Abstract:
:The German Collaborative Glomerulonephritis Therapy Study, which celebrated its 10th anniversary in 1996, has collected data on more than 1,000 patients with biopsy-proven glomerulonephritis. 929 patients could be evaluated and 500 were treated according to at least one of various protocols developed for a randomized controlled trial. Current results show that prednisolone is effective in minimal-change nephropathy, and in combination with other immunosuppressants it can reduce proteinuria in individual cases of focal and segmental glomerulosclerosis, membranous glomerulonephritis and nephrotic IgA nephropathy. The majority of tested treatment protocols did not prove to be superior to symptomatic therapy for long-term outcome.
journal_name
Kidney Blood Press Resjournal_title
Kidney & blood pressure researchauthors
Risler T,Braun N,Bach D,Fünfstück R,Grabensee B,Grupp C,Haufe C,Heering P,Keller F,Krämer B,Müller GA,Schollmeyer P,Stein G,Zäuner Idoi
10.1159/000174073subject
Has Abstractpub_date
1996-01-01 00:00:00pages
196-200issue
3-4eissn
1420-4096issn
1423-0143journal_volume
19pub_type
临床试验,杂志文章,随机对照试验abstract::The effects on glomerular hemodynamics of angiotensin-converting enzyme (ACE) inhibition with captopril and of angiotensin II receptor blockade with EXP 3174, an active metabolite of losartan, either alone or in combination, were compared in anesthetized dogs. Administration of EXP 3174 intrarenally led to an increase...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000174256
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND:Flucloxacillin is an important antimicrobial drug in the treatment of infections with Staphylococcus aureus and therefore is often used in staphylococcal infections. Furthermore, flucloxacillin has a high protein binding rate as for example ceftriaxone or teicoplanin--drugs which have formerly been character...
journal_title:Kidney & blood pressure research
pub_type: 临床试验,杂志文章
doi:10.1159/000070997
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND/AIMS:Chronic renal allograft dysfunction (CRAD) is a leading cause of long-term renal allograft loss. Oxidative stress may account for the nonspecific interstitial fibrosis and tubular atrophy that occur in CRAD. An antioxidant intervention via Nrf2 signaling pathway activation might be a promising therapy f...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000487501
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Mesenchymal stem cells (MSC) improve renal function and renovascular hypertension in the 2-kidney 1-clip model (2K-1C). While MSC play an immunomodulatory role, induce neoangiogenesis, and reduce fibrosis, they do not correct sodium loss by the contra-lateral kidney. OBJECTIVES:We investigated the tubular f...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000503346
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND/AIMS:Endothelial-to-mesenchymal transition (EndMT) of glomerular endothelial cells (GEnCs) can induce albuminuria in diabetic nephropathy. Melatonin attenuates diabetic nephropathy, but its role and mechanism in EndMT of GEnCs in diabetic nephropathy remain unknown. METHODS:The effect of melatonin on EndMT ...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000493380
更新日期:2018-01-01 00:00:00
abstract::Primary cardiac hemangioma is a very rare benign vascular tumor, with valvular hemangiomas being even less frequent as valves are generally avascular structures. We present the first case of mitral valve hemangioma in a renal transplant recipient. Patient presented with progressive dyspnea. Transesophageal echocardiog...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章,评审
doi:10.1159/000343395
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:1,25-Dihydroxyvitamin D(3) is mainly synthesized by renal proximal tubular cells. More recently, it has been shown to affect cell growth and TGF-beta(1) synthesis in glomerular and tubular renal cells in vitro, and to prevent glomerulosclerosis in vivo in subtotally nephrectomized rats. The mechanisms involv...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000054213
更新日期:2001-01-01 00:00:00
abstract::In the pathogenesis of anti-neutrophil cytoplasm antibodies (ANCA)-associated vasculitis, T cell contribution is indicated by T cell-dependent ANCA production combined with the presence of T cells in inflammatory infiltrates. However, the exact pathogenic role of T cells in ANCA-associated vasculitis remains to be det...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章,评审
