Abstract:
:Angiotensin-(1-7), (Ang-(1-7)), a metabolite of Ang II and /or Ang I, was infused into the renal artery (i.r.a) of anesthetized dogs in order to demonstrate its possible direct renal action. The dose administered, 15 Ig/kg BW/min in isotonic saline (0.072 ml/kg BW/min) throughout the experiment, did not influence the systemic arterial pressure and water and sodium excretion from the contralateral noninfused kidney. Renal blood flow (RBF) was measured by an electromagnetic flowmeter, glomerular filtration rate (GFR) by (exogenous) creatinine clearance. In other groups of animals, either EXP 3174, an AT-1 receptor antagonist alone (30 Ig/kg BW/ min) or together with Ang-(1-7) (15 Ig/kg BW/min), were infused. In the last group, the AT-2 receptor antagonist PD 123319, 10 Ig/kg BW/min, was added to the infusion of Ang-(1-7). A small but significant decrease of RBF from 4.51+/-0.32 to 3.8+/-0.29 ml/g BW/min occurred after Ang-(1-7); this decrease was very similar when PD 123319 was added. However, an increase to 4.98+/-0.34 ml/g BW/min was seen after the addition of EXP 3174 to the i.r.a. infusion of Ang-(1-7); this increase was similar to the increase observed after EXP 3174 alone (5.21+/-0.33; p<0.02 in both cases). A very small but significant increase in GFR was seen after Ang-(1-7) + EXP 3174 or after the AT-1 blocker alone (0.64+/-0.049 and 0.62+/-0.05 vs. 0.6+/-0.05 ml/g BW/min in the Time Control Group, p<0.01 and 0.05, respectively). Water, sodium and urea excretion rates were increased in all groups infused with Ang-(1-7); after the combination of Ang-(1-7) + EXP 3174, all increases were higher than after every substance alone; however, statistical significance (p<0.05) was reached in sodium excretion values only. Potassium excretion rates were increased just in those groups in which EXP 3174 was present in the infusion fluid. In summary, Ang-(1-7) i.r.a. infusion in the dog is followed by increases in water, sodium and urea (but not potassium) excretion rates, highly probably of tubular origin. This effect is not completely blocked by the AT-1 - and not at all by the AT-2 receptor antagonist - thus indirectly suggesting another receptor could play a role. A small decrease in RBF disappears after EXP 3174, thus indicating an AT-1 receptor action.
journal_name
Kidney Blood Press Resjournal_title
Kidney & blood pressure researchauthors
Heller J,Kramer HJ,Malý J,Cervenka L,Horácek Vdoi
10.1159/000025959keywords:
subject
Has Abstractpub_date
2000-01-01 00:00:00pages
89-94issue
2eissn
1420-4096issn
1423-0143pii
25959journal_volume
23pub_type
杂志文章abstract:AIMS:The aim of this study was to screen several novel genes associated with renal cell carcinoma (RCC), and analyze the gene functions and signal pathways which were critical to RCCs with DNA microarray. METHODS:The gene expression profile of GSE781 was downloaded from Gene Expression Omnibus database, including 9 RC...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000355726
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND/AIMS:We have reported that the long-term administration of angiotensin II receptor blockers (ARBs) induced unusual proliferative changes of renal afferent arteriolar smooth muscle cells (SMCs) in rats, associated with the overproduction of renin. In this study, we examined that a direct renin inhibitor (DRI:...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000443459
更新日期:2016-01-01 00:00:00
abstract::The value of neutrophil-gelatinase-associated lipocalin (NGAL) was highlighted as a novel biomarker for the detection of acute renal failure. We tested the hypothesis whether NGAL could represent an early biomarker of contrast-induced nephropathy (CIN) in 100 patients with normal serum creatinine values undergoing per...
