Abstract:
BACKGROUND/AIMS:Rapamycin inhibits cyst growth in polycystic kidney disease by targeting the mammalian target of rapamycin (mTOR). To determine if this is a class effect of the mTOR inhibitors, we examined the effect of everolimus, the analogue of rapamycin, on disease progression in the Han:SPRD rat model of polycystic kidney disease. METHODS:Four-week-old male heterozygous cystic (Cy/+) and wild-type normal (+/+) Han:SPRD rats were administered everolimus or vehicle (3 mg/kg/day) by gavage for 5 weeks. Kidney function and whole-blood trough levels of everolimus were monitored. After treatment kidney weight and cyst volume density were assessed. Tubule epithelial cell proliferation was assessed by BrdU staining. RESULTS:Everolimus trough levels between 5 and 7 microg/l were sufficient to significantly reduce kidney and cyst volume density by approximately 50 and 40%, respectively. The steady decrease of kidney function in Cy/+ rats was reduced by 30% compared with vehicle-treated Cy/+ rats. Everolimus treatment markedly reduced the number of 5-bromo-2-deoxyuridine-labeled nuclei in cyst epithelia. Body weight gain and kidney function were impaired in everolimus-treated wild-type rats. CONCLUSION:Moderate dosage of everolimus inhibits cystogenesis in Han:SPRD rats. The inhibitory effect of everolimus appears to represent a class effect of mTOR inhibitors.
journal_name
Kidney Blood Press Resjournal_title
Kidney & blood pressure researchauthors
Wu M,Wahl PR,Le Hir M,Wackerle-Men Y,Wuthrich RP,Serra ALdoi
10.1159/000104818subject
Has Abstractpub_date
2007-01-01 00:00:00pages
253-9issue
4eissn
1420-4096issn
1423-0143pii
000104818journal_volume
30pub_type
杂志文章abstract:BACKGROUND:Cardiovascular complications are a major cause of morbidity and mortality in chronic renal failure (CRF) patients. Chronic anemia is a complication of CRF and a cardiovascular risk factor per se. It was the aim of the present study to clarify whether uremia and anemia are additive or supra-additive with resp...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000317943
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND/AIMS:Chronic kidney disease (CKD) is often accompanied by hyperlipidemia, which accelerates progression of the disease. Podocyte injury can lead to dysfunction of the glomerular filtration barrier, which is associated with proteinuria, a risk marker for the progression of CKD. Our previous studies demonstrat...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000487673
更新日期:2018-01-01 00:00:00
abstract::The value of neutrophil-gelatinase-associated lipocalin (NGAL) was highlighted as a novel biomarker for the detection of acute renal failure. We tested the hypothesis whether NGAL could represent an early biomarker of contrast-induced nephropathy (CIN) in 100 patients with normal serum creatinine values undergoing per...
journal_title:Kidney & blood pressure research
pub_type: 临床试验,杂志文章
doi:10.1159/000109102
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:The biological properties of oxidized and non-oxidized PTH are substantially different. Oxidized PTH (oxPTH) loses its PTH receptor-stimulating properties, whereas non-oxidized PTH (n-oxPTH) is a full agonist of the receptor. This was described in more than 20 well published studies in the 1970(s) and 80(s)....