doi:10.1159/000072987
更新日期:2003-01-01 00:00:00
abstract::In the failing heart, the local angiotensin II concentration is increased, and the extent of cardiac angiotensin II release is related to the clinical signs of heart failure. The enzymes involved in myocardial generation of angiotensin II are the angiotensin-converting enzyme (ACE) and chymases. While myocardial angio...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章,评审
doi:10.1159/000090189
更新日期:2005-01-01 00:00:00
abstract::The aim of this study was to investigate whether the renoprotective effect of angiotensin-converting enzyme inhibitors (ACEIs) following 5/6 renal mass reduction is due in part to the potentiation of kinins. Three groups of rats with 5/6 renal mass reduction were studied during the 14 weeks following surgery. One grou...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000025890
更新日期:1998-01-01 00:00:00
abstract:BACKGROUNDS:ANCA-associated vasculitis (AAV) frequently present with a chronic relapsing course. Relapse leads to an increased need for therapeutic agents and consequent toxicity. SUMMARY:When referring to the available options for the management of AAV, the efficacy of glucocorticoids (GCs) is unquestionable. However...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章,评审
doi:10.1159/000509608
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND/AIMS:Ischemia/reperfusion (I/R) is the most common cause of acute renal injury. I/R-induced oxidative stress is involved in the development of acute renal injury, which can be reversed by supplementation with L-arginine, a precursor of nitric oxide (NO). This study was conducted to evaluate alterations in th...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000480362
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND/AIMS:The kidney plays a critical role in the control of blood pressure and its elevation in salt-induced hypertension. Mitochondrial dysfunction, especially in energy metabolism, has been associated with hypertension. Here, we aimed to investigate mitochondrial function and metabolic features in renal mitoch...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000479846
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND/AIMS:Excessive phosphate concentrations trigger vascular calcification, an active process promoted by osteoinduction of vascular smooth muscle cells (VSMCs) with increased expression and activity of transcription factor RUNX2 (Core-binding factor α1, CBFA1), alkaline phosphatase (ALPL), TGFß1, transcription ...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000368524
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND/AIMS:Refugee dialysis is a worldwide growing dilemma with limited experience. This report presents the largest hemodialysis (HD) patient registry data of Syrian refugees in Turkey. METHODS:Demographic, clinical, laboratory, and dialysis practice data of 345 Syrian HD patients during one year were collected ...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000498832
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND/AIMS:Post-transplant hypertension is highly prevalent in renal transplant recipients and is a risk factor for graft loss, cardiovascular disease and death. Glucocorticoid is used to prevent rejection, but simultaneously increases the risk of post-transplant hypertension. The glucocorticoid-induced transcript...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000485862
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Studies have demonstrated that cholesterol variability is an independent predictor of cerebrovascular and cardiovascular events. OBJECTIVE:This study aimed to investigate the association of visit-to-visit variability in total cholesterol (TC) with kidney decline in a Chinese community-based population. MET...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000501367
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND/AIMS:Aortic arch calcification (AoAC) is frequently detected in maintenance hemodialysis (MHD) patients and is associated with cardiovascular and all-cause mortality. We investigated the factors associated with AoAC and analyzed the relationship between the factors including bone-derived biomarkers and AoAC....