journal_title:Kidney & blood pressure research
pub_type: 临床试验,杂志文章
doi:10.1159/000109102
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND/AIMS:Excessive phosphate concentrations trigger vascular calcification, an active process promoted by osteoinduction of vascular smooth muscle cells (VSMCs) with increased expression and activity of transcription factor RUNX2 (Core-binding factor α1, CBFA1), alkaline phosphatase (ALPL), TGFß1, transcription ...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000368524
更新日期:2015-01-01 00:00:00
abstract:INTRODUCTION:Renal dysfunction is a frequent complication in patients suffering from β-thalassemia major (β-TM). The aim of this study was to analyze the renal function and urine metabolomic profile of β-TM patients undergoing transfusions and deferasirox (DFX) therapy, in order to better characterize and shed light on...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000507369
更新日期:2020-01-01 00:00:00
abstract:INTRODUCTION:Cardiovascular disease is one of the main causes of morbidity and mortality in patients with autosomal dominant polycystic kidney disease (ADPKD). Autonomic dysfunction is associated with an increased risk for all cardiovascular events in the general population and can be evaluated with heart rate variabil...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000502419
更新日期:2019-01-01 00:00:00
abstract:AIM:To assess the influence on blood pressure in schoolchildren, of elevated sodium (Na(+)) and nitrate (NO(-)(3)) levels in the drinking water. METHODS:The blood pressure was recorded in three groups of age- and weight-matched schoolchildren (fourth and fifth graders) ingesting differing Na(+) and NO(-)(3) concentrat...
journal_title:Kidney & blood pressure research
pub_type: 临床试验,杂志文章
doi:10.1159/000025989
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Magnoline is an active ingredient of magnolia fargesii with anti-inflammatory and anti-platelet effects. The objective is to explore the renoprotection of magnoline in diabetic rats and its effects on P-selectin. METHODS:Thirty-six rats were randomized into 4 groups-normal control group (C), d...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000350146
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND/AIMS:Renalase (gene name RNLS), a recently discovered enzyme with monoamine oxidase activity, is implicated in the degradation of catecholamines. Recent studies indicate that common variations in the gene with RNLS are associated with hypertension. The aim of this study was to examine the association between...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000368460
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND AND METHODS:We investigated kidney function, renal endothelin-1 concentration, prepro-endothelin-1 mRNA as well as endothelin receptor A and B mRNA expression and receptor properties in normotensive Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHR) with intact renal nerves and 7 days after re...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000094571
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:The oxidative stress-responsive kinase 1 (OSR1) participates in the WNK-(with no K) kinase dependent regulation of renal salt excretion and blood pressure. Little is known, however, about the role of OSR1 in the regulation of further renal transport systems. The present study analyzed the effect of OSR1 on N...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000343405
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND/AIMS:Angiotensin converting enzyme 2 (ACE2) is highly expressed in the kidney and recognized to be renoprotective by degrading Angiotensin II to Angiotensin (1-7) in diabetic nephropathy. However, little is known about the role of urinary ACE2 (UACE2) in diabetes. The present study was performed to evaluate ...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000368486
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND/AIM:Serum gamma-glutamyltransferase (GGT), a biomarker of oxidative stress, is associated with an increased risk of diabetes and hypertension. However, it is not known whether higher serum GGT is independently associated with chronic kidney disease (CKD). Therefore, we examined the association between serum ...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000274463
更新日期:2010-01-01 00:00:00
abstract::Progressive renal disease poses an increasing problem for the medical community. Though the causes of end-stage renal failure are multiple, the histologic pictures of chronic renal disease are remarkably similar being characterized by interstitial infiltration, fibrosis, tubular atrophy and dilatation. This similarity...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章,评审
doi:10.1159/000025911
更新日期:1999-01-01 00:00:00
abstract:BACKGROUND/AIMS:Calcium sensing receptor (CaSR) is expressed, among others also in testis. Cinacalcet binds to the CaSR, increases sensitivity of CaSR to serum calcium and is used in the treatment of secondary hyperparathyroidism (sHPT) in chronic hemodialysis patients (HDP). In most of male HDP, serum testosterone con...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000368541
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND/AIMS:This study aimed to report the clinical efficacy of continuous renal replacement therapy (CRRT) in combination with ultrasound-guided percutaneous transhepatic gallbladder drainage (PTGD) (CRRT+PTGD) in the treatment of acute severe biliary pancreatitis (ASBP). METHODS:Between January 2010 and January ...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000485437
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND/AIMS:This experimental study was designed to investigate protective and therapeutic effects of Dexpanthenol (Dxp), an alcoholic analogue of pantothenic acid, on kidney damage induced by ischemia-reperfusion (I/R) in rats. METHODS:Forty rats were randomly divided into a control group and 4 I/R groups (1 h is...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000343411
更新日期:2012-01-01 00:00:00
abstract:BACKGROUNDS:ANCA-associated vasculitis (AAV) frequently present with a chronic relapsing course. Relapse leads to an increased need for therapeutic agents and consequent toxicity. SUMMARY:When referring to the available options for the management of AAV, the efficacy of glucocorticoids (GCs) is unquestionable. However...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章,评审
doi:10.1159/000509608
更新日期:2020-01-01 00:00:00
abstract::In developed countries, the incidence of end-stage renal failure is constantly increasing, and uremia will soon be a disease typically found in mature and elderly adults. Almost invariably, the physical condition of the elderly patient with terminal uremia is extremely poor, and therapeutic approach complex. Frequent ...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章,评审
doi:10.1159/000164277
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND/AIMS:The aim of our study was to retrospectively analyse data of 520 Czech patients with IgA nephropathy (IgAN) and to specify the risk factors affecting renal survival of IgAN patients. METHODS:Cox proportional hazards regression model was used to evaluate the effects of different variables on renal surviv...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000368467
更新日期:2014-01-01 00:00:00
abstract::The German Collaborative Glomerulonephritis Therapy Study, which celebrated its 10th anniversary in 1996, has collected data on more than 1,000 patients with biopsy-proven glomerulonephritis. 929 patients could be evaluated and 500 were treated according to at least one of various protocols developed for a randomized ...
