Association between serum gamma-glutamyltransferase and chronic kidney disease among US adults.

Abstract:

BACKGROUND/AIM:Serum gamma-glutamyltransferase (GGT), a biomarker of oxidative stress, is associated with an increased risk of diabetes and hypertension. However, it is not known whether higher serum GGT is independently associated with chronic kidney disease (CKD). Therefore, we examined the association between serum GGT levels and CKD in a representative sample of US adults. METHODS:We conducted a cross-sectional study of 9,516 National Health and Nutrition Examination Survey 1999-2002 participants >or=18 years of age (52.40% women). Serum GGT was categorized into quartiles for the analysis. CKD (n = 622) was defined as an estimated glomerular filtration rate of <60 ml/min/1.73 m(2). RESULTS AND CONCLUSION:Higher serum GGT levels were not associated with CKD after adjusting for age, sex, race/ethnicity, education levels, smoking, alcohol intake, body mass index (BMI), diabetes, hypertension and serum cholesterol. Compared to quartile 1 of GGT, the odds ratio (95% confidence interval) of CKD associated with quartile 4 was 1.02 (0.81-1.28); p trend = 0.377. Subgroup analyses that examined the relation between GGT and CKD by gender, alcohol intake, and BMI categories also showed a consistent null association. In summary, there was no association between increasing levels of serum GGT and CKD in a sample of US adults.

journal_name

Kidney Blood Press Res

authors

Teppala S,Shankar A,Li J,Wong TY,Ducatman A

doi

10.1159/000274463

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

1-6

issue

1

eissn

1420-4096

issn

1423-0143

pii

000274463

journal_volume

33

pub_type

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