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000350149
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND/AIMS:Calcium sensing receptor (CaSR) is expressed, among others also in testis. Cinacalcet binds to the CaSR, increases sensitivity of CaSR to serum calcium and is used in the treatment of secondary hyperparathyroidism (sHPT) in chronic hemodialysis patients (HDP). In most of male HDP, serum testosterone con...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000368541
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Treating non-diabetic proteinuric patients with advanced renal disease with an angiotensin-converting enzyme (ACE) inhibitor is still subject to discussion. This study aims to determine the cost-effectiveness of ACE inhibitor therapy in this patient population in the Netherlands. METHODS:We compared two str...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000350142
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:The oxidative stress-responsive kinase 1 (OSR1) participates in the WNK-(with no K) kinase dependent regulation of renal salt excretion and blood pressure. Little is known, however, about the role of OSR1 in the regulation of further renal transport systems. The present study analyzed the effect of OSR1 on N...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000343405
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND/AIMS:Interleukin (IL)-18, a member of the IL-1 cytokine superfamily, is recognized as an important regulator of immune responses. The aim of our study was to investigate the IL-18 levels in serum and urine from children with idiopathic nephrotic syndrome (INS) during relapse and remission, and to evaluate th...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000124284
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND/AIMS:ET-1 has independent effects on blood pressure regulation in vivo, it is involved in tubular water and salt excretion, promotes constriction of smooth muscle cells, modulates sympathetic nerve activity, and activates the liberation of nitric oxide. To determine the net effect of these partially countera...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章,meta分析,评审
doi:10.1159/000450567
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND/AIMS:The presence of protein-energy wasting (PEW) among dialysis patients is a crucial risk factor for outcomes. The complicated pathogenesis of PEW makes it difficult to assess and treat. This single-center retrospective study focuses on the association between nutritional markers and the outcomes of contin...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000485926
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND/AIMS:Renal tubulointerstitium plays an important role in the development and progression of diabetic nephropathy. METHODS:With the present study, we aimed at evaluating the levels of neutrophil gelatinase-associated lipocalin (NGAL), a tubular stress protein, in serum (sNGAL) and urine (uNGAL) from a cohort...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000209379
更新日期:2009-01-01 00:00:00
abstract::The interaction between renal nerves, endothelins acting via endothelin-A receptors and vasopressin in the regulation of renal excretory function was investigated. In conscious intact and renal denervated diabetes insipidus (DI) Brattleboro rats, as well as their controls, Long-Evans (LE) rats, an infusion of 16.4 nmo...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000054199
更新日期:2001-01-01 00:00:00
abstract::Since reports of the first data on cytokines in renal diseases about 10 years ago, the field has seen an explosive growth over the last decade. It is now realized that cytokines can be synthesized by many different types of cells, including glomerular cells, upon adequate stimulation and exert a wide range of actions ...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章,评审
doi:10.1159/000174088
更新日期:1996-01-01 00:00:00
abstract:BACKGROUND/AIMS:IgA nephropathy is associated with aberrant O-glycosylation of IgA1, which is recognized by autoantibodies leading to the formation of circulating immune complexes. Some of them, after deposition into kidney mesangium, trigger glomerular injury. In patients with active disease nonresponding to angiotens...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000487903
更新日期:2018-01-01 00:00:00
abstract::The effects on glomerular hemodynamics of angiotensin-converting enzyme (ACE) inhibition with captopril and of angiotensin II receptor blockade with EXP 3174, an active metabolite of losartan, either alone or in combination, were compared in anesthetized dogs. Administration of EXP 3174 intrarenally led to an increase...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000174256
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Magnoline is an active ingredient of magnolia fargesii with anti-inflammatory and anti-platelet effects. The objective is to explore the renoprotection of magnoline in diabetic rats and its effects on P-selectin. METHODS:Thirty-six rats were randomized into 4 groups-normal control group (C), d...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000350146
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:Co-deposition of mannose-binding lectin (MBL) and IgG4 anti-phospholipase A2 receptor (anti-PLA2R) autoantibodies under subepithelial cells has been observed in patients with idiopathic membranous nephropathy (iMN), but the relationships of MBL deposition to iMN severity and progression remain unclear. METHO...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000508665
