Abstract:
BACKGROUND/AIMS:Interleukin (IL)-18, a member of the IL-1 cytokine superfamily, is recognized as an important regulator of immune responses. The aim of our study was to investigate the IL-18 levels in serum and urine from children with idiopathic nephrotic syndrome (INS) during relapse and remission, and to evaluate the role of IL-18 in this disease. METHODS:67 children with INS, aged 3-16 years, and 15 normal controls were included in the study. The patients were divided into two groups according to activity of the disease: I (n = 37) - INS in relapse, II (n = 30) - INS in remission. Serum and urinary IL-18 were determined by ELISA and in urine related to the urinary creatinine (Cr) concentration. Serum creatinine, protein, albumin and 24-hour proteinuria were measured in children with INS. RESULTS:Urinary IL-18 concentration was significantly higher in group I (213.51 +/- 162.15 pg/mg Cr) compared to group II (64.74 +/- 10.95 pg/mg Cr) and to normal controls (37.03 +/- 4.1 pg/mg Cr, p < 0.001). Serum IL-18 concentration was significantly higher in group I than in the controls (146.4 +/- 30.2 and 113 +/- 10 pg/ml, respectively; p < 0.05); the differences between either groups I and II or group II and controls were not significant. Urinary IL-18 correlated positively with serum IL-18 and with urinary protein excretion, but no correlations were found with other laboratory data. CONCLUSION:Increased serum and urine IL-18 levels were observed during relapse of INS. These findings indicate the association between the active phase of INS and the levels of IL-18 and can suggest the role of this cytokine in the INS development. The changes in urinary IL-18 excretion in the course of INS are connected with the disease activity.
journal_name
Kidney Blood Press Resjournal_title
Kidney & blood pressure researchauthors
Kiliś-Pstrusińska K,Medyńska A,Zwolińska D,Wawro Adoi
10.1159/000124284subject
Has Abstractpub_date
2008-01-01 00:00:00pages
122-6issue
2eissn
1420-4096issn
1423-0143pii
000124284journal_volume
31pub_type
杂志文章abstract:INTRODUCTION:Diabetic nephropathy (DN) is a serious complication of diabetes mellitus and is considered to be a sterile inflammatory disease. Increasing evidence suggest that pyroptosis and subsequent inflammatory response play a key role in the pathogenesis of DN. However, the underlying cellular and molecular mechani...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000508372
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND/AIMS:Refugee dialysis is a worldwide growing dilemma with limited experience. This report presents the largest hemodialysis (HD) patient registry data of Syrian refugees in Turkey. METHODS:Demographic, clinical, laboratory, and dialysis practice data of 345 Syrian HD patients during one year were collected ...
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journal_title:Kidney & blood pressure research
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doi:10.1159/000355740
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abstract::Although primary cilia are increasingly recognized to play sensory roles in several cellular systems, their role in vascular smooth muscle cells (VSMCs) has not been defined. We examined in situ position/orientation of primary cilia and ciliary proteins in VSMCs and tested the hypothesis that primary cilia of VSMCs ex...
