Abstract：
:In the failing heart, the local angiotensin II concentration is increased, and the extent of cardiac angiotensin II release is related to the clinical signs of heart failure. The enzymes involved in myocardial generation of angiotensin II are the angiotensin-converting enzyme (ACE) and chymases. While myocardial angiotensin II is mainly generated by chymases in the human heart, ACE inhibitors nevertheless improve left ventricular (LV) function, attenuate LV remodelling and reduce mortality in heart failure patients. These beneficial actions of ACE inhibitors, however, relate to their beneficial effect on kinin metabolism. Angiotensin II type 1 receptor (AT1) antagonists also mediate part of their beneficial effects through increased bradykinin formation. However, in contrast to ACE inhibitors, AT1 receptor antagonists attenuate downstream signalling of angiotensin II-induced AT1 receptor activation, which increases the activity of existing proteins (e.g. NADPH oxidase) and the de novo synthesis of proteins (e.g. inducible nitric oxide synthase, tumor necrosis factor-alpha ) in cardiomyocytes. Given the multiple actions of AT1 receptor activation on cardiomyocyte and non-cardiomyocyte function in the presence of an increased myocardial AngII concentration, the reduction of cardiovascular mortality and rate of hospitalization following AT1 receptor blockade in heart failure patients not receiving ACE inhibitors is not surprising. Most importantly, the beneficial effects of AT1 receptor blockade are not only achieved when used as an alternative to ACE inhibition, but also when used on top of ACE inhibitors.
journal_name
Kidney Blood Press Resjournal_title
Kidney & blood pressure researchauthors
Schulz R,Heusch Gdoi
10.1159/000090189keywords:
subject
Has Abstractpub_date
2005-01-01 00:00:00pages
349-52issue
5-6eissn
1420-4096issn
1423-0143pii
90189journal_volume
28pub_type
杂志文章,评审abstract：BACKGROUND/AIMS:Diabetes mellitus can exacerbate renal ischemia-reperfusion (I/R) injury (RI/RI). The aim of the present study was to evaluate the protective effect of GSK-3β inhibition (TDZD-8) on I/R-induced renal injury through the Nrf2/HO-1 pathway in a streptozocin (STZ)-induced diabetic rat model. METHODS:STZ-in...
journal_title：Kidney & blood pressure research
pub_type： 杂志文章
doi：10.1159/000477947
更新日期：2017-01-01 00:00:00
abstract：:A 70-year-old female patient with advanced Shy-Drager syndrome exhibited severe orthostatic hypotension, low serum catecholamine levels, and autonomic dysfunction. She was bedridden despite oral medication with fludrocortisone, etilefrin, dihydroergotamine, L-dopa, yohimbine, and amezinium methyl sulfate. Only intrave...
journal_title：Kidney & blood pressure research
pub_type： 杂志文章
doi：10.1159/000025846
更新日期：1998-01-01 00:00:00
abstract：BACKGROUND/AIMS:Renal tubulointerstitial fibrosis (TIF) is the common pathway of progressive chronic kidney disease. Inflammation has been widely accepted as the major driving force of TIF. Cystathionine β-synthase (CBS) is the first and rate-limiting enzyme in the transsulfuration pathway. CBS is considered to play pr...
journal_title：Kidney & blood pressure research
pub_type： 杂志文章
doi：10.1159/000479295
更新日期：2017-01-01 00:00:00
abstract：BACKGROUND/AIMS:Refugee dialysis is a worldwide growing dilemma with limited experience. This report presents the largest hemodialysis (HD) patient registry data of Syrian refugees in Turkey. METHODS:Demographic, clinical, laboratory, and dialysis practice data of 345 Syrian HD patients during one year were collected ...
journal_title：Kidney & blood pressure research
pub_type： 杂志文章
doi：10.1159/000498832
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND:There is limited evidence on the etiology and outcomes of renal infarction. A provoking factor is identified only in one- to two-thirds of patients. METHODS:This is a retrospective observational study. The clinical characteristics and outcomes of patients with acute renal infarction were studied; the sample...
