Functional subtypes of renal alpha1-adrenoceptor in spontaneously hypertensive rats with streptozotocin-induced experimental diabetic nephropathy.

abstract：BACKGROUND/AIMS:The WNK-dependent STE20/SPS1-related proline/alanine-rich kinase SPAK participates in the regulation of NaCl and Na(+),K(+),2Cl(-) cotransport and thus renal salt excretion. The present study explored whether SPAK has similarly the potential to regulate the epithelial Na(+) channel (ENaC). METHODS:ENaC...

journal_title：Kidney & blood pressure research

authors： Ahmed M,Salker MS,Elvira B,Umbach AT,Fakhri H,Saeed AM,Shumilina E,Hosseinzadeh Z,Lang F

更新日期：2015-01-01 00:00:00

abstract：:Cardiovascular (CV) morbidity and mortality is greatly enhanced in patients with chronic kidney disease, compared to the non-renal population. One key element of this high CV burden appears to be arterial stiffness, as an expression of premature vascular aging. Increased arterial stiffness in renal patients may be a c...

journal_title：Kidney & blood pressure research

authors： Gusbeth-Tatomir P,Covic A

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND/AIMS:The role of COX-2 for renal function during renal development, for physiology and pathophysiology of renal diseases and the side effects of available COX-2 inhibitors, has gained increasing interest. We aimed therefore to review the respective role of renal COX-2. METHODS:Review of relevant recent publ...

journal_title：Kidney & blood pressure research

authors： Krämer BK,Kammerl MC,Kömhoff M

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND/AIMS:The kidney plays a critical role in the control of blood pressure and its elevation in salt-induced hypertension. Mitochondrial dysfunction, especially in energy metabolism, has been associated with hypertension. Here, we aimed to investigate mitochondrial function and metabolic features in renal mitoch...

journal_title：Kidney & blood pressure research

authors： Wang Z,Sun Q,Sun N,Liang M,Tian Z

更新日期：2017-01-01 00:00:00

abstract：:Currently, the pathogenesis of nondipper hypertension remains largely unclear in patients without any renal or endocrine pathology. It is well known that overt hypothyroidism is strongly associated with diastolic hypertension. However, no study has addressed the pathogenic role of TSH, free T3 (FT3), and free T4 (FT4)...

journal_title：Kidney & blood pressure research

authors： Kanbay M,Turgut F,Karakurt F,Isik B,Alkan R,Akcay A,Yigitoglu R,Covic A

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND/AIMS:The presence of protein-energy wasting (PEW) among dialysis patients is a crucial risk factor for outcomes. The complicated pathogenesis of PEW makes it difficult to assess and treat. This single-center retrospective study focuses on the association between nutritional markers and the outcomes of contin...

journal_title：Kidney & blood pressure research

authors： Yan X,Yang X,Xie X,Xiang S,Zhang X,Shou Z,Chen J

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND/AIMS:ET-1 has independent effects on blood pressure regulation in vivo, it is involved in tubular water and salt excretion, promotes constriction of smooth muscle cells, modulates sympathetic nerve activity, and activates the liberation of nitric oxide. To determine the net effect of these partially countera...

journal_title：Kidney & blood pressure research

authors： Lu YP,Tsuprykov O,Vignon-Zellweger N,Heiden S,Hocher B

更新日期：2016-01-01 00:00:00

abstract：BACKGROUNDS:ANCA-associated vasculitis (AAV) frequently present with a chronic relapsing course. Relapse leads to an increased need for therapeutic agents and consequent toxicity. SUMMARY:When referring to the available options for the management of AAV, the efficacy of glucocorticoids (GCs) is unquestionable. However...

journal_title：Kidney & blood pressure research

authors： Fenoglio R,Roccatello D,Sciascia S

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Renal involvement in Takayasu's arteritis (TA) effects the disease outcome and endovascular treatment is an effective treatment of choice. We investigated nitric oxide (NO) levels and the effect of endovascular treatment in renovascular hypertensive TA patients. METHODS:In five hypertensive patients with re...

journal_title：Kidney & blood pressure research

authors： Parildar Z,Gulter C,Parildar M,Oran I,Erdener D,Memis A

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND AND METHODS:We investigated kidney function, renal endothelin-1 concentration, prepro-endothelin-1 mRNA as well as endothelin receptor A and B mRNA expression and receptor properties in normotensive Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHR) with intact renal nerves and 7 days after re...