journal_title:Kidney & blood pressure research
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journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000493380
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journal_title:Kidney & blood pressure research
pub_type: 杂志文章
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journal_title:Kidney & blood pressure research
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abstract:UNLABELLED:Anaemia is frequently found in patients with chronic heart failure (CHF) and has been associated with an increase in mortality and morbidity, impaired cardiac and renal function and a reduced quality of life (QoL) compared with non-anaemic CHF patients. Correction of anaemia with recombinant human erythropoi...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
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journal_title:Kidney & blood pressure research
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journal_title:Kidney & blood pressure research
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doi:10.1159/000339026
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journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000073942
更新日期:2003-01-01 00:00:00
abstract::Heart failure and chronic kidney disease share a number of risk factors and pathophysiological pathways. Renal insufficiency is common in patients with chronic heart failure (CHF). The aim of the study was to assess whether neutrophil gelatinase-associated lipocalin (NGAL) could represent a novel, sensitive marker of ...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000208989
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND/AIMS:To gain insight into the effect of arginine vasopressin (AVP) on renal hemodynamics in hypertensive rats, we investigated the vasoconstrictive response to AVP on total renal blood flow (RBF) and total and zonal glomerular filtration rate (GFR) in young and old spontaneously hypertensive rats (SHR). A hy...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
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abstract:BACKGROUND/AIMS:Additional validation study was warranted to confirm the clinical significance of C score, which was recently added to the Oxford classification for immunoglobulin A nephropathy (IgAN). METHODS:We performed a multicenter retrospective cohort study in four hospitals in Korea. Patients who had biopsied g...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章,多中心研究
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abstract:BACKGROUND/AIMS:Subclinical hypovolemia may contribute to allograft dysfunction in long-term kidney transplant (KT) patients. In order to predict responsiveness to saline hydration, indices for tubular transport were investigated. METHODS:Fifty-four clinically euvolemic long-term KT patients with recently aggravated a...
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doi:10.1159/000341124
更新日期:2012-01-01 00:00:00
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journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000368460
更新日期:2014-01-01 00:00:00
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journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000330717
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND/AIMS:We examined the factors associated with blood pressure variability in a multi-ethnicity prospective study in China to gain more evidence to guide the prevention and management of hypertension through risk factor intervention. METHODS:A total of 318 consecutive adult subjects aged 29-94 years with suspe...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000477424
更新日期:2017-01-01 00:00:00
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journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000443429
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abstract:BACKGROUND/AIMS:Diabetes mellitus can exacerbate renal ischemia-reperfusion (I/R) injury (RI/RI). The aim of the present study was to evaluate the protective effect of GSK-3β inhibition (TDZD-8) on I/R-induced renal injury through the Nrf2/HO-1 pathway in a streptozocin (STZ)-induced diabetic rat model. METHODS:STZ-in...
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journal_title:Kidney & blood pressure research
pub_type: 杂志文章,meta分析
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pub_type: 杂志文章
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更新日期:2010-01-01 00:00:00
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journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000443430
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND/AIMS:Excessive phosphate concentrations trigger vascular calcification, an active process promoted by osteoinduction of vascular smooth muscle cells (VSMCs) with increased expression and activity of transcription factor RUNX2 (Core-binding factor α1, CBFA1), alkaline phosphatase (ALPL), TGFß1, transcription ...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000368524
更新日期:2015-01-01 00:00:00
abstract::To clarify whether the ovaries have a potential to attenuate the aggravating effect of testosterone (T) on glomerular injury, we investigated the effect of T in female rats with or without ovaries, using Adriamycin (ADR)-induced nephropathy in female Sprague-Dawley rats. Group 1 consisted of female control rats, group...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000174110
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND:1,25-Dihydroxyvitamin D(3) is mainly synthesized by renal proximal tubular cells. More recently, it has been shown to affect cell growth and TGF-beta(1) synthesis in glomerular and tubular renal cells in vitro, and to prevent glomerulosclerosis in vivo in subtotally nephrectomized rats. The mechanisms involv...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000054213
更新日期:2001-01-01 00:00:00
abstract:BACKGROUNDS:ANCA-associated vasculitis (AAV) frequently present with a chronic relapsing course. Relapse leads to an increased need for therapeutic agents and consequent toxicity. SUMMARY:When referring to the available options for the management of AAV, the efficacy of glucocorticoids (GCs) is unquestionable. However...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章,评审
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更新日期:2020-01-01 00:00:00
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journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000501687
更新日期:2019-01-01 00:00:00
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journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000174052
更新日期:1996-01-01 00:00:00
abstract::The present investigation examined the possible influence of urinary calcium excretion on the concentration of renal calbindin-D28k. Thiazide diuretics stimulate calcium transport across the epithelial cells of the distal tubule, which express calbindin-D28k in high concentrations. Calbindin-D28k is assumed to facilit...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000174153
更新日期:1997-01-01 00:00:00