Abstract:
BACKGROUND/AIMS:The metabolic syndrome (MetS), as assessed using dichotomous criteria, is associated with increased risk of future chronic kidney disease (CKD), though this relationship is unclear among African Americans, who have lower risk for MetS but higher risk for CKD. METHODS:We performed logistic regression using a sex- and race-specific MetS-severity z-score to assess risk of incident CKD among 2,627 African-American participants of the Jackson Heart Study, assessed at baseline and 8 years later. Based on quartile of baseline MetS severity, we further assessed prevalence of being in the lowest quartile of baseline GFR, the lowest quartile of relative GFR at follow-up, microalbuminuria and incident CKD. RESULTS:Higher MetS-severity was associated with higher prevalence of GFR in the lowest quartile at baseline among males and females. Among African-American females but not males, higher baseline MetS-severity was associated with a higher prevalence of baseline elevations in microabuminuria (p<0.01), steep decline in GFR (p<0.001) and a higher incidence of CKD (p<0.0001). Women in increasing quartiles of baseline MetS-severity exhibited a linear trend toward higher odds of future CKD (p<0.05), with those in the 4th quartile of MetS-severity (compared to the 1st) having an odds ratio of 2.47 (95% confidence interval 1.13, 5.37); no such relationship was seen among men (p value for trend 0.49). CONCLUSION:MetS-severity exhibited sex-based interactions regarding risk for future GFR deterioration and CKD, with increasing risk in women but not men. These data may have implications for triggering CKD screening among African-American women with higher degrees of MetS-severity.
journal_name
Kidney Blood Press Resjournal_title
Kidney & blood pressure researchauthors
DeBoer MD,Filipp SL,Musani SK,Sims M,Okusa MD,Gurka Mdoi
10.1159/000488829subject
Has Abstractpub_date
2018-01-01 00:00:00pages
555-567issue
2eissn
1420-4096issn
1423-0143pii
000488829journal_volume
43pub_type
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journal_title:Kidney & blood pressure research
pub_type: 临床试验,杂志文章
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journal_title:Kidney & blood pressure research
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journal_title:Kidney & blood pressure research
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journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000483023
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journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000098435
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journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000450561
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journal_title:Kidney & blood pressure research
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doi:10.1159/000054213
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journal_title:Kidney & blood pressure research
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journal_title:Kidney & blood pressure research
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journal_title:Kidney & blood pressure research
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journal_title:Kidney & blood pressure research
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journal_title:Kidney & blood pressure research
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journal_title:Kidney & blood pressure research
pub_type: 杂志文章
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journal_title:Kidney & blood pressure research
pub_type: 杂志文章
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