journal_title:Kidney & blood pressure research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000174073
更新日期:1996-01-01 00:00:00
abstract:BACKGROUND/AIMS:Kidney function is critical for homocysteine (Hcy) clearance, and plasma Hcy levels are frequently increased in patients with renal failure. Microalbuminuria (MAU) is an important marker of early renal damage caused by hypertension. At present, there is insufficient evidence on the relationship between ...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000486013
更新日期:2017-01-01 00:00:00
abstract:AIM:The aim of the present study was to evaluate the influence of cycle exercise during hemodialysis (HD) on patients' physical proficiency, muscle strength, quality of life and selected laboratory parameters. PATIENTS AND METHODS:In a group of 29 (15 female, 14 male) HD patients (age 64.2 ± 13.1 years), 3 months of c...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000335411
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND/AIMS:Refugee dialysis is a worldwide growing dilemma with limited experience. This report presents the largest hemodialysis (HD) patient registry data of Syrian refugees in Turkey. METHODS:Demographic, clinical, laboratory, and dialysis practice data of 345 Syrian HD patients during one year were collected ...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000498832
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND/AIMS:Hypertensive patients present with increased oxidative stress and frequently receive angiotensin II (ANGII) receptor type I blockers (ARB) for blood pressure (BP) reduction. Recent studies revealed an important role of ANGII in maintaining vascular oxidative homeostasis, including sustaining normal sodi...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000450562
更新日期:2016-01-01 00:00:00
abstract::In the pathogenesis of anti-neutrophil cytoplasm antibodies (ANCA)-associated vasculitis, T cell contribution is indicated by T cell-dependent ANCA production combined with the presence of T cells in inflammatory infiltrates. However, the exact pathogenic role of T cells in ANCA-associated vasculitis remains to be det...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章,评审
doi:10.1159/000072987
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND/AIMS:ET-1 has independent effects on blood pressure regulation in vivo, it is involved in tubular water and salt excretion, promotes constriction of smooth muscle cells, modulates sympathetic nerve activity, and activates the liberation of nitric oxide. To determine the net effect of these partially countera...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章,meta分析,评审
doi:10.1159/000450567
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND/AIMS:The association between ACYP2(Acylphosphatase 2) polymorphisms and immunoglobulin A nephropathy (IgAN) risk in the Chinese Han population remains unclear. We aimed to evaluate the association between ACYP2 polymorphisms and IgAN risk by performing a case-control study. METHODS:Eleven ACYP2 single nucle...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000501703
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND/AIMS:The WNK-dependent STE20/SPS1-related proline/alanine-rich kinase SPAK participates in the regulation of NaCl and Na(+),K(+),2Cl(-) cotransport and thus renal salt excretion. The present study explored whether SPAK has similarly the potential to regulate the epithelial Na(+) channel (ENaC). METHODS:ENaC...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000368509
更新日期:2015-01-01 00:00:00
abstract::In the failing heart, the local angiotensin II concentration is increased, and the extent of cardiac angiotensin II release is related to the clinical signs of heart failure. The enzymes involved in myocardial generation of angiotensin II are the angiotensin-converting enzyme (ACE) and chymases. While myocardial angio...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章,评审
doi:10.1159/000090189
更新日期:2005-01-01 00:00:00