Abstract：
BACKGROUND/AIMS:Kidney function is critical for homocysteine (Hcy) clearance, and plasma Hcy levels are frequently increased in patients with renal failure. Microalbuminuria (MAU) is an important marker of early renal damage caused by hypertension. At present, there is insufficient evidence on the relationship between Hcy and microalbuminuria. METHODS:This is a 1: 2 matched, hospital-based case-control study. At initial visit, out of 1535 outpatients with no prior history of medication, 450 qualified subjects were selected based on inclusion and exclusion criteria. The concentration of Hcy in the serum was evaluated using a cyclic enzyme method. MAU was defined by a urine albumin/creatinine ratio (UACR) between 30 μg/mg and 300 μg/mg. RESULTS:A total of 450 patients were included in this study (150 in the MAU group and 300 in the non-MAU group). The MAU group had higher mean systolic blood pressure (SBP), mean diastolic blood pressure (DBP), heart rate (HR) and plasma Hcy levels than did the non-MAU group. The area under the receiver operating characteristics (ROC) curves was 0.772 (95% CI: 0.724-0.819, P < 0.001) with a cut-off value of 15.0, and the sensitivity and specificity of Hcy in predicting the MAU status in hypertensive patients were 49.3% and 92.3%, respectively. Multiple logistic regression modelling suggested that patients with a higher Hcy level (> 15 µmol/L) were more likely to have MAU (95% CI: 5.650-16.543, P < 0.001). The other predictive factor for MAU was 24-h mean SBP (95% CI: 0.941-0.993, P = 0.015). CONCLUSION:This matched case-control study indicates that Hcy may increase the susceptibility of essential hypertensive subjects to MAU.
journal_name
Kidney Blood Press Resjournal_title
Kidney & blood pressure researchauthors
Kuang ZM,Wang Y,Feng SJ,Jiang L,Cheng WLdoi
10.1159/000486013subject
Has Abstractpub_date
2017-01-01 00:00:00pages
1303-1311issue
6eissn
1420-4096issn
1423-0143pii
000486013journal_volume
42pub_type
杂志文章abstract：:Although primary cilia are increasingly recognized to play sensory roles in several cellular systems, their role in vascular smooth muscle cells (VSMCs) has not been defined. We examined in situ position/orientation of primary cilia and ciliary proteins in VSMCs and tested the hypothesis that primary cilia of VSMCs ex...
journal_title：Kidney & blood pressure research
pub_type： 杂志文章
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journal_title：Kidney & blood pressure research
pub_type： 杂志文章,meta分析,评审
doi：10.1159/000450567
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doi：10.1159/000475484
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journal_title：Kidney & blood pressure research
pub_type： 杂志文章,评审
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journal_title：Kidney & blood pressure research
pub_type： 杂志文章
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journal_title：Kidney & blood pressure research
pub_type： 杂志文章
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journal_title：Kidney & blood pressure research
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journal_title：Kidney & blood pressure research
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journal_title：Kidney & blood pressure research
pub_type： 杂志文章
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journal_title：Kidney & blood pressure research
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journal_title：Kidney & blood pressure research
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journal_title：Kidney & blood pressure research
pub_type： 杂志文章,评审
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