Ambulatory infusion of noradrenaline for long-term treatment of Shy-Drager syndrome.

Abstract:

:A 70-year-old female patient with advanced Shy-Drager syndrome exhibited severe orthostatic hypotension, low serum catecholamine levels, and autonomic dysfunction. She was bedridden despite oral medication with fludrocortisone, etilefrin, dihydroergotamine, L-dopa, yohimbine, and amezinium methyl sulfate. Only intravenous application of noradrenaline (30 ng/kg/min) provided complete mobilization. After implantation of a port-a-cath system, intravenous noradrenaline treatment could be continued on an outpatient basis. Over the following 5 years, the patient was throughout sufficiently mobile and did not show any significant side effects of this treatment. However, during the 5th year she suffered from nonhemorrhagic brain stem infarction due to cerebral hypoperfusion after orthostatic stress in the absence of noradrenaline infusion. We conclude that ambulatory noradrenaline infusion is a new valuable tool for long-term treatment of advanced Shy-Drager syndrome.

journal_name

Kidney Blood Press Res

authors

Kribben A,Bremer C,Fritschka E,Koeppen S,Ahrens O,Philipp T

doi

10.1159/000025846

subject

Has Abstract

pub_date

1998-01-01 00:00:00

pages

70-3

issue

1

eissn

1420-4096

issn

1423-0143

pii

kbr21070

journal_volume

21

pub_type

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