Abstract:
BACKGROUND AND AIM:Cinacalcet effectively reduces calcium in patients with persistent hyperparathyroidism (HPT) after kidney transplantation. We aimed to assess the association of cinacalcet with a decrease in renal function based on a meta-analysis of observational studies in kidney transplant patients with persistent HPT. METHOD:Meta-analysis of observational studies, no randomized controlled studies were available. We calculated the mean difference between renal function before cinacalcet and at 3 months on cinacalcet treatment for each study. Pooled analyses are based on random effects models. RESULTS:Pooling the studies on kidney transplant patients with persistent HPT (8 studies, n = 115), we found a significant reduction in renal function (p = 0.008). The effect size was 5 μmol/l (p < 0.0001) when pooling the 7 studies where serum creatinine levels were reported. Meta-regression analysis revealed that there was an association between renal function and the amount of calcium reduction under treatment with cinacalcet. A higher delta change in serum calcium levels was associated with a decrease in renal function at 3 months of cinacalcet treatment. CONCLUSION:Cinacalcet treatment was associated with a decline of renal function in kidney transplant recipients with persistent HPT. Our meta-analysis underscores the need for frequent monitoring of creatinine and calcium levels during cinacalcet treatment.
journal_name
Kidney Blood Press Resjournal_title
Kidney & blood pressure researchauthors
Henschkowski J,Bischoff-Ferrari HA,Wüthrich RP,Serra ALdoi
10.1159/000323902subject
Has Abstractpub_date
2011-01-01 00:00:00pages
97-103issue
2eissn
1420-4096issn
1423-0143pii
000323902journal_volume
34pub_type
杂志文章,meta分析abstract:BACKGROUND/AIMS:Lipopolysaccharides (LPS) binding to Toll-like receptor 4 (TLR4) activate NADPH oxidase gp91 subunit-mediated inflammation and oxidative damage. Recognizing the high binding affinity of sialic acid (SA) with LPS, we further explored the preventive potential of SA pretreatment on LPS-evoked acute renal f...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000443430
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abstract::In the Prague hypertensive rat (PHR), a strain of genetic hypertension derived from Wistar, administration of various antihypertensive drugs (AHD) during the developmental phase of hypertension (weeks 5-9 of life) prevents the rise of blood pressure. However, only drugs blocking the renin-angiotensin system (RAS, i.e....
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000025898
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abstract:BACKGROUND:Studies have demonstrated that cholesterol variability is an independent predictor of cerebrovascular and cardiovascular events. OBJECTIVE:This study aimed to investigate the association of visit-to-visit variability in total cholesterol (TC) with kidney decline in a Chinese community-based population. MET...
journal_title:Kidney & blood pressure research
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journal_title:Kidney & blood pressure research
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journal_title:Kidney & blood pressure research
pub_type: 杂志文章
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abstract::Cardiovascular (CV) morbidity and mortality is greatly enhanced in patients with chronic kidney disease, compared to the non-renal population. One key element of this high CV burden appears to be arterial stiffness, as an expression of premature vascular aging. Increased arterial stiffness in renal patients may be a c...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章,评审
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abstract:BACKGROUND/AIMS:Calcium sensing receptor (CaSR) is expressed, among others also in testis. Cinacalcet binds to the CaSR, increases sensitivity of CaSR to serum calcium and is used in the treatment of secondary hyperparathyroidism (sHPT) in chronic hemodialysis patients (HDP). In most of male HDP, serum testosterone con...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000368541
更新日期:2016-01-01 00:00:00
abstract::Fibroblast growth factor 23 (FGF23) is released primarily from osteoblasts/osteocytes in bone. In cooperation with the transmembrane protein Klotho, FGF23 is a powerful inhibitor of 1α 25OH Vitamin D Hydroxylase (Cyp27b1) and thus of the formation of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3). As 1,25(OH)2D3 up-regulates ...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章,评审
doi:10.1159/000495393
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND/AIM:Serum gamma-glutamyltransferase (GGT), a biomarker of oxidative stress, is associated with an increased risk of diabetes and hypertension. However, it is not known whether higher serum GGT is independently associated with chronic kidney disease (CKD). Therefore, we examined the association between serum ...
