Suppressed activities of cathepsins and metalloproteinases in the chronic model of puromycin aminonucleoside nephrosis.

abstract：AIMS:To investigate whether the regulation of aquaporin (AQP) channels is altered by inhibition of type 2 11beta-hydroxysteroid dehydrogenase (11betaHSD2). METHODS:Male Sprague-Dawley rats were treated with glycyrrhizic acid (GA, 2 g/l drinking water) for 7 days. The expression of AQP2 and AQP3 was determined in the k...

journal_title：Kidney & blood pressure research

authors： Ma SK,Nam KI,Kim SW,Bae EH,Choi KC,Lee J

更新日期：2007-01-01 00:00:00

abstract：:Post-transplant hypertension is a common occurrence during treatment with calcineurin inhibitors (CNIs) in kidney transplant population. The pathogenesis of vasoconstriction induced by CNIs involves vascular tone alterations and kidney sodium transport regulation. Among the factors involved a key role is played by the...

journal_title：Kidney & blood pressure research

authors： Calò LA,Ravarotto V,Simioni F,Naso E,Marchini F,Bonfante L,Furian L,Rigotti P

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND/AIMS:Lung dysfunction associates with increased mortality but the impact of chronic kidney disease (CKD) is less clear. We evaluated lung function and its association with mortality among individuals with normal to severely reduced glomerular filtration rate (GFR). METHODS:404 individuals representing GFR c...

journal_title：Kidney & blood pressure research

authors： Mukai H,Ming P,Lindholm B,Heimbürger O,Barany P,Stenvinkel P,Qureshi AR

更新日期：2018-01-01 00:00:00

abstract：:Cardiovascular (CV) morbidity and mortality is greatly enhanced in patients with chronic kidney disease, compared to the non-renal population. One key element of this high CV burden appears to be arterial stiffness, as an expression of premature vascular aging. Increased arterial stiffness in renal patients may be a c...

journal_title：Kidney & blood pressure research

authors： Gusbeth-Tatomir P,Covic A

更新日期：2007-01-01 00:00:00

abstract：:Renal proximal tubular Na/phosphate cotransport is the key target in the control of renal phosphate handling. Using molecular tools for the type II Na/phosphate cotransporter, it could be documented that altered brush border membrane phosphate transport reflects a state of altered brush border expression of the specif...

journal_title：Kidney & blood pressure research

authors： Murer H,Lötscher M,Kaissling B,Biber J

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND/AIMS:The WNK-dependent STE20/SPS1-related proline/alanine-rich kinase SPAK participates in the regulation of NaCl and Na(+),K(+),2Cl(-) cotransport and thus renal salt excretion. The present study explored whether SPAK has similarly the potential to regulate the epithelial Na(+) channel (ENaC). METHODS:ENaC...

journal_title：Kidney & blood pressure research

authors： Ahmed M,Salker MS,Elvira B,Umbach AT,Fakhri H,Saeed AM,Shumilina E,Hosseinzadeh Z,Lang F

更新日期：2015-01-01 00:00:00

abstract：INTRODUCTION:Cardiovascular disease is one of the main causes of morbidity and mortality in patients with autosomal dominant polycystic kidney disease (ADPKD). Autonomic dysfunction is associated with an increased risk for all cardiovascular events in the general population and can be evaluated with heart rate variabil...

journal_title：Kidney & blood pressure research

authors： Lai S,Mangiulli M,Perrotta AM,Di Lazzaro Giraldi G,Testorio M,Rosato E,Cianci R,Gigante A

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Vascular accesses (especially polytetrafluoroethylene grafts) with a permanently low flow (Qa <600 ml/min) are prone to thrombosis and thus have short patency. The reason for a permanently low flow is usually medial calcinosis of the inflow artery in diabetics. We retrospectively studied the long-term patenc...

journal_title：Kidney & blood pressure research

authors： Malik J,Tuka V,Chytilova E,Mokrejsova M,Masek M,Slavikova M

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND AND AIM:Cinacalcet effectively reduces calcium in patients with persistent hyperparathyroidism (HPT) after kidney transplantation. We aimed to assess the association of cinacalcet with a decrease in renal function based on a meta-analysis of observational studies in kidney transplant patients with persistent...

journal_title：Kidney & blood pressure research

authors： Henschkowski J,Bischoff-Ferrari HA,Wüthrich RP,Serra AL

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND/AIMS:The metabolic syndrome (MetS), as assessed using dichotomous criteria, is associated with increased risk of future chronic kidney disease (CKD), though this relationship is unclear among African Americans, who have lower risk for MetS but higher risk for CKD. METHODS:We performed logistic regression us...

