Neutrophil gelatinase-associated lipocalin as an early biomarker of nephropathy in diabetic patients.

abstract：BACKGROUND/AIMS:Post-transplant hypertension is highly prevalent in renal transplant recipients and is a risk factor for graft loss, cardiovascular disease and death. Glucocorticoid is used to prevent rejection, but simultaneously increases the risk of post-transplant hypertension. The glucocorticoid-induced transcript...

journal_title：Kidney & blood pressure research

authors： Hamada AM,Yamamoto I,Nakada Y,Kobayashi A,Koike Y,Miki J,Yamada H,Tanno Y,Ohkido I,Tsuboi N,Yamamoto H,Urashima M,Yokoo T

更新日期：2017-01-01 00:00:00

abstract：:Currently, the pathogenesis of nondipper hypertension remains largely unclear in patients without any renal or endocrine pathology. It is well known that overt hypothyroidism is strongly associated with diastolic hypertension. However, no study has addressed the pathogenic role of TSH, free T3 (FT3), and free T4 (FT4)...

journal_title：Kidney & blood pressure research

authors： Kanbay M,Turgut F,Karakurt F,Isik B,Alkan R,Akcay A,Yigitoglu R,Covic A

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Metabolic acidosis may be diagnosed as chronic (cMA) if it persists for at least 5 days, although an exact definition has not been provided by any guidelines yet. The most common cause is CKD; numerous less-known diseases can also account for cMA. SUMMARY:In recent years, CKD-associated cMA has been propose...

journal_title：Kidney & blood pressure research

authors： Patschan D,Patschan S,Ritter O

更新日期：2020-01-01 00:00:00

abstract：:The aim of this study was to investigate whether the renoprotective effect of angiotensin-converting enzyme inhibitors (ACEIs) following 5/6 renal mass reduction is due in part to the potentiation of kinins. Three groups of rats with 5/6 renal mass reduction were studied during the 14 weeks following surgery. One grou...

journal_title：Kidney & blood pressure research

authors： MacLaughlin M,Monserrat AJ,Muller A,Matoso M,Amorena C

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND/AIMS:The role of endothelin (ET) in cardiovascular remodeling was investigated by treating uninephrectomized spontaneously hypertensive rats of the stroke-prone strain (UNX-SHRsp) on normal- or high (3%)-salt diet with the selective ET(A) receptor blocker LU 135252. METHODS:SHRsp on normal or high salt were...

journal_title：Kidney & blood pressure research

authors： Orth SR,Schiele G,Banas B,Ritz E,Amann K

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Cardiovascular disease caused by atherosclerosis remains a major cause of morbidity and mortality in patients with end-stage renal disease (ESRD). We evaluated the potential association of cardiovascular risk factors including asymmetric dimethyl L-arginine (ADMA) and the soluble receptor for advanced glycat...

journal_title：Kidney & blood pressure research

authors： Pitha J,Teplan V,Kalousova M,Racek J,Stollova M,Marečková O,Lanska V

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND/AIMS:The main purpose of the present study was to determine the effect of peritoneal charge barrier dysfunction on hypoalbuminemia during CAPD. METHODS:We measured the association of dialysis dose, peritoneal equilibration test (PET) results (ratio of dialysate and plasma creatinine), and peritoneal charge ...

journal_title：Kidney & blood pressure research

authors： Yu GQ,Chen J,Li JX

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Cardiovascular complications are a major cause of morbidity and mortality in chronic renal failure (CRF) patients. Chronic anemia is a complication of CRF and a cardiovascular risk factor per se. It was the aim of the present study to clarify whether uremia and anemia are additive or supra-additive with resp...

journal_title：Kidney & blood pressure research

authors： Jürgensen JS,Grimm R,Benz K,Philipp S,Eckardt KU,Amann K

更新日期：2010-01-01 00:00:00

abstract：:Cardiovascular (CV) morbidity and mortality is greatly enhanced in patients with chronic kidney disease, compared to the non-renal population. One key element of this high CV burden appears to be arterial stiffness, as an expression of premature vascular aging. Increased arterial stiffness in renal patients may be a c...

journal_title：Kidney & blood pressure research

authors： Gusbeth-Tatomir P,Covic A

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND/AIMS:ET-1 has independent effects on blood pressure regulation in vivo, it is involved in tubular water and salt excretion, promotes constriction of smooth muscle cells, modulates sympathetic nerve activity, and activates the liberation of nitric oxide. To determine the net effect of these partially countera...

journal_title：Kidney & blood pressure research

authors： Lu YP,Tsuprykov O,Vignon-Zellweger N,Heiden S,Hocher B

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND/AIMS:This experimental study was designed to investigate protective and therapeutic effects of Dexpanthenol (Dxp), an alcoholic analogue of pantothenic acid, on kidney damage induced by ischemia-reperfusion (I/R) in rats. METHODS:Forty rats were randomly divided into a control group and 4 I/R groups (1 h is...

