans, who have lower risk for MetS but higher risk for CKD. METHODS:We performed logistic regression us...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000488829
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Fatty acid-bearing albumin [FA(+) albumin] exerts more deleterious effects in tubular cells than albumin alone. We investigated the effect of FA(+) albumin on the vascular cell adhesion molecule-1 (VCAM-1) expression and elucidated the underlying signaling pathways. We further examined the effect of L-carnit...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000289576
更新日期:2010-01-01 00:00:00
abstract:AIMS AND METHODS:By analyzing data from 2,861 individuals who underwent general health screening 2 years running, we have investigated the impact of changes in waist circumference (WC) and body mass index (BMI) over a 1-year period on systolic blood pressure (BPs). We termed WC, BMI, and BPs at the first visit as WC1, ...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000264233
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Mesenchymal stem cells (MSC) improve renal function and renovascular hypertension in the 2-kidney 1-clip model (2K-1C). While MSC play an immunomodulatory role, induce neoangiogenesis, and reduce fibrosis, they do not correct sodium loss by the contra-lateral kidney. OBJECTIVES:We investigated the tubular f...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000503346
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND/AIMS:Lowering dialysate temperature to increase intradialytic hemodynamic stability may interfere with the ultrafiltration-dependent intradialytic autonomic cardiovascular regulation. The present study aimed to investigate hemodynamic and autonomic responses depending on dialysate temperature and the presenc...
journal_title:Kidney & blood pressure research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000141926
更新日期:2008-01-01 00:00:00
abstract::In the present study, the effects of hexachlorobenzene (HCB) on lipid peroxidation and heme metabolism in the different constitutive suborgans of the kidney were determined. For this purpose, conjugated diene and malondialdehyde levels, as lipid peroxidation parameters, and porphyrin accumulation, uroporphyrinogen dec...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000025950
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND:Metabolic acidosis may be diagnosed as chronic (cMA) if it persists for at least 5 days, although an exact definition has not been provided by any guidelines yet. The most common cause is CKD; numerous less-known diseases can also account for cMA. SUMMARY:In recent years, CKD-associated cMA has been propose...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章,评审
doi:10.1159/000510829
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND AND METHODS:We investigated kidney function, renal endothelin-1 concentration, prepro-endothelin-1 mRNA as well as endothelin receptor A and B mRNA expression and receptor properties in normotensive Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHR) with intact renal nerves and 7 days after re...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000094571
更新日期:2006-01-01 00:00:00
abstract::The interaction between renal nerves, endothelins acting via endothelin-A receptors and vasopressin in the regulation of renal excretory function was investigated. In conscious intact and renal denervated diabetes insipidus (DI) Brattleboro rats, as well as their controls, Long-Evans (LE) rats, an infusion of 16.4 nmo...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000054199
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND/AIMS:Rapamycin inhibits cyst growth in polycystic kidney disease by targeting the mammalian target of rapamycin (mTOR). To determine if this is a class effect of the mTOR inhibitors, we examined the effect of everolimus, the analogue of rapamycin, on disease progression in the Han:SPRD rat model of polycysti...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000104818
更新日期:2007-01-01 00:00:00
abstract:INTRODUCTION:Diabetic nephropathy (DN) is a serious complication of diabetes mellitus and is considered to be a sterile inflammatory disease. Increasing evidence suggest that pyroptosis and subsequent inflammatory response play a key role in the pathogenesis of DN. However, the underlying cellular and molecular mechani...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000508372
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND/AIMS:This study aimed to report the clinical efficacy of continuous renal replacement therapy (CRRT) in combination with ultrasound-guided percutaneous transhepatic gallbladder drainage (PTGD) (CRRT+PTGD) in the treatment of acute severe biliary pancreatitis (ASBP). METHODS:Between January 2010 and January ...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000485437
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Though the association between microalbuminuria (MA) and inflammatory markers has been studied, the possible gender differences in these associations have not yet been analyzed. Our study aims to analyze the role of gender in the associations of MA and inflammatory markers. METHODS:1,060 hypertensive patien...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000266477
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND/AIMS:The role of endothelin (ET) in cardiovascular remodeling was investigated by treating uninephrectomized spontaneously hypertensive rats of the stroke-prone strain (UNX-SHRsp) on normal- or high (3%)-salt diet with the selective ET(A) receptor blocker LU 135252. METHODS:SHRsp on normal or high salt were...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000108626
更新日期:2007-01-01 00:00:00