Abstract:
BACKGROUND/AIMS:To prevent contrast induced renal dysfunction a periprocedural prophylactic hydration is applied. Due to dilution it should cause a drop in serum creatinine concentration (SCR). Surprisingly, no reduction in SCR after contrast admission is found in up to 25% of patients as early as 12-18 hours after coronary angiography/angioplasty. This study aims to find a clinical explanation as well as predict circumstances for this phenomenon. METHODS:Retrospective clinical and laboratory data was used from 341 patients who underwent elective coronary angiography/angioplasty, received a prophylactic hydration, and had serum creatinine concentration measured prior to, and 12-18 hours after invasive procedure with iodine contrast administration. To exclude an improper hydration due to no creatinine decrease, the number of red blood cells was analysed as well as hemoglobin and hematocrit in blood donations collected during the study time points. RESULTS:The resulting lack of serum creatinine reduction could be explained by dehydration (measured by increase in number of RBC, HGB and HCT) only in 13.5% , 10.8%, and 20% of cases, respectively. Any form of abnormal glucose metabolism combined with either baseline serum creatinine concentration <0.87 mg/dL or creatinine clearance >86.77 mL/min, or GFR by CKD EPI >80.08 mL/min/1.73 m2, or GFR by MDRD >74.48 mL/min/1.73 m2 were the predictors for no creatinine decrease at outcome. Additionally, it was demonstrated that the lack of creatinine decrease was more often observed among those patients whose initial renal function was better than in the subjects with reduction of SCR. CONCLUSIONS:This observation requires further prospective investigation on extended group of patients.
journal_name
Kidney Blood Press Resjournal_title
Kidney & blood pressure researchauthors
Burchardt P,Rzezniczak J,Synowiec T,Angerer D,Palasz A,Zurawski Jdoi
10.1159/000443425subject
Has Abstractpub_date
2016-01-01 00:00:00pages
222-30issue
2eissn
1420-4096issn
1423-0143pii
000443425journal_volume
41pub_type
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journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000174256
更新日期:1997-01-01 00:00:00
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journal_title:Kidney & blood pressure research
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doi:10.1159/000355726
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journal_title:Kidney & blood pressure research
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journal_title:Kidney & blood pressure research
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doi:10.1159/000450562
更新日期:2016-01-01 00:00:00
abstract::Fibroblast growth factor 23 (FGF23) is released primarily from osteoblasts/osteocytes in bone. In cooperation with the transmembrane protein Klotho, FGF23 is a powerful inhibitor of 1α 25OH Vitamin D Hydroxylase (Cyp27b1) and thus of the formation of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3). As 1,25(OH)2D3 up-regulates ...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章,评审
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更新日期:2018-01-01 00:00:00
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journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000339026
更新日期:2012-01-01 00:00:00
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journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000110082
更新日期:2007-01-01 00:00:00
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journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000174110
更新日期:1997-01-01 00:00:00
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journal_title:Kidney & blood pressure research
pub_type: 杂志文章,评审
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journal_title:Kidney & blood pressure research
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doi:10.1159/000489749
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journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000025898
更新日期:1998-01-01 00:00:00
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journal_title:Kidney & blood pressure research
pub_type: 临床试验,杂志文章
doi:10.1159/000066348
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND/AIMS:Kidney function is critical for homocysteine (Hcy) clearance, and plasma Hcy levels are frequently increased in patients with renal failure. Microalbuminuria (MAU) is an important marker of early renal damage caused by hypertension. At present, there is insufficient evidence on the relationship between ...
journal_title:Kidney & blood pressure research
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doi:10.1159/000486013
更新日期:2017-01-01 00:00:00
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journal_title:Kidney & blood pressure research
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doi:10.1159/000485437
更新日期:2017-01-01 00:00:00
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journal_title:Kidney & blood pressure research
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doi:10.1159/000339707
更新日期:2012-01-01 00:00:00
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journal_title:Kidney & blood pressure research
pub_type: 杂志文章,评审
doi:10.1159/000025911
更新日期:1999-01-01 00:00:00
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journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000054209
更新日期:2001-01-01 00:00:00
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journal_title:Kidney & blood pressure research
pub_type: 杂志文章,meta分析
doi:10.1159/000493661
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND/AIMS:The metabolic syndrome (MetS), as assessed using dichotomous criteria, is associated with increased risk of future chronic kidney disease (CKD), though this relationship is unclear among African Americans, who have lower risk for MetS but higher risk for CKD. METHODS:We performed logistic regression us...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000488829
更新日期:2018-01-01 00:00:00
abstract::In the pathogenesis of anti-neutrophil cytoplasm antibodies (ANCA)-associated vasculitis, T cell contribution is indicated by T cell-dependent ANCA production combined with the presence of T cells in inflammatory infiltrates. However, the exact pathogenic role of T cells in ANCA-associated vasculitis remains to be det...
journal_title:Kidney & blood pressure research
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doi:10.1159/000501687
更新日期:2019-01-01 00:00:00
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journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000355754
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND/AIMS:The WNK-dependent STE20/SPS1-related proline/alanine-rich kinase SPAK participates in the regulation of NaCl and Na(+),K(+),2Cl(-) cotransport and thus renal salt excretion. The present study explored whether SPAK has similarly the potential to regulate the epithelial Na(+) channel (ENaC). METHODS:ENaC...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000368509
更新日期:2015-01-01 00:00:00
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journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000335950
更新日期:2012-01-01 00:00:00
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journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000368486
更新日期:2015-01-01 00:00:00
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journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000350149
更新日期:2013-01-01 00:00:00
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journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000368470
更新日期:2014-01-01 00:00:00
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journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000503346
更新日期:2019-01-01 00:00:00
abstract::Angiotensin-(1-7), (Ang-(1-7)), a metabolite of Ang II and /or Ang I, was infused into the renal artery (i.r.a) of anesthetized dogs in order to demonstrate its possible direct renal action. The dose administered, 15 Ig/kg BW/min in isotonic saline (0.072 ml/kg BW/min) throughout the experiment, did not influence the ...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000025959
更新日期:2000-01-01 00:00:00