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND/AIMS:We explored the effects of catechins (decaffeinated green tea extracts containing (-)-epicatechin, (-)-epigallocatechin, (-)-epicatechin gallate and (-)-epigallocatechin gallate) on atherosclerosis risk factors, oxidized low-density lipoprotein (oxLDL) and its primary metabolite, phosphatidylcholine hyd...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000485082
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND/AIMS:Cardiovascular morbidity and mortality are high in patients with chronic kidney disease. We evaluated the influence of small differences in preoperative kidney function on mortality and complications following cardiac surgery. METHODS:This is an observational study that included adult patients undergoi...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000335950
更新日期:2012-01-01 00:00:00
abstract::Fibroblast growth factor 23 (FGF23) is released primarily from osteoblasts/osteocytes in bone. In cooperation with the transmembrane protein Klotho, FGF23 is a powerful inhibitor of 1α 25OH Vitamin D Hydroxylase (Cyp27b1) and thus of the formation of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3). As 1,25(OH)2D3 up-regulates ...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章,评审
doi:10.1159/000495393
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND/AIMS:OSR1 (oxidative-stress-responsive kinase 1) participates in the regulation of renal tubular ion transport, cell volume and blood pressure. Whether OSR1 contributes to the regulation of organic solute transport remained; however, elusive. The present study thus explored the OSR1 sensitivity of the peptid...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000368469
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Diabetic nephropathy constitutes a large proportion of end-stage kidney failure in diabetic patients. However, the underlying molecular mechanisms remain unclear. METHODS:Db/db diabetic mouse models and high glucose (HG)-induced human renal mesangial cells (HRMCs) were used as research models in vivo and in...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000508078
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND/AIMS:High mobility group box 1 (HMGB1) is an important mediator of the inflammatory response. It has been implicated in the pathogenesis of autoimmune diseases, atherosclerosis, and obesity. However, the effects of HMGB1 on diabetic nephropathy remain unclear. Here, we investigated the potential roles and me...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000485045
更新日期:2017-01-01 00:00:00
abstract::Inhibitors of angiotensin-converting enzyme (ACE) or beta isoforms of protein kinase C (PKC) are nephroprotective in diabetes mellitus. We investigated the influence of streptozotocin (STZ)-induced diabetes mellitus and of treatment with the ACE inhibitor lisinopril (4 mg/kg p.o. twice daily for 4 weeks) on the expres...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000066789
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:Cardiac death is increased in peritoneal dialysis (PD) patients. Pulse wave velocity (PWV) is a measurement of arterial stiffness, and previous reports linked PWV to increased extracellular water (ECW). As cyclers and icodextrin are increasingly used, we wished to determine whether this association between P...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000503424
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND/AIMS:The metabolic syndrome (MetS), as assessed using dichotomous criteria, is associated with increased risk of future chronic kidney disease (CKD), though this relationship is unclear among African Americans, who have lower risk for MetS but higher risk for CKD. METHODS:We performed logistic regression us...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000488829
更新日期:2018-01-01 00:00:00
abstract::The high mortality rate seen in dialysis patients is related to long-standing high blood pressure and the presence of other traditional as well as non-traditional risk factors for cardiovascular disease. Hypertension is associated with increased risk for left ventricular hypertrophy, coronary artery disease, congestiv...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章,评审
doi:10.1159/000070987
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:In uremic patients coronary surgery and the entire perioperative management is demanding. METHODS:We analyzed retrospectively data from all patients requiring chronic hemodialysis who under went coronary artery bypass grafting (CABG) between January 1 2001 and December 31 2004 at the Deutsches Herzzentrum B...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000090180
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:Hypertension in the elderly is commonly characterized by an elevation of pulse pressure. With regard to advanced arteriosclerosis and limited physical fitness, doubt was casted whether elderly patients still achieve relevant cardiovascular benefits by physical exercise. The present work examines the impact o...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章,随机对照试验
doi:10.1159/000104093
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:The antiproteinuric effect of angiotensin-converting enzyme (ACE) inhibitors appears to vary depending on the ACE insertion (I)/deletion (D) genotype in non-diabetic nephropathy. This interaction may be overcome by using an angiotensin II receptor blocker. We evaluated the short-term antiproteinuric effect o...
journal_title:Kidney & blood pressure research
pub_type: 临床试验,杂志文章
doi:10.1159/000095736
更新日期:2006-01-01 00:00:00