Effects of magnoline on P-selectin's expression in diabetic rats and its reno-protection.

abstract：BACKGROUND/AIMS:Angiotensin converting enzyme 2 (ACE2) is highly expressed in the kidney and recognized to be renoprotective by degrading Angiotensin II to Angiotensin (1-7) in diabetic nephropathy. However, little is known about the role of urinary ACE2 (UACE2) in diabetes. The present study was performed to evaluate ...

journal_title：Kidney & blood pressure research

authors： Liang Y,Deng H,Bi S,Cui Z,A L,Zheng D,Wang Y

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Elevated serum uric acid experimentally stimulates renal vasoconstriction and activation of the renin- angiotensin system and consequently modulates erythropoietin (EPO) production. We used a dopamine-induced glomerular filtration response test (DIR) to assess whether elevated uric acid is associated with do...

journal_title：Kidney & blood pressure research

authors： Sulikowska B,Johnson RJ,Odrowąż-Sypniewska G,Manitius J

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND/AIMS:This experimental study was designed to investigate protective and therapeutic effects of Dexpanthenol (Dxp), an alcoholic analogue of pantothenic acid, on kidney damage induced by ischemia-reperfusion (I/R) in rats. METHODS:Forty rats were randomly divided into a control group and 4 I/R groups (1 h is...

journal_title：Kidney & blood pressure research

authors： Altintas R,Parlakpinar H,Beytur A,Vardi N,Polat A,Sagir M,Odabas GP

更新日期：2012-01-01 00:00:00

abstract：:Backgroud/Aims: The aim of this study was to investigate the potential renoprotective effect of rapamycin on the autophagy of podocytes treated with the supernatant of mesangial cells cultured with aggregated IgA1 (aIgA1) from immunoglobulin A nephropathy (IgAN) patients. METHODS:Monomeric IgA1 (mIgA1) was isolated f...

journal_title：Kidney & blood pressure research

authors： Liang S,Jin J,Lin B,Gong J,Li Y,He Q

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND/AIMS:Aortic arch calcification (AoAC) is frequently detected in maintenance hemodialysis (MHD) patients and is associated with cardiovascular and all-cause mortality. We investigated the factors associated with AoAC and analyzed the relationship between the factors including bone-derived biomarkers and AoAC....

journal_title：Kidney & blood pressure research

authors： Nitta K,Hanafusa N,Okazaki M,Komatsu M,Kawaguchi H,Tsuchiya K

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND/AIMS:The metabolic syndrome (MetS), as assessed using dichotomous criteria, is associated with increased risk of future chronic kidney disease (CKD), though this relationship is unclear among African Americans, who have lower risk for MetS but higher risk for CKD. METHODS:We performed logistic regression us...

journal_title：Kidney & blood pressure research

authors： DeBoer MD,Filipp SL,Musani SK,Sims M,Okusa MD,Gurka M

更新日期：2018-01-01 00:00:00

abstract：:Recently, Chlamydia pneumoniae is the microorganism frequently implicated in the infection-based inflammatory atherogenous hypothesis. Although in vitro experimental data and initial sero-epidemiologic, pathology-based studies and antibiotic trials supported this interesting hypothesis, later data are conflicting. Som...

journal_title：Kidney & blood pressure research

authors： Tsirpanlis G

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND/AIMS:High mobility group box 1 (HMGB1) is an important mediator of the inflammatory response. It has been implicated in the pathogenesis of autoimmune diseases, atherosclerosis, and obesity. However, the effects of HMGB1 on diabetic nephropathy remain unclear. Here, we investigated the potential roles and me...

journal_title：Kidney & blood pressure research

authors： Zhang H,Zhang R,Chen J,Shi M,Li W,Zhang X

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND/AIMS:To determine the effect of arterial blood pressure (BP) reduction on endocan and soluble cell adhesion molecules' (sCAM) plasma concentration and expression of their ligands on circulatory leukocyte subpopulations. METHODS:24 hypertensive subjects of both sexes (age: 53±8 yrs) were treated with Ca-chan...

journal_title：Kidney & blood pressure research

authors： Tadzic R,Mihalj M,Vcev A,Ennen J,Tadzic A,Drenjancevic I

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:The oxidative stress-responsive kinase 1 (OSR1) participates in the WNK-(with no K) kinase dependent regulation of renal salt excretion and blood pressure. Little is known, however, about the role of OSR1 in the regulation of further renal transport systems. The present study analyzed the effect of OSR1 on N...

journal_title：Kidney & blood pressure research

authors： Pathare G,Föller M,Daryadel A,Mutig K,Bogatikov E,Fajol A,Almilaji A,Michael D,Stange G,Voelkl J,Wagner CA,Bachmann S,Lang F

