Abstract:
:The high mortality rate seen in dialysis patients is related to long-standing high blood pressure and the presence of other traditional as well as non-traditional risk factors for cardiovascular disease. Hypertension is associated with increased risk for left ventricular hypertrophy, coronary artery disease, congestive heart failure and cerebrovascular complications. High blood pressure is frequent and difficult to control in the dialysis population. Available therapeutic options to normalize blood pressure in these patients include dietary salt and fluid restriction in combination with reduction of dialysate sodium concentration. A possible treatment option for these patients may be long, slow hemodialysis (3 x 8 h per week); short daily hemodialysis (2-3 h 7 times per week); nocturnal hemodialysis (6-7 times overnight per week). Reduction of residual renal function is a major cause of blood pressure increase in the peritoneal dialysis patient population. Therefore, hyperhydration should be avoided. If antihypertensive medication is needed, ACE inhibitors, beta-blockers and/or calcium channel blockers are recommended. Optimal blood pressure in dialysis patients is not different from recommendations for the general population.
journal_name
Kidney Blood Press Resjournal_title
Kidney & blood pressure researchauthors
Hörl MP,Hörl WHdoi
10.1159/000070987keywords:
subject
Has Abstractpub_date
2003-01-01 00:00:00pages
76-81issue
2eissn
1420-4096issn
1423-0143pii
70987journal_volume
26pub_type
杂志文章,评审abstract::The value of neutrophil-gelatinase-associated lipocalin (NGAL) was highlighted as a novel biomarker for the detection of acute renal failure. We tested the hypothesis whether NGAL could represent an early biomarker of contrast-induced nephropathy (CIN) in 100 patients with normal serum creatinine values undergoing per...
journal_title:Kidney & blood pressure research
pub_type: 临床试验,杂志文章
doi:10.1159/000109102
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND/AIM:Expression of the constitutively active form of serum and glucocorticoid-dependent kinase ((S422D)SGK1) in Xenopus oocytes has recently been shown to upregulate endogenous Na(+)/K(+)-ATPase activity, an effect presumably participating in the regulation of cellular K(+) uptake and transepithelial Na(+) tr...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000068699
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND/AIMS:The WNK-dependent STE20/SPS1-related proline/alanine-rich kinase SPAK participates in the regulation of NaCl and Na(+),K(+),2Cl(-) cotransport and thus renal salt excretion. The present study explored whether SPAK has similarly the potential to regulate the epithelial Na(+) channel (ENaC). METHODS:ENaC...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000368509
更新日期:2015-01-01 00:00:00
abstract::Since reports of the first data on cytokines in renal diseases about 10 years ago, the field has seen an explosive growth over the last decade. It is now realized that cytokines can be synthesized by many different types of cells, including glomerular cells, upon adequate stimulation and exert a wide range of actions ...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章,评审
doi:10.1159/000174088
更新日期:1996-01-01 00:00:00
abstract:BACKGROUND/AIMS:The role of endothelin (ET) in cardiovascular remodeling was investigated by treating uninephrectomized spontaneously hypertensive rats of the stroke-prone strain (UNX-SHRsp) on normal- or high (3%)-salt diet with the selective ET(A) receptor blocker LU 135252. METHODS:SHRsp on normal or high salt were...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000108626
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Magnoline is an active ingredient of magnolia fargesii with anti-inflammatory and anti-platelet effects. The objective is to explore the renoprotection of magnoline in diabetic rats and its effects on P-selectin. METHODS:Thirty-six rats were randomized into 4 groups-normal control group (C), d...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000350146
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Cardiovascular disease caused by atherosclerosis remains a major cause of morbidity and mortality in patients with end-stage renal disease (ESRD). We evaluated the potential association of cardiovascular risk factors including asymmetric dimethyl L-arginine (ADMA) and the soluble receptor for advanced glycat...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000316709
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND/AIMS:Kidney function is critical for homocysteine (Hcy) clearance, and plasma Hcy levels are frequently increased in patients with renal failure. Microalbuminuria (MAU) is an important marker of early renal damage caused by hypertension. At present, there is insufficient evidence on the relationship between ...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000486013