journal_title：Kidney & blood pressure research

authors： Altintas R,Parlakpinar H,Beytur A,Vardi N,Polat A,Sagir M,Odabas GP

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND/AIMS:To prevent contrast induced renal dysfunction a periprocedural prophylactic hydration is applied. Due to dilution it should cause a drop in serum creatinine concentration (SCR). Surprisingly, no reduction in SCR after contrast admission is found in up to 25% of patients as early as 12-18 hours after cor...

journal_title：Kidney & blood pressure research

authors： Burchardt P,Rzezniczak J,Synowiec T,Angerer D,Palasz A,Zurawski J

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Vascular accesses (especially polytetrafluoroethylene grafts) with a permanently low flow (Qa <600 ml/min) are prone to thrombosis and thus have short patency. The reason for a permanently low flow is usually medial calcinosis of the inflow artery in diabetics. We retrospectively studied the long-term patenc...

journal_title：Kidney & blood pressure research

authors： Malik J,Tuka V,Chytilova E,Mokrejsova M,Masek M,Slavikova M

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND AND METHODS:We investigated kidney function, renal endothelin-1 concentration, prepro-endothelin-1 mRNA as well as endothelin receptor A and B mRNA expression and receptor properties in normotensive Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHR) with intact renal nerves and 7 days after re...

journal_title：Kidney & blood pressure research

authors： Girchev RA,Bäcker A,Markova PP,Kramer HJ

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND/AIMS:Cardiorenal syndrome type 1 (CRS1) is a syndrome characterized by a rapid worsening of cardiac function leading to acute kidney injury (AKI). The aims of this study were to investigate the risk factors and the prognosis of CRS1 in elderly patients. METHODS:A total of 312 elderly patients (≥60 years old...

journal_title：Kidney & blood pressure research

authors： Hu W,He W,Liu W,Fang X,Wu Y,Yu F,Hao W

更新日期：2016-01-01 00:00:00

abstract：:Pravastatin is a potent inhibitor of HMG-CoA reductase and is effective in lowering serum lipid levels. Recent studies have shown that pravastatin also reduces the oxidative modification of low-density lipoprotein (LDL). To determine whether pravastatin has a direct effect on glomerular mesangial cells, we have measur...

journal_title：Kidney & blood pressure research

authors： Chen HC,Guh JY,Shin SJ,Tomino Y,Lai YH

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Mesenchymal stem cells (MSC) improve renal function and renovascular hypertension in the 2-kidney 1-clip model (2K-1C). While MSC play an immunomodulatory role, induce neoangiogenesis, and reduce fibrosis, they do not correct sodium loss by the contra-lateral kidney. OBJECTIVES:We investigated the tubular f...

journal_title：Kidney & blood pressure research

authors： Varela VA,Oliveira-Sales EB,Maquigussa E,Borges FT,Gattai PP,Novaes ADS,Shimoura CG,Campos RR,Boim MA

更新日期：2019-01-01 00:00:00

abstract：:MicroRNAs (miRNAs) are short, single-stranded, noncoding RNAs that modulate many key biological processes by simultaneously suppressing multiple target genes. Among them, miR-26a, a conserved miRNA among vertebrates, is highly expressed in various tissues. Accumulating evidence demonstrates that miR-26a plays pivotal ...

journal_title：Kidney & blood pressure research

authors： Li X,Pan X,Fu X,Yang Y,Chen J,Lin W

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND/AIMS:The deposition of β2-microglobulin induced by reactive inflammation causing carpal tunnel syndrome (CTS) is one of the complications of dialysis-related amyloidosis in maintenance hemodialysis (MHD) patients. Air pollution levels, especially particulate matter with an aerodynamic diameter of <2.5 mm (PM...

journal_title：Kidney & blood pressure research

authors： Weng CH,Hu CC,Yen TH,Huang WH

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND/AIMS:Excessive phosphate concentrations trigger vascular calcification, an active process promoted by osteoinduction of vascular smooth muscle cells (VSMCs) with increased expression and activity of transcription factor RUNX2 (Core-binding factor α1, CBFA1), alkaline phosphatase (ALPL), TGFß1, transcription ...

journal_title：Kidney & blood pressure research

authors： Alesutan I,Musculus K,Castor T,Alzoubi K,Voelkl J,Lang F

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Fatty acid-bearing albumin [FA(+) albumin] exerts more deleterious effects in tubular cells than albumin alone. We investigated the effect of FA(+) albumin on the vascular cell adhesion molecule-1 (VCAM-1) expression and elucidated the underlying signaling pathways. We further examined the effect of L-carnit...