journal_title：Kidney & blood pressure research

authors： DeBoer MD,Filipp SL,Musani SK,Sims M,Okusa MD,Gurka M

更新日期：2018-01-01 00:00:00

abstract：INTRODUCTION:There is still no evidence whether human peritoneal mesothelial cells (HPMC) from patients with end-stage renal failure are altered in cell viability or show a different pattern of the release of proinflammatory cytokines. Also the serum of patients with uremia may contain substances stimulating the cytoki...

journal_title：Kidney & blood pressure research

authors： Plum J,Fleisch MC,Razeghi P,Fusshöller A,Lordnejad MR,Grabensee B

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND/AIMS:The contribution of preexisting hypercholesterolemia to diabetic nephropathy remains unclear. We assessed the impact of hypercholesterolemia on diabetic nephropathy using a double knockout (DKO) mouse, null for the low-density lipoprotein receptor (LDLRNDASH;/NDASH;) and the apoB mRNA editing catalytic ...

journal_title：Kidney & blood pressure research

authors： Hammad SM,Hazen-Martin DJ,Sohn M,Eldridge L,Powell-Braxton L,Won W,Lyons TJ

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:Hypertension in the elderly is commonly characterized by an elevation of pulse pressure. With regard to advanced arteriosclerosis and limited physical fitness, doubt was casted whether elderly patients still achieve relevant cardiovascular benefits by physical exercise. The present work examines the impact o...

journal_title：Kidney & blood pressure research

authors： Westhoff TH,Franke N,Schmidt S,Vallbracht-Israng K,Meissner R,Yildirim H,Schlattmann P,Zidek W,Dimeo F,van der Giet M

更新日期：2007-01-01 00:00:00

abstract：AIMS AND METHODS:Our aim was to evaluate the antihypertensive efficacy and tolerability of angiotensin II type 1 (AT1) receptor antagonists. Valsartan or candesartan cilexetil was administered to 11 dialysis patients with elevated blood pressure. The patients (6 male, 5 female; mean age +/- SD 61+/-11 years) were on re...

journal_title：Kidney & blood pressure research

authors： Tepel M,van der Giet M,Zidek W

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND/AIMS:We previously showed that urine and serum Angiopoietin-2 (Ang-2) levels increased significantly with the degree of albuminuria in diabetes patients, but the reasons remain unclear. Consequently we aimed to determine whether there was an association between Ang-2, inflammatory cytokines (TNF-α and IL-18)...

journal_title：Kidney & blood pressure research

authors： He FF,Li HQ,Huang QX,Wang QY,Jiang HJ,Chen S,Su H,Zhang C,Wang YM

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Studies have demonstrated that cholesterol variability is an independent predictor of cerebrovascular and cardiovascular events. OBJECTIVE:This study aimed to investigate the association of visit-to-visit variability in total cholesterol (TC) with kidney decline in a Chinese community-based population. MET...

journal_title：Kidney & blood pressure research

authors： Yan Y,Huang Y,Zhou D,Tang S,Feng YQ

更新日期：2019-01-01 00:00:00

abstract：BACKGROUNDS:ANCA-associated vasculitis (AAV) frequently present with a chronic relapsing course. Relapse leads to an increased need for therapeutic agents and consequent toxicity. SUMMARY:When referring to the available options for the management of AAV, the efficacy of glucocorticoids (GCs) is unquestionable. However...

journal_title：Kidney & blood pressure research

authors： Fenoglio R,Roccatello D,Sciascia S

更新日期：2020-01-01 00:00:00

abstract：AIMS:The aim of this study was to screen several novel genes associated with renal cell carcinoma (RCC), and analyze the gene functions and signal pathways which were critical to RCCs with DNA microarray. METHODS:The gene expression profile of GSE781 was downloaded from Gene Expression Omnibus database, including 9 RC...

journal_title：Kidney & blood pressure research

authors： Li W,Zhu W,Che J,Sun W,Liu M,Peng B,Zheng J

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND/AIMS:We have reported that the long-term administration of angiotensin II receptor blockers (ARBs) induced unusual proliferative changes of renal afferent arteriolar smooth muscle cells (SMCs) in rats, associated with the overproduction of renin. In this study, we examined that a direct renin inhibitor (DRI:...

journal_title：Kidney & blood pressure research

authors： Nagai Y,Nakanishi K,Yamanaka N

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND/AIMS:Excessive phosphate concentrations trigger vascular calcification, an active process promoted by osteoinduction of vascular smooth muscle cells (VSMCs) with increased expression and activity of transcription factor RUNX2 (Core-binding factor α1, CBFA1), alkaline phosphatase (ALPL), TGFß1, transcription ...

journal_title：Kidney & blood pressure research

authors： Alesutan I,Musculus K,Castor T,Alzoubi K,Voelkl J,Lang F

更新日期：2015-01-01 00:00:00

abstract：AIM:This study investigated the impact of hypertension combined with diabetic nephropathy on rat renal alpha(1)-adrenoceptor subtype composition. METHODS:In streptozotocin-induced diabetic spontaneously hypertensive rats (SHR), diabetic nephropathy developed as reflected by increased kidney index, plasma creatinine, a...