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND/AIMS:To determine the effect of arterial blood pressure (BP) reduction on endocan and soluble cell adhesion molecules' (sCAM) plasma concentration and expression of their ligands on circulatory leukocyte subpopulations. METHODS:24 hypertensive subjects of both sexes (age: 53±8 yrs) were treated with Ca-chan...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000350064
更新日期:2013-01-01 00:00:00
abstract::Inhibitors of type 4 dipeptidyl peptidase (DDP-4) were developed and approved for the oral treatment of type 2 diabetes. Its mode of action is to inhibit the degradation of incretins, such as type 1 glucagon like peptide (GLP-1), and GIP. GLP-1 stimulates glucose-dependent insulin secretion from pancreatic beta-cells ...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章,评审
doi:10.1159/000339028
更新日期:2012-01-01 00:00:00
abstract::Despite developments in the technology of dialysis procedures and improvements in the understanding of systemic derangements related to chronic kidney disease (CKD), cardiovascular disease is the major cause of death. Unfortunately, the leading subset of cardiovascular disease death is sudden cardiac death (SCD). To d...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章,评审
doi:10.1159/000326904
更新日期:2011-01-01 00:00:00
abstract::Glomerulosclerosis and tubulointerstitial fibrosis are the hallmarks of chronic renal diseases. In the present study, we have investigated the potential involvement of various proteinases in these alterations in the model of puromycin aminonucleoside (PAN) nephrosis. Two groups of male Wistar rats were given either th...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000025917
更新日期:1999-01-01 00:00:00
abstract::Although primary cilia are increasingly recognized to play sensory roles in several cellular systems, their role in vascular smooth muscle cells (VSMCs) has not been defined. We examined in situ position/orientation of primary cilia and ciliary proteins in VSMCs and tested the hypothesis that primary cilia of VSMCs ex...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000132462
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Though the association between microalbuminuria (MA) and inflammatory markers has been studied, the possible gender differences in these associations have not yet been analyzed. Our study aims to analyze the role of gender in the associations of MA and inflammatory markers. METHODS:1,060 hypertensive patien...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000266477
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND/AIMS:Rapamycin inhibits cyst growth in polycystic kidney disease by targeting the mammalian target of rapamycin (mTOR). To determine if this is a class effect of the mTOR inhibitors, we examined the effect of everolimus, the analogue of rapamycin, on disease progression in the Han:SPRD rat model of polycysti...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000104818
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND/AIMS:Endothelial-to-mesenchymal transition (EndMT) of glomerular endothelial cells (GEnCs) can induce albuminuria in diabetic nephropathy. Melatonin attenuates diabetic nephropathy, but its role and mechanism in EndMT of GEnCs in diabetic nephropathy remain unknown. METHODS:The effect of melatonin on EndMT ...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000493380
更新日期:2018-01-01 00:00:00
abstract::Dopamine (DA) is a natriuretic hormone synthesized in the kidneys by conversion of filtered 3,4-dihydroxyphenylalanine (L-Dopa), and is activated during hypervolaemia and increased dietary sodium intake. The natriuretic activity of endogenous DA is controversial, however, and the regulation of renal DA synthesis has y...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000174052
更新日期:1996-01-01 00:00:00
abstract:BACKGROUND/AIMS:The kidney plays a critical role in the control of blood pressure and its elevation in salt-induced hypertension. Mitochondrial dysfunction, especially in energy metabolism, has been associated with hypertension. Here, we aimed to investigate mitochondrial function and metabolic features in renal mitoch...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000479846
更新日期:2017-01-01 00:00:00
abstract::Angiotensin-(1-7), (Ang-(1-7)), a metabolite of Ang II and /or Ang I, was infused into the renal artery (i.r.a) of anesthetized dogs in order to demonstrate its possible direct renal action. The dose administered, 15 Ig/kg BW/min in isotonic saline (0.072 ml/kg BW/min) throughout the experiment, did not influence the ...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000025959
