Abstract：
UNLABELLED:Anaemia is frequently found in patients with chronic heart failure (CHF) and has been associated with an increase in mortality and morbidity, impaired cardiac and renal function and a reduced quality of life (QoL) compared with non-anaemic CHF patients. Correction of anaemia with recombinant human erythropoietin (epoetin) has been associated with an improvement in CHF in both controlled and uncontrolled studies. The present study describes our findings in a series of 78 consecutive patients with symptomatic CHF and anaemia (haemoglobin (Hb) level <12.0 g/dl) treated with epoetin beta and, if necessary, intravenous iron sucrose. Over a mean observation period of 20.7 +/- 12.1 months, mean Hb levels increased from 10.2 +/- 1.1 to 13.5 +/- 1.2 g/dl, p < 0.01. New York Heart Association (NYHA) functional class, left ventricular ejection fraction (LVEF) were significantly improved and the number of hospitalizations was significantly reduced with the period before treatment (all p < 0.01). Serum creatinine and creatinine clearance (CCr) were 2.2 +/- 0.9 mg/dl and 32.5 +/- 26.5 ml/min, respectively, at baseline, and remained stable over the observation period. Interestingly, >90% of the patients had concomitant mild-to-moderate chronic kidney disease at baseline and study end (CKD), as defined by the accepted diagnostic criterion of a CCr <60 ml/min. CONCLUSIONS:The correction of the anaemia with epoetin beta together with initial intravenous iron supplementation, resulted in significant improvements in NYHA class and cardiac function, and a reduction in hospitalization rate. Moreover, renal function was maintained stable in most patients.
journal_name
Kidney Blood Press Resjournal_title
Kidney & blood pressure researchauthors
Silverberg DS,Wexler D,Blum M,Iaina A,Sheps D,Keren G,Scherhag A,Schwartz Ddoi
10.1159/000081621keywords:
subject
Has Abstractpub_date
2005-01-01 00:00:00pages
41-7issue
1eissn
1420-4096issn
1423-0143pii
81621journal_volume
28pub_type
杂志文章abstract：:Since reports of the first data on cytokines in renal diseases about 10 years ago, the field has seen an explosive growth over the last decade. It is now realized that cytokines can be synthesized by many different types of cells, including glomerular cells, upon adequate stimulation and exert a wide range of actions ...
journal_title：Kidney & blood pressure research
pub_type： 杂志文章,评审
doi：10.1159/000174088
更新日期：1996-01-01 00:00:00
abstract：BACKGROUND AND METHODS:We investigated kidney function, renal endothelin-1 concentration, prepro-endothelin-1 mRNA as well as endothelin receptor A and B mRNA expression and receptor properties in normotensive Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHR) with intact renal nerves and 7 days after re...
journal_title：Kidney & blood pressure research
pub_type： 杂志文章
doi：10.1159/000094571
更新日期：2006-01-01 00:00:00
abstract：BACKGROUND/AIMS:Ischemia/reperfusion (I/R) is the most common cause of acute renal injury. I/R-induced oxidative stress is involved in the development of acute renal injury, which can be reversed by supplementation with L-arginine, a precursor of nitric oxide (NO). This study was conducted to evaluate alterations in th...
journal_title：Kidney & blood pressure research
pub_type： 杂志文章
doi：10.1159/000480362
更新日期：2017-01-01 00:00:00
abstract：BACKGROUND/AIMS:Refugee dialysis is a worldwide growing dilemma with limited experience. This report presents the largest hemodialysis (HD) patient registry data of Syrian refugees in Turkey. METHODS:Demographic, clinical, laboratory, and dialysis practice data of 345 Syrian HD patients during one year were collected ...
journal_title：Kidney & blood pressure research
pub_type： 杂志文章
doi：10.1159/000498832
更新日期：2019-01-01 00:00:00
abstract：:Obesity increases the risk for chronic kidney disease (CKD). By analyzing data on individuals who underwent general health screening in two consecutive years, we investigated whether changes in body mass index (BMI) or waist circumference (WC) were associated with the appearance or disappearance of the CKD components;...