journal_title：Kidney & blood pressure research
pub_type： 杂志文章
doi：10.1159/000503425
更新日期：2019-01-01 00:00:00
abstract：:Dopamine (DA) is a natriuretic hormone synthesized in the kidneys by conversion of filtered 3,4-dihydroxyphenylalanine (L-Dopa), and is activated during hypervolaemia and increased dietary sodium intake. The natriuretic activity of endogenous DA is controversial, however, and the regulation of renal DA synthesis has y...
journal_title：Kidney & blood pressure research
pub_type： 杂志文章
doi：10.1159/000174052
更新日期：1996-01-01 00:00:00
abstract：BACKGROUND/AIMS:This study aimed to report the clinical efficacy of continuous renal replacement therapy (CRRT) in combination with ultrasound-guided percutaneous transhepatic gallbladder drainage (PTGD) (CRRT+PTGD) in the treatment of acute severe biliary pancreatitis (ASBP). METHODS:Between January 2010 and January ...
journal_title：Kidney & blood pressure research
pub_type： 杂志文章
doi：10.1159/000485437
更新日期：2017-01-01 00:00:00
abstract：BACKGROUND/AIMS:To determine the effect of arterial blood pressure (BP) reduction on endocan and soluble cell adhesion molecules' (sCAM) plasma concentration and expression of their ligands on circulatory leukocyte subpopulations. METHODS:24 hypertensive subjects of both sexes (age: 53±8 yrs) were treated with Ca-chan...
journal_title：Kidney & blood pressure research
pub_type： 杂志文章
doi：10.1159/000350064
更新日期：2013-01-01 00:00:00
abstract：:The value of neutrophil-gelatinase-associated lipocalin (NGAL) was highlighted as a novel biomarker for the detection of acute renal failure. We tested the hypothesis whether NGAL could represent an early biomarker of contrast-induced nephropathy (CIN) in 100 patients with normal serum creatinine values undergoing per...
journal_title：Kidney & blood pressure research
pub_type： 临床试验,杂志文章
doi：10.1159/000109102
更新日期：2007-01-01 00:00:00
abstract：:To clarify whether the ovaries have a potential to attenuate the aggravating effect of testosterone (T) on glomerular injury, we investigated the effect of T in female rats with or without ovaries, using Adriamycin (ADR)-induced nephropathy in female Sprague-Dawley rats. Group 1 consisted of female control rats, group...
journal_title：Kidney & blood pressure research
pub_type： 杂志文章
doi：10.1159/000174110
更新日期：1997-01-01 00:00:00
abstract：:The high mortality rate seen in dialysis patients is related to long-standing high blood pressure and the presence of other traditional as well as non-traditional risk factors for cardiovascular disease. Hypertension is associated with increased risk for left ventricular hypertrophy, coronary artery disease, congestiv...
journal_title：Kidney & blood pressure research
pub_type： 杂志文章,评审
doi：10.1159/000070987
更新日期：2003-01-01 00:00:00
abstract：BACKGROUND/AIMS:Apparent treatment resistant hypertension (aTRH) is highly prevalent in patients with type 2 diabetes (T2D) and chronic kidney disease (CKD). The impact of aTRH and achievement of recommended blood pressure (BP) values on the rate of glomerular filtration rate (eGFR) loss in CKD patients is poorly known...
journal_title：Kidney & blood pressure research
pub_type： 杂志文章
doi：10.1159/000488255
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND/AIMS:Rapamycin inhibits cyst growth in polycystic kidney disease by targeting the mammalian target of rapamycin (mTOR). To determine if this is a class effect of the mTOR inhibitors, we examined the effect of everolimus, the analogue of rapamycin, on disease progression in the Han:SPRD rat model of polycysti...