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND/AIM:Our aim was to determine whether altered human β-defensin (HBD), pro-inflammatory cytokines including interleukin (IL)-6 and tumor necrotic factor (TNF)-α could increase the risk of developing and exacerbation of chronic kidney disease (CKD), especially for patients with diabetic nephropathy (DN). METHO...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000355740
更新日期:2013-01-01 00:00:00
abstract::Fibroblast growth factor 23 (FGF23) is released primarily from osteoblasts/osteocytes in bone. In cooperation with the transmembrane protein Klotho, FGF23 is a powerful inhibitor of 1α 25OH Vitamin D Hydroxylase (Cyp27b1) and thus of the formation of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3). As 1,25(OH)2D3 up-regulates ...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章,评审
doi:10.1159/000495393
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:To evaluate the relationship between FGF23 and changes in biochemical parameters, left ventricle mass index, coronary, aortic and, valve calcifications. METHODS:Totally 185 patients with chronic renal disease were included in this prospective, cross-sectional study. The patients were stratified according to...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000339026
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND/AIMS:Apparent treatment resistant hypertension (aTRH) is highly prevalent in patients with type 2 diabetes (T2D) and chronic kidney disease (CKD). The impact of aTRH and achievement of recommended blood pressure (BP) values on the rate of glomerular filtration rate (eGFR) loss in CKD patients is poorly known...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000488255
更新日期:2018-01-01 00:00:00
abstract:BACKGROUNDS:ANCA-associated vasculitis (AAV) frequently present with a chronic relapsing course. Relapse leads to an increased need for therapeutic agents and consequent toxicity. SUMMARY:When referring to the available options for the management of AAV, the efficacy of glucocorticoids (GCs) is unquestionable. However...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章,评审
doi:10.1159/000509608
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND/AIMS:IgA nephropathy is associated with aberrant O-glycosylation of IgA1, which is recognized by autoantibodies leading to the formation of circulating immune complexes. Some of them, after deposition into kidney mesangium, trigger glomerular injury. In patients with active disease nonresponding to angiotens...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000487903
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND/AIMS:The presence of protein-energy wasting (PEW) among dialysis patients is a crucial risk factor for outcomes. The complicated pathogenesis of PEW makes it difficult to assess and treat. This single-center retrospective study focuses on the association between nutritional markers and the outcomes of contin...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000485926
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND/AIMS:The deposition of β2-microglobulin induced by reactive inflammation causing carpal tunnel syndrome (CTS) is one of the complications of dialysis-related amyloidosis in maintenance hemodialysis (MHD) patients. Air pollution levels, especially particulate matter with an aerodynamic diameter of <2.5 mm (PM...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000484422
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND/AIMS:We explored the effects of catechins (decaffeinated green tea extracts containing (-)-epicatechin, (-)-epigallocatechin, (-)-epicatechin gallate and (-)-epigallocatechin gallate) on atherosclerosis risk factors, oxidized low-density lipoprotein (oxLDL) and its primary metabolite, phosphatidylcholine hyd...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000485082
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND/AIMS:We previously showed that urine and serum Angiopoietin-2 (Ang-2) levels increased significantly with the degree of albuminuria in diabetes patients, but the reasons remain unclear. Consequently we aimed to determine whether there was an association between Ang-2, inflammatory cytokines (TNF-α and IL-18)...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000368510
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND/AIMS:Angiotensin-converting enzyme inhibitors and angiotensin II receptor antagonists have beneficial effects on impaired fibrinolytic activity of hypertensive patients. The aim of the study was to evaluate the effect of antialdosterone treatment on impaired fibrinolysis of hypertensive patients. METHODS:Fo...
journal_title:Kidney & blood pressure research
pub_type: 临床试验,杂志文章
doi:10.1159/000066348
更新日期:2002-01-01 00:00:00