journal_title：Kidney & blood pressure research

authors： Girchev RA,Bäcker A,Markova PP,Kramer HJ

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND/AIMS:Angiotensin converting enzyme 2 (ACE2) is highly expressed in the kidney and recognized to be renoprotective by degrading Angiotensin II to Angiotensin (1-7) in diabetic nephropathy. However, little is known about the role of urinary ACE2 (UACE2) in diabetes. The present study was performed to evaluate ...

journal_title：Kidney & blood pressure research

authors： Liang Y,Deng H,Bi S,Cui Z,A L,Zheng D,Wang Y

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND/AIM:Calcifications of large arteries are frequent in chronic kidney disease (CKD) and may contribute to the high cardiovascular risk in this population. The aim of this study was to examine whether abdominal aortic calcification volume (AACV) was a predictor of the rate of decline in glomerular filtration ra...

journal_title：Kidney & blood pressure research

authors： Jansson H,Saeed A,Svensson MK,Finnved K,Hellström M,Guron G

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVE:Co-deposition of mannose-binding lectin (MBL) and IgG4 anti-phospholipase A2 receptor (anti-PLA2R) autoantibodies under subepithelial cells has been observed in patients with idiopathic membranous nephropathy (iMN), but the relationships of MBL deposition to iMN severity and progression remain unclear. METHO...

journal_title：Kidney & blood pressure research

authors： Zhang Y,Liu Y,Liang L,Liu L,Tang X,Tang L,Chen P,Chen J,Wang Z,Cao W,Chen Q,Zhao N,Xu D

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND/AIMS:Hypertensive patients present with increased oxidative stress and frequently receive angiotensin II (ANGII) receptor type I blockers (ARB) for blood pressure (BP) reduction. Recent studies revealed an important role of ANGII in maintaining vascular oxidative homeostasis, including sustaining normal sodi...

journal_title：Kidney & blood pressure research

authors： Mihalj M,Tadzic R,Vcev A,Rucevic S,Drenjancevic I

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND/AIMS:Puumala virus causes nephropathia epidemica (NE), a milder form of hemorrhagic fever with renal syndrome that occurs in Central and Northern Europe. Several studies have sought to identify risk factors for severe NE. However, elevated procalcitonin (PCT) levels have not previously been investigated as a...

journal_title：Kidney & blood pressure research

authors： Latus J,Kitterer D,Segerer S,Artunc F,Alscher MD,Braun N

更新日期：2015-01-01 00:00:00

abstract：:NGAL (neutrophil gelatinase-associated lipocalin) is an acute phase protein, participating in antibacterial immunity. NGAL forms a complex with metalloproteinase 9 (MMP-9), thereby increasing its activity and preventing its degradation. NGAL is freely filtered through the glomerular membrane and reabsorbed by endocyto...

journal_title：Kidney & blood pressure research

authors： Helanova K,Spinar J,Parenica J

更新日期：2014-01-01 00:00:00

abstract：:Inhibitors of angiotensin-converting enzyme (ACE) or beta isoforms of protein kinase C (PKC) are nephroprotective in diabetes mellitus. We investigated the influence of streptozotocin (STZ)-induced diabetes mellitus and of treatment with the ACE inhibitor lisinopril (4 mg/kg p.o. twice daily for 4 weeks) on the expres...

journal_title：Kidney & blood pressure research

authors： Pfaff IL,Vallon V

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND/AIMS:This study aimed to investigate the potential beneficial anti-proteinuric effect of an add-on aldosterone blockade and the impact of the aldosterone escape phenomenon. METHODS:We retrospectively analyzed data of 304 patients with persistent proteinuria, who were administered spironolactone (25 mg/day) ...

journal_title：Kidney & blood pressure research

authors： Kim HY,Bae EH,Ma SK,Kim SW

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND/AIM:Serum gamma-glutamyltransferase (GGT), a biomarker of oxidative stress, is associated with an increased risk of diabetes and hypertension. However, it is not known whether higher serum GGT is independently associated with chronic kidney disease (CKD). Therefore, we examined the association between serum ...

journal_title：Kidney & blood pressure research

authors： Teppala S,Shankar A,Li J,Wong TY,Ducatman A

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND/AIMS:To determine the effect of arterial blood pressure (BP) reduction on endocan and soluble cell adhesion molecules' (sCAM) plasma concentration and expression of their ligands on circulatory leukocyte subpopulations. METHODS:24 hypertensive subjects of both sexes (age: 53±8 yrs) were treated with Ca-chan...