journal_title：Kidney & blood pressure research
pub_type： 杂志文章
doi：10.1159/000104818
更新日期：2007-01-01 00:00:00
abstract：BACKGROUND:Urine osmolality indicates the ability of the kidney to concentrate the urine and reflects the antidiuretic action of vasopressin. However, results about the association between urine osmolality and adverse renal outcomes in chronic kidney disease (CKD) are conflicting. We investigated the association betwee...
journal_title：Kidney & blood pressure research
pub_type： 杂志文章
doi：10.1159/000502291
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND/AIMS:Ischemia/reperfusion (I/R) is the most common cause of acute renal injury. I/R-induced oxidative stress is involved in the development of acute renal injury, which can be reversed by supplementation with L-arginine, a precursor of nitric oxide (NO). This study was conducted to evaluate alterations in th...
journal_title：Kidney & blood pressure research
pub_type： 杂志文章
doi：10.1159/000480362
更新日期：2017-01-01 00:00:00
abstract：AIMS AND METHODS:Our aim was to evaluate the antihypertensive efficacy and tolerability of angiotensin II type 1 (AT1) receptor antagonists. Valsartan or candesartan cilexetil was administered to 11 dialysis patients with elevated blood pressure. The patients (6 male, 5 female; mean age +/- SD 61+/-11 years) were on re...
journal_title：Kidney & blood pressure research
pub_type： 杂志文章
doi：10.1159/000054209
更新日期：2001-01-01 00:00:00
abstract：BACKGROUND:Uremic toxins have been shown to promote glomerular hypertrophy. The present study was performed to elucidate the relation between uremic toxins and tubulointerstitial changes. METHODS:Sixty male Sprague-Dawley rats underwent 2/3 nephrectomy (Nx; n = 30) and 4/5 Nx (n = 30). Experiments were initiated 2 wee...
journal_title：Kidney & blood pressure research
pub_type： 杂志文章
doi：10.1159/000080935
更新日期：2005-01-01 00:00:00
abstract：BACKGROUND:Vascular accesses (especially polytetrafluoroethylene grafts) with a permanently low flow (Qa <600 ml/min) are prone to thrombosis and thus have short patency. The reason for a permanently low flow is usually medial calcinosis of the inflow artery in diabetics. We retrospectively studied the long-term patenc...
journal_title：Kidney & blood pressure research
pub_type： 杂志文章
doi：10.1159/000316702
更新日期：2010-01-01 00:00:00
abstract：BACKGROUND/AIMS:Kidney function is critical for homocysteine (Hcy) clearance, and plasma Hcy levels are frequently increased in patients with renal failure. Microalbuminuria (MAU) is an important marker of early renal damage caused by hypertension. At present, there is insufficient evidence on the relationship between ...
journal_title：Kidney & blood pressure research
pub_type： 杂志文章
doi：10.1159/000486013
更新日期：2017-01-01 00:00:00
abstract：BACKGROUND/AIM:Our aim was to determine whether altered human β-defensin (HBD), pro-inflammatory cytokines including interleukin (IL)-6 and tumor necrotic factor (TNF)-α could increase the risk of developing and exacerbation of chronic kidney disease (CKD), especially for patients with diabetic nephropathy (DN). METHO...
journal_title：Kidney & blood pressure research
pub_type： 杂志文章
doi：10.1159/000355740
更新日期：2013-01-01 00:00:00
abstract：:Renal proximal tubular Na/phosphate cotransport is the key target in the control of renal phosphate handling. Using molecular tools for the type II Na/phosphate cotransporter, it could be documented that altered brush border membrane phosphate transport reflects a state of altered brush border expression of the specif...
journal_title：Kidney & blood pressure research
pub_type： 杂志文章,评审
doi：10.1159/000174063
更新日期：1996-01-01 00:00:00
abstract：BACKGROUND/AIMS:To gain insight into the effect of arginine vasopressin (AVP) on renal hemodynamics in hypertensive rats, we investigated the vasoconstrictive response to AVP on total renal blood flow (RBF) and total and zonal glomerular filtration rate (GFR) in young and old spontaneously hypertensive rats (SHR). A hy...