journal_title:Kidney & blood pressure research
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doi:10.1159/000274463
更新日期:2010-01-01 00:00:00
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journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000054225
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abstract:BACKGROUND/AIMS:The WNK-dependent STE20/SPS1-related proline/alanine-rich kinase SPAK participates in the regulation of NaCl and Na(+),K(+),2Cl(-) cotransport and thus renal salt excretion. The present study explored whether SPAK has similarly the potential to regulate the epithelial Na(+) channel (ENaC). METHODS:ENaC...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000368509
更新日期:2015-01-01 00:00:00
abstract:BACKGROUNDS:ANCA-associated vasculitis (AAV) frequently present with a chronic relapsing course. Relapse leads to an increased need for therapeutic agents and consequent toxicity. SUMMARY:When referring to the available options for the management of AAV, the efficacy of glucocorticoids (GCs) is unquestionable. However...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章,评审
doi:10.1159/000509608
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND/AIMS:Interleukin (IL)-18, a member of the IL-1 cytokine superfamily, is recognized as an important regulator of immune responses. The aim of our study was to investigate the IL-18 levels in serum and urine from children with idiopathic nephrotic syndrome (INS) during relapse and remission, and to evaluate th...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000124284
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND/AIMS:High mobility group box 1 (HMGB1) is an important mediator of the inflammatory response. It has been implicated in the pathogenesis of autoimmune diseases, atherosclerosis, and obesity. However, the effects of HMGB1 on diabetic nephropathy remain unclear. Here, we investigated the potential roles and me...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000485045
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abstract:BACKGROUND/AIMS:Lung dysfunction associates with increased mortality but the impact of chronic kidney disease (CKD) is less clear. We evaluated lung function and its association with mortality among individuals with normal to severely reduced glomerular filtration rate (GFR). METHODS:404 individuals representing GFR c...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000488699
更新日期:2018-01-01 00:00:00
abstract::The effects on glomerular hemodynamics of angiotensin-converting enzyme (ACE) inhibition with captopril and of angiotensin II receptor blockade with EXP 3174, an active metabolite of losartan, either alone or in combination, were compared in anesthetized dogs. Administration of EXP 3174 intrarenally led to an increase...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000174256
更新日期:1997-01-01 00:00:00
abstract::Primary cardiac hemangioma is a very rare benign vascular tumor, with valvular hemangiomas being even less frequent as valves are generally avascular structures. We present the first case of mitral valve hemangioma in a renal transplant recipient. Patient presented with progressive dyspnea. Transesophageal echocardiog...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章,评审
doi:10.1159/000343395
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND/AIMS:Diabetes mellitus can exacerbate renal ischemia-reperfusion (I/R) injury (RI/RI). The aim of the present study was to evaluate the protective effect of GSK-3β inhibition (TDZD-8) on I/R-induced renal injury through the Nrf2/HO-1 pathway in a streptozocin (STZ)-induced diabetic rat model. METHODS:STZ-in...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000477947
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND/AIMS:The contribution of preexisting hypercholesterolemia to diabetic nephropathy remains unclear. We assessed the impact of hypercholesterolemia on diabetic nephropathy using a double knockout (DKO) mouse, null for the low-density lipoprotein receptor (LDLRNDASH;/NDASH;) and the apoB mRNA editing catalytic ...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000073942
更新日期:2003-01-01 00:00:00
abstract::The aim of this study was to investigate whether the renoprotective effect of angiotensin-converting enzyme inhibitors (ACEIs) following 5/6 renal mass reduction is due in part to the potentiation of kinins. Three groups of rats with 5/6 renal mass reduction were studied during the 14 weeks following surgery. One grou...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000025890
更新日期:1998-01-01 00:00:00
abstract:AIM:This study investigated the impact of hypertension combined with diabetic nephropathy on rat renal alpha(1)-adrenoceptor subtype composition. METHODS:In streptozotocin-induced diabetic spontaneously hypertensive rats (SHR), diabetic nephropathy developed as reflected by increased kidney index, plasma creatinine, a...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000249149
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND/AIMS:Angiotensin converting enzyme 2 (ACE2) is highly expressed in the kidney and recognized to be renoprotective by degrading Angiotensin II to Angiotensin (1-7) in diabetic nephropathy. However, little is known about the role of urinary ACE2 (UACE2) in diabetes. The present study was performed to evaluate ...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000368486
更新日期:2015-01-01 00:00:00
abstract:INTRODUCTION:Diabetic nephropathy (DN) is a serious complication of diabetes mellitus and is considered to be a sterile inflammatory disease. Increasing evidence suggest that pyroptosis and subsequent inflammatory response play a key role in the pathogenesis of DN. However, the underlying cellular and molecular mechani...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000508372
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND/AIMS:Renalase (gene name RNLS), a recently discovered enzyme with monoamine oxidase activity, is implicated in the degradation of catecholamines. Recent studies indicate that common variations in the gene with RNLS are associated with hypertension. The aim of this study was to examine the association between...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000368460
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND/AIM:Calcifications of large arteries are frequent in chronic kidney disease (CKD) and may contribute to the high cardiovascular risk in this population. The aim of this study was to examine whether abdominal aortic calcification volume (AACV) was a predictor of the rate of decline in glomerular filtration ra...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000501687
更新日期:2019-01-01 00:00:00
abstract::Backgroud/Aims: The aim of this study was to investigate the potential renoprotective effect of rapamycin on the autophagy of podocytes treated with the supernatant of mesangial cells cultured with aggregated IgA1 (aIgA1) from immunoglobulin A nephropathy (IgAN) patients. METHODS:Monomeric IgA1 (mIgA1) was isolated f...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000475484
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND/AIMS:Refugee dialysis is a worldwide growing dilemma with limited experience. This report presents the largest hemodialysis (HD) patient registry data of Syrian refugees in Turkey. METHODS:Demographic, clinical, laboratory, and dialysis practice data of 345 Syrian HD patients during one year were collected ...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000498832
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journal_title:Kidney & blood pressure research
pub_type: 杂志文章,meta分析,评审
doi:10.1159/000450567
更新日期:2016-01-01 00:00:00
abstract::Recently, Chlamydia pneumoniae is the microorganism frequently implicated in the infection-based inflammatory atherogenous hypothesis. Although in vitro experimental data and initial sero-epidemiologic, pathology-based studies and antibiotic trials supported this interesting hypothesis, later data are conflicting. Som...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章,评审
doi:10.1159/000078146
更新日期:2004-01-01 00:00:00
abstract::Although primary cilia are increasingly recognized to play sensory roles in several cellular systems, their role in vascular smooth muscle cells (VSMCs) has not been defined. We examined in situ position/orientation of primary cilia and ciliary proteins in VSMCs and tested the hypothesis that primary cilia of VSMCs ex...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000132462
更新日期:2008-01-01 00:00:00