Genetic variants in renalase and blood pressure responses to dietary salt and potassium interventions: a family-based association study.

Abstract:

BACKGROUND/AIMS:Renalase (gene name RNLS), a recently discovered enzyme with monoamine oxidase activity, is implicated in the degradation of catecholamines. Recent studies indicate that common variations in the gene with RNLS are associated with hypertension. The aim of this study was to examine the association between genetic variants in RNLS and blood pressure (BP) responses to strict dietary interventions of salt and potassium intake. METHODS:A total of 334 subjects from 124 families were selected and sequentially maintained on a low-salt diet for 7 days (3.0 g/day, NaCl), then a high-salt diet for 7 days (18.0 g/day, NaCl), high-salt diet with potassium supplementation for another 7 days (4.5 g/day, KCl). RESULTS:SNPs rs919115 and rs792205 of the RNLS gene were significantly associated with diastolic BP (DBP) and mean arterial pressure (MAP) responses to high-salt intervention. In addition, rs12356177 was significantly associated with systolic BP (SBP) and DBP responses to low-salt diet, and SBP, DBP or MAP during the high-salt intervention. Unfortunately, no associations for the 7 RNLS SNPs with BP response to high-salt diet with potassium supplementation reached nominal statistical significance. CONCLUSIONS:This family-based study indicates that genetic variants in the RNLS gene are significantly associated with BP responses to dietary salt intake.

journal_name

Kidney Blood Press Res

authors

Wang Y,Chu C,Ren J,Mu JJ,Wang D,Liu FQ,Ren KY,Guo TS,Yuan ZY

doi

10.1159/000368460

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

497-506

issue

5

eissn

1420-4096

issn

1423-0143

pii

000368460

journal_volume

39

pub_type

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