Cytokines and glomerular injury.

abstract：BACKGROUND/AIMS:Rapamycin inhibits cyst growth in polycystic kidney disease by targeting the mammalian target of rapamycin (mTOR). To determine if this is a class effect of the mTOR inhibitors, we examined the effect of everolimus, the analogue of rapamycin, on disease progression in the Han:SPRD rat model of polycysti...

journal_title：Kidney & blood pressure research

authors： Wu M,Wahl PR,Le Hir M,Wackerle-Men Y,Wuthrich RP,Serra AL

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND/AIMS:We have reported that the long-term administration of angiotensin II receptor blockers (ARBs) induced unusual proliferative changes of renal afferent arteriolar smooth muscle cells (SMCs) in rats, associated with the overproduction of renin. In this study, we examined that a direct renin inhibitor (DRI:...

journal_title：Kidney & blood pressure research

authors： Nagai Y,Nakanishi K,Yamanaka N

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND/AIMS:IgA nephropathy is the most prevalent form of primary glomerulonephritis worldwide. Among patients with kidney disease, hypertension is one of the most important risk factors of disease progression. Considering the limited evidence regarding the appropriate blood pressure (BP) goal for patients with IgA...

journal_title：Kidney & blood pressure research

authors： Zheng Y,Wang Y,Liu S,Wu J,Duan S,Zhu H,Wu D,Cai G,Chen X

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND/AIMS:Acute kidney injury (AKI) is a serious complication of sepsis and has a high morbidity and mortality rate. Caspase-11 induces pyroptosis, a form of programmed cell death that plays a critical role in endotoxic shock, but its role in tubular epithelial cell death and whether it contributes to sepsis-asso...

journal_title：Kidney & blood pressure research

authors： Ye Z,Zhang L,Li R,Dong W,Liu S,Li Z,Liang H,Wang L,Shi W,Malik AB,Cheng KT,Liang X

更新日期：2019-01-01 00:00:00

abstract：:Although primary cilia are increasingly recognized to play sensory roles in several cellular systems, their role in vascular smooth muscle cells (VSMCs) has not been defined. We examined in situ position/orientation of primary cilia and ciliary proteins in VSMCs and tested the hypothesis that primary cilia of VSMCs ex...

journal_title：Kidney & blood pressure research

authors： Lu CJ,Du H,Wu J,Jansen DA,Jordan KL,Xu N,Sieck GC,Qian Q

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND AND AIM:Cinacalcet effectively reduces calcium in patients with persistent hyperparathyroidism (HPT) after kidney transplantation. We aimed to assess the association of cinacalcet with a decrease in renal function based on a meta-analysis of observational studies in kidney transplant patients with persistent...

journal_title：Kidney & blood pressure research

authors： Henschkowski J,Bischoff-Ferrari HA,Wüthrich RP,Serra AL

更新日期：2011-01-01 00:00:00

abstract：:The renin-angiotensin-aldosterone system (RAAS) blockade is currently the best-documented treatment strategy to delay the progression of chronic nephropathies. Angiotensin-converting enzyme inhibitors (CEIs) or angiotensin II type 1 receptor antagonists (ARBs) should be used in every normotensive and hypertensive pati...

journal_title：Kidney & blood pressure research

authors： Tylicki L,Larczynski W,Rutkowski B

更新日期：2005-01-01 00:00:00

abstract：AIMS:The aim of this study was to screen several novel genes associated with renal cell carcinoma (RCC), and analyze the gene functions and signal pathways which were critical to RCCs with DNA microarray. METHODS:The gene expression profile of GSE781 was downloaded from Gene Expression Omnibus database, including 9 RC...

journal_title：Kidney & blood pressure research

authors： Li W,Zhu W,Che J,Sun W,Liu M,Peng B,Zheng J

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND/AIMS:Interleukin (IL)-18, a member of the IL-1 cytokine superfamily, is recognized as an important regulator of immune responses. The aim of our study was to investigate the IL-18 levels in serum and urine from children with idiopathic nephrotic syndrome (INS) during relapse and remission, and to evaluate th...

journal_title：Kidney & blood pressure research

authors： Kiliś-Pstrusińska K,Medyńska A,Zwolińska D,Wawro A

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND/AIMS:Chronic kidney disease (CKD) is often accompanied by hyperlipidemia, which accelerates progression of the disease. Podocyte injury can lead to dysfunction of the glomerular filtration barrier, which is associated with proteinuria, a risk marker for the progression of CKD. Our previous studies demonstrat...

