Pretreatment of Sialic Acid Efficiently Prevents Lipopolysaccharide-Induced Acute Renal Failure and Suppresses TLR4/gp91-Mediated Apoptotic Signaling.

abstract：AIMS AND METHODS:By analyzing data from 2,861 individuals who underwent general health screening 2 years running, we have investigated the impact of changes in waist circumference (WC) and body mass index (BMI) over a 1-year period on systolic blood pressure (BPs). We termed WC, BMI, and BPs at the first visit as WC1, ...

journal_title：Kidney & blood pressure research

authors： Ishizaka N,Ishizaka Y,Toda E,Koike K,Yamakado M,Nagai R

更新日期：2009-01-01 00:00:00

abstract：:In the Prague hypertensive rat (PHR), a strain of genetic hypertension derived from Wistar, administration of various antihypertensive drugs (AHD) during the developmental phase of hypertension (weeks 5-9 of life) prevents the rise of blood pressure. However, only drugs blocking the renin-angiotensin system (RAS, i.e....

journal_title：Kidney & blood pressure research

authors： Heller J,Hellerová S

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND/AIMS:The role of endothelin (ET) in cardiovascular remodeling was investigated by treating uninephrectomized spontaneously hypertensive rats of the stroke-prone strain (UNX-SHRsp) on normal- or high (3%)-salt diet with the selective ET(A) receptor blocker LU 135252. METHODS:SHRsp on normal or high salt were...

journal_title：Kidney & blood pressure research

authors： Orth SR,Schiele G,Banas B,Ritz E,Amann K

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND/AIMS:The metabolic syndrome (MetS), as assessed using dichotomous criteria, is associated with increased risk of future chronic kidney disease (CKD), though this relationship is unclear among African Americans, who have lower risk for MetS but higher risk for CKD. METHODS:We performed logistic regression us...

journal_title：Kidney & blood pressure research

authors： DeBoer MD,Filipp SL,Musani SK,Sims M,Okusa MD,Gurka M

更新日期：2018-01-01 00:00:00

abstract：:The German Collaborative Glomerulonephritis Therapy Study, which celebrated its 10th anniversary in 1996, has collected data on more than 1,000 patients with biopsy-proven glomerulonephritis. 929 patients could be evaluated and 500 were treated according to at least one of various protocols developed for a randomized ...

journal_title：Kidney & blood pressure research

authors： Risler T,Braun N,Bach D,Fünfstück R,Grabensee B,Grupp C,Haufe C,Heering P,Keller F,Krämer B,Müller GA,Schollmeyer P,Stein G,Zäuner I

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND/AIMS:Interleukin (IL)-18, a member of the IL-1 cytokine superfamily, is recognized as an important regulator of immune responses. The aim of our study was to investigate the IL-18 levels in serum and urine from children with idiopathic nephrotic syndrome (INS) during relapse and remission, and to evaluate th...

journal_title：Kidney & blood pressure research

authors： Kiliś-Pstrusińska K,Medyńska A,Zwolińska D,Wawro A

更新日期：2008-01-01 00:00:00

abstract：:Patients affected by end-stage renal disease (ESRD) show quite lower physical activity and exercise capacity when compared to healthy individuals. In addition, a sedentary lifestyle is favoured by lack of a specific counseling on exercise implementation in the nephrology care setting. Increasing physical activity leve...

journal_title：Kidney & blood pressure research

authors： Capitanini A,Lange S,D'Alessandro C,Salotti E,Tavolaro A,Baronti ME,Giannese D,Cupisti A

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND/AIM:Serum gamma-glutamyltransferase (GGT), a biomarker of oxidative stress, is associated with an increased risk of diabetes and hypertension. However, it is not known whether higher serum GGT is independently associated with chronic kidney disease (CKD). Therefore, we examined the association between serum ...

journal_title：Kidney & blood pressure research

authors： Teppala S,Shankar A,Li J,Wong TY,Ducatman A

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND/AIMS:OSR1 (oxidative-stress-responsive kinase 1) participates in the regulation of renal tubular ion transport, cell volume and blood pressure. Whether OSR1 contributes to the regulation of organic solute transport remained; however, elusive. The present study thus explored the OSR1 sensitivity of the peptid...

journal_title：Kidney & blood pressure research

authors： Warsi J,Elvira B,Bissinger R,Shumilina E,Hosseinzadeh Z,Lang F

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Vascular accesses (especially polytetrafluoroethylene grafts) with a permanently low flow (Qa <600 ml/min) are prone to thrombosis and thus have short patency. The reason for a permanently low flow is usually medial calcinosis of the inflow artery in diabetics. We retrospectively studied the long-term patenc...