journal_title：Kidney & blood pressure research
pub_type： 杂志文章
doi：10.1159/000215739
更新日期：2009-01-01 00:00:00
abstract：BACKGROUND/AIMS:Excessive phosphate concentrations trigger vascular calcification, an active process promoted by osteoinduction of vascular smooth muscle cells (VSMCs) with increased expression and activity of transcription factor RUNX2 (Core-binding factor α1, CBFA1), alkaline phosphatase (ALPL), TGFß1, transcription ...
journal_title：Kidney & blood pressure research
pub_type： 杂志文章
doi：10.1159/000368524
更新日期：2015-01-01 00:00:00
abstract：:Progressive renal disease poses an increasing problem for the medical community. Though the causes of end-stage renal failure are multiple, the histologic pictures of chronic renal disease are remarkably similar being characterized by interstitial infiltration, fibrosis, tubular atrophy and dilatation. This similarity...
journal_title：Kidney & blood pressure research
pub_type： 杂志文章,评审
doi：10.1159/000025911
更新日期：1999-01-01 00:00:00
abstract：BACKGROUND/AIMS:Additional validation study was warranted to confirm the clinical significance of C score, which was recently added to the Oxford classification for immunoglobulin A nephropathy (IgAN). METHODS:We performed a multicenter retrospective cohort study in four hospitals in Korea. Patients who had biopsied g...
journal_title：Kidney & blood pressure research
pub_type： 杂志文章,多中心研究
doi：10.1159/000497808
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND:Hypertension in the elderly is commonly characterized by an elevation of pulse pressure. With regard to advanced arteriosclerosis and limited physical fitness, doubt was casted whether elderly patients still achieve relevant cardiovascular benefits by physical exercise. The present work examines the impact o...
journal_title：Kidney & blood pressure research
pub_type： 杂志文章,随机对照试验
doi：10.1159/000104093
更新日期：2007-01-01 00:00:00
abstract：BACKGROUND/AIMS:Lung dysfunction associates with increased mortality but the impact of chronic kidney disease (CKD) is less clear. We evaluated lung function and its association with mortality among individuals with normal to severely reduced glomerular filtration rate (GFR). METHODS:404 individuals representing GFR c...
journal_title：Kidney & blood pressure research
pub_type： 杂志文章
doi：10.1159/000488699
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND/AIMS:Calcium sensing receptor (CaSR) is expressed, among others also in testis. Cinacalcet binds to the CaSR, increases sensitivity of CaSR to serum calcium and is used in the treatment of secondary hyperparathyroidism (sHPT) in chronic hemodialysis patients (HDP). In most of male HDP, serum testosterone con...
journal_title：Kidney & blood pressure research
pub_type： 杂志文章
doi：10.1159/000368541
更新日期：2016-01-01 00:00:00
abstract：:Angiotensin-(1-7), (Ang-(1-7)), a metabolite of Ang II and /or Ang I, was infused into the renal artery (i.r.a) of anesthetized dogs in order to demonstrate its possible direct renal action. The dose administered, 15 Ig/kg BW/min in isotonic saline (0.072 ml/kg BW/min) throughout the experiment, did not influence the ...
journal_title：Kidney & blood pressure research
pub_type： 杂志文章
doi：10.1159/000025959
更新日期：2000-01-01 00:00:00
abstract：BACKGROUND/AIMS:Renalase (gene name RNLS), a recently discovered enzyme with monoamine oxidase activity, is implicated in the degradation of catecholamines. Recent studies indicate that common variations in the gene with RNLS are associated with hypertension. The aim of this study was to examine the association between...
journal_title：Kidney & blood pressure research
pub_type： 杂志文章
doi：10.1159/000368460
更新日期：2014-01-01 00:00:00
abstract：BACKGROUND:Urine osmolality indicates the ability of the kidney to concentrate the urine and reflects the antidiuretic action of vasopressin. However, results about the association between urine osmolality and adverse renal outcomes in chronic kidney disease (CKD) are conflicting. We investigated the association betwee...