journal_title：Kidney & blood pressure research

authors： Liu T,Chen XM,Sun JY,Jiang XS,Wu Y,Yang S,Huang HZ,Ruan XZ,Du XG

更新日期：2018-01-01 00:00:00

abstract：:In the present study, the effects of hexachlorobenzene (HCB) on lipid peroxidation and heme metabolism in the different constitutive suborgans of the kidney were determined. For this purpose, conjugated diene and malondialdehyde levels, as lipid peroxidation parameters, and porphyrin accumulation, uroporphyrinogen dec...

journal_title：Kidney & blood pressure research

authors： Fernández-Tomé MC,Billi de Catabbi SC,Aldonatti C,San Martin de Viale LC,Sterin-Speziale NB

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND/AIMS:High mobility group box 1 (HMGB1) is an important mediator of the inflammatory response. It has been implicated in the pathogenesis of autoimmune diseases, atherosclerosis, and obesity. However, the effects of HMGB1 on diabetic nephropathy remain unclear. Here, we investigated the potential roles and me...

journal_title：Kidney & blood pressure research

authors： Zhang H,Zhang R,Chen J,Shi M,Li W,Zhang X

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND/AIMS:To date, there is no imaging technique to assess tubular function in vivo. Blood oxygen level-dependent magnetic resonance imaging (BOLD MRI) measures tissue oxygenation based on the transverse relaxation rate (R2*). The present study investigates whether BOLD MRI can assess tubular function using a tub...

journal_title：Kidney & blood pressure research

authors： Bauer F,Wald J,Bauer FJ,Dahlkamp LM,Seibert FS,Pagonas N,Gedat E,Babel N,Zidek W,von Bodman C,Noldus J,Liermann D,Westhoff TH

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND/AIMS:Post-transplant hypertension is highly prevalent in renal transplant recipients and is a risk factor for graft loss, cardiovascular disease and death. Glucocorticoid is used to prevent rejection, but simultaneously increases the risk of post-transplant hypertension. The glucocorticoid-induced transcript...

journal_title：Kidney & blood pressure research

authors： Hamada AM,Yamamoto I,Nakada Y,Kobayashi A,Koike Y,Miki J,Yamada H,Tanno Y,Ohkido I,Tsuboi N,Yamamoto H,Urashima M,Yokoo T

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND/AIMS:The contribution of preexisting hypercholesterolemia to diabetic nephropathy remains unclear. We assessed the impact of hypercholesterolemia on diabetic nephropathy using a double knockout (DKO) mouse, null for the low-density lipoprotein receptor (LDLRNDASH;/NDASH;) and the apoB mRNA editing catalytic ...

journal_title：Kidney & blood pressure research

authors： Hammad SM,Hazen-Martin DJ,Sohn M,Eldridge L,Powell-Braxton L,Won W,Lyons TJ

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND/AIMS:Excessive phosphate concentrations trigger vascular calcification, an active process promoted by osteoinduction of vascular smooth muscle cells (VSMCs) with increased expression and activity of transcription factor RUNX2 (Core-binding factor α1, CBFA1), alkaline phosphatase (ALPL), TGFß1, transcription ...

journal_title：Kidney & blood pressure research

authors： Alesutan I,Musculus K,Castor T,Alzoubi K,Voelkl J,Lang F

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Renal involvement in Takayasu's arteritis (TA) effects the disease outcome and endovascular treatment is an effective treatment of choice. We investigated nitric oxide (NO) levels and the effect of endovascular treatment in renovascular hypertensive TA patients. METHODS:In five hypertensive patients with re...

journal_title：Kidney & blood pressure research

authors： Parildar Z,Gulter C,Parildar M,Oran I,Erdener D,Memis A

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND/AIMS:The role of endothelin (ET) in cardiovascular remodeling was investigated by treating uninephrectomized spontaneously hypertensive rats of the stroke-prone strain (UNX-SHRsp) on normal- or high (3%)-salt diet with the selective ET(A) receptor blocker LU 135252. METHODS:SHRsp on normal or high salt were...

journal_title：Kidney & blood pressure research

authors： Orth SR,Schiele G,Banas B,Ritz E,Amann K

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND/AIMS:This experimental study was designed to investigate protective and therapeutic effects of Dexpanthenol (Dxp), an alcoholic analogue of pantothenic acid, on kidney damage induced by ischemia-reperfusion (I/R) in rats. METHODS:Forty rats were randomly divided into a control group and 4 I/R groups (1 h is...

journal_title：Kidney & blood pressure research

authors： Altintas R,Parlakpinar H,Beytur A,Vardi N,Polat A,Sagir M,Odabas GP

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND/AIMS:ET-1 has independent effects on blood pressure regulation in vivo, it is involved in tubular water and salt excretion, promotes constriction of smooth muscle cells, modulates sympathetic nerve activity, and activates the liberation of nitric oxide. To determine the net effect of these partially countera...