journal_title：Kidney & blood pressure research

authors： Malik J,Tuka V,Chytilova E,Mokrejsova M,Masek M,Slavikova M

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND/AIMS:Serum/Glucocorticoid Regulated Kinase 1 (SGK1) plays a significant role in regulating renal Na(+) reabsorption, K(+) secretion, and blood pressure (BP). This study aimed to assess the association of common genetic variants in the SGK1 gene with BP responses to controlled dietary sodium or potassium inte...

journal_title：Kidney & blood pressure research

authors： Chu C,Wang Y,Wang M,Mu JJ,Liu FQ,Wang L,Ren KY,Wang D,Yuan ZY

更新日期：2015-01-01 00:00:00

abstract：:Cardiovascular (CV) morbidity and mortality is greatly enhanced in patients with chronic kidney disease, compared to the non-renal population. One key element of this high CV burden appears to be arterial stiffness, as an expression of premature vascular aging. Increased arterial stiffness in renal patients may be a c...

journal_title：Kidney & blood pressure research

authors： Gusbeth-Tatomir P,Covic A

更新日期：2007-01-01 00:00:00

abstract：:Heart failure and chronic kidney disease share a number of risk factors and pathophysiological pathways. Renal insufficiency is common in patients with chronic heart failure (CHF). The aim of the study was to assess whether neutrophil gelatinase-associated lipocalin (NGAL) could represent a novel, sensitive marker of ...

journal_title：Kidney & blood pressure research

authors： Poniatowski B,Malyszko J,Bachorzewska-Gajewska H,Malyszko JS,Dobrzycki S

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND/AIMS:To prevent contrast induced renal dysfunction a periprocedural prophylactic hydration is applied. Due to dilution it should cause a drop in serum creatinine concentration (SCR). Surprisingly, no reduction in SCR after contrast admission is found in up to 25% of patients as early as 12-18 hours after cor...

journal_title：Kidney & blood pressure research

authors： Burchardt P,Rzezniczak J,Synowiec T,Angerer D,Palasz A,Zurawski J

更新日期：2016-01-01 00:00:00

abstract：:The renin-angiotensin-aldosterone system (RAAS) blockade is currently the best-documented treatment strategy to delay the progression of chronic nephropathies. Angiotensin-converting enzyme inhibitors (CEIs) or angiotensin II type 1 receptor antagonists (ARBs) should be used in every normotensive and hypertensive pati...

journal_title：Kidney & blood pressure research

authors： Tylicki L,Larczynski W,Rutkowski B

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Treating non-diabetic proteinuric patients with advanced renal disease with an angiotensin-converting enzyme (ACE) inhibitor is still subject to discussion. This study aims to determine the cost-effectiveness of ACE inhibitor therapy in this patient population in the Netherlands. METHODS:We compared two str...

journal_title：Kidney & blood pressure research

authors： Adarkwah CC,Gandjour A,Akkerman M,Evers S

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND/AIMS:Angiotensin converting enzyme 2 (ACE2) is highly expressed in the kidney and recognized to be renoprotective by degrading Angiotensin II to Angiotensin (1-7) in diabetic nephropathy. However, little is known about the role of urinary ACE2 (UACE2) in diabetes. The present study was performed to evaluate ...

journal_title：Kidney & blood pressure research

authors： Liang Y,Deng H,Bi S,Cui Z,A L,Zheng D,Wang Y

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND/AIMS:Excessive phosphate concentrations trigger vascular calcification, an active process promoted by osteoinduction of vascular smooth muscle cells (VSMCs) with increased expression and activity of transcription factor RUNX2 (Core-binding factor α1, CBFA1), alkaline phosphatase (ALPL), TGFß1, transcription ...

journal_title：Kidney & blood pressure research

authors： Alesutan I,Musculus K,Castor T,Alzoubi K,Voelkl J,Lang F

更新日期：2015-01-01 00:00:00

abstract：:Progressive renal disease poses an increasing problem for the medical community. Though the causes of end-stage renal failure are multiple, the histologic pictures of chronic renal disease are remarkably similar being characterized by interstitial infiltration, fibrosis, tubular atrophy and dilatation. This similarity...

journal_title：Kidney & blood pressure research

authors： Strutz F,Müller GA

更新日期：1999-01-01 00:00:00

abstract：:Inhibitors of angiotensin-converting enzyme (ACE) or beta isoforms of protein kinase C (PKC) are nephroprotective in diabetes mellitus. We investigated the influence of streptozotocin (STZ)-induced diabetes mellitus and of treatment with the ACE inhibitor lisinopril (4 mg/kg p.o. twice daily for 4 weeks) on the expres...

journal_title：Kidney & blood pressure research

authors： Pfaff IL,Vallon V

更新日期：2002-01-01 00:00:00

abstract：:The value of neutrophil-gelatinase-associated lipocalin (NGAL) was highlighted as a novel biomarker for the detection of acute renal failure. We tested the hypothesis whether NGAL could represent an early biomarker of contrast-induced nephropathy (CIN) in 100 patients with normal serum creatinine values undergoing per...