更新日期：2012-01-01 00:00:00

abstract：INTRODUCTION:Diabetic nephropathy (DN) is a serious complication of diabetes mellitus and is considered to be a sterile inflammatory disease. Increasing evidence suggest that pyroptosis and subsequent inflammatory response play a key role in the pathogenesis of DN. However, the underlying cellular and molecular mechani...

journal_title：Kidney & blood pressure research

authors： Zhan JF,Huang HW,Huang C,Hu LL,Xu WW

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND/AIMS:The WNK-dependent STE20/SPS1-related proline/alanine-rich kinase SPAK participates in the regulation of NaCl and Na(+),K(+),2Cl(-) cotransport and thus renal salt excretion. The present study explored whether SPAK has similarly the potential to regulate the epithelial Na(+) channel (ENaC). METHODS:ENaC...

journal_title：Kidney & blood pressure research

authors： Ahmed M,Salker MS,Elvira B,Umbach AT,Fakhri H,Saeed AM,Shumilina E,Hosseinzadeh Z,Lang F

更新日期：2015-01-01 00:00:00

abstract：:The German Collaborative Glomerulonephritis Therapy Study, which celebrated its 10th anniversary in 1996, has collected data on more than 1,000 patients with biopsy-proven glomerulonephritis. 929 patients could be evaluated and 500 were treated according to at least one of various protocols developed for a randomized ...

journal_title：Kidney & blood pressure research

authors： Risler T,Braun N,Bach D,Fünfstück R,Grabensee B,Grupp C,Haufe C,Heering P,Keller F,Krämer B,Müller GA,Schollmeyer P,Stein G,Zäuner I

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND/AIMS:The kinases SPAK (SPS1-related proline/alanine-rich kinase) and OSR1 (oxidative stress-responsive kinase 1) participate in the regulation of the NaCl cotransporter NCC and the Na+, K+, 2Cl- cotransporter NKCC2. The kinases are regulated by WNK (with-no-K[Lys]) kinases. Mutations of genes encoding WNK ki...

journal_title：Kidney & blood pressure research

authors： Elvira B,Munoz C,Borras J,Chen H,Warsi J,Ajay SS,Shumilina E,Lang F

更新日期：2014-01-01 00:00:00

abstract：:Inhibitors of type 4 dipeptidyl peptidase (DDP-4) were developed and approved for the oral treatment of type 2 diabetes. Its mode of action is to inhibit the degradation of incretins, such as type 1 glucagon like peptide (GLP-1), and GIP. GLP-1 stimulates glucose-dependent insulin secretion from pancreatic beta-cells ...

journal_title：Kidney & blood pressure research

authors： Hocher B,Reichetzeder C,Alter ML

更新日期：2012-01-01 00:00:00

abstract：:In the pathogenesis of anti-neutrophil cytoplasm antibodies (ANCA)-associated vasculitis, T cell contribution is indicated by T cell-dependent ANCA production combined with the presence of T cells in inflammatory infiltrates. However, the exact pathogenic role of T cells in ANCA-associated vasculitis remains to be det...

journal_title：Kidney & blood pressure research

authors： Sanders JS,Stegeman CA,Kallenberg CG

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND/AIMS:This study aimed to report the clinical efficacy of continuous renal replacement therapy (CRRT) in combination with ultrasound-guided percutaneous transhepatic gallbladder drainage (PTGD) (CRRT+PTGD) in the treatment of acute severe biliary pancreatitis (ASBP). METHODS:Between January 2010 and January ...

journal_title：Kidney & blood pressure research

authors： Zhu Q,Pan X,Cao Y,Wang H,Yu N,Liu F,Yang S,Wang Y,Sun Y,Wang Z

更新日期：2017-01-01 00:00:00

abstract：:The effects on glomerular hemodynamics of angiotensin-converting enzyme (ACE) inhibition with captopril and of angiotensin II receptor blockade with EXP 3174, an active metabolite of losartan, either alone or in combination, were compared in anesthetized dogs. Administration of EXP 3174 intrarenally led to an increase...

journal_title：Kidney & blood pressure research

authors： Heller J,Kramer HJ,Horácek V

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND/AIMS:Kidney function is critical for homocysteine (Hcy) clearance, and plasma Hcy levels are frequently increased in patients with renal failure. Microalbuminuria (MAU) is an important marker of early renal damage caused by hypertension. At present, there is insufficient evidence on the relationship between ...

journal_title：Kidney & blood pressure research

authors： Kuang ZM,Wang Y,Feng SJ,Jiang L,Cheng WL

更新日期：2017-01-01 00:00:00

abstract：:Angiotensin-(1-7), (Ang-(1-7)), a metabolite of Ang II and /or Ang I, was infused into the renal artery (i.r.a) of anesthetized dogs in order to demonstrate its possible direct renal action. The dose administered, 15 Ig/kg BW/min in isotonic saline (0.072 ml/kg BW/min) throughout the experiment, did not influence the ...