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000494441
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND/AIMS:The role of endothelin (ET) in cardiovascular remodeling was investigated by treating uninephrectomized spontaneously hypertensive rats of the stroke-prone strain (UNX-SHRsp) on normal- or high (3%)-salt diet with the selective ET(A) receptor blocker LU 135252. METHODS:SHRsp on normal or high salt were...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000108626
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:There is limited evidence on the etiology and outcomes of renal infarction. A provoking factor is identified only in one- to two-thirds of patients. METHODS:This is a retrospective observational study. The clinical characteristics and outcomes of patients with acute renal infarction were studied; the sample...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000503425
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND/AIMS:Lipopolysaccharides (LPS) binding to Toll-like receptor 4 (TLR4) activate NADPH oxidase gp91 subunit-mediated inflammation and oxidative damage. Recognizing the high binding affinity of sialic acid (SA) with LPS, we further explored the preventive potential of SA pretreatment on LPS-evoked acute renal f...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000443430
更新日期:2016-01-01 00:00:00
abstract::Dopamine (DA) is a natriuretic hormone synthesized in the kidneys by conversion of filtered 3,4-dihydroxyphenylalanine (L-Dopa), and is activated during hypervolaemia and increased dietary sodium intake. The natriuretic activity of endogenous DA is controversial, however, and the regulation of renal DA synthesis has y...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000174052
更新日期:1996-01-01 00:00:00
abstract:BACKGROUND/AIMS:To date, there is no imaging technique to assess tubular function in vivo. Blood oxygen level-dependent magnetic resonance imaging (BOLD MRI) measures tissue oxygenation based on the transverse relaxation rate (R2*). The present study investigates whether BOLD MRI can assess tubular function using a tub...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000485600
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND/AIMS:The contribution of preexisting hypercholesterolemia to diabetic nephropathy remains unclear. We assessed the impact of hypercholesterolemia on diabetic nephropathy using a double knockout (DKO) mouse, null for the low-density lipoprotein receptor (LDLRNDASH;/NDASH;) and the apoB mRNA editing catalytic ...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000073942
更新日期:2003-01-01 00:00:00
abstract::Although primary cilia are increasingly recognized to play sensory roles in several cellular systems, their role in vascular smooth muscle cells (VSMCs) has not been defined. We examined in situ position/orientation of primary cilia and ciliary proteins in VSMCs and tested the hypothesis that primary cilia of VSMCs ex...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000132462
更新日期:2008-01-01 00:00:00
abstract::Recently, Chlamydia pneumoniae is the microorganism frequently implicated in the infection-based inflammatory atherogenous hypothesis. Although in vitro experimental data and initial sero-epidemiologic, pathology-based studies and antibiotic trials supported this interesting hypothesis, later data are conflicting. Som...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章,评审
doi:10.1159/000078146
更新日期:2004-01-01 00:00:00
abstract:INTRODUCTION:Diabetic nephropathy (DN) and hypertensive nephrosclerosis (HN) represent the most common causes of chronic kidney disease (CKD) and many patients progress to -end-stage renal disease. Patients are treated primarily through the management of cardiovas-cular risk factors and hypertension; however patients w...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000505187
更新日期:2020-01-01 00:00:00
abstract::Renal proximal tubular Na/phosphate cotransport is the key target in the control of renal phosphate handling. Using molecular tools for the type II Na/phosphate cotransporter, it could be documented that altered brush border membrane phosphate transport reflects a state of altered brush border expression of the specif...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章,评审
doi:10.1159/000174063
更新日期:1996-01-01 00:00:00
abstract::The present investigation examined the possible influence of urinary calcium excretion on the concentration of renal calbindin-D28k. Thiazide diuretics stimulate calcium transport across the epithelial cells of the distal tubule, which express calbindin-D28k in high concentrations. Calbindin-D28k is assumed to facilit...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000174153
更新日期:1997-01-01 00:00:00
abstract:AIM:To assess the influence on blood pressure in schoolchildren, of elevated sodium (Na(+)) and nitrate (NO(-)(3)) levels in the drinking water. METHODS:The blood pressure was recorded in three groups of age- and weight-matched schoolchildren (fourth and fifth graders) ingesting differing Na(+) and NO(-)(3) concentrat...
journal_title:Kidney & blood pressure research
pub_type: 临床试验,杂志文章
doi:10.1159/000025989
更新日期:2000-01-01 00:00:00