Abstract:
BACKGROUND:Though the association between microalbuminuria (MA) and inflammatory markers has been studied, the possible gender differences in these associations have not yet been analyzed. Our study aims to analyze the role of gender in the associations of MA and inflammatory markers. METHODS:1,060 hypertensive patients were assessed for MA (albumin-creatinine ratio), plasma levels of HsCRP (high-sensitivity C-reactive protein), IL-18, and sCD40L (soluble CD40 ligand). Patients with diabetes mellitus, metabolic syndrome and overt nephropathy were excluded. RESULTS:Mean age was 46 +/- 9.6 years, with 560 males and 500 females. The prevalence of MA was 35.6% (n = 378). MA was associated with HsCRP (OR: 2.13, CI: 1.155-3.168, p = 0.001) and sCD40L (OR: 2.35, CI: 1.014-3.912, p = 0.013) in the premenopausal females, whereas in males (OR: 1.83, CI: 1.037-3.920, p = 0.023) and postmenopausal females (OR: 2.31, CI: 1.688-3.274, p = 0.031) MA was associated only with HsCRP and not with sCD40L or IL-18. CONCLUSIONS:Association between MA and HsCRP is consistent in all hypertensive patients. However, MA is associated with sCD40L only in premenopausal females and not in males and postmenopausal females.
journal_name
Kidney Blood Press Resjournal_title
Kidney & blood pressure researchauthors
Shantha GP,Kumar AA,Bharadhi MK,Arthur Pdoi
10.1159/000266477subject
Has Abstractpub_date
2009-01-01 00:00:00pages
434-9issue
6eissn
1420-4096issn
1423-0143pii
000266477journal_volume
32pub_type
杂志文章abstract::Pravastatin is a potent inhibitor of HMG-CoA reductase and is effective in lowering serum lipid levels. Recent studies have shown that pravastatin also reduces the oxidative modification of low-density lipoprotein (LDL). To determine whether pravastatin has a direct effect on glomerular mesangial cells, we have measur...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000049428
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND/AIMS:To prevent contrast induced renal dysfunction a periprocedural prophylactic hydration is applied. Due to dilution it should cause a drop in serum creatinine concentration (SCR). Surprisingly, no reduction in SCR after contrast admission is found in up to 25% of patients as early as 12-18 hours after cor...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000443425
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND/AIMS:Refugee dialysis is a worldwide growing dilemma with limited experience. This report presents the largest hemodialysis (HD) patient registry data of Syrian refugees in Turkey. METHODS:Demographic, clinical, laboratory, and dialysis practice data of 345 Syrian HD patients during one year were collected ...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000498832
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Flucloxacillin is an important antimicrobial drug in the treatment of infections with Staphylococcus aureus and therefore is often used in staphylococcal infections. Furthermore, flucloxacillin has a high protein binding rate as for example ceftriaxone or teicoplanin--drugs which have formerly been character...
journal_title:Kidney & blood pressure research
pub_type: 临床试验,杂志文章
doi:10.1159/000070997
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:To evaluate the relationship between FGF23 and changes in biochemical parameters, left ventricle mass index, coronary, aortic and, valve calcifications. METHODS:Totally 185 patients with chronic renal disease were included in this prospective, cross-sectional study. The patients were stratified according to...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000339026
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND/AIMS:Interleukin (IL)-18, a member of the IL-1 cytokine superfamily, is recognized as an important regulator of immune responses. The aim of our study was to investigate the IL-18 levels in serum and urine from children with idiopathic nephrotic syndrome (INS) during relapse and remission, and to evaluate th...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000124284
更新日期:2008-01-01 00:00:00
abstract::In the Prague hypertensive rat (PHR), a strain of genetic hypertension derived from Wistar, administration of various antihypertensive drugs (AHD) during the developmental phase of hypertension (weeks 5-9 of life) prevents the rise of blood pressure. However, only drugs blocking the renin-angiotensin system (RAS, i.e....
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000025898
更新日期:1998-01-01 00:00:00
abstract::Renal proximal tubular Na/phosphate cotransport is the key target in the control of renal phosphate handling. Using molecular tools for the type II Na/phosphate cotransporter, it could be documented that altered brush border membrane phosphate transport reflects a state of altered brush border expression of the specif...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章,评审
doi:10.1159/000174063
更新日期:1996-01-01 00:00:00
abstract::The high mortality rate seen in dialysis patients is related to long-standing high blood pressure and the presence of other traditional as well as non-traditional risk factors for cardiovascular disease. Hypertension is associated with increased risk for left ventricular hypertrophy, coronary artery disease, congestiv...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章,评审
doi:10.1159/000070987
更新日期:2003-01-01 00:00:00
abstract::In the pathogenesis of anti-neutrophil cytoplasm antibodies (ANCA)-associated vasculitis, T cell contribution is indicated by T cell-dependent ANCA production combined with the presence of T cells in inflammatory infiltrates. However, the exact pathogenic role of T cells in ANCA-associated vasculitis remains to be det...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章,评审
doi:10.1159/000072987
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND/AIMS:The presence of protein-energy wasting (PEW) among dialysis patients is a crucial risk factor for outcomes. The complicated pathogenesis of PEW makes it difficult to assess and treat. This single-center retrospective study focuses on the association between nutritional markers and the outcomes of contin...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000485926
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND/AIMS:Apparent treatment resistant hypertension (aTRH) is highly prevalent in patients with type 2 diabetes (T2D) and chronic kidney disease (CKD). The impact of aTRH and achievement of recommended blood pressure (BP) values on the rate of glomerular filtration rate (eGFR) loss in CKD patients is poorly known...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000488255
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Urine osmolality indicates the ability of the kidney to concentrate the urine and reflects the antidiuretic action of vasopressin. However, results about the association between urine osmolality and adverse renal outcomes in chronic kidney disease (CKD) are conflicting. We investigated the association betwee...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000502291
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND/AIMS:Aortic arch calcification (AoAC) is frequently detected in maintenance hemodialysis (MHD) patients and is associated with cardiovascular and all-cause mortality. We investigated the factors associated with AoAC and analyzed the relationship between the factors including bone-derived biomarkers and AoAC....