journal_title：Kidney & blood pressure research

authors： Lu YP,Tsuprykov O,Vignon-Zellweger N,Heiden S,Hocher B

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND/AIMS:The presence of protein-energy wasting (PEW) among dialysis patients is a crucial risk factor for outcomes. The complicated pathogenesis of PEW makes it difficult to assess and treat. This single-center retrospective study focuses on the association between nutritional markers and the outcomes of contin...

journal_title：Kidney & blood pressure research

authors： Yan X,Yang X,Xie X,Xiang S,Zhang X,Shou Z,Chen J

更新日期：2017-01-01 00:00:00

abstract：:Pravastatin is a potent inhibitor of HMG-CoA reductase and is effective in lowering serum lipid levels. Recent studies have shown that pravastatin also reduces the oxidative modification of low-density lipoprotein (LDL). To determine whether pravastatin has a direct effect on glomerular mesangial cells, we have measur...

journal_title：Kidney & blood pressure research

authors： Chen HC,Guh JY,Shin SJ,Tomino Y,Lai YH

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND/AIMS:Cardiorenal syndrome type 1 (CRS1) is a syndrome characterized by a rapid worsening of cardiac function leading to acute kidney injury (AKI). The aims of this study were to investigate the risk factors and the prognosis of CRS1 in elderly patients. METHODS:A total of 312 elderly patients (≥60 years old...

journal_title：Kidney & blood pressure research

authors： Hu W,He W,Liu W,Fang X,Wu Y,Yu F,Hao W

更新日期：2016-01-01 00:00:00

abstract：:Angiotensin-(1-7), (Ang-(1-7)), a metabolite of Ang II and /or Ang I, was infused into the renal artery (i.r.a) of anesthetized dogs in order to demonstrate its possible direct renal action. The dose administered, 15 Ig/kg BW/min in isotonic saline (0.072 ml/kg BW/min) throughout the experiment, did not influence the ...

journal_title：Kidney & blood pressure research

authors： Heller J,Kramer HJ,Malý J,Cervenka L,Horácek V

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND/AIMS:We examined the factors associated with blood pressure variability in a multi-ethnicity prospective study in China to gain more evidence to guide the prevention and management of hypertension through risk factor intervention. METHODS:A total of 318 consecutive adult subjects aged 29-94 years with suspe...

journal_title：Kidney & blood pressure research

authors： Li W,Yu Y,Liang D,Jia EZ

更新日期：2017-01-01 00:00:00

abstract：INTRODUCTION:There is still no evidence whether human peritoneal mesothelial cells (HPMC) from patients with end-stage renal failure are altered in cell viability or show a different pattern of the release of proinflammatory cytokines. Also the serum of patients with uremia may contain substances stimulating the cytoki...

journal_title：Kidney & blood pressure research

authors： Plum J,Fleisch MC,Razeghi P,Fusshöller A,Lordnejad MR,Grabensee B

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND/AIMS:The metabolic syndrome (MetS), as assessed using dichotomous criteria, is associated with increased risk of future chronic kidney disease (CKD), though this relationship is unclear among African Americans, who have lower risk for MetS but higher risk for CKD. METHODS:We performed logistic regression us...

journal_title：Kidney & blood pressure research

authors： DeBoer MD,Filipp SL,Musani SK,Sims M,Okusa MD,Gurka M

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND/AIMS:The association between ACYP2(Acylphosphatase 2) polymorphisms and immunoglobulin A nephropathy (IgAN) risk in the Chinese Han population remains unclear. We aimed to evaluate the association between ACYP2 polymorphisms and IgAN risk by performing a case-control study. METHODS:Eleven ACYP2 single nucle...

journal_title：Kidney & blood pressure research

authors： Jin G,Liang Y,Yan X,Zhang L,Li Z,Yin A,Wang X,Tian P

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:In uremic patients coronary surgery and the entire perioperative management is demanding. METHODS:We analyzed retrospectively data from all patients requiring chronic hemodialysis who under went coronary artery bypass grafting (CABG) between January 1 2001 and December 31 2004 at the Deutsches Herzzentrum B...

journal_title：Kidney & blood pressure research

authors： Krabatsch T,Yeter R,Hetzer R

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:1,25-Dihydroxyvitamin D(3) is mainly synthesized by renal proximal tubular cells. More recently, it has been shown to affect cell growth and TGF-beta(1) synthesis in glomerular and tubular renal cells in vitro, and to prevent glomerulosclerosis in vivo in subtotally nephrectomized rats. The mechanisms involv...

journal_title：Kidney & blood pressure research

authors： Weinreich T,Wüthrich RP,Booy C,Binswanger U

更新日期：2001-01-01 00:00:00