journal_title：Kidney & blood pressure research

authors： Khan MA,Sattar MA,Abdullah NA,Abdulla MH,Salman IM,Kazi RN,Swarup KR,Rathore HA,Basri F,Hussain NM,Dewa A,Johns EJ

更新日期：2009-01-01 00:00:00

abstract：:Progressive renal disease poses an increasing problem for the medical community. Though the causes of end-stage renal failure are multiple, the histologic pictures of chronic renal disease are remarkably similar being characterized by interstitial infiltration, fibrosis, tubular atrophy and dilatation. This similarity...

journal_title：Kidney & blood pressure research

authors： Strutz F,Müller GA

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND/AIMS:Angiotensin-converting enzyme inhibitors and angiotensin II receptor antagonists have beneficial effects on impaired fibrinolytic activity of hypertensive patients. The aim of the study was to evaluate the effect of antialdosterone treatment on impaired fibrinolysis of hypertensive patients. METHODS:Fo...

journal_title：Kidney & blood pressure research

authors： Yalcin AI,Dincer M,Aslan V,Gulbas Z

更新日期：2002-01-01 00:00:00

abstract：:Patients affected by end-stage renal disease (ESRD) show quite lower physical activity and exercise capacity when compared to healthy individuals. In addition, a sedentary lifestyle is favoured by lack of a specific counseling on exercise implementation in the nephrology care setting. Increasing physical activity leve...

journal_title：Kidney & blood pressure research

authors： Capitanini A,Lange S,D'Alessandro C,Salotti E,Tavolaro A,Baronti ME,Giannese D,Cupisti A

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND/AIMS:The role of COX-2 for renal function during renal development, for physiology and pathophysiology of renal diseases and the side effects of available COX-2 inhibitors, has gained increasing interest. We aimed therefore to review the respective role of renal COX-2. METHODS:Review of relevant recent publ...

journal_title：Kidney & blood pressure research

authors： Krämer BK,Kammerl MC,Kömhoff M

更新日期：2004-01-01 00:00:00

abstract：UNLABELLED:Anaemia is frequently found in patients with chronic heart failure (CHF) and has been associated with an increase in mortality and morbidity, impaired cardiac and renal function and a reduced quality of life (QoL) compared with non-anaemic CHF patients. Correction of anaemia with recombinant human erythropoi...

journal_title：Kidney & blood pressure research

authors： Silverberg DS,Wexler D,Blum M,Iaina A,Sheps D,Keren G,Scherhag A,Schwartz D

更新日期：2005-01-01 00:00:00

abstract：INTRODUCTION:Diabetic nephropathy (DN) and hypertensive nephrosclerosis (HN) represent the most common causes of chronic kidney disease (CKD) and many patients progress to -end-stage renal disease. Patients are treated primarily through the management of cardiovas-cular risk factors and hypertension; however patients w...

journal_title：Kidney & blood pressure research

authors： Smith A,Iablokov V,Mazza M,Guarnerio S,Denti V,Ivanova M,Stella M,Piga I,Chinello C,Heijs B,van Veelen PA,Benediktsson H,Muruve DA,Magni F

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Post-transplant diabetes mellitus (PTDM) is a common and serious metabolic complication. Genetic polymorphisms of angiotensin-converting enzyme (ACE) and angiotensinogen (AGT) genes have been reported to be related to diabetes mellitus and insulin sensitivity; however, the role of these genes in the developm...

journal_title：Kidney & blood pressure research

authors： Lee Sr,Moon JY,Lee SH,Ihm CG,Lee TW,Kim SK,Chung JH,Kang SW,Kim TH,Park SJ,Kim YH,Jeong KH

更新日期：2013-01-01 00:00:00

abstract：:The high mortality rate seen in dialysis patients is related to long-standing high blood pressure and the presence of other traditional as well as non-traditional risk factors for cardiovascular disease. Hypertension is associated with increased risk for left ventricular hypertrophy, coronary artery disease, congestiv...

journal_title：Kidney & blood pressure research

authors： Hörl MP,Hörl WH

更新日期：2003-01-01 00:00:00

abstract：:In the present study, the effects of hexachlorobenzene (HCB) on lipid peroxidation and heme metabolism in the different constitutive suborgans of the kidney were determined. For this purpose, conjugated diene and malondialdehyde levels, as lipid peroxidation parameters, and porphyrin accumulation, uroporphyrinogen dec...

journal_title：Kidney & blood pressure research

authors： Fernández-Tomé MC,Billi de Catabbi SC,Aldonatti C,San Martin de Viale LC,Sterin-Speziale NB

更新日期：2000-01-01 00:00:00