journal_title：Kidney & blood pressure research
pub_type： 杂志文章
doi：10.1159/000502291
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND/AIMS:The contribution of preexisting hypercholesterolemia to diabetic nephropathy remains unclear. We assessed the impact of hypercholesterolemia on diabetic nephropathy using a double knockout (DKO) mouse, null for the low-density lipoprotein receptor (LDLRNDASH;/NDASH;) and the apoB mRNA editing catalytic ...
journal_title：Kidney & blood pressure research
pub_type： 杂志文章
doi：10.1159/000073942
更新日期：2003-01-01 00:00:00
abstract：BACKGROUND:Post-transplant diabetes mellitus (PTDM) is a common and serious metabolic complication. Genetic polymorphisms of angiotensin-converting enzyme (ACE) and angiotensinogen (AGT) genes have been reported to be related to diabetes mellitus and insulin sensitivity; however, the role of these genes in the developm...
journal_title：Kidney & blood pressure research
pub_type： 杂志文章
doi：10.1159/000343404
更新日期：2013-01-01 00:00:00
abstract：BACKGROUND/AIM:Serum gamma-glutamyltransferase (GGT), a biomarker of oxidative stress, is associated with an increased risk of diabetes and hypertension. However, it is not known whether higher serum GGT is independently associated with chronic kidney disease (CKD). Therefore, we examined the association between serum ...
journal_title：Kidney & blood pressure research
pub_type： 杂志文章
doi：10.1159/000274463
更新日期：2010-01-01 00:00:00
abstract：AIMS:The aim of this study was to screen several novel genes associated with renal cell carcinoma (RCC), and analyze the gene functions and signal pathways which were critical to RCCs with DNA microarray. METHODS:The gene expression profile of GSE781 was downloaded from Gene Expression Omnibus database, including 9 RC...
journal_title：Kidney & blood pressure research
pub_type： 杂志文章
doi：10.1159/000355726
更新日期：2013-01-01 00:00:00
abstract：BACKGROUND/AIMS:We explored the effects of catechins (decaffeinated green tea extracts containing (-)-epicatechin, (-)-epigallocatechin, (-)-epicatechin gallate and (-)-epigallocatechin gallate) on atherosclerosis risk factors, oxidized low-density lipoprotein (oxLDL) and its primary metabolite, phosphatidylcholine hyd...
journal_title：Kidney & blood pressure research
pub_type： 杂志文章
doi：10.1159/000485082
更新日期：2017-01-01 00:00:00
abstract：BACKGROUND/AIMS:Post-transplant hypertension is highly prevalent in renal transplant recipients and is a risk factor for graft loss, cardiovascular disease and death. Glucocorticoid is used to prevent rejection, but simultaneously increases the risk of post-transplant hypertension. The glucocorticoid-induced transcript...
journal_title：Kidney & blood pressure research
pub_type： 杂志文章
doi：10.1159/000485862
更新日期：2017-01-01 00:00:00
abstract：OBJECTIVES:This prospective, randomized study was to investigate the role of nicorandil in the prevention of contrast-induced nephropathy (CIN) in patients with chronic renal dysfunction undergoing an elective coronary procedure. METHODS:A total of 252 eligible patients were enrolled in this study and allocated into t...
journal_title：Kidney & blood pressure research
pub_type： 杂志文章,随机对照试验
doi：10.1159/000503160
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND/AIMS:The kinases SPAK (SPS1-related proline/alanine-rich kinase) and OSR1 (oxidative stress-responsive kinase 1) participate in the regulation of the NaCl cotransporter NCC and the Na+, K+, 2Cl- cotransporter NKCC2. The kinases are regulated by WNK (with-no-K[Lys]) kinases. Mutations of genes encoding WNK ki...
