Abstract:
BACKGROUND:Hypertension in the elderly is commonly characterized by an elevation of pulse pressure. With regard to advanced arteriosclerosis and limited physical fitness, doubt was casted whether elderly patients still achieve relevant cardiovascular benefits by physical exercise. The present work examines the impact of pulse pressure as a footprint of vascular ageing on cardiovascular benefits of endurance training in elderly hypertensives. METHODS:54 patients > or =60 years with systolic 24-hour ambulatory blood pressure (ABP) >140 mm Hg and/or antihypertensive treatment and diastolic ABP < or =90 mm Hg were randomly assigned to sedentary activity or a 12-week treadmill exercise program (target lactate 2.5 +/- 0.5 mmol/l). RESULTS:Exercise significantly decreased systolic and diastolic ABP by 8.5 +/- 8.2 and 5.1 +/- 3.7 mm Hg (p < 0.001 each) and increased physical performance. Arterial compliance remained unchanged, whereas endothelium-dependent vasodilation--measured by flow-mediated dilation--significantly increased from 5.6 +/- 1.7 to 7.9 +/- 3.0% (p < 0.007). After adjustment for initial systolic ABP, pulse pressure did not affect the change of BP. CONCLUSION:The exercise-induced reduction of BP, which is mediated by improved endothelial function, is independent of pulse pressure. Thus, physical exercise is a helpful adjunct to control BP even in old hypertensives with markedly increased arterial stiffness.
journal_name
Kidney Blood Press Resjournal_title
Kidney & blood pressure researchauthors
Westhoff TH,Franke N,Schmidt S,Vallbracht-Israng K,Meissner R,Yildirim H,Schlattmann P,Zidek W,Dimeo F,van der Giet Mdoi
10.1159/000104093subject
Has Abstractpub_date
2007-01-01 00:00:00pages
240-7issue
4eissn
1420-4096issn
1423-0143pii
000104093journal_volume
30pub_type
杂志文章,随机对照试验abstract:BACKGROUND/AIMS:To date, there is no imaging technique to assess tubular function in vivo. Blood oxygen level-dependent magnetic resonance imaging (BOLD MRI) measures tissue oxygenation based on the transverse relaxation rate (R2*). The present study investigates whether BOLD MRI can assess tubular function using a tub...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
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journal_title:Kidney & blood pressure research
pub_type: 杂志文章
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journal_title:Kidney & blood pressure research
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journal_title:Kidney & blood pressure research
pub_type: 杂志文章,meta分析,评审
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journal_title:Kidney & blood pressure research
pub_type: 杂志文章
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journal_title:Kidney & blood pressure research
pub_type: 杂志文章
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journal_title:Kidney & blood pressure research
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journal_title:Kidney & blood pressure research
pub_type: 临床试验,杂志文章
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journal_title:Kidney & blood pressure research
pub_type: 杂志文章
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journal_title:Kidney & blood pressure research
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pub_type: 杂志文章
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journal_title:Kidney & blood pressure research
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journal_title:Kidney & blood pressure research
pub_type: 杂志文章,评审
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pub_type: 杂志文章
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journal_title:Kidney & blood pressure research
pub_type: 杂志文章,评审
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更新日期:1996-01-01 00:00:00
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journal_title:Kidney & blood pressure research
pub_type: 杂志文章,评审
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更新日期:2014-01-01 00:00:00
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journal_title:Kidney & blood pressure research
pub_type: 杂志文章
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更新日期:2008-01-01 00:00:00
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pub_type: 杂志文章,meta分析
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journal_title:Kidney & blood pressure research
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journal_title:Kidney & blood pressure research
pub_type: 杂志文章
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journal_title:Kidney & blood pressure research
pub_type: 杂志文章
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更新日期:2017-01-01 00:00:00
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pub_type: 临床试验,杂志文章
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