journal_title：Kidney & blood pressure research
pub_type： 杂志文章
doi：10.1159/000054225
更新日期：2001-01-01 00:00:00
abstract：BACKGROUND/AIMS:The Janus kinase 3 JAK3 participates in the signaling of immune cells. Lack of JAK3 triggers inflammatory bowel disease, which in turn has been shown to affect intestinal activity of the epithelial Na(+) channel ENaC and thus colonic sodium absorption. At least in theory, inflammatory bowel disease in J...
journal_title：Kidney & blood pressure research
pub_type： 杂志文章
doi：10.1159/000355731
更新日期：2013-01-01 00:00:00
abstract：BACKGROUND/AIMS:Lung dysfunction associates with increased mortality but the impact of chronic kidney disease (CKD) is less clear. We evaluated lung function and its association with mortality among individuals with normal to severely reduced glomerular filtration rate (GFR). METHODS:404 individuals representing GFR c...
journal_title：Kidney & blood pressure research
pub_type： 杂志文章
doi：10.1159/000488699
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND/AIMS:The aim of our study was to retrospectively analyse data of 520 Czech patients with IgA nephropathy (IgAN) and to specify the risk factors affecting renal survival of IgAN patients. METHODS:Cox proportional hazards regression model was used to evaluate the effects of different variables on renal surviv...
journal_title：Kidney & blood pressure research
pub_type： 杂志文章
doi：10.1159/000368467
更新日期：2014-01-01 00:00:00
abstract：BACKGROUND/AIMS:Subclinical hypovolemia may contribute to allograft dysfunction in long-term kidney transplant (KT) patients. In order to predict responsiveness to saline hydration, indices for tubular transport were investigated. METHODS:Fifty-four clinically euvolemic long-term KT patients with recently aggravated a...
journal_title：Kidney & blood pressure research
pub_type： 杂志文章
doi：10.1159/000341124
更新日期：2012-01-01 00:00:00
abstract：BACKGROUND/AIMS:Renal tubulointerstitium plays an important role in the development and progression of diabetic nephropathy. METHODS:With the present study, we aimed at evaluating the levels of neutrophil gelatinase-associated lipocalin (NGAL), a tubular stress protein, in serum (sNGAL) and urine (uNGAL) from a cohort...
journal_title：Kidney & blood pressure research
pub_type： 杂志文章
doi：10.1159/000209379
更新日期：2009-01-01 00:00:00
abstract：:The aim of this study was to investigate whether the renoprotective effect of angiotensin-converting enzyme inhibitors (ACEIs) following 5/6 renal mass reduction is due in part to the potentiation of kinins. Three groups of rats with 5/6 renal mass reduction were studied during the 14 weeks following surgery. One grou...
journal_title：Kidney & blood pressure research
pub_type： 杂志文章
doi：10.1159/000025890
更新日期：1998-01-01 00:00:00
abstract：BACKGROUND/AIMS:High mobility group box 1 (HMGB1) is an important mediator of the inflammatory response. It has been implicated in the pathogenesis of autoimmune diseases, atherosclerosis, and obesity. However, the effects of HMGB1 on diabetic nephropathy remain unclear. Here, we investigated the potential roles and me...
journal_title：Kidney & blood pressure research
pub_type： 杂志文章
doi：10.1159/000485045
更新日期：2017-01-01 00:00:00
abstract：:In the present study, the effects of hexachlorobenzene (HCB) on lipid peroxidation and heme metabolism in the different constitutive suborgans of the kidney were determined. For this purpose, conjugated diene and malondialdehyde levels, as lipid peroxidation parameters, and porphyrin accumulation, uroporphyrinogen dec...
journal_title：Kidney & blood pressure research
pub_type： 杂志文章
doi：10.1159/000025950
更新日期：2000-01-01 00:00:00