journal_title：Kidney & blood pressure research
pub_type： 杂志文章
doi：10.1159/000355812
更新日期：2014-01-01 00:00:00
abstract：BACKGROUND/AIMS:Chronic kidney disease (CKD) is one of the major complications of hypertension. It is not only associated with the future burden of end-stage renal disease but also affects mortality and cardiovascular outcomes caused by hypertension. To help understand the pathogenesis and early prevention of progressi...
journal_title：Kidney & blood pressure research
pub_type： 杂志文章
doi：10.1159/000443443
更新日期：2016-01-01 00:00:00
abstract：BACKGROUND:Fatty acid-bearing albumin [FA(+) albumin] exerts more deleterious effects in tubular cells than albumin alone. We investigated the effect of FA(+) albumin on the vascular cell adhesion molecule-1 (VCAM-1) expression and elucidated the underlying signaling pathways. We further examined the effect of L-carnit...
journal_title：Kidney & blood pressure research
pub_type： 杂志文章
doi：10.1159/000289576
更新日期：2010-01-01 00:00:00
abstract：BACKGROUND/AIMS:To prevent contrast induced renal dysfunction a periprocedural prophylactic hydration is applied. Due to dilution it should cause a drop in serum creatinine concentration (SCR). Surprisingly, no reduction in SCR after contrast admission is found in up to 25% of patients as early as 12-18 hours after cor...
journal_title：Kidney & blood pressure research
pub_type： 杂志文章
doi：10.1159/000443425
更新日期：2016-01-01 00:00:00
abstract：BACKGROUND/AIMS:Angiotensin-converting enzyme inhibitors and angiotensin II receptor antagonists have beneficial effects on impaired fibrinolytic activity of hypertensive patients. The aim of the study was to evaluate the effect of antialdosterone treatment on impaired fibrinolysis of hypertensive patients. METHODS:Fo...
journal_title：Kidney & blood pressure research
pub_type： 临床试验,杂志文章
doi：10.1159/000066348
更新日期：2002-01-01 00:00:00
abstract：:Backgroud/Aims: The aim of this study was to investigate the potential renoprotective effect of rapamycin on the autophagy of podocytes treated with the supernatant of mesangial cells cultured with aggregated IgA1 (aIgA1) from immunoglobulin A nephropathy (IgAN) patients. METHODS:Monomeric IgA1 (mIgA1) was isolated f...
journal_title：Kidney & blood pressure research
pub_type： 杂志文章
doi：10.1159/000475484
更新日期：2017-01-01 00:00:00
abstract：BACKGROUND/AIMS:Endothelial-to-mesenchymal transition (EndMT) of glomerular endothelial cells (GEnCs) can induce albuminuria in diabetic nephropathy. Melatonin attenuates diabetic nephropathy, but its role and mechanism in EndMT of GEnCs in diabetic nephropathy remain unknown. METHODS:The effect of melatonin on EndMT ...
journal_title：Kidney & blood pressure research
pub_type： 杂志文章
doi：10.1159/000493380
更新日期：2018-01-01 00:00:00
abstract：:The present investigation examined the possible influence of urinary calcium excretion on the concentration of renal calbindin-D28k. Thiazide diuretics stimulate calcium transport across the epithelial cells of the distal tubule, which express calbindin-D28k in high concentrations. Calbindin-D28k is assumed to facilit...
journal_title：Kidney & blood pressure research
pub_type： 杂志文章
doi：10.1159/000174153
更新日期：1997-01-01 00:00:00
abstract：BACKGROUND/AIMS:The deposition of β2-microglobulin induced by reactive inflammation causing carpal tunnel syndrome (CTS) is one of the complications of dialysis-related amyloidosis in maintenance hemodialysis (MHD) patients. Air pollution levels, especially particulate matter with an aerodynamic diameter of <2.5 mm (PM...
journal_title：Kidney & blood pressure research
pub_type： 杂志文章
doi：10.1159/000484422
更新日期：2017-01-01 00:00:00