journal_title：Kidney & blood pressure research

authors： Tadzic R,Mihalj M,Vcev A,Ennen J,Tadzic A,Drenjancevic I

更新日期：2013-01-01 00:00:00

abstract：:The effects on glomerular hemodynamics of angiotensin-converting enzyme (ACE) inhibition with captopril and of angiotensin II receptor blockade with EXP 3174, an active metabolite of losartan, either alone or in combination, were compared in anesthetized dogs. Administration of EXP 3174 intrarenally led to an increase...

journal_title：Kidney & blood pressure research

authors： Heller J,Kramer HJ,Horácek V

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:Treating non-diabetic proteinuric patients with advanced renal disease with an angiotensin-converting enzyme (ACE) inhibitor is still subject to discussion. This study aims to determine the cost-effectiveness of ACE inhibitor therapy in this patient population in the Netherlands. METHODS:We compared two str...

journal_title：Kidney & blood pressure research

authors： Adarkwah CC,Gandjour A,Akkerman M,Evers S

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND/AIMS:The association between ACYP2(Acylphosphatase 2) polymorphisms and immunoglobulin A nephropathy (IgAN) risk in the Chinese Han population remains unclear. We aimed to evaluate the association between ACYP2 polymorphisms and IgAN risk by performing a case-control study. METHODS:Eleven ACYP2 single nucle...

journal_title：Kidney & blood pressure research

authors： Jin G,Liang Y,Yan X,Zhang L,Li Z,Yin A,Wang X,Tian P

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND AND AIM:Cinacalcet effectively reduces calcium in patients with persistent hyperparathyroidism (HPT) after kidney transplantation. We aimed to assess the association of cinacalcet with a decrease in renal function based on a meta-analysis of observational studies in kidney transplant patients with persistent...

journal_title：Kidney & blood pressure research

authors： Henschkowski J,Bischoff-Ferrari HA,Wüthrich RP,Serra AL

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Cardiovascular complications are a major cause of morbidity and mortality in chronic renal failure (CRF) patients. Chronic anemia is a complication of CRF and a cardiovascular risk factor per se. It was the aim of the present study to clarify whether uremia and anemia are additive or supra-additive with resp...

journal_title：Kidney & blood pressure research

authors： Jürgensen JS,Grimm R,Benz K,Philipp S,Eckardt KU,Amann K

更新日期：2010-01-01 00:00:00

abstract：:To clarify whether the ovaries have a potential to attenuate the aggravating effect of testosterone (T) on glomerular injury, we investigated the effect of T in female rats with or without ovaries, using Adriamycin (ADR)-induced nephropathy in female Sprague-Dawley rats. Group 1 consisted of female control rats, group...

journal_title：Kidney & blood pressure research

authors： Sakemi T,Ohtsuka N,Tomiyoshi Y,Morito F

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND/AIMS:Calcium sensing receptor (CaSR) is expressed, among others also in testis. Cinacalcet binds to the CaSR, increases sensitivity of CaSR to serum calcium and is used in the treatment of secondary hyperparathyroidism (sHPT) in chronic hemodialysis patients (HDP). In most of male HDP, serum testosterone con...

journal_title：Kidney & blood pressure research

authors： Kuczera P,Adamczak M,Wiecek A

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND/AIMS:To date, there is no imaging technique to assess tubular function in vivo. Blood oxygen level-dependent magnetic resonance imaging (BOLD MRI) measures tissue oxygenation based on the transverse relaxation rate (R2*). The present study investigates whether BOLD MRI can assess tubular function using a tub...

journal_title：Kidney & blood pressure research

authors： Bauer F,Wald J,Bauer FJ,Dahlkamp LM,Seibert FS,Pagonas N,Gedat E,Babel N,Zidek W,von Bodman C,Noldus J,Liermann D,Westhoff TH

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:In the Chronic REnal Disease in Turkey-CREDIT Study, a large populationbased study on 10,748 adults, the prevalence of chronic kidney disease (CKD) and relationship between CKD and other cardiovascular risk factors had been studied. METHODS:This report presents the results of CREDIT study on the prevalence,...

journal_title：Kidney & blood pressure research

authors： Altun B,Süleymanlar G,Utaş C,Arınsoy T,Ateş K,Ecder T,Camsarı T,Serdengeçti K

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Cardiovascular disease caused by atherosclerosis remains a major cause of morbidity and mortality in patients with end-stage renal disease (ESRD). We evaluated the potential association of cardiovascular risk factors including asymmetric dimethyl L-arginine (ADMA) and the soluble receptor for advanced glycat...

journal_title：Kidney & blood pressure research

authors： Pitha J,Teplan V,Kalousova M,Racek J,Stollova M,Marečková O,Lanska V

更新日期：2010-01-01 00:00:00