journal_title：Kidney & blood pressure research

authors： Heller J,Kramer HJ,Malý J,Cervenka L,Horácek V

更新日期：2000-01-01 00:00:00

abstract：INTRODUCTION:There is still no evidence whether human peritoneal mesothelial cells (HPMC) from patients with end-stage renal failure are altered in cell viability or show a different pattern of the release of proinflammatory cytokines. Also the serum of patients with uremia may contain substances stimulating the cytoki...

journal_title：Kidney & blood pressure research

authors： Plum J,Fleisch MC,Razeghi P,Fusshöller A,Lordnejad MR,Grabensee B

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Mesenchymal stem cells (MSC) improve renal function and renovascular hypertension in the 2-kidney 1-clip model (2K-1C). While MSC play an immunomodulatory role, induce neoangiogenesis, and reduce fibrosis, they do not correct sodium loss by the contra-lateral kidney. OBJECTIVES:We investigated the tubular f...

journal_title：Kidney & blood pressure research

authors： Varela VA,Oliveira-Sales EB,Maquigussa E,Borges FT,Gattai PP,Novaes ADS,Shimoura CG,Campos RR,Boim MA

更新日期：2019-01-01 00:00:00

abstract：:Although primary cilia are increasingly recognized to play sensory roles in several cellular systems, their role in vascular smooth muscle cells (VSMCs) has not been defined. We examined in situ position/orientation of primary cilia and ciliary proteins in VSMCs and tested the hypothesis that primary cilia of VSMCs ex...

journal_title：Kidney & blood pressure research

authors： Lu CJ,Du H,Wu J,Jansen DA,Jordan KL,Xu N,Sieck GC,Qian Q

更新日期：2008-01-01 00:00:00

abstract：:Pravastatin is a potent inhibitor of HMG-CoA reductase and is effective in lowering serum lipid levels. Recent studies have shown that pravastatin also reduces the oxidative modification of low-density lipoprotein (LDL). To determine whether pravastatin has a direct effect on glomerular mesangial cells, we have measur...

journal_title：Kidney & blood pressure research

authors： Chen HC,Guh JY,Shin SJ,Tomino Y,Lai YH

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:The antiproteinuric effect of angiotensin-converting enzyme (ACE) inhibitors appears to vary depending on the ACE insertion (I)/deletion (D) genotype in non-diabetic nephropathy. This interaction may be overcome by using an angiotensin II receptor blocker. We evaluated the short-term antiproteinuric effect o...

journal_title：Kidney & blood pressure research

authors： Park HC,Choi HY,Kim BS,Kang SW,Choi KH,Ha SK,Lee HY,Han DS

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND/AIMS:The deposition of β2-microglobulin induced by reactive inflammation causing carpal tunnel syndrome (CTS) is one of the complications of dialysis-related amyloidosis in maintenance hemodialysis (MHD) patients. Air pollution levels, especially particulate matter with an aerodynamic diameter of <2.5 mm (PM...

journal_title：Kidney & blood pressure research

authors： Weng CH,Hu CC,Yen TH,Huang WH

更新日期：2017-01-01 00:00:00

abstract：AIMS:The aim of this study was to screen several novel genes associated with renal cell carcinoma (RCC), and analyze the gene functions and signal pathways which were critical to RCCs with DNA microarray. METHODS:The gene expression profile of GSE781 was downloaded from Gene Expression Omnibus database, including 9 RC...

journal_title：Kidney & blood pressure research

authors： Li W,Zhu W,Che J,Sun W,Liu M,Peng B,Zheng J

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND/AIMS:Rapamycin inhibits cyst growth in polycystic kidney disease by targeting the mammalian target of rapamycin (mTOR). To determine if this is a class effect of the mTOR inhibitors, we examined the effect of everolimus, the analogue of rapamycin, on disease progression in the Han:SPRD rat model of polycysti...

journal_title：Kidney & blood pressure research

authors： Wu M,Wahl PR,Le Hir M,Wackerle-Men Y,Wuthrich RP,Serra AL

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND/AIMS:The kidney plays a critical role in the control of blood pressure and its elevation in salt-induced hypertension. Mitochondrial dysfunction, especially in energy metabolism, has been associated with hypertension. Here, we aimed to investigate mitochondrial function and metabolic features in renal mitoch...

journal_title：Kidney & blood pressure research

authors： Wang Z,Sun Q,Sun N,Liang M,Tian Z

更新日期：2017-01-01 00:00:00

abstract：:Patients affected by end-stage renal disease (ESRD) show quite lower physical activity and exercise capacity when compared to healthy individuals. In addition, a sedentary lifestyle is favoured by lack of a specific counseling on exercise implementation in the nephrology care setting. Increasing physical activity leve...

journal_title：Kidney & blood pressure research

authors： Capitanini A,Lange S,D'Alessandro C,Salotti E,Tavolaro A,Baronti ME,Giannese D,Cupisti A

更新日期：2014-01-01 00:00:00