journal_title：Kidney & blood pressure research

authors： Baek JE,Yang WS,Chang JW,Kim SB,Park SK,Park JS,Lee SK

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:The biological properties of oxidized and non-oxidized PTH are substantially different. Oxidized PTH (oxPTH) loses its PTH receptor-stimulating properties, whereas non-oxidized PTH (n-oxPTH) is a full agonist of the receptor. This was described in more than 20 well published studies in the 1970(s) and 80(s)....

journal_title：Kidney & blood pressure research

authors： Hocher B,Oberthür D,Slowinski T,Querfeld U,Schaefer F,Doyon A,Tepel M,Roth HJ,Grön HJ,Reichetzeder C,Betzel C,Armbruster FP

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND/AIMS:The aim of our study was to retrospectively analyse data of 520 Czech patients with IgA nephropathy (IgAN) and to specify the risk factors affecting renal survival of IgAN patients. METHODS:Cox proportional hazards regression model was used to evaluate the effects of different variables on renal surviv...

journal_title：Kidney & blood pressure research

authors： Maixnerova D,Neprasova M,Skibova J,Mokrisova J,Rysava R,Reiterova J,Jancova E,Merta M,Zadrazil J,Honsova E,Tesar V

更新日期：2014-01-01 00:00:00

abstract：UNLABELLED:Anaemia is frequently found in patients with chronic heart failure (CHF) and has been associated with an increase in mortality and morbidity, impaired cardiac and renal function and a reduced quality of life (QoL) compared with non-anaemic CHF patients. Correction of anaemia with recombinant human erythropoi...

journal_title：Kidney & blood pressure research

authors： Silverberg DS,Wexler D,Blum M,Iaina A,Sheps D,Keren G,Scherhag A,Schwartz D

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND/AIMS:The presence of protein-energy wasting (PEW) among dialysis patients is a crucial risk factor for outcomes. The complicated pathogenesis of PEW makes it difficult to assess and treat. This single-center retrospective study focuses on the association between nutritional markers and the outcomes of contin...

journal_title：Kidney & blood pressure research

authors： Yan X,Yang X,Xie X,Xiang S,Zhang X,Shou Z,Chen J

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND AND AIM:Cinacalcet effectively reduces calcium in patients with persistent hyperparathyroidism (HPT) after kidney transplantation. We aimed to assess the association of cinacalcet with a decrease in renal function based on a meta-analysis of observational studies in kidney transplant patients with persistent...

journal_title：Kidney & blood pressure research

authors： Henschkowski J,Bischoff-Ferrari HA,Wüthrich RP,Serra AL

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND/AIMS:The contribution of preexisting hypercholesterolemia to diabetic nephropathy remains unclear. We assessed the impact of hypercholesterolemia on diabetic nephropathy using a double knockout (DKO) mouse, null for the low-density lipoprotein receptor (LDLRNDASH;/NDASH;) and the apoB mRNA editing catalytic ...

journal_title：Kidney & blood pressure research

authors： Hammad SM,Hazen-Martin DJ,Sohn M,Eldridge L,Powell-Braxton L,Won W,Lyons TJ

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND/AIMS:Acute kidney injury (AKI) is a serious complication of sepsis and has a high morbidity and mortality rate. Caspase-11 induces pyroptosis, a form of programmed cell death that plays a critical role in endotoxic shock, but its role in tubular epithelial cell death and whether it contributes to sepsis-asso...

journal_title：Kidney & blood pressure research

authors： Ye Z,Zhang L,Li R,Dong W,Liu S,Li Z,Liang H,Wang L,Shi W,Malik AB,Cheng KT,Liang X

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND/AIMS:The role of COX-2 for renal function during renal development, for physiology and pathophysiology of renal diseases and the side effects of available COX-2 inhibitors, has gained increasing interest. We aimed therefore to review the respective role of renal COX-2. METHODS:Review of relevant recent publ...

journal_title：Kidney & blood pressure research

authors： Krämer BK,Kammerl MC,Kömhoff M

更新日期：2004-01-01 00:00:00

abstract：:The value of neutrophil-gelatinase-associated lipocalin (NGAL) was highlighted as a novel biomarker for the detection of acute renal failure. We tested the hypothesis whether NGAL could represent an early biomarker of contrast-induced nephropathy (CIN) in 100 patients with normal serum creatinine values undergoing per...

journal_title：Kidney & blood pressure research

authors： Bachorzewska-Gajewska H,Malyszko J,Sitniewska E,Malyszko JS,Pawlak K,Mysliwiec M,Lawnicki S,Szmitkowski M,Dobrzycki S

更新日期：2007-01-01 00:00:00