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000494441
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND/AIMS:We previously showed that urine and serum Angiopoietin-2 (Ang-2) levels increased significantly with the degree of albuminuria in diabetes patients, but the reasons remain unclear. Consequently we aimed to determine whether there was an association between Ang-2, inflammatory cytokines (TNF-α and IL-18)...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000368510
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND/AIMS:Ischemia/reperfusion (I/R) is the most common cause of acute renal injury. I/R-induced oxidative stress is involved in the development of acute renal injury, which can be reversed by supplementation with L-arginine, a precursor of nitric oxide (NO). This study was conducted to evaluate alterations in th...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000480362
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND/AIM:Serum gamma-glutamyltransferase (GGT), a biomarker of oxidative stress, is associated with an increased risk of diabetes and hypertension. However, it is not known whether higher serum GGT is independently associated with chronic kidney disease (CKD). Therefore, we examined the association between serum ...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000274463
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:1,25-Dihydroxyvitamin D(3) is mainly synthesized by renal proximal tubular cells. More recently, it has been shown to affect cell growth and TGF-beta(1) synthesis in glomerular and tubular renal cells in vitro, and to prevent glomerulosclerosis in vivo in subtotally nephrectomized rats. The mechanisms involv...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000054213
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND/AIMS:IgA nephropathy is associated with aberrant O-glycosylation of IgA1, which is recognized by autoantibodies leading to the formation of circulating immune complexes. Some of them, after deposition into kidney mesangium, trigger glomerular injury. In patients with active disease nonresponding to angiotens...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000487903
更新日期:2018-01-01 00:00:00
abstract:AIM:To assess the influence on blood pressure in schoolchildren, of elevated sodium (Na(+)) and nitrate (NO(-)(3)) levels in the drinking water. METHODS:The blood pressure was recorded in three groups of age- and weight-matched schoolchildren (fourth and fifth graders) ingesting differing Na(+) and NO(-)(3) concentrat...
journal_title:Kidney & blood pressure research
pub_type: 临床试验,杂志文章
doi:10.1159/000025989
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND:Hypertension in the elderly is commonly characterized by an elevation of pulse pressure. With regard to advanced arteriosclerosis and limited physical fitness, doubt was casted whether elderly patients still achieve relevant cardiovascular benefits by physical exercise. The present work examines the impact o...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章,随机对照试验
doi:10.1159/000104093
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND/AIMS:We have reported that the long-term administration of angiotensin II receptor blockers (ARBs) induced unusual proliferative changes of renal afferent arteriolar smooth muscle cells (SMCs) in rats, associated with the overproduction of renin. In this study, we examined that a direct renin inhibitor (DRI:...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000443459
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND/AIMS:The contribution of preexisting hypercholesterolemia to diabetic nephropathy remains unclear. We assessed the impact of hypercholesterolemia on diabetic nephropathy using a double knockout (DKO) mouse, null for the low-density lipoprotein receptor (LDLRNDASH;/NDASH;) and the apoB mRNA editing catalytic ...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000073942
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:Cardiovascular disease caused by atherosclerosis remains a major cause of morbidity and mortality in patients with end-stage renal disease (ESRD). We evaluated the potential association of cardiovascular risk factors including asymmetric dimethyl L-arginine (ADMA) and the soluble receptor for advanced glycat...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000316709
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:Cardiac death is increased in peritoneal dialysis (PD) patients. Pulse wave velocity (PWV) is a measurement of arterial stiffness, and previous reports linked PWV to increased extracellular water (ECW). As cyclers and icodextrin are increasingly used, we wished to determine whether this association between P...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000503424
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND/AIMS:Renal tubulointerstitium plays an important role in the development and progression of diabetic nephropathy. METHODS:With the present study, we aimed at evaluating the levels of neutrophil gelatinase-associated lipocalin (NGAL), a tubular stress protein, in serum (sNGAL) and urine (uNGAL) from a cohort...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000209379
更新日期:2009-01-01 00:00:00
abstract::In developed countries, the incidence of end-stage renal failure is constantly increasing, and uremia will soon be a disease typically found in mature and elderly adults. Almost invariably, the physical condition of the elderly patient with terminal uremia is extremely poor, and therapeutic approach complex. Frequent ...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章,评审
doi:10.1159/000164277
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND/AIMS:Post-transplant hypertension is highly prevalent in renal transplant recipients and is a risk factor for graft loss, cardiovascular disease and death. Glucocorticoid is used to prevent rejection, but simultaneously increases the risk of post-transplant hypertension. The glucocorticoid-induced transcript...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000485862
更新日期:2017-01-01 00:00:00
abstract::A 70-year-old female patient with advanced Shy-Drager syndrome exhibited severe orthostatic hypotension, low serum catecholamine levels, and autonomic dysfunction. She was bedridden despite oral medication with fludrocortisone, etilefrin, dihydroergotamine, L-dopa, yohimbine, and amezinium methyl sulfate. Only intrave...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000025846
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND/AIMS:Calcium sensing receptor (CaSR) is expressed, among others also in testis. Cinacalcet binds to the CaSR, increases sensitivity of CaSR to serum calcium and is used in the treatment of secondary hyperparathyroidism (sHPT) in chronic hemodialysis patients (HDP). In most of male HDP, serum testosterone con...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000368541
更新日期:2016-01-01 00:00:00