journal_title：Kidney & blood pressure research

authors： Bachorzewska-Gajewska H,Malyszko J,Sitniewska E,Malyszko JS,Pawlak K,Mysliwiec M,Lawnicki S,Szmitkowski M,Dobrzycki S

更新日期：2007-01-01 00:00:00

abstract：:A 70-year-old female patient with advanced Shy-Drager syndrome exhibited severe orthostatic hypotension, low serum catecholamine levels, and autonomic dysfunction. She was bedridden despite oral medication with fludrocortisone, etilefrin, dihydroergotamine, L-dopa, yohimbine, and amezinium methyl sulfate. Only intrave...

journal_title：Kidney & blood pressure research

authors： Kribben A,Bremer C,Fritschka E,Koeppen S,Ahrens O,Philipp T

更新日期：1998-01-01 00:00:00

abstract：:In the present study, the effects of hexachlorobenzene (HCB) on lipid peroxidation and heme metabolism in the different constitutive suborgans of the kidney were determined. For this purpose, conjugated diene and malondialdehyde levels, as lipid peroxidation parameters, and porphyrin accumulation, uroporphyrinogen dec...

journal_title：Kidney & blood pressure research

authors： Fernández-Tomé MC,Billi de Catabbi SC,Aldonatti C,San Martin de Viale LC,Sterin-Speziale NB

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND/AIMS:Peritoneal dialysis (PD) has gained interest over the last decade as a viable option for early start dialysis. It is still unknown if shorter break-in periods and less time for proper patient evaluation and training could influence technique survival in comparison to planned-start PD. METHODS:A prospec...

journal_title：Kidney & blood pressure research

authors： Silva BC,Adelina E,Pereira BJ,Cordeiro L,Rodrigues CE,Duarte RJ,Abensur H,Elias RM

更新日期：2018-01-01 00:00:00

abstract：:In the pathogenesis of anti-neutrophil cytoplasm antibodies (ANCA)-associated vasculitis, T cell contribution is indicated by T cell-dependent ANCA production combined with the presence of T cells in inflammatory infiltrates. However, the exact pathogenic role of T cells in ANCA-associated vasculitis remains to be det...

journal_title：Kidney & blood pressure research

authors： Sanders JS,Stegeman CA,Kallenberg CG

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND/AIMS:Hypertensive patients present with increased oxidative stress and frequently receive angiotensin II (ANGII) receptor type I blockers (ARB) for blood pressure (BP) reduction. Recent studies revealed an important role of ANGII in maintaining vascular oxidative homeostasis, including sustaining normal sodi...

journal_title：Kidney & blood pressure research

authors： Mihalj M,Tadzic R,Vcev A,Rucevic S,Drenjancevic I

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND/AIMS:High mobility group box 1 (HMGB1) is an important mediator of the inflammatory response. It has been implicated in the pathogenesis of autoimmune diseases, atherosclerosis, and obesity. However, the effects of HMGB1 on diabetic nephropathy remain unclear. Here, we investigated the potential roles and me...

journal_title：Kidney & blood pressure research

authors： Zhang H,Zhang R,Chen J,Shi M,Li W,Zhang X

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:There is limited evidence on the etiology and outcomes of renal infarction. A provoking factor is identified only in one- to two-thirds of patients. METHODS:This is a retrospective observational study. The clinical characteristics and outcomes of patients with acute renal infarction were studied; the sample...

journal_title：Kidney & blood pressure research

authors： García-García A,Demelo-Rodríguez P,Ordieres-Ortega L,Cervilla-Muñoz E,García-Fernández-Bravo I,Pulfer MD,López-Aparicio A,Galeano-Valle F,Del Toro-Cervera J

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Urine osmolality indicates the ability of the kidney to concentrate the urine and reflects the antidiuretic action of vasopressin. However, results about the association between urine osmolality and adverse renal outcomes in chronic kidney disease (CKD) are conflicting. We investigated the association betwee...

journal_title：Kidney & blood pressure research

authors： Lee MJ,Chang TI,Lee J,Kim YH,Oh KH,Lee SW,Kim SW,Park JT,Yoo TH,Kang SW,Choi KH,Ahn C,Han SH

更新日期：2019-01-01 00:00:00

abstract：INTRODUCTION:There is still no evidence whether human peritoneal mesothelial cells (HPMC) from patients with end-stage renal failure are altered in cell viability or show a different pattern of the release of proinflammatory cytokines. Also the serum of patients with uremia may contain substances stimulating the cytoki...

journal_title：Kidney & blood pressure research

authors： Plum J,Fleisch MC,Razeghi P,Fusshöller A,Lordnejad MR,Grabensee B

更新日期：2